Article
Infectious Diseases
Hugo Testaert, Margaux Bouet, Florent Valour, Anne Gigandon, Marie -Edith Lafon, Francois Philit, Agathe Senechal, Jean-Sebastien Casalegno, Elodie Blanchard, Jerome Le Pavec, Florence Ader
Summary: This study analysed the impact of antimicrobial treatments on functional outcomes in adult lung transplant recipients with RSV-confirmed infection. It was found that 28.8% of recipients developed new allograft dysfunction at 3 months post-infection. Ribavirin treatment and azithromycin prophylaxis did not prevent decline in lung function.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Cardiac & Cardiovascular Systems
Siddhartha G. Kapnadak, Eric D. Morrell, Travis Hee Wai, Christopher H. Goss, Pali D. Shah, Christian A. Merlo, Ramsey R. Hachem, Kathleen J. Ramos
Summary: This study investigated the practices of azithromycin use among lung transplant providers internationally. The results showed significant variations in indications, timing, and dosing of azithromycin, with even inconsistencies within the same center. Most providers initiated azithromycin after the occurrence of risk factors and/or events related to chronic lung allograft dysfunction (CLAD).
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Rayoun Ramendra, Andrew T. Sage, Jonathan Yeung, Juan C. Fernandez-Castillo, Marcelo Cuesta, Meghan Aversa, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee, Tereza Martinu
Summary: This study investigates the utility of measuring total bile acids (TBA) in donor large airway bronchial wash (LABW) to predict the performance of donor lungs and recipient outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Andreacarola Urso, Miguel M. Leiva-Juarez, Domenica F. Briganti, Beatrice Aramini, Luke Benvenuto, Joseph Costa, Renu Nandakumar, Estela Area Gomez, Hilary Y. Robbins, Lori Shah, Meghan Aversa, Joshua R. Sonnet, Selim Arcasoy, Serge Cremers, Frank D'Ovidio
Summary: The study found that high levels of bile acids and predominance of conjugated bile acids are independent predictors of chronic lung allograft dysfunction, mortality, and bacterial infections. Primary conjugated bile acids are associated with changes in airway lipidome and bacterial infections.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Critical Care Medicine
Jamie L. Todd, Jeremy M. Weber, Francine L. Kelly, Megan L. Neely, Hillary Mulder, Courtney W. Frankel, Andrew Nagler, Christopher Mccrae, Paul Newbold, Jim Kreindler, Scott M. Palmer
Summary: BALF eosinophilia is an independent predictor of future CLAD risk in lung transplant recipients, associated with acute rejection, lung injury, and pulmonary fungal detection. Established CLAD induces expression of type 2 inflammatory signals, highlighting the need for further research to clarify the role of type 2 pathway-specific interventions in CLAD prevention or treatment.
Article
Engineering, Biomedical
Bozica Kovacevic, Melissa Jones, Corina Ionescu, Daniel Walker, Susbin Wagle, Jacqueline Chester, Thomas Foster, Daniel Brown, Momir Mikov, Armin Mooranian, Hani Al-Salami
Summary: Endogenous bile acids serve as lipid stabilizers, aiding the uptake of lipophilic nutrients through micelle formation and saponification effects, with various applications in pharmaceutical sciences. Their unique physico-chemical profile allows them to modulate immune cell signaling pathways and provide potential clinical therapies for cardio-metabolic disorders. In addition, their antioxidant, anti-inflammatory, and immunosuppressant properties make them effective in reducing blood pressure and alleviating hypertension, while also enhancing the immunogenicity of encapsulated cells for bioartificial organ transplantations.
