Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 12, Issue 4, Pages 812-819Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-6143.2011.03873.x
Keywords
MHC; nonhuman primate; transplant
Categories
Funding
- Yerkes National Primate Research Center [RR00165]
- NIH [2U19 AI051731, 2P01 AI044644, R01 AI34495, HL 56067, P01 CA 142106]
- Burroughs Wellcome Fund Career Award in the Biomedical Sciences
- [5K08 AI065822]
- [1R01 HL095791]
- [2U24 RR018109]
Ask authors/readers for more resources
Nonhuman primate (NHP) models play a critical role in the translation of novel therapies for transplantation to the clinic. However, although MHC disparity significantly affects the outcome of transplantation, until recently, experiments using NHP models were performed without the ability to rigorously control the degree of MHC disparity in transplant cohorts. In this review, we discuss several key technical breakthroughs in the field, which have finally enabled detailed immunogenetic data to be incorporated into NHP transplantation studies. These advances have created a new gold-standard for NHP transplantation research, which incorporates detailed information regarding the degree of relatedness and the degree of MHC haplotype disparity between transplant pairs and the precise MHC alleles that both donors and recipients express. The adoption of this new standard promises to increase the rigor of NHP transplantation studies and to ensure that these experiments are optimally translatable to patient care.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available