Article
Immunology
Allison J. Kwong, W. Ray Kim, John Lake, Peter G. Stock, Connie J. Wang, James B. Wetmore, Marc L. Melcher, Andrew Wey, Nicholas Salkowski, Jon J. Snyder, Ajay K. Israni
Summary: A study found that livers with macrovesicular steatosis are less likely to be transplanted due to their higher risk of graft failure. To facilitate the use of these higher-risk organs, the SRTR now includes the variable of macrovesicular steatosis in their risk-adjustment models.
Article
Surgery
Takayuki Yamamoto, Srilakshmi Atthota, Divyansh Agarwal, Kerry Crisalli, Malcolm Macconmara, Tsukasa Nakamura, Richard Teo, Leigh Anne Dageforde, Shoko Kimura, Nahel Elias, Heidi Yeh, Adel Bozorgzadeh, Tatsuo Kawai, James F. Markmann
Summary: This study compares the outcomes of liver allografts preserved using portable normothermic machine perfusion (NMP) and ischemic cold storage (ICS) in liver transplantation procedures. It concludes that NMP can significantly reduce the incidence of early allograft dysfunction, reperfusion syndrome, and ischemic cholangiopathy after donation after circulatory death (DCD) liver transplantation.
Article
Urology & Nephrology
Simon Ville, Marine Lorent, Clarisse Kerleau, Anders Asberg, Christophe Legendre, Emmanuel Morelon, Fanny Buron, Valerie Garrigue, Moglie Le Quintrec, Sophie Girerd, Marc Ladriere, Laetitia Albano, Antoine Sicard, Denis Glotz, Carmen Lefaucheur, Julien Branchereau, David Jacobi, Magali Giral
Summary: The study found a lower incidence of delayed graft function in patients whose kidney clamping occurred between midnight and noon, while the declamping time was not associated with kidney graft outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Woo Yeong Park, Yoon Kyung Chang, Young Soo Kim, Kyubok Jin, Chul Woo Yang, Seungyeup Han, Byung Ha Chung
Summary: This study evaluated the impact of acute kidney injury (AKI) on post-transplant clinical outcomes for deceased donor (DD) kidney transplantation (KT) using the Kidney Donor Profile Index (KDPI) system. The results showed that KT from DDs with AKI stage 3 had an adverse impact on the allograft outcome, especially in the high KDPI-KTR group. Therefore, careful management of deceased donors with high KDPI scores is important to prevent severe AKI prior to transplantation.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Esli Medina-Morales, Mohamed Ismail, Romelia Barba Bernal, Yazan Abboud, Leandro Sierra, Daniela Goyes, Ana Marenco-Flores, Behnam Saberi, Vilas Patwardhan, Alan Bonder
Summary: This study compares the outcomes of living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT) in patients with primary biliary cholangitis (PBC). The results show that LDLT has superior patient survival compared to DDLT, and there is no significant difference in graft survival between the two methods. The study also identifies predictors of poor post-transplant outcomes in PBC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Charat Thongprayoon, Jing Miao, Caroline C. Jadlowiec, Shennen A. Mao, Michael A. Mao, Napat Leeaphorn, Wisit Kaewput, Pattharawin Pattharanitima, Supawit Tangpanithandee, Pajaree Krisanapan, Pitchaphon Nissaisorakarn, Matthew Cooper, Wisit Cheungpasitporn
Summary: Using unsupervised machine learning, the study identified three clinically distinct clusters of recipients in diabetic deceased donor kidney transplants with differing outcomes. The findings highlight opportunities to improve utilization of high KDPI kidneys from diabetic donors for recipients with survival-limiting comorbidities, as observed in Cluster 1.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Urology & Nephrology
Enric Miret Alomar, Francesc Moreso, Nestor Toapanta, David Lorente, Marina Triquell, Teresa Pont, Santiago Perez-Hoyos, Daniel Seron, Juan Morote, Enrique Trilla
Summary: The study found that macroscopic appraisal of kidney grafts is reproducible between surgeons and can improve the accuracy of clinical preimplantational prediction scores. Specifically, features such as adherent perirenal fat and surface roughness are associated with transplant outcomes.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Article
Surgery
Fabian Echterdiek, Daniel Kitterer, Juergen Dippon, Matthias Ott, Gregor Paul, Joerg Latus, Vedat Schwenger
Summary: Kidney transplantation from donors with acute kidney injury, especially in elderly donors, does not result in significantly worse outcomes compared to transplantation from donors without acute kidney injury. With careful selection, satisfactory outcomes can be achieved in kidney transplantation from elderly donors with acute kidney injury.
