Article
Transplantation
Eri Ataka, Yuta Matsukuma, Kenji Ueki, Akihiro Tsuchimoto, Yasuhiro Okabe, Kosuke Masutani, Masafumi Nakamura, Toshiaki Nakano, Takanari Kitazono
Summary: This study found that smoking is associated with subclinical pathological injury in the kidneys, specifically renal arteriolar hyalinization and glomerular ischemia. The risk of these pathological changes increases with longer smoking duration and higher smoking pack-years. However, smoking is not associated with intimal thickening of small-medium arteries and interstitial fibrosis and tubular atrophy.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Gertjan Lugthart, Carlijn C. E. Jordans, Anne P. J. de Pagter, Dorine Bresters, Cornelia M. Jol-van der Zijde, Joell E. Bense, Roos W. G. van Rooij-Kouwenhoven, Ram N. Sukhai, Marloes Louwerens, Eiske M. Dorresteijn, Arjan C. Lankester
Summary: This study evaluated pediatric HSCT survivors and found that within ten years post-HSCT, eGFR decreased and 17% of patients developed CKD, with severe prolonged AKI being the main risk factor. Regular monitoring of eGFR, urine, and blood pressure is crucial for identifying patients at risk of CKD and providing nephroprotective interventions.
KIDNEY INTERNATIONAL
(2021)
Review
Immunology
Xinyin Liu, Xiaoran Wang, Peipei Zhang, Yiwen Fang, Yanyan Liu, Yueyue Ding, Wen Zhang
Summary: In recent years, there has been increasing interest in the role of intestinal homeostasis in health and its complex interactions with other organs. This review aims to elucidate the new mechanisms underlying immune-related chronic kidney diseases (CKD). The findings suggest that the gut-lung-kidney axis plays a significant role in the development of CKD, with the lungs affecting kidney function through intestinal mediation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Jose Manuel Munoz-Terol, Jose L. Rocha, Pablo Castro-de La Nuez, Emilio Garcia-Cabrera, Angel Vilches-Arenas
Summary: Chronic kidney disease is a non-communicable disease that is growing rapidly in terms of morbidity and mortality. Renal transplantation is the first choice for end-stage kidney disease patients, while dialysis is an alternative. This study aims to assess the potential years of life lost by patients on renal replacement therapy. The average potential years of life lost for dialysis patients is 9.0 years, while this figure decreases to 2.2 years for kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Sergi Codina, Anna Manonelles, Maria Tormo, Anna Sola, Josep M. Cruzado
Summary: Chronic kidney disease is on the rise globally, with kidney transplantation being the preferred choice for renal replacement therapy. Despite advancements, kidney allograft functional deterioration after transplantation remains a challenge. Clinical advances in improving long-term kidney allograft survival have been limited, indicating the need for new approaches and a holistic view to address CKaD.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Samantha Sze-Yee Lee, Darren John Beales, Fred K. Chen, Seyhan Yazar, David Alonso-Caneiro, David A. Mackey
Summary: Inflammation and cigarette smoking are associated with macular diseases, choroidal and retinal thinning. A study found that participants with increasing or high CRP trajectories had thinner choroids, and every additional pack-year smoked was linked to thinner retinas, indicating a dose-dependent relationship. These associations suggest an increased risk of future visual impairment or eye disease associated with these risk factors since young adulthood.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Taehee Kim, Sang Hyuk Kim, Hayoung Choi, Tae Rim Shin, Hwan Il Kim, Seung Hun Jang, Ji Young Hong, Myung Goo Lee, Soojie Chung, In Gyu Hyun, Yun Su Sim
Summary: The clinical outcomes of lung cancer patients with chronic kidney disease (CKD) are controversial, and there is insufficient evidence regarding the treatment and prognosis of lung cancer in patients with CKD. This study evaluated the clinical course and prognostic factors of moderate CKD patients with lung cancer.