Review
Pharmacology & Pharmacy
Min Young Kim, Daniel C. Brennan
Summary: Significant progress has been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) in recent decades, but effective treatment for chronic ABMR remains a challenge. Chronic ABMR has a distinct phenotype from active ABMR and is mainly caused by de novo donor specific antibodies (DSA), leading to progressive graft injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Pascal Pedini, Benjamin Coiffard, Nicem Cherouat, Sylvia Casas, Frederic Fina, Audrey Boutonnet, Jean Baptiste Baudey, Printil Aho, Agnes Basire, Sophie Simon, Coralie Frassati, Jacques Chiaroni, Martine Reynaud-Gaubert, Christophe Picard
Summary: This study aims to determine the clinical relevance of donor-derived cfDNA and cfDNA fragment size profiles in events such as acute rejection or infection during the first month after lung transplantation. The results show that the percentage of donor-derived cfDNA is higher in injured graft patients, and quantification of small sizes of DNA can accurately identify infection. Therefore, combining the quantification of donor-derived cfDNA and small DNA sizes can classify different types of graft injuries.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul Habert, Elsa Chetrit, Benjamin Coiffard, Fabienne Bregeon, Pascal Thomas, Anderson Loundou, Julien Bermudez, Martine Reynaud-Gaubert, Jean-Yves Gaubert
Summary: This study found that chest CT can predict the occurrence of CLAD in lung transplant patients. Moderate pulmonary artery stenosis, mosaic pattern of lung parenchyma, consolidations, and pleural effusions were identified as risk factors for CLAD.
INSIGHTS INTO IMAGING
(2023)
Article
Microbiology
Jose Caparros-Martin, Montserrat Saladie, S. Patricia Agudelo-Romero, F. Jerry Reen, Robert S. Ware, Peter D. Sly, Stephen M. Stick, Fergal O'Gara
Summary: We found a link between intestinal microbiota-related metabolites bile acids (BA) and inflammation in the bronchoalveolar lavage fluid (BALF) of children with stable CF lung disease. In this study, we analyzed 121 BALF specimens from 12-month-old infants with CF to investigate the relationship between inflammation and microbial composition in early CF lung disease, as well as the impact of azithromycin on BA detection in BALF. We found that the detection of BA in BALF was strongly associated with airway inflammation, exacerbation episodes, antibiotic use, lung damage, and distinct microbial profiles.
Article
Multidisciplinary Sciences
Elvin Koh, In Young Hwang, Hui Ling Lee, Ryan De Sotto, Jonathan Wei Jie Lee, Yung Seng Lee, John C. March, Matthew Wook Chang
Summary: This study demonstrates that engineering probiotics to restore intestinal bile salt metabolism can effectively inhibit Clostridioides difficile infection, presenting a microbiome-based antimicrobial strategy. The engineered probiotics limited the growth of C. difficile in vitro and significantly reduced CDI in model mice, indicating their potential as an intervention for this infection.
NATURE COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Elena Yukie Uebayashi, Hideaki Okajima, Miki Yamamoto, Eri Ogawa, Tatsuya Okamoto, Hironori Haga, Etsurou Hatano
Summary: Antibody-mediated rejection (AMR) of liver allograft transplantation has gained clinical awareness as a potential cause of chronic liver injury and graft failure. The accurate incidence, diagnostic criteria, and treatment protocols of chronic AMR in pediatric patients remain unclear and further research is needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Michael D. Parkes, Kieran Halloran, Alim Hirji, Shane Pon, Justin Weinkauf, Irina L. Timofte, Greg I. Snell, Glen P. Westall, Jan Havlin, Robert Lischke, Andrea Zajacova, Ramsey Hachem, Daniel Kreisel, Deborah Levine, Bartosz Kubisa, Maria Piotrowska, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Philip F. Halloran
Summary: The study revealed that CLAD primarily reflects severe parenchymal injury-induced changes and dedifferentiation rather than inflammation. Fibrillar collagen genes were increased in CLAD, indicating matrix changes, and normal transcripts were decreased.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