CLINICAL TRANSPLANTATION
(2022)
Article
Surgery
Ane M. Andres, Jose Luis Encinas, Alba Sanchez-Galan, Javier Serradilla Rodriguez, Karla Estefania, Rocio Gonzalez Sacristan, Alida Alcolea, Pilar Serrano, Belen Estebanez, Inigo Velasco Leon, Paula Burgos, Alvaro Gonzalez Rocafort, Bunty Ramchandani, Belen Calderon, Cristina Verdu, Esperanza Jimenez, Paloma Talayero, Pablo Stringa, Itziar de la Pena Navarro, Esther Ramos, Francisco Hernandez Oliveros
Summary: The shortage of pediatric multivisceral donors leads to long waiting times and high mortality rates for pediatric patients. The use of donors after cardiac death, particularly with normothermic regional perfusion, has increased for solid organ transplantation, except for the intestine. This case demonstrates the possibility of reducing waiting time for patients through multivisceral transplantation from donors after cardiac death.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Isaac E. Hall, Peter Philip Reese, Sherry G. Mansour, Sumit Mohan, Yaqi Jia, Heather R. Thiessen-Philbrook, Daniel C. Brennan, Mona D. Doshi, Thangamani Muthukumar, Enver Akalin, Meera Nair Harhay, Bernd Schroeppel, Pooja Singh, Francis L. Weng, Jonathan S. Bromberg, Chirag R. Parikh
Summary: A study on kidney transplant recipients found that deceased-donor AKI was independently associated with lower risk for BKV infection, contrary to the initial hypothesis. Data from the OPTN database also showed that donor AKI was linked to lower risk for graft failure attributed to BKV.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Surgery
Kathleen Yu, Syed A. Husain, Kristen King, Jacob S. Stevens, Chirag R. Parikh, Sumit Mohan
Summary: Acute kidney injury (AKI) severity is a strong risk factor for kidney nonprocurement in deceased organ donors. Efforts to address the organ shortage should focus on encouraging the procurement and utilization of kidneys from deceased donors with severe AKI, given the large prevalence of donor AKI and successful transplant outcomes with these kidneys.
CLINICAL TRANSPLANTATION
(2022)
Review
Medicine, General & Internal
Ahmed S. Ghoneima, Richard X. Sousa X. Da Silva, Martina A. Gosteli, Adam D. Barlow, Philipp Kron
Summary: The high demand for organs in kidney transplantation has led to the widespread use of machine perfusion technologies. This study provides a systematic review of the developments in this field over the past 10 years and compares different perfusion techniques. The results show that dynamic preservation strategies, such as hypothermic machine perfusion, have lower rates of delayed graft function and have the potential to improve outcomes in kidney transplantation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Arianna Barbetta, Mayada Aljehani, Michelle Kim, Christine Tien, Aaron Ahearn, Hannah Schilperoort, Linda Sher, Juliet Emamaullee
Summary: A systematic review comparing adult living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) found that LDLT is associated with improved patient survival, reduced waiting time, and lower MELD score, despite an increased risk of biliary complications. Hepatic artery thrombosis rates did not differ between the two types of transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Wei-Chen Lee, Ting-Jung Wu, Chih-Hsien Cheng, Yu-Chao Wang, Hao-Chien Hung, Jin-Chiao Lee, Tsung-Han Wu, Hong-Shiue Chou, Chen-Fang Lee, Kun-Ming Chan
Summary: Liver transplantation can be done using deceased or living donor grafts. Deceased liver grafts, obtained from brain- or circulation-death patients, usually have some degree of damage. This study compared the metabolomics of deceased and living donor grafts. Deceased liver grafts had increased levels of certain lipid metabolites and amino acids compared to living donor grafts. The elevation of lipid metabolites can be used as an indicator of liver graft suffering.