Review
Environmental Sciences
Yue Chen, Fan Cao, Jian-Ping Xiao, Xin-Yu Fang, Xue-Rong Wang, Li-Hong Ding, De-Guang Wang, Hai-Feng Pan
Summary: Chronic kidney disease is closely associated with air pollution exposure, which can increase the risk of CKD incidence and progression, as well as worsen kidney damage in ESKD patients. Air pollutants may exacerbate kidney damage through various mechanisms such as elevated blood pressure, worsening oxidative stress and inflammatory response.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Barbara Infante, Francesco Bellanti, Michele Correale, Paola Pontrelli, Rossana Franzin, Serena Leo, Martina Calvaruso, Silvia Mercuri, Giuseppe Stefano Netti, Elena Ranieri, Natale Daniele Brunetti, Giuseppe Grandaliano, Loreto Gesualdo, Gaetano Serviddio, Giuseppe Castellano, Giovanni Stallone
Summary: This study demonstrated that the use of mTOR inhibitors in immunosuppressive protocols can prevent the occurrence and signs of cardiovascular aging in kidney transplant recipients.
Letter
Medicine, General & Internal
Brendon G. Neuen, Robert Fletcher, Hiddo J. L. Heerspink
Summary: The editorial suggests that the benefit of empagliflozin in slowing the progression of chronic kidney disease is less evident among patients who do not receive RAS blockade. This is because this subgroup only accounts for 15% of the overall trial population, resulting in less precise effect estimates and wider confidence intervals.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Paulina Mertowska, Sebastian Mertowski, Iwona Smarz-Widelska, Ewelina Grywalska
Summary: The increasing number of late-diagnosed kidney disease patients has become a serious problem affecting people from all backgrounds. The full etiology of this issue is not yet fully understood, although genetic susceptibility, infections, immune disorders, or high blood pressure have been suggested as contributing factors. Difficulties in timely and accurate diagnosis are due to the lack of research on early molecular markers and insufficient educational and preventive efforts among the public, resulting in delayed detection of kidney diseases. Interleukins play an important role in homeostasis and disease progression, including kidney diseases, by performing various biological functions and interacting with other cells and tissues in the body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Theodoros Tourountzis, Georgios Lioulios, Asimina Fylaktou, Eleni Moysidou, Aikaterini Papagianni, Maria Stangou
Summary: The gut microbiome plays a crucial role in various aspects of human health, including immune system function. Chronic kidney disease has a unique effect on the gut microbiome, leading to the accumulation of harmful metabolites and contributing to the progression of renal failure. Changes in the gut microbiome are observed in patients with end stage renal disease, both during hemodialysis and after kidney transplantation.
Review
Medicine, General & Internal
Kamyar Kalantar-Zadeh, Tazeen H. Jafar, Dorothea Nitsch, Brendon L. Neuen, Vlado Perkovic
Summary: Chronic kidney disease is a progressive disease with no cure, and preserving kidney function through lifestyle adjustments and pharmacological interventions can improve outcomes. A plant-dominant, low-protein, and low-salt diet may help mitigate glomerular hyperfiltration and preserve renal function. Various pharmacotherapies can also be used to alter intrarenal haemodynamics and protect the kidney from further damage.
Article
Medicine, General & Internal
Deok-Gie Kim, Shin Hwang, Jong Man Kim, Je Ho Ryu, Young Kyoung You, Donglak Choi, Bong-Wan Kim, Dong-Sik Kim, Yang Won Nah, Tae-Seok Kim, Jai Young Cho, Geun Hong, Jae Do Yang, Jaryung Han, Suk-Won Suh, Kwan Woo Kim, Yun Kyung Jung, Ju Ik Moon, Jun Young Lee, Sung Hwa Kim, Jae Geun Lee, Myoung Soo Kim, Kwang-Woong Lee, Dong Jin Joo
Summary: This study identified pre- and post-transplant non-renal risk factors for chronic kidney disease (CKD) following liver transplants. Age, gender, body mass index, pre-transplant diabetes, and performance status were found to be baseline risk factors for CKD. Recurrent hepatocellular carcinoma and infection were identified as significant post-transplant risk factors for CKD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nynke Wijbenga, Rogier A. S. Hoek, Bas J. Mathot, Leonard Seghers, Catharina C. Moor, Joachim G. J. V. Aerts, Daniel Bos, Olivier C. Manintveld, Merel E. Hellemons
Summary: Exhaled breath analysis using an electronic nose (eNose) is a promising novel biomarker for the diagnosis and phenotyping of chronic lung allograft dysfunction (CLAD). eNose technology could be a valuable addition to the diagnostic armamentarium for suspected graft failure in lung transplant recipients (LTR).
