Article
Medicine, General & Internal
Zhi-yu Zou, Lin-rui Dai, Yi-bo Hou, Chen-zhen Yu, Ren-jie Chen, Yan-yan Chen, Bin Liu, Hui-bo Shi, Nian-qiao Gong, Zhi-shui Chen, Song Chen, Sheng Chang, Wei-jie Zhang
Summary: This study found that an immunosuppressive regimen of SRL combined with low-dose ER-TAC is equally effective and safe as standard immunosuppressive regimens for renal transplant recipients, and may improve graft renal function and medication adherence.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Marcel G. Naik, Wolfgang Arns, Klemens Budde, Fritz Diekmann, Frank Eitner, Wilfried Gwinner, Nils Heyne, Jan Steffen Jurgensen, Christian Morath, Udo Riester, Katharina M. Heller, Michael Fischereder
Summary: The study retrospectively analyzed 726 renal transplant recipients converted to sirolimus, showing lower cancer incidence rates after conversion. Patients with prior malignancy were older but had lower cancer rates after conversion. Renal function and graft survival were better in all cancer types compared to patients converted to sirolimus without cancers. Patient survival was largely dependent on tumor entity.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Hematology
Katie Maurer, Vincent T. Ho, Eno Inyang, Corey Cutler, John Koreth, Roman M. Shapiro, Mahasweta Gooptu, Rizwan Romee, Sarah Nikiforow, Joseph H. Antin, Catherine J. Wu, Jerome Ritz, Robert J. Soiffer, Haesook T. Kim
Summary: PTCY prophylaxis is associated with lower rates of relapse and chronic GVHD in patients who receive HLA-matched unrelated donor PBSCT, improving overall survival and reducing nonrelapse mortality.
Article
Urology & Nephrology
Siah Kim, Anita van Zwieten, Melanie Wyld, Maleeka Ladhani, Chandana Guha, Amanda Dominello, Kylie-Ann Mallitt, Anna Francis, Roslyn B. Mannon, Germaine Wong
Summary: Based on data from Australia and New Zealand, females constitute a larger proportion of kidney donors to male recipients. The relationship between recipient and donor is a factor that modifies the association between recipient gender and donor gender. Older recipients residing in remote areas are more likely to receive kidneys from female donors.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Medicine, General & Internal
Asuncion Sancho, Eva Gavela, Julia Kanter, Sandra Beltran, Cristina Castro, Veronica Escudero, Jonay Pantoja, Pablo Molina, Belen Vizcaino, Mercedes Gonzalez, Emma Calatayud, Ana Avila
Summary: This study found that female kidney transplant recipients under 60 years of age had lower graft survival compared to male recipients. There were no gender differences in graft or patient survival in the overall study population. The poorer graft survival in female recipients was attributed to the higher immunological risk and more frequent use of expanded criteria donors in this group.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Bastian N. Ruijter, Ron Wolterbeek, Mitchell Hew, Marjolein van Reeven, Danny van der Helm, Jeroen Dubbeld, Maarten E. Tushuizen, Herold Metselaar, Ann C. T. M. Vossen, Bart van Hoek
Summary: This study examined the effect of an EBV VL monitoring strategy on the incidence of PTLD after liver transplant in adults. The results suggest that monitoring EBV VL may reduce PTLD incidence, but larger studies are needed to confirm these findings.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Uttom Nandi, Ichioma Onyesom, Dennis Douroumis
Summary: The study investigated the effect of sirolimus encapsulated liposomes on cancer therapy, finding that factors such as incubation time and lipid composition influenced their antiproliferative effect. Both conventional and Stealth liposomes demonstrated antiproliferative effects against prostate cancer cells, with the nanoparticles being internalized in the cytoplasm. Further development of sirolimus liposomes for targeted drug delivery to cancer sites using specific antibodies showed promising results.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Midas B. Mulder, Bart van Hoek, Aad P. van den Berg, Wojciech G. Polak, Ian P. J. Alwayn, Koert P. de Jong, Brenda C. M. de Winter, Elke Verhey-Hart, Nicole S. Erler, Caroline M. den Hoed, Herold J. Metselaar
Summary: The aim of this study was to compare the effects of low-dose sirolimus and low-dose extended-release tacrolimus with normal-dose extended-release tacrolimus on renal function and rejection, graft and patient survival rates at 36 months after transplantation. This was an open-label, multicenter randomized controlled trial. The study found that there was no significant difference in the incidence of chronic kidney disease at 36 months between the groups, but in the intention-to-treat population, the interventional group had higher estimated glomerular filtration rate at 6 months.
