Article
Oncology
Fang Jiang, Jin-Kai Lin, Yang Xiang, Zhuo-fan Xu, Xi-Run Wan, Feng-Zhi Feng, Tong Ren, Jun-Jun Yang, Jun Zhao
Summary: This study aimed to evaluate the influence of lung metastases on the clinical course of gestational trophoblastic neoplasia (GTN) and identify lung imaging characteristics that impact treatment outcomes. The results showed that lung metastases were associated with an increased risk of treatment resistance and recurrence in GTN patients, especially when pulmonary nodules were larger than 1.8 cm.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Jie Xu, Xin Zhi, Lu Xie, Xin Sun, Xingyu Liu, Kuisheng Liu, Wei Guo
Summary: Patients with extensive lung/pleural metastases of Ewing sarcoma have a poor prognosis, even if they achieve complete remission after systemic therapy. Local recurrence is the main pattern, with all recurrent lesions exactly matching the original metastatic lesions. Whole lung irradiation is not sufficient to prevent local recurrence in the lung or pleura. More aggressive local treatment is necessary.
Article
Oncology
Simona Bruzas, Oleg Gluz, Nadia Harbeck, Peter Schmid, Javier Cortes, Jens Blohmer, Christine Seiberling, Ouafaa Chiari, Hakima Harrach, Beyhan Ataseven, Satyendra Shenoy, Mark H. Dyson, Eugen Traut, Ingo Theuerkauf, Daniel Gebauer, Sherko Kuemmel, Mattea Reinisch
Summary: A significant number of early breast cancer patients experience relapse after neoadjuvant therapy, even if the tumors achieved pathologic complete response (pCR). Gene expression analysis revealed that recurrent tumors had lower expression of estrogen receptor signaling and immune-related expression parameters compared to primary tumors. Interindividual analysis showed that patients with any relapse or distant relapse had lower expression of major histocompatibility complex class II in their primary tumors. Additionally, primary tumors with later distant relapse had higher homologous recombination deficiency. Although these associations did not remain statistically significant after adjusting for false discovery rate, our findings suggest that transcriptomic analysis has potential prognostic value for early breast cancer patients at risk of relapse and should be further investigated.
Article
Oncology
Hui Jun Lim, Ruxin Wong, Yen Sin Koh, Zhirui Shaun Ho, Chin-Ann Johnny Ong, Mohamad Farid, Ching Ching Melissa Teo
Summary: This study validated the predictive ability of Sarculator in recurrent RPS patients, providing detailed analysis of age, tumor characteristics, and relapse patterns, suggesting the applicability of the Sarculator tool in the Asian population. Results indicate that patient survival outcomes are influenced by multiple factors, necessitating further therapeutic strategies to improve the prognosis of patients with recurrent RPS.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
S. Salah, Y. H. To, O. Khozouz, T. Ismail, S. Yaser, A. Alnsour, O. Shahin, I. Sultan, R. Abuhijlih, H. Halalsheh, F. Abuhijla, J. Lewin
Summary: Irinotecan and temozolomide (IT) chemotherapy shows similar efficacy and favorable toxicity in pediatric and adult patients with relapsed Ewing sarcoma, with superior median progression-free survival (PFS) observed in the pediatric cohort. The results suggest that IT regimen is effective for relapsed ES in both pediatric and adult populations.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Review
Oncology
Pia Weskamp, Dominic Ufton, Marius Drysch, Johannes Maximilian Wagner, Mehran Dadras, Marcus Lehnhardt, Bjoern Behr, Christoph Wallner
Summary: This systematic review and meta-analysis identified risk factors and prognostic indicators for the development and recurrence of soft tissue sarcomas (STS). Results showed that smoking, genetic predisposition, chronic inflammation, and toxins were associated with the development of STS, while margin of resection, chemotherapy, and radiation were associated with a higher risk of relapse.
