Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Inesa Navasardyan, Benjamin Bonavida
Summary: The T cell-mediated immune response plays a key role in combating infectious diseases and cancer, with complex underlying mechanisms. The iNOS/.NO mechanism regulates various cells and tissues that control the anti-tumor T cell response. The concentration and exposure time of .NO can have different effects on immune responses mediated by T cells.
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Tassya Cataldi Cardoso, Marianna Araujo Rocha, Matheus M. L. Monteiro, Vinicius Santos Alves, Luiz Eduardo Baggio Savio, Claudia Lucia Martins Silva
Summary: The signaling of endothelial P2Y(2) receptor contributes to the adhesion of metastatic prostate cancer cells, suggesting a potential mechanism to reduce prostate cancer metastasis through the blockade of downstream signaling.
Article
Immunology
Sigrid Dubois, Thomas A. Waldmann, Jurgen R. Muller
Summary: The bone marrow-derived dendritic cells showed effective killing of T cell lymphomas in mice, with the cytotoxicity being mediated by NO metabolites. The study suggests that dendritic cell adaptive immunotherapy can be used as a treatment against T cell lymphomas in mice.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Food Science & Technology
Yang Liu, Kevin D. Croft, Jonathan M. Hodgson, Trevor Mori, Natalie C. Ward
Summary: Endothelial dysfunction may lead to atherosclerosis, while dietary nitrate/nitrite shows significant benefits on cardiovascular homeostasis. Research suggests that nitrate/nitrite may enhance eNOS activation by stimulating AMPK signaling pathway, potentially contributing to vascular protective effects.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Peripheral Vascular Disease
Sarah M. McCann Haworth, Zhengbing Zhuge, Carina Nihlen, Matilda Fornell Von Rosen, Eddie Weitzberg, Jon O. Lundberg, Rafael T. Krmar, Josefine Nasiell, Mattias Carlstrom
Summary: This study reveals that in patients with pre-eclampsia, red blood cells exhibit increased arginase activity and expression, which are correlated with disease severity. Red blood cells can mediate endothelial dysfunction in pre-eclampsia through arginase-dependent and oxidative stress-dependent mechanisms. Targeting red blood cell arginase may offer a novel treatment approach for pre-eclampsia.
JOURNAL OF HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Xuehui Fan, Lukas Cyganek, Katja Nitschke, Stefanie Uhlig, Philipp Nuhn, Karen Bieback, Daniel Duerschmied, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin
Summary: This study compared the electrophysiological and functional properties of endothelial cells derived from human induced pluripotent stem cells with primary human cardiac microvascular endothelial cells. The results demonstrated that the two types of endothelial cells were similar in terms of ion channel function, membrane receptor signaling, and physiological cell functions, although some differences were observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Jia-Ning Syu, Hung-Yu Lin, Tun Yu Huang, Der-Yen Lee, En-Pei Isabel Chiang, Feng-Yao Tang
Summary: In this study, it was found that trimethylamine-N-oxide (TMAO) has detrimental effects on the neovascularization of human endothelial progenitor cells (hEPCs), while docosahexaenoic acid (DHA) could alleviate these effects. The mechanism involves upregulation of miR-221 level, inactivation of Akt/eNOS and MAPK/ERK signaling cascades, suppression of ?-GCS protein, and decreased levels of glutathione (GSH) and GSH/GSSG ratio. DHA reverses these effects by suppressing miR-221 level, activating Akt/eNOS and MAPK/ERK signaling cascades, increasing expression of ?-GCS protein, and increasing cellular GSH level and GSH/GSSG ratio in hEPCs.
Article
Cell Biology
Thaina Omia Bueno-Pereira, Priscila Rezeck Nunes, Mariana Bertozzi Matheus, Ananda Lini Vieira da Rocha, Valeria Cristina Sandrim
Summary: This study investigated the effect of NEB on NO synthesis in endothelial cells incubated with plasma from PE patients. The results showed that NEB can increase NO levels by activating eNOS and β(3)-adrenergic receptors.
Article
Neurosciences
Ana Sierra-Martin, Julio Navascues, Veronika E. Neubrand, M. Rosario Sepulveda, David Martin-Oliva, Miguel A. Cuadros, Jose L. Marin-Teva
Summary: This study found that LPS stimulation leads to apoptotic cell death of immature microglia, which in turn promotes the death of ganglion cells in the retina. This cell death may be mediated by the phagocytic activity of microglia, although a non-phagocytic mechanism cannot be excluded. Therefore, the release of NO by microglia under LPS stimulation is an important mechanism underlying ganglion cell death during retinal development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Multidisciplinary Sciences
Winnie Enns, Anna von Rossum, Jonathan Choy
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Review
Immunology
Anna von Rossum, Ismail Laher, Jonathan C. Choy
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Immunology
Anna von Rossum, Kevin Rey, Winnie Enns, Sukhbir Manku, Rajan Cheema, Grace E. MacEwan, Jonathan C. Choy
Article
Cardiac & Cardiovascular Systems
Sukhbir Manku, Wendy Wong, Zongshu Luo, Michael A. Seidman, Zainab Alabdurubalnabi, Kevin Rey, Winnie Enns, J. Antonio Avina-Zubieta, Kamran Shojania, Jonathan C. Choy
CARDIOVASCULAR PATHOLOGY
(2018)
Article
Immunology
Kevin Rey, Sukhbir Manku, Winnie Enns, Thea Van Rossum, Kevin Bushell, Ryan D. Morin, Fiona S. L. Brinkman, Jonathan C. Choy
Article
Microbiology
Jason R. Nesbitt, Elizabeth Y. Steves, Cole R. Schonhofer, Alissa Cait, Sukhbir S. Manku, Juliana H. F. Yeung, Andrew J. Bennet, Kelly M. McNagny, Jonathan C. Choy, Michael R. Hughes, Margo M. Moore
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Hematology
Nichole K. Escalante, Anna von Rossum, Martin Lee, Jonathan C. Choy
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2011)
Article
Hematology
Anna von Rossum, Winnie Enns, Yu P. Shi, Grace E. MacEwan, Mehrnoush Malekesmaeli, Ryan Brinkman, Jonathan C. Choy
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2014)
Review
Biochemistry & Molecular Biology
J. C. Choy
CELL DEATH AND DIFFERENTIATION
(2010)
Article
Biochemistry & Molecular Biology
Anna von Rossum, Randall Krall, Nichole K. Escalante, Jonathan C. Choy
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Martin Lee, Jonathan C. Choy
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Immunology
Usman Ahmad, Rahmat Ali, Amir H. Lebastchi, Lingfeng Qin, Sheng-fu L. Lo, Alexander O. Yakimov, Salman F. Khan, Jonathan C. Choy, Arnar Geirsson, Jordan S. Pober, George Tellides
JOURNAL OF IMMUNOLOGY
(2010)
Article
Immunology
Arthur C. Liu, Martin Lee, Bruce M. McManus, Jonathan C. Choy
JOURNAL OF IMMUNOLOGY
(2012)
Article
Medical Laboratory Technology
Kevin Rey, Jonathan C. Choy
CLINICS IN LABORATORY MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Martin Lee, Christine Wang, Steven W. Jin, Mark P. Labrecque, Timothy V. Beischlag, Mark A. Brockman, Jonathan C. Choy
FREE RADICAL BIOLOGY AND MEDICINE
(2019)