Review
Immunology
G. van der Elst, H. Varol, M. Hermans, C. C. Baan, J. P. Duong-van Huyen, D. A. Hesselink, R. Kramann, M. Rabant, M. E. J. Reinders, J. H. von der Thuesen, T. P. P. van den Bosch, M. C. Clahsen-van Groningen
Summary: Mast cells are innate immune cells that play multiple roles in immune responses. In addition to their involvement in allergies, they also participate in allograft tolerance and rejection by interacting with regulatory T cells, effector T cells, and B cells, and releasing cytokines and other mediators. Mast cell mediators have both pro- and anti-inflammatory actions, but they overall favor pro-fibrotic pathways. Interestingly, they are also considered to have potential protective effects in tissue remodeling post-injury. This manuscript provides an in-depth understanding of the functional diversity of mast cells in kidney transplants, proposing a model that highlights their dual protective and harmful capabilities in this setting.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Engineering, Multidisciplinary
Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao
Summary: Innate immune cells, particularly macrophages, play critical roles in transplant response. Macrophages, as the predominant infiltrated cells in allografts, have diverse functions and can either promote or protect against graft rejection. Understanding the complex roles of macrophages and developing specific immunosuppressive drugs targeting macrophages are crucial for improving the long-term survival of organ grafts.
Review
Pharmacology & Pharmacy
Srijan Dubey, Sayak Ghosh, Debosmita Goswami, Debapriya Ghatak, Rudranil De
Summary: Macrophages are immune cells that can engulf and destroy target cells, including tumor cells. Some macrophages undergo a change to become polarized M2 macrophages while devouring cancer cells. M2 macrophages play important roles in metastasis, tumor suppression, and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Anil Dangi, Irma Husain, Collin Z. Jordan, Shuangjin Yu, Naveen Natesh, Xiling Shen, Jean Kwun, Xunrong Luo
Summary: This study found that resident macrophages in the donor kidney rapidly expanded during the early stages of kidney transplantation and were induced to express high levels of Ccl8. This led to the infiltration of recipient monocytes, their differentiation into resident macrophages, and subsequent expression of Ccl8. Enhanced infiltration of recipient T cells followed. Targeting the CCL8-CCR8 axis shows promise for reducing early kidney allograft inflammation.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Medicine, General & Internal
Elena Cantero-Navarro, Sandra Rayego-Mateos, Macarena Orejudo, Lucia Tejedor-Santamaria, Antonio Tejera-Munoz, Ana Belen Sanz, Laura Marquez-Exposito, Vanessa Marchant, Laura Santos-Sanchez, Jesus Egido, Alberto Ortiz, Teresa Bellon, Raul R. Rodrigues-Diez, Marta Ruiz-Ortega
Summary: Inflammation plays a crucial role in kidney disease, with immune cells contributing to both repair and progression depending on the stage of injury. The plasticity and complexity of immune cells pose challenges in translating findings from mouse models to human renal diseases.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Kiseleva Viktoriia, Vishnyakova Polina, Elchaninov Andrey, Fatkhudinov Timur, Sukhikh Gennady
Summary: Macrophages, as innate immune cells with plasticity, are of interest for cell therapy. M1 and M2 are the two main macrophage populations, known as pro- and anti-inflammatory cells. This review focuses on the M2 macrophages and their potential use in regenerative medicine, including their ontogenesis, functions, subpopulations, and factors that induce polarization. Recent attempts at stable macrophage polarization using genetic modifications are also discussed.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yunhua Tang, Jiali Wang, Yixi Zhang, Jun Li, Maogen Chen, Yifang Gao, Meiqin Dai, Shengjie Lin, Xiaoshun He, Chenglin Wu, Xiaomin Shi
Summary: In this study, single-cell RNA sequencing technology was used to analyze graft-infiltrating cells in a mouse heart transplant model. The results identified different cell types and states associated with acute rejection, including specific macrophage and endothelial cell populations. The upregulation of Ubiquitin D in rejection was also validated as a potential biomarker for rejection in the clinic.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ksenija Korotkaja, Juris Jansons, Karina Spunde, Zhanna Rudevica, Anna Zajakina
Summary: Reprogramming TAMs is a promising strategy for cancer immunotherapy. In this study, a new 3D model was established to investigate macrophage programming in the presence of cancer cell spheroids. The findings showed that the profile of cytokines, chemokines, and surface markers of 3D-cultured macrophages did not differ conceptually from monolayer-cultured M1 and M2-programmed macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Matthew R. D'Costa, Andrew Bentall, Aleksandar Denic, Carrie A. Schinstock, Massini A. Merzkani, Walter D. Park, Margaret S. Ryan, Mariam P. Alexander, Byron H. Smith, Manish J. Gandhi, Mark D. Stegall
Summary: The study compared HLA-identical living donor kidney transplants with non-HLA-identical living donor kidney transplants and found that HLA-identical transplants were associated with higher graft survival rates and lower rejection rates. Chronic histologic changes were similar between the two groups, suggesting that these changes may not be associated with HLA mismatches. New management approaches may be needed to prevent these lesions.