Teresa Brevini, Mailis Maes, Gwilym J. Webb, Binu John, Claudia D. Fuchs, Gustav Buescher, Lu Wang, Chelsea Griffiths, Marnie L. Brown, William E. Scott, Pehuen Pereyra-Gerber, William T. H. Gelson, Stephanie Brown, Scott Dillon, Daniele Muraro, Jo Sharp, Megan Neary, Helen Box, Lee Tatham, James Stewart, Paul Curley, Henry Pertinez, Sally Forrest, Petra Mlcochova, Sagar S. Varankar, Mahnaz Darvish-Damavandi, Victoria L. Mulcahy, Rhoda E. Kuc, Thomas L. Williams, James A. Heslop, Davide Rossetti, Olivia C. Tysoe, Vasileios Galanakis, Marta Vila-Gonzalez, Thomas W. M. Crozier, Johannes Bargehr, Sanjay Sinha, Sara S. Upponi, Corrina Fear, Lisa Swift, Kourosh Saeb-Parsy, Susan E. Davies, Axel Wester, Hannes Hagstrom, Espen Melum, Darran Clements, Peter Humphreys, Jo Herriott, Edyta Kijak, Helen Cox, Chloe Bramwell, Anthony Valentijn, Christopher J. R. Illingworth, Bassam Dahman, Dustin R. Bastaich, Raphaella D. Ferreira, Thomas Marjot, Eleanor Barnes, Andrew M. Moon, Alfred S. Barritt, Ravindra K. Gupta, Stephen Baker, Anthony P. Davenport, Gareth Corbett, Vassilis G. Gorgoulis, Simon J. A. Buczacki, Joo-Hyeon Lee, Nicholas J. Matheson, Michael Trauner, Andrew J. Fisher, Paul Gibbs, Andrew J. Butler, Christopher J. E. Watson, George F. Mells, Gordon Dougan, Andrew Owen, Ansgar W. Lohse, Ludovic Vallier, Fotios Sampaziotis
Summary: Modulating the expression of angiotensin-converting enzyme 2 (ACE2) through farnesoid X receptor (FXR) can reduce susceptibility to SARS-CoV-2 infection, as shown in various tissues and organoids in vitro, in vivo, and ex vivo. The use of z-guggulsterone and ursodeoxycholic acid (UDCA) can downregulate ACE2 and decrease viral infection, including in the nasal epithelium. Clinical data also indicate positive outcomes with UDCA treatment in SARS-CoV-2 infection. These findings suggest that targeting the FXR-ACE2 pathway could be a potential strategy for preventing COVID-19.
Article
Respiratory System
Kathrin Kahnert, Franziska C. Trudzinski, Christiane Berger, Dieter Munker, Katrin Milger, Michael Irlbeck, Roland Tomasi, Christian Schneider, Sebastian Michel, Alessandro Ghiani, Felix J. F. Herth, Juergen Behr, Rudolf A. Joerres, Nikolaus Kneidinger
Summary: This study demonstrated that oxygenated hemoglobin (OxyHem) predicts the survival rate of lung transplant recipients after the onset of chronic lung allograft dysfunction (CLAD). OxyHem outperformed hemoglobin (Hb) or oxygen saturation in predicting survival. A reduction of 1 g/dL in OxyHem increased the risk of death after CLAD by 14%, and values below 11 g/dL corresponded to an 80% increase in mortality risk.
Article
Psychology, Clinical
Jessica Rassart, Carine Van Wanseele, Lynn Debrun, Koen Matthijs, Philip Moons, Liesbet Van Bulck, Seher Arat, Lukas Van Oudenhove, Koen Luyckx
Summary: This study examined how adults with inflammatory bowel disease (IBD) integrate their illness into their identity and link illness identity to important patient-reported outcomes. The results showed that adults with IBD had higher scores on rejection and engulfment, and lower scores on acceptance compared to adults with congenital heart disease (CHD), refractory epilepsy (RE), and multisystemic connective tissue disorders (MSDs). Higher engulfment scores were associated with more depressive symptoms, lower life satisfaction, and a poorer health status and health-related quality of life (HRQoL), while higher enrichment scores were related to more life satisfaction and a better HRQoL. Rejection and acceptance were not uniquely related to any of the outcomes.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Psychology, Social
Leni Raemen, Laurence Claes, Margaux Verschueren, Lukas Van Oudenhove, Sarah Vandekerkhof, Ine Triangle, Koen Luyckx
Summary: This paper includes two studies that examine the relationship between identity functioning and (psychological characteristics of) somatic symptoms. The findings suggest that identity disturbance is significantly associated with somatic symptoms, and anxiety and depressive symptoms mediate this relationship.