Article
Medicine, General & Internal
Duilio Pagano, Ester Badami, Giovanni Zito, Pier Giulio Conaldi, Ivan Vella, Barbara Buscemi, Giandomenico Amico, Rosalia Busa, Paola Salis, Sergio Li Petri, Fabrizio di Francesco, Sergio Calamia, Pasquale Bonsignore, Alessandro Tropea, Caterina Accardo, Salvatore Piazza, Salvatore Gruttadauria
Summary: This study aimed to evaluate the impact of the immune system after graft reperfusion during kidney transplantation in adults in order to identify predictive biomarkers. The study found that the percentage of T-lymphocytes in the liver perfusate was significantly associated with delayed functional recovery and secondary infection. However, there was no significant association between the proportions of NK cells and NK-T cells with clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Laura Bojke, Marta O. Soares, Karl Claxton, Abigail Colson, Aimee Fox, Chris Jackson, Dina Jankovic, Alec Morton, Linda D. Sharples, Andrea Taylor
Summary: This article focuses on establishing reference case methods for expert elicitation to inform health care decision making. Methods choices for elicitation lack empirical evidence supporting recommendations, but reference case methods have been determined for health technology assessment. The reference methods prioritize experts with substantive knowledge, eliciting quantities directly observed by experts, and individual elicitation of beliefs. Further applied examples and experimental evidence comparing methods are recommended.
MEDICAL DECISION MAKING
(2022)
Article
Cardiac & Cardiovascular Systems
Linda Sharples, Priya Sastry, Carol Freeman, Colin Bicknell, Yi-Da Chiu, Srinivasa Rao Vallabhaneni, Andrew Cook, Joanne Gray, Andrew McCarthy, Peter McMeekin, Luke Vale, Stephen Large
Summary: The study aimed to observe, describe, and evaluate management and timing of intervention for patients with untreated thoracic aortic aneurysms. It found that the risk of death increased with aneurysm size at baseline and with growth, while hospital admissions also increased with aneurysm size.
EUROPEAN HEART JOURNAL
(2022)
Review
Health Care Sciences & Services
Linda Sharples, Priya Sastry, Carol Freeman, Joanne Gray, Andrew McCarthy, Yi-Da Chiu, Colin Bicknell, Peter McMeekin, S. Rao Vallabhaneni, Andrew Cook, Luke Vale, Stephen Large
Summary: The study investigates the timing and intervention choice for chronic thoracic aortic aneurysms. It found that small aneurysms require close observation, while larger aneurysms require timely intervention. Endovascular stent grafting and open surgical replacement are successful treatments for carefully selected patients. The study also found that factors such as female gender, older age, and increasing diameter have a negative impact on patient survival and quality of life.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Linda D. Sharples, Christine Mills, Yi-Da Chiu, Simon Fynn, Helen M. Holcombe, Samer A. M. Nashef
Summary: Adding AF surgery to cardiac operations can increase the rate of returning to sinus rhythm, but it does not impact quality of life or survival. There is a slight decrease in stroke incidence, but no improvement in overall survival or quality-adjusted survival. Additionally, no other clinical outcomes showed significant differences.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
Shuping J. Li, Tara Seedher, Linda D. Sharples, Sally C. Benton, Christopher Mathews, Rhian Gabe, Peter Sasieni, Stephen W. Duffy
Summary: This study analyzed data from the NHS Bowel Cancer Screening Programme and found that increasing the fecal hemoglobin (f-Hb) threshold was more efficient than increasing the interscreening interval in terms of reducing colonoscopy requirements and detecting colorectal cancer and other abnormalities.
BRITISH JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Helen A. Blake, Linda D. Sharples, Katie Harron, Jan H. van der Meulen, Kate Walker
Summary: The study compares the pairwise and spine linkage approaches using real-world data, and finds that the spine linkage method can be an efficient alternative with little difference compared to the pairwise linkage approach.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Health Care Sciences & Services
Kamaryn T. Tanner, Linda D. Sharples, Rhian M. Daniel, Ruth H. Keogh
Summary: This study introduces two methods, path-specific effects and additive hazards model with exposure splitting, to address statistical challenges in mediation analysis for time-to-event outcomes and longitudinal observational data. Both methods are applied to observational datasets and found to produce unbiased estimates, although estimates may be biased if the data are measured infrequently.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Biology
John N. S. Matthews, Sofia Bazakou, Robin Henderson, Linda D. Sharples
Summary: This paper focuses on complete case analysis of complete crossover designs, which can be used to estimate the difference between principal stratum strategy and hypothetical strategy estimands. The results show that the difference between these estimands exceeds 5% only when the trial is severely affected by dropouts or if the within-subject correlation is low.