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Navin Suthahar, Kan Wang, Victor W. Zwartkruis, Stephan J. L. Bakker, Silvio E. Inzucchi, Tim R. Eijgenraam, Fariba Ahmadizar, Eric G. Sijbrands, Ron T. Gansevoort, Lyanne M. Kieneker, Dirk J. van Veldhuisen, Maryam Kavousi, Rudolf A. de Boer
Summary: Relative fat mass (RFM), a novel anthropometric equation based on height and waist measurements, is strongly associated with incident type-2 diabetes (T2D) and shows potential as a predictor of future diabetes risk in the general population, outperforming BMI, waist circumference, and waist-to-hip ratio.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Sonia Roldan Munoz, Douwe Postmus, Sieta T. de Vries, Liana Gross-Martirosyan, Priya Bahri, Hans Hillege, Peter G. M. Mol
Summary: This study explores the differences in the communication of safety issues related to SGLT2 inhibitors among medicines regulatory agencies. The study finds that regulators' opinions on the need to communicate safety issues are influenced by their level of concern. Furthermore, the characteristics of the safety issue, demographic and professional characteristics of the regulators, and their attitudes also influence their level of concern.
Letter
Respiratory System
Cindy M. M. de Jong, Chantal Visser, Remy H. H. Bemelmans, Wim G. Boersma, Bram van den Borst, J. Louise I. Burggraaf, Suzanne C. Cannegieter, Arina J. ten Cate-Hoek, F. Nanne Croles, Harald J. Faber, Laura M. Faber, Merel E. Hellemons, Lisa M. Hessels, Menno Huisman, Pieter W. Kamphuisen, Stephanie C. E. Koster, Lucia J. M. Kroft, Ivo van der Lee, Jenneke Leentjens, Karina Meijer, Maarten K. Ninaber, Brigitte M. Sondermeijer, Susanne Stads, Anton Vonk Noordegraaf, Kristien Winckers, Marieke J. H. A. Kruip, Frederikus A. Klok
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Rehabilitation
L. Martine Bek, Merel E. Hellemons, Julia C. Berentschot, Marieke M. Visser, Susanne M. Huijts, Jasper van Bommel, Michel E. van Genderen, Joachim G. J. Aerts, Gerard M. Ribbers, Rita J. G. van den Berg-Emons, Majanka H. Heijenbrok-Kal, CO FLOW collaboration Grp
Summary: This study evaluated the impact of different care pathways on cognitive and psychological outcomes for COVID-19 survivors. The results showed that there was cognitive and psychological recovery within 6 months after hospitalization, but cognitive deficits persisted at 12 months. Recovery differed depending on the rehabilitation settings, and additional cognitive or psychological support may be necessary for individuals undergoing medical or community-based rehabilitation.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Amaal E. Abdulle, Martin F. Bourgonje, Lyanne M. Kieneker, Sacha la Bastide-van Gemert, Sanne J. Gordijn, Clara Hidden, Tom Nilsen, Ron T. Gansevoort, Douwe J. Mulder, Robin P. F. Dullaart, Martin H. de Borst, Stephan J. L. Bakker, Harry van Goor
Summary: Circulating levels of NGAL are associated with acute kidney injury, severity and progression of CKD. This study investigated NGAL as a potential biomarker for new-onset CKD and found that higher plasma NGAL concentrations are associated with an increased risk of developing CKD in the general population, mainly driven by renal function decline.
Article
Biochemistry & Molecular Biology
Maria Camila Trillos-Almanza, Hanna Wessel, Magnolia Martinez-Aguilar, Eline H. van den Berg, Rianne M. Douwes, Han Moshage, Margery A. Connelly, Stephan J. L. Bakker, Vincent E. de Meijer, Robin P. F. Dullaart, Hans Blokzijl
Summary: Decreased circulating BCAA levels in end-stage liver disease (ESLD) patients are associated with disease severity and impaired muscle function. These findings suggest that BCAA may serve as a useful prognostic marker for assessing liver disease severity.