Article
Immunology
Elisabet Van Loon, Baptiste Lamarthee, Thomas Barba, Sandra Claes, Maarten Coemans, Henriette de Loor, Marie-Paule Emonds, Priyanka Koshy, Dirk Kuypers, Paul Proost, Aleksandar Senev, Ben Sprangers, Claire Tinel, Olivier Thaunat, Amaryllis H. Van Craenenbroeck, Dominique Schols, Maarten Naesens
Summary: Through multiplex assay, we found that kidney transplant patients with donor-specific anti-human leukocyte antigen antibodies and histological rejection have increased levels of pro-inflammatory cytokines in blood. Even in patients without histological rejection, elevated pro-inflammatory cytokine levels can be observed. These findings challenge the concept of histology as the gold standard for identifying ongoing allo-immune activation after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lakhveer Singh, Sakshi Bajaj, Manoj Gadewar, Nitin Verma, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kaithwas, Manjari Singh
Summary: The novel coronavirus SARS-CoV-2 initiates its life cycle within alveolar type-2 pneumocytes, activating the host immune response and leading to the phagocytosis of infected cells. The virus itself is not the direct cause of death, but rather the aberrant host immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Alex Yashchenko, Sarah J. Bland, Cheng J. Song, Ummey Khalecha Bintha Ahmed, Rachel Sharp, Isabella G. Darby, Audrey M. Cordova, Morgan E. Smith, Jeremie M. Lever, Zhang Li, Ernald J. Aloria, Shuja Khan, Bibi Maryam, Shanrun Liu, Michael R. Crowley, Kenneth L. Jones, Lauren A. Zenewicz, James F. George, Michal Mrug, David K. Crossman, Katharina Hopp, Stavros Stavrakis, Mary B. Humphrey, Florent Ginhoux, Kurt A. Zimmerman
Summary: Kidney macrophages in healthy mice exhibit cellular heterogeneity, with four major subsets of monocytes and two major subsets of kidney resident macrophages. The expression of Ccr2 in kidney resident macrophages is not solely derived from Ly6c(hi) monocytes, and Ccr2 expression reflects their spatial distribution in the kidney cortex. The gene Cx3cr1 regulates the heterogeneity of kidney resident macrophages and plays a role in niche-specific disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Gangcheng Kong, Yuqi Chen, Zongtao Liu, Yixuan Wang, Huadong Li, Chao Guo
Summary: This study investigated the mechanism of IL-10 in macrophage-related chronic rejection after mouse heart transplantation. It found that IL-10 downregulated miR-155 and activated SOCS5, thereby promoting macrophage M2 polarization to relieve chronic rejection.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Zhiqi Zhai, Yue Fu, Xinyue Zhang, Yi Zhang, Chao Zhou, Xiaojia Huang, Linhong Deng
Summary: In this study, the effects of QU-loaded liposomes on macrophage-mediated lung inflammation were investigated. The results showed that liposomal QU inhibited lung inflammation and had no obvious toxicity on vital organs in septic mice. Mechanistically, the anti-inflammatory effects of liposomal QU were associated with inhibition of NF-κB-dependent cytokine production and inflammasome activation in macrophages.