Article
Endocrinology & Metabolism
Kamaryn T. Tanner, Rhian M. Daniel, Diana Bilton, Nicholas J. Simmonds, Linda D. Sharples, Ruth H. Keogh
Summary: This study investigated the potential mediating factors, including lung function, pulmonary exacerbations, and nutritional status, through which cystic fibrosis-related diabetes (CFRD) affects the composite outcome of mortality or transplant in adult cystic fibrosis (CF) patients. The results showed that pulmonary exacerbations were the strongest mediator of the effect, attributing to a significant proportion of the total effect. Other factors may also contribute to the influence of CFRD on patient survival.
Article
Immunology
Jyoti Sehjal, Linda D. Sharples, Ruth H. Keogh, Kate Walker, Andreas Prachalias, Nigel Heaton, Tommy Ivanics, Jan van der Meulen, David Wallace
Summary: This study reveals time-varying differences in the hazard of all-cause mortality after liver transplantation between hepatocellular carcinoma (HCC) recipients and non-HCC recipients. It also provides evidence that some HCC patients have extra-hepatic spread at the time of transplantation, which has implications for post-transplant surveillance protocols.
Article
Endocrinology & Metabolism
Ramzi A. Ajjan, Simon R. Heller, Colin C. Everett, Armando Vargas-Palacios, Ruchi Higham, Linda Sharples, Diana A. Gorog, Alice Rogers, Catherine Reynolds, Catherine Fernandez, Pedro Rodrigues, Thozhukat Sathyapalan, Robert F. Storey, Deborah D. Stocken
Summary: This study analyzed the impact of modern glucose-monitoring strategies on glycemic and patient-related outcomes in individuals with type 2 diabetes (T2D) and recent myocardial infarction (MI). The results showed that compared with self-monitoring of blood glucose (SMBG), intermittently scanned continuous glucose monitoring (isCGM) marginally increased time in range and significantly reduced hypoglycemic exposure in T2D individuals with MI, while equally improving HbA(1c). These findings explain the cost effectiveness of isCGM.
Article
Medicine, General & Internal
Chris P. Gale, Deborah Stocken, Suleman Aktaa, Catherine Reynolds, Rachael Gilberts, David Brieger, Kathryn Carruthers, Derek P. Chew, Shaun G. Goodman, Catherine Fernandez, Linda Sharples, Andrew Yan, Keith Fox
Summary: This study aimed to determine the effectiveness of risk stratification using the Global Registry of Acute Coronary Events (GRACE) risk score (GRS) for patients with suspected non-ST elevation acute coronary syndrome. The results showed that the use of GRS did not improve adherence to guideline recommended management or reduce cardiovascular events at 12 months.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Letter
Cardiac & Cardiovascular Systems
Samer A. M. Nashef, Linda D. Sharples
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
G. E. Smith, J. Long, T. Wallace, D. Carradice, I. C. Chetter
Summary: A national research strategy for vascular disease in the UK was established by the Vascular Research Collaborative through a modified Delphi approach involving multidisciplinary vascular clinical specialists. Two rounds of online surveys resulted in 83 prioritized research questions related to critical lower-limb ischaemia, diabetic foot disease, amputation, wound healing, carotid plaque morphology, and service organization/delivery. These results are expected to drive the UK national vascular research agenda for the next 5-10 years.
Article
Social Sciences, Mathematical Methods
Kamaryn T. Tanner, Linda D. Sharples, Rhian M. Daniel, Ruth H. Keogh
Summary: This study demonstrates how landmarking can be combined with machine learning to enhance dynamic survival prediction. By using discrete time survival analysis techniques and integrating machine learning algorithms, the proposed approach shows potential in practical applications.
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY
(2021)