LIVER TRANSPLANTATION
(2023)
Article
Virology
Andrea Erba, Catia Marzolini, Katharina Rentsch, Marcel Stoeckle, Manuel Battegay, Michael Mayr, Maja Weisser
Summary: This case reports on an HIV-infected renal transplant recipient who switched from ritonavir to cobicistat as the pharmacokinetic booster, leading to a progressive decrease in tacrolimus concentrations. The unexpected observation highlights the fact that ritonavir and cobicistat are not fully interchangeable as pharmacokinetic boosters.
Article
Transplantation
Danilo Radunovic, Milena Dapcevic, Vladimir Prelevic, Filip Tomovic, Marina Ratkovic, Nikolina Basic Jukic
Summary: Posttransplant lymphoproliferative disorder is a serious complication for organ transplant patients on immunosuppressive therapy, with isolated cases in the gastrointestinal tract being rare. Early identification and treatment of this disorder play a crucial role in patient management and survival.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Kimberley D. Katleba, Paramita M. Ghosh, Maria Mudryj
Summary: Multiple studies have shown the importance of androgen receptor (AR) splice variants (SVs) in prostate cancer progression and their diagnostic utility. However, studies have found that AR-SVs are also expressed in non-prostatic malignancies and have diverse roles in tumorigenesis. AR-SVs also play a role in non-cancer pathologies.
Article
Multidisciplinary Sciences
M. Yahya Ahmed, Nadia Aziz Salman, Sarbjinder Sandhu, M. Okan Cakir, Alan M. Seddon, Christian Kuehne, G. Hossein Ashrafi
Summary: Human papillomavirus (HPV) infection has been linked to multiple cancers and there have been conflicting studies regarding the presence of high-risk HPV in prostate cancer (PCa). This study, the first of its kind in the UK, analyzed prostate tissues for the presence of high-risk HPV DNA and confirmed its existence in 32.7% of analyzed samples, with HPV 35 being the most frequent type. Additionally, the study found a higher positivity rate of high-risk HPV in abnormal prostate tissues compared to normal prostate condition. The expression of HPV E7 protein in HPV DNA positive prostate tissues further suggests a potential relationship between HPV and the progression of certain cases of prostate cancer.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Mariana Bertoncelli Tanaka, Kirpal Sahota, James Burn, Alison Falconer, Mathias Winkler, Hashim U. Ahmed, Tina G. Rashid
Summary: The risk of prostate cancer in transgender women who have not undergone gender-affirming hormone therapy or surgery is the same as cis males. For transgender women on hormone therapy or after surgery, the incidence of prostate cancer is lower but diagnosis and treatment is more complex. Future research is needed to develop evidence-based guidelines for managing prostate cancer in transgender women.
Review
Oncology
Francesco Ziglioli, Annalisa Patera, Gianmarco Isgro, Davide Campobasso, Giulio Guarino, Umberto Maestroni
Summary: This review summaries recent studies on potential lifestyle factors that may affect the development of prostate cancer. The findings suggest that being overweight or obese increases the risk of advanced prostate cancer, particularly considering factors such as body mass index, waist circumference, and waist-hip ratio. The effects of smoking and alcohol consumption on prostate cancer risk are still unclear, while dietary fibers and blood glucose levels may play a role in modifying risk. Inconsistent results were found regarding the associations between vitamins and prostate cancer risk.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Maria Grazia Maddalone, Marco Oderda, Giulio Mengozzi, Iacopo Gesmundo, Francesco Novelli, Mirella Giovarelli, Paolo Gontero, Sergio Occhipinti
Summary: Urinary zinc levels may serve as an important parameter for diagnosing and predicting prostate cancer. Patients with prostate cancer have lower levels of zinc in their urine, and there is an inverse correlation with tumor stage. Combining zinc with other standard parameters can enhance diagnostic performance, suggesting that urinary zinc may be an early and non-invasive biomarker for prostate cancer.