Article
Neurosciences
Silvia Papalini, Laura Neefs, Tom Beckers, Lukas Van Oudenhove, Bram Vervliet
Summary: This study found that prolonged fasting decreases unnecessary avoidance during signaled safety. This effect is mediated by a reduction in relief pleasantness during signaled absence of threat. Fasting also reduces relief during fear extinction learning. Therefore, fasting can optimize avoidance and safety learning.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Oncology
Tom Vandaele, Jan Van Slambrouck, Viktor Proesmans, Paul Clement, Maarten Lambrecht, Philippe Nafteux, Dirk Van Raemdonck, Laurens J. Ceulemans
Summary: This review provides an overview of the current literature on hyperthermic intrathoracic chemotherapy (HITHOC) for thymoma with pleural dissemination (TPD). The results suggest that combining cytoreductive surgery and HITHOC is feasible and safe for TPD, but there is significant heterogeneity in the literature, calling for further research to better understand the additional benefit of HITHOC in TPD treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Tom Vandaele, Jan Van Slambrouck, Viktor Proesmans, Paul Clement, Maarten Lambrecht, Philippe Nafteux, Dirk Van Raemdonck, Laurens J. Ceulemans
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Laura P. M. H. de Rooij, Lisa M. Becker, Laure Anne Teuwen, Bram Boeckx, Sander Jansen, Simon Feys, Stijn Verleden, Laurens Liesenborghs, Anna K. Stalder, Sasha Libbrecht, Tina Van Buyten, Gino Philips, Abhishek Subramanian, Sebastien J. Dumas, Elda Meta, Mila Borri, Liliana Sokol, Amelie Dendooven, Anh Co K. Truong, Jan Gunst, Pierre Van Mol, Jasmin D. Haslbauer, Katerina Rohlenova, Thomas Menter, Robbert Boudewijns, Vincent Geldhof, Stefan Vinckier, Jacob Amersfoort, Wim Wuyts, Dirk Van Raemdonck, Werner Jacobs, Laurens J. Ceulemans, Birgit Weynand, Bernard Thienpont, Martin Lammens, Mark Kuehnel, Guy Eelen, Mieke Dewerchin, Luc Schoonjans, Danny Jonigk, Jo van Dorpe, Alexandar Tzankov, Els Wauters, Massimiliano Mazzone, Johan Neyts, Joost Wauters, Diether Lambrechts, Peter Carmeliet
Summary: This study provides new insights into the abundance, expression patterns, and interactomes of endothelial cell (EC) subtypes in COVID-19 and idiopathic pulmonary fibrosis (IPF). The findings suggest the importance of ECs in the pathophysiology of both conditions and may contribute to future investigations into the progression and treatment of COVID-19 and IPF.
CARDIOVASCULAR RESEARCH
(2023)
Article
Respiratory System
Janne Goossens, Anne-Charlotte Jonckheere, Sven F. Seys, Ellen Dilissen, Tatjana Decaesteker, Camille Goossens, Koen Peers, Vincent Vanbelle, Jeroen Stappers, Sven Aertgeerts, Barbara De Wilde, Jasmine Leus, Sophie Verelst, Marc Raes, Lieven Dupont, Dominique M. Bullens
Summary: The study investigated the effects of intense exercise and air pollution exposure on the airway barrier and exercise-induced bronchoconstriction (EIB) in adolescent elite athletes. Results showed that athletes had increased markers of air pollution exposure, epithelial damage, and airway inflammation compared with controls. The incidence of EIB in athletes was also linked to prior exposure to PM10 and PM2.5.
