Review
Immunology
Lara Cabezas, Thomas Jouve, Paolo Malvezzi, Benedicte Janbon, Diane Giovannini, Lionel Rostaing, Johan Noble
Summary: Chronic kidney disease is a significant public-health problem, and kidney transplantation is a better alternative to dialysis. Antibody-mediated rejection is a major complication following kidney transplantation. TCZ appears to be a safe and effective treatment for managing antibody-mediated rejection and reducing injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Surgery
Edmund Huang, Angela Q. Maldonado, Christian Kjellman, Stanley C. Jordan
Summary: Imlifidase, derived from Streptococcus pyogenes, is a novel agent with potential for HLA desensitization and antibody-mediated rejection in kidney transplantation. Clinical trials have shown rapid degradation of anti-HLA donor-specific antibodies, facilitating HLA-incompatible transplantation. Early experiences with imilfidase highlight considerations regarding kinetics of antibodies, timing of complementary therapies, and interference with cross match assays.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Lynn D. Cornell
Summary: ABMR in the kidney can present with a wide range of clinical presentations and histopathologic patterns. The current Banff 2019 classification recognizes four diagnostic categories, but there are limitations in adequately representing the spectrum of antibody associated injury in allograft.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Elodie Bailly, Camila Macedo, Jason Ossart, Kevin Louis, Xinyan Gu, Bala Ramaswami, Carol Bentlejewski, Adriana Zeevi, Parmjeet Randhawa, Carmen Lefaucheur, Diana Metes
Summary: CD160+ IL-21R+ NK cells play a crucial role in kidney allograft antibody-mediated rejection. These cells exhibit distinct phenotypic and functional characteristics and are involved in the rejection response by activating multiple signaling pathways.
KIDNEY INTERNATIONAL
(2023)
Review
Immunology
Carrie Schinstock, Anat Tambur, Mark Stegall
Summary: Significant advancements have been made in HLA antibody detection techniques and understanding outcomes of solid organ transplant in the presence of HLA antibody over the past 50 years. Kidney paired donation programs have become widespread, deceased donor allocation policies have changed, and new therapeutic options show promise in reducing HLA antibody production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
D. Marshall Brinkley, MariaSanta Mangione, Sallyanne C. C. Fossey, Kimberly M. Harrison, Sandip Zalawadiya, Aniket S. S. Rali, Hasan K. K. Siddiqi, JoAnn Lindenfeld, Kelly H. H. Schlendorf
Summary: We studied the efficacy of a desensitization regimen in heart transplant candidates and found that it effectively removed C1q negative antibodies and decreased HLA class I antibodies. This led to successful transplants in 76% of patients with a 1-year survival rate of 89%. The desensitization protocol was modestly effective for class I antibodies and combined with selective crossing of C1q negative antigens.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Vincent Pernin, Nicole Bec, Anais Beyze, Alexis Bourgeois, Ilan Szwarc, Coralie Champion, Anthony Chauvin, Celine Rene, Georges Mourad, Pierre Merville, Jonathan Visentin, Helene Perrochia, Lionel Couzi, Christian Larroque, Moglie Le Quintrec
Summary: The glycosylation profile of IgG3 dnDSA is associated with the risk of ABMR occurrence, with low sialylation and high GlcNAc bisection being potentially predictive factors. Further studies are needed to confirm the clinical significance of DSA glycosylation in predicting ABMR and graft survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Nissrin Alachkar, Nada Alachkar
Summary: Diagnosing kidney allograft rejection is complex and subjective, but an automated Banff classification could make assessment easier and improve accuracy.