Article
Multidisciplinary Sciences
Yuta Kubota, Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga, Hiroshi Tsumura
Summary: In this study, a systematic review and meta-analysis were conducted to assess the surrogacy of intermediate end-points for overall survival (OS) in patients with rhabdomyosarcoma (RMS). The results showed a marginal correlation between event-free survival (EFS) and OS, but the surrogacy of EFS for OS cannot be confirmed.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Wencong He, Yunhong Tan, Zexuan Song, Binbin Liu, Yiting Wang, Ping He, Hui Xia, Fei Huang, Chunfa Liu, Huiwen Zheng, Shaojun Pei, Dongxin Liu, Aijing Ma, Xiaolong Cao, Bing Zhao, Xichao Ou, Shengfen Wang, Yanlin Zhao
Summary: Endogenous relapse is the main cause of tuberculosis recurrence in Hunan province. It is necessary to extend the post-treatment follow-up period for better management of tuberculosis patients. Caution should be exercised when using fluoroquinolones in the treatment of tuberculosis relapse.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Oncology
Fumiaki Takatsu, Hiromasa Yamamoto, Yasuaki Tomioka, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuhito Takahashi, Shinichi Toyooka
Summary: This study retrospectively analyzed patients with retroperitoneal sarcoma metastasized to the lungs and found that age, disease-free interval, and size of metastasis were associated with prognosis. Pulmonary metastasectomy can be an effective management strategy for these patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Naoki Matsuda, Hiromasa Yamamoto, Tomohiro Habu, Kazuma Iwata, Kei Matsubara, Shin Tanaka, Kohei Hashimoto, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Tomohiro Toji, Mikio Okazaki, Seiichiro Sugimoto, Katsuhito Takahashi, Shinichi Toyooka
Summary: This study found that tumor-infiltrating lymphocytes (TILs), tertiary lymphoid structures (TLSs), and neutrophil-to-lymphocyte ratio (NLR) are closely associated with the prognosis of patients with pulmonary metastases from uterine leiomyosarcoma. Specifically, high expression of CD3-positive TILs, CD8-positive TILs, TLSs, and low NLR levels are correlated with better prognosis.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Stefano Radaelli, Sandro Pasquali, Chiara Colombo, Dario Callegaro, Roberta Sanfilippo, Silvia Stacchiotti, Salvatore Provenzano, Claudia Sangalli, Carlo Morosi, Marta Barisella, Rosalba Miceli, Marco Fiore, Alessandro Gronchi
Summary: This study analyzed the histopathologic margins, perioperative treatments, and patient outcomes in primary myxofibrosarcoma (MFS) patients. The status of histopathologic margins, tumor grade, and size were found to independently predict local recurrence, distant metastasis, and overall survival in MFS patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Arash Najafi, Thierry de Baere, Edouard Purenne, Amine Bayar, Marc Al Ahmar, Alexandre Delpla, Charles Roux, Khaled Madani, Jessica Assouline, Frederic Deschamps, Lambros Tselikas
Summary: This study identified significant predictive variables for local tumor progression (LTP) after RFA of pulmonary metastases, including factors such as proximity to large bronchi or vessels, minimal ablation margin, and central-peripheral ablation offset/ablation zone size. In the multiple regression model, only a minimal ablation margin <= 5 mm remained a significant risk factor for LTP. Immediate post-RFA evaluation of ablation margins to ensure a minimal ablation margin of at least 5 mm may lead to improved lung RFA outcomes.
EUROPEAN RADIOLOGY
(2021)
Review
Surgery
Rebecca Varley, Munir Tarazi, Madhav Dave, Shahd Mobarak, Martyn C. Stott, Minas Baltatzis, Thomas Satyadas
Summary: A systematic review and meta-analysis comparing liver transplantation for non-resectable colorectal liver metastases with palliative chemotherapy found potential survival benefit of LT over chemotherapy, but highlighted the need for rigorous justification regarding organ availability and allocation ethics. Improvements in post-liver resection patient management and palliative chemotherapy regimens are also deemed essential.
WORLD JOURNAL OF SURGERY
(2021)
Article
Oncology
Giammauro Berardi, Joanne Chou, Mithat Gonen, Vinod P. Balachandran, Jeffrey Drebin, William R. Jarnagin, T. Peter Kingham, Kevin C. Soares, Alice Wei, Michael D'Angelica
Summary: The aim of this study was to predict treatment failure in patients undergoing upfront resection of colorectal liver metastases (CRLM) using a nomogram. The results showed that primary tumor characteristics, as well as the number and size of metastases, were associated with treatment failure. The findings suggest the potential use of the nomogram to identify high-risk patients and guide future treatment decisions.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yura Ahn, Sang Min Lee, Min Seon Kim, Sehoon Choi, Seonok Kim, Kyung-Hyun Do, Joon Beom Seo
Summary: In patients with bone and soft-tissue sarcoma, a shorter volume doubling time (VDT) of pulmonary metastases is associated with subsequent new metastases after metastasectomy and worse overall survival (OS).
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