Article
Respiratory System
Vincent Geudens, Jan Van Slambrouck, Gitte Aerts, Lynn Willems, Tinne Goos, Janne Kaes, Andrea Zajacova, Iwein Gyselinck, Celine Aelbrecht, Astrid Vermaut, Hanne Beeckmans, Marie Vermant, Charlotte De Fays, Annelore Sacreas, Lucia Aversa, Michaela Orlitova, Arno Vanstapel, Ivan Josipovic, Matthieu N. Boone, John E. McDonough, Birgit Weynand, Charles Pilette, Wim Janssens, Lieven Dupont, Wim A. Wuyts, Geert M. Verleden, Dirk E. van Raemdonck, Robin Vos, Ghislaine Gayan-Ramirez, Laurens J. Ceulemans, Bart M. Vanaudenaerde
Summary: This study assessed disease progression in COVID-19 patients using in vivo CT and ex vivo microCT, and described the changes in lung volume and density as well as airway morphology. Results showed that COVID-19 lung volumes decreased and densities increased over time, mainly in the lower lobes. Ex vivo microCT revealed a 60% reduction in lung volume compared to controls, and increased visibility of airways in COVID-19 lungs, possibly due to fibrosis and increased airway diameter. Small-partition microCT further showed deformations in airway morphology and heterogeneous fibrotic organization in severely affected regions, which was confirmed by histology.
JOURNAL OF THORACIC DISEASE
(2023)
Meeting Abstract
Critical Care Medicine
C. De Fays, H. Beeckmans, P. Kerckhof, V. Geudens, A. Vermaut, I. Gyselinck, T. Goos, M. Vermant, J. Kaes, J. Van Slambrouck, Y. Mohamady, L. Willems, L. Aversa, K. Maes, C. Aelbrecht, S. Everaerts, J. E. Mcdonough, L. J. De Sadeleer, S. Gohy, J. Ambroise, W. A. Wuyts, W. L. Janssens, L. J. Ceulemans, D. E. M. Van Raemdonck, R. Vos, T. Hackett, J. C. Hogg, N. Kaminski, C. Pilette, G. Gayan-Ramirez, B. Vanaudenaerde
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Annalisa Barbarossa, Dirk Van Raemdonck, Walter Weder, Laurens J. Ceulemans
Summary: Secondary pneumothorax due to emphysema is a life-threatening condition that often requires surgery. In this case, we used LVRS to not only remove part of the lung but also close the fistula. The patient experienced improved lung function and quality of life after urgent and elective LVRS surgeries, with resolution of the air leak.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Villavicencio, A. Kashem, G. Loor, E. D'Silva, M. Hartwig, K. Ghadimi, F. Ius, S. Jawad, N. Langer, A. Osho, S. Chandrashekaran, T. Machuca, P. Sanchez, K. Subramaniam, D. Van Raemdonck, A. Neyrinck, S. Huddleston, A. Shaffer, B. Lahr, Y. Toyoda
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
H. Beeckmans, P. Kerckhof, J. McDonough, L. De Sadeleer, J. Kaes, A. Sacreas, C. Aelbrecht, A. Vanstapel, K. Maes, H. Schoemans, E. Wauters, A. Neyrinck, G. Verleden, L. Dupont, L. Godinas, D. Van Raemdonck, B. Vanaudenaerde, R. Vos
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. Hooft, J. Kaes, T. Heigl, H. Beeckmans, P. Kerckhof, A. Vanstapel, X. Jin, J. Slambrouck, C. Vandervelde, D. Van Raemdonck, N. Kaminski, J. McDonough, L. Ceulemans, R. Vos, B. Vanaudenaerde
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Kaes, E. Vanhulle, L. Seldeslachts, C. Hooft, H. Beeckmans, X. Jin, P. Kerckhof, J. Van Slambrouck, D. Van Raemelonck, G. Vande Velde, L. Naesens, D. Schols, L. J. Ceulemans, R. Vos, K. Vertneire, B. M. Vanaudenaerde
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Biochemical Research Methods
Jan Van Slambrouck, Charlotte Schoenaers, Lies Laenen, Xin Jin, Kurt Beuselinck, Ann Verdonck, Joost Wauters, Geert Molenberghs, Bart M. Vanaudenaerde, Robin Vos, Peter Mombaerts, Katrien Lagrou, Laurens J. Ceulemans
Summary: The ability to detect SARS-CoV-2 RNA or antigen in BAL fluid samples using point-of-care tests (POCTs) can reduce the risk of developing severe COVID-19 after lung transplantation.
JOURNAL OF VIROLOGICAL METHODS
(2024)