Review
Medicine, General & Internal
Farah Abuazzam, Casey Dubrawka, Tarek Abdulhadi, Gwendolyn Amurao, Louai Alrata, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad
Summary: Despite advances in immunosuppressive medications, antibody-mediated rejection (AMR) remains a major cause of kidney allograft failure. Recent developments in understanding the pathophysiology of AMR and new therapeutic options have emerged. Surveillance protocols using donor-derived cell-free DNA and gene profile testing have allowed for early detection of AMR. Ongoing clinical trials offer opportunities for improving outcomes in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Jules Weinhard, Johan Noble, Thomas Jouve, Paolo Malvezzi, Lionel Rostaing
Summary: Tocilizumab, used as an adjunct therapy in desensitization, shows potential in hindering B-cell maturation and improving long-term efficacy by reducing anti-HLA rebound, although its short-term effectiveness is not significant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Kevin Louis, Paul Fadakar, Camila Macedo, Masaki Yamada, Michelle Lucas, Xinyan Gu, Adriana Zeevi, Parmjeet Randhawa, Carmen Lefaucheur, Diana Metes
Summary: This study used high dimensional flow cytometry to analyze the status of regulatory T cells and transitional B cells in kidney transplant recipients. It found that in patients with antibody-mediated rejection (ABMR), both cell types were significantly reduced in numbers, which correlated with inflammatory antibody responses, microvascular inflammation, and kidney allograft loss.
KIDNEY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Jiu Deng, Yahui Ji, Fengjiao Zhu, Lina Liu, Linmei Li, Xue Bai, Huibing Li, Xianming Liu, Yong Luo, Bingcheng Lin, Yao Lu
Summary: This study demonstrates the mapping of different secretomes from paired neuron-immune single cells, providing insights into how neurons and immune cells interact through the complex secretome network.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Johan Noble, Diane Giovannini, Reda Laamech, Farida Imerzoukene, Benedicte Janbon, Laura Marchesi, Paolo Malvezzi, Thomas Jouve, Lionel Rostaing
Summary: In this study, tocilizumab (TCZ) showed potential in preventing clinical and histological deterioration of chronic antibody-mediated rejection (cABMR) in kidney transplant recipients, but its effectiveness may be limited in patients with more severe conditions. Randomized studies are needed to further evaluate the risk/benefit profile of TCZ in cABMR.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Florian Kaelble, Caner Suesal, Luiza Pego da Silva, Claudius Speer, Louise Benning, Christian Nusshag, Lien Pham, Hien Tran, Matthias Schaier, Claudia Sommerer, Joerg Beimler, Arianeb Mehrabi, Martin Zeier, Christian Morath
Summary: Living donor kidney transplant recipients with pre-existing sensitization can achieve good graft outcomes with desensitization protocols, comparable to standard-risk recipients. Adequate patient selection and close immunological monitoring are crucial to minimize rejection episodes and graft loss.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Annie Qiu, Anabel Miller, Flavia Dei Zotti, Manjula Santhanakrishnan, Jeanne E. Hendrickson, Maria Tredicine, Sean R. Stowell, Chance John Luckey, James C. Zimring, Krystalyn E. Hudson
Summary: Passive immunization with anti-D can prevent maternal alloimmunization to RhD, but it may fail in some cases and even enhance alloimmunization. This study identified that FcγRIV on splenic conventional dendritic cells (cDCs) is required for IgG2c-mediated enhancement of RBC alloantibody production. FcγRI can cause RBC clearance without increasing alloimmunization. These findings have implications for the standardization of antibody subclasses in immunoprophylaxis preparations.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Surgery
Norine W. Chan, Mary Moya-Mendez, Jacqueline B. Henson, Hamed Zaribafzadeh, Mark P. Sendak, Nrupen A. Bhavsar, Suresh Balu, Allan D. Kirk, Lisa M. McElroy
Summary: This study examines the availability of social determinants of health (SDOH) data in national data sources for end-stage organ disease (ESOD) and transplant patients. The results highlight the need for improvement in SDOH data collection systems and standardization in order to facilitate health equity research.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Christine Park, Tyler Schappe, Sarah Peskoe, Dinushika Mohottige, Norine W. Chan, Nrupen A. Bhavsar, Jane Pendergast, Allan D. Kirk, Lisa M. McElroy