BIOMEDICAL MATERIALS
(2023)
Article
Immunology
Susana Lopez-Lopez, Maria Jose Romero de avila, Maria Julia Gonzalez-Gomez, Maria Luisa Nueda, Victoriano Baladron, Eva M. Monsalve, Jose Javier Garcia-Ramirez, Maria Jose M. Diaz-Guerra
Summary: IL-13 signaling induces NOTCH4 receptor expression and activates M2 macrophages, contributing to tissue repair and anti-inflammatory responses. However, excessive NOTCH4 signaling may lead to the progression of severe pathologies, such as allergic airway inflammation and asthma. The study suggests that NOTCH4 could be a potential target for the treatment of these diseases.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Surgery
Jeff Reeve, Georg A. Boehmig, Farsad Eskandary, Gunilla Einecke, Gaurav Gupta, Katelynn Madill-Thomsen, Martina Mackova, Philip F. Halloran
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Urology & Nephrology
Olivier Aubert, Sarah Higgins, Yassine Bouatou, Daniel Yoo, Marc Raynaud, Denis Viglietti, Marion Rabant, Luis Hidalgo, Denis Glotz, Christophe Legendre, Michel Delahousse, Nikhil Shah, Banu Sis, Patricia Campbell, Michael Mengel, Xavier Jouven, Jean-Paul Duong Van Huyen, Carmen Lefaucheur, Alexandre Loupy
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Urology & Nephrology
Malte Ziemann, Wolfgang Altermann, Katharina Angert, Wolfgang Arns, Anette Bachmann, Tamam Bakchoul, Bernhard Banas, Annette von Borstel, Klemens Budde, Vanessa Ditt, Gunilla Einecke, Ute Eisenberger, Thorsten Feldkamp, Siegfried Goerg, Martina Guthoff, Antje Habicht, Michael Hallensleben, Falko M. Heinemann, Nicole Hessler, Christian Hugo, Matthias Kaufmann, Teresa Kauke, Martina Koch, Inke R. Koenig, Christine Kurschat, Claudia Lehmann, Matthias Marget, Anja Muehlfeld, Martin Nitschke, Luiza Pego da Silva, Carmen Quick, Axel Rahmel, Thomas Rath, Petra Reinke, Lutz Renders, Florian Sommer, Bernd Spriewald, Oliver Staeck, Dirk Stippel, Caner Suesal, Bernhard Thiele, Daniel Zecher, Nils Lachmann
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Medicine, Research & Experimental
Andrew G. Masoud, Jiaxin Lin, Abul K. Azad, Maikel A. Farhan, Conrad Fischer, Lin F. Zhu, Hao Zhang, Banu Sis, Zamaneh Kassiri, Ronald B. Moore, Daniel Kim, Colin C. Anderson, John C. Vederas, Benjamin A. Adam, Gavin Y. Oudit, Allan G. Murray
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Surgery
Michael S. Balzer, Stephanie Pankow, Robert Claus, Eva Dumann, Stephan Ruben, Hermann Haller, Gunilla Einecke
TRANSPLANT INTERNATIONAL
(2020)
Article
Surgery
Katelynn Madill-Thomsen, Agnieszka Perkowska-Ptasinska, Georg A. Boehmig, Farsad Eskandary, Gunilla Einecke, Gaurav Gupta, Philip F. Halloran
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Hematology
Virginie Royal, Nelson Leung, Stephan Troyanov, Samih H. Nasr, Laure Ecotiere, Richard LeBlanc, Benjamin A. Adam, Andrea Angioi, Mariam P. Alexander, Anna Maria Asunis, Antonella Barreca, Paola Bianco, Camille Cohen, Maria E. Drosou, Huma Fatima, Roberta Fenoglio, Francois Gougeon, Jean-Michel Goujon, Guillermo A. Herrera, Bertrand Knebelmann, Nicola Lepori, Francesca Maletta, Rita Manso, Shveta S. Motwani, Antonello Pani, Marion Rabant, Helmut G. Rennke, Dario Rocatello, Frida Rosenblum, Paul W. Sanders, Afonso Santos, Karina Soto, Banu Sis, Guy Touchard, Christopher P. Venner, Frank Bridoux