Article
Biochemistry & Molecular Biology
Manuela Yepes-Calderon, Daan Kremer, Adrian Post, Camilo G. G. Sotomayor, Ulrike Seidel, Patricia Huebbe, Tim J. J. Knobbe, Kai Lueersen, Michele F. F. Eisenga, Eva Corpeleijn, Martin H. H. De Borst, Gerjan J. J. Navis, Gerald Rimbach, Stephan J. L. Bakker
Summary: A study found that kidney transplant recipients have an increased risk of cardiovascular mortality. It also revealed an association between post-transplantation copper status and the risk of cardiovascular mortality, with a potential effect modification by sex. Among male recipients, higher plasma copper concentration was independently associated with a higher risk of cardiovascular mortality, while this association was absent among female recipients.
Letter
Immunology
Sara Biere-Rafi, Kasper Janssen, Ernst Jurgens, Sandra Kooij, Merel Hellemons
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemical Research Methods
Nynke Wijbenga, Marjolein M. Muller, Rogier A. S. Hoek, Bas J. Mathot, Leonard Seghers, Joachim G. J. Aerts, Brenda C. M. de Winter, Daniel Bos, Olivier C. Manintveld, Merel E. Hellemons
Summary: Close monitoring of immunosuppressant levels is essential for preventing complications after lung transplantation. The use of electronic nose technology as a non-invasive alternative for therapeutic drug monitoring shows weak correlation and inaccurate diagnostic and categorization capacity.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Medicine, General & Internal
Evelien E. Quint, Avril J. Haanstra, Yvonne van der Veen, Heleen Maring, Stefan P. Berger, Adelita Ranchor, Stephan J. L. Bakker, Evelyn Finnema, Robert A. Pol, Coby Annema, PreCareTx Investigators
Summary: The study aims to examine the effectiveness of a multimodal prehabilitation programme on the health status of kidney transplant candidates, and to explore the potential of implementing prehabilitation in daily clinical practice. The study will be conducted as a randomized controlled trial, with participants assigned to either a prehabilitation group or a care as usual group. The results of the study will be disseminated at international conferences and in peer-reviewed journals.
Letter
Cardiac & Cardiovascular Systems
Tamas Szili-Torok, Yuanxin Xu, Martin H. H. de Borst, Stephan J. L. Bakker, Uwe J. F. Tietge
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Immunology
Jelle R. Miedema, Matthijs L. Janssen, Jan von der Thuesen, Henrik Endeman, Anton W. Langerak, Merel E. Hellemons, Els van Nood, Bas W. A. Peeters, Sara J. Baart, Marco W. J. Schreurs
Summary: This study aimed to determine whether antibodies against AT1R and ETAR are specifically related to COVID-19 disease pathogenesis or increased during any severe respiratory illness. The results showed significantly increased AT1R and ETAR antibody titers in COVID-19 patients compared to controls, while these titers were not correlated with inflammatory markers or long-term symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Julia C. Berentschot, Hemmo A. Drexhage, Daniel G. Aynekulu Mersha, Annemarie J. M. Wijkhuijs, Corine H. Geurtsvankessel, Marion P. G. Koopmans, Jolanda J. C. Voermans, Rudi W. Hendriks, Nicole M. A. Nagtzaam, Maaike de Bie, Majanka H. Heijenbrok-Kal, L. Martine Bek, Gerard M. Ribbers, Rita J. G. van den Berg-emons, Joachim G. J. V. Aerts, Willem A. Dik, Merel E. Hellemons
Summary: This study investigated the clinical and immune characteristics of fatigued and non-fatigued long COVID patients. The results showed that fatigued patients had more severe clinical profiles and cognitive dysfunction compared to non-fatigued patients. Immune abnormalities, including low-grade inflammation and signs of T-lymphocyte senescence, were found in the entire group of long COVID patients. The severity of fatigue was associated with increased monocyte activation, inflammatory gene expression, and higher CD8(+) T-lymphocyte counts.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Francesco Merlo, Dion Groothof, Farnaz Khatami, Noushin Sadat Ahanchi, Faina Wehrli, Stephan J. L. Bakker, Michele F. Eisenga, Taulant Muka
Summary: The risk of chronic diseases increases with age and after menopause, potentially due to an increase in bodily iron. This study investigated how iron biomarkers change with age, sex, and menopausal status. The results showed that iron accumulates differently depending on sex, age, and menopausal status, with women, especially those in menopause, showing higher iron levels compared to men and premenopausal women.
JOURNAL OF CLINICAL MEDICINE
(2023)