Summary: The choice of deprivation index has an impact on conclusions about deprivation extent and identifying the most deprived communities. This study aimed to determine correlations among commonly used deprivation indices for transplant populations. Different deprivation indices were compared using a retrospective cohort of liver or kidney transplant patients. The choice of deprivation index affects the applicability of research findings on social risk and clinical outcomes. Careful selection of indices based on intended use and variable relevance is necessary for transplant populations.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Mary E. Knatterud, Richard L. Simmons, William Payne, Peter Stock, Blanche Chavers, Nancy Ascher, Dixon Kaufman, Alan Kirk, Shafique Keshavjee, Abhinav Humar, Swaytha Ganesh, Christopher Hughes, Raja Kandaswamy, Arthur J. Matas
Summary: Dr. John S Najarian (1927-2020), the chairman of the University of Minnesota's Department of Surgery, was a trailblazer in surgery, clinical immunology, and transplantation. A delayed Festschrift was held on May 20, 2022, to honor his achievements. During the event, speakers discussed his numerous contributions to surgery, transplantation, and resident/fellow training, as well as ongoing research efforts to improve clinical outcomes. It is worth mentioning that Dr. Najarian was the founder of the journal Clinical Transplantation.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Shu Li, Imran J. Anwar, Aidan J. Canning, Tuan Vo-Dinh, Allan D. Kirk, He Xu
Summary: Porcine vascular endothelial cells release extracellular vesicles expressing SLA-I, which can directly initiate T cell-mediated immune responses through xenorecognition and costimulation, suggesting a potential role in xenograft rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Editorial Material
Surgery
Flavio Vincenti, Klemens Budde, Josep Grinyo, Lionel Rostaing, Allan D. Kirk, Christian P. Larsen
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Andrew Adams, Linda C. Cendales, David K. C. Cooper, Emanuele Cozzi, John Gill, Eric Judd, Eliezer Katz, Allan D. Kirk, Jay A. Fishman, Peter P. Reese, Anji Wall, James F. Markmann
Summary: The US FDA held a meeting to discuss regulatory expectations for xenotransplantation products, and a summary was compiled by a committee, focusing on 7 key topics including preclinical evidence, porcine kidney function, ethical aspects, clinical trial design, infectious disease issues, industry perspectives, and regulatory oversight.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Rondi B. Gelbard, Hannah Hensman, Seth Schobel, Linda Stempora, Eric Gann, Dimitrios Moris, Christopher J. Dente, Timothy G. Buchman, Allan D. Kirk, Eric Elster
Summary: This study aimed to explore whether assessment of cell phenotypes using flow cytometry (FCM) could be used to identify pulmonary infection after thoracic trauma. The results showed that Acute Physiology and Chronic Health Evaluation score, highest pulse rate in first 24 hours, and frequency of CD4(+) central memory cells were the three key variables for identifying pulmonary infection after thoracic trauma. The study suggests that clinical and FCM data have diagnostic utility in the early identification of patients at risk of nosocomial pneumonia (PNA) following thoracic injury.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Cell Biology
Imran J. Anwar, Dora M. Berman, Isabel Delaura, Qimeng Gao, Melissa A. Willman, Allison Miller, Alan Gill, Cindy Gill, Steve Perrin, Camillo Ricordi, Philip Ruiz, Mingqing Song, Joseph M. Ladowski, Allan D. Kirk, Norma S. Kenyon
Summary: This study investigated the anti-CD40 ligand (CD40L) immunosuppressant AT-1501 and found that it can enhance the survival and function of both islet and kidney allografts in nonhuman primate models, with better outcomes compared to conventional immunosuppression.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Surgery
M. Song, K. Samy, B. M. Martin, Q. Gao, B. Collins, X. Luo, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
A. D. Kirk, J. Shoji, D. Wojciechowski, J. Kim, W. Xu, T. M. Wilson, F. Vincenti
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
S. Li, I. J. Anwar, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
S. Li, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, C. Z. Jordan, B. I. Shaw, Q. Gao, I. DeLaura, A. Dangi, I. Husain, M. Ribeiro, J. M. Ladowski, X. Luo, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, M. S. Mulvihill, R. Schmitz, B. I. Shaw, Z. W. Fitch, T. How, S. Li, H. Xu, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
I. J. Anwar, Q. Gao, I. DeLaura, A. Miller, B. I. Shaw, K. Krynychka, A. D. Kirk
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)