Article
Infectious Diseases
Pang Y. Young, Thomas F. Mueller, Banu Sis, Thomas A. Churchill, Rachel G. Khadaroo
SURGICAL INFECTIONS
(2020)
Article
Surgery
Gunilla Einecke, Jeff Reeve, Gaurav Gupta, Georg A. Boehmig, Farsad Eskandary, Jonathan S. Bromberg, Klemens Budde, Philip F. Halloran
Summary: In this study, the focus was on clinical and molecular features of kidney transplant patients after indication biopsy to predict the risk of transplant failure. The results showed that factors such as estimated GFR, proteinuria, time posttransplant, donor-specific antibody, as well as molecular and histologic features reflecting injury were more important predictors of failure compared to rejection activity.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Philip F. Halloran, Georg A. Bohmig, Jonathan S. Bromberg, Klemens Budde, Gaurav Gupta, Gunilla Einecke, Farsad Eskandary, Katelynn Madill-Thomsen, Jeff Reeve
Summary: The study found that certain injury elements in kidney transplant are selective for specific pathologic mechanisms, with Dimension 3 being a newly discovered dimension involving genes related to epithelial polarity.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Public, Environmental & Occupational Health
Tabea Stocklassa, Bianca Borchert-Morlins, Nima Memaran, Gunilla Einecke, Roland Schmitt, Nicolas Richter, Florian Wr Vondran, Elena Bauer, Sabrina Markefke, Anette Melk, Bernhard M. W. Schmidt
Summary: The study found that women have better cardiovascular disease outcomes and blood pressure control after transplantation, and CCB treatment has a positive impact on LVMI and PWV in women, indicating the need for further research on the effects of gender on cardiovascular risk in transplant recipients and the use of CCBs.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Biology
Jenny N. Tran, Oliver P. Gunther, Karen R. Sherwood, Franz Fenninger, Lenka L. Allan, James Lan, Ruth Sapir-Pichhadze, Rene Duquesnoy, Frans Claas, Steven G. E. Marsh, W. Robert McMaster, Paul A. Keown
Summary: The study used high throughput sequencing, structural biology, and computational simulation to determine the frequencies of HLA alleles and antibody-defined epitopes in renal transplant patients and donors, demonstrating the feasibility of HLA epitope matching using data from a national transplantation program. Eplets were found to be more common and uniformly distributed between donors and recipients compared to HLA isoforms.
COMMUNICATIONS BIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Jeffery M. Venner, Charles N. Bernstein
Summary: Immunomodulators, such as thiopurines and methotrexate, play a significant role in the treatment of inflammatory bowel diseases. Despite the availability of other treatment options, these drugs are still widely used, especially for maintaining remission and in combination therapy with other medications.
GASTROENTEROLOGY REPORT
(2022)
Meeting Abstract
Surgery
A. Toelke, J. Schmitz, W. Dai, K. Diahovets, A. Khalifa, K. Niculovic, I. Albers, H. Haller, H. -H. Kreipe, T. Feldkamp, U. Eisenberger, C. Brandenberger, N. Richter, G. Einecke, J. Menne, A. Muenster-Kuehnel, J. H. Braesen
TRANSPLANT INTERNATIONAL
(2019)
Meeting Abstract
Surgery
G. Einecke, J. Reeve, P. F. Halloran
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)