Article
Oncology
Jack L. Demaree, Richard J. Ortiz, Xuezhu Cai, Dipak Aggarwal, Ilakya Senthilkumar, Christopher Lawson, Praveen Kulkarni, Bruce S. Cushing, Craig Ferris
Summary: This study used multimodal magnetic resonance imaging to assess the effects of psychostimulant exposure on brain morphology and functional connectivity in rats. The results showed that chronic psychostimulant treatment during juvenility and peri-adolescence led to decreased connectivity between brain regions, with minimal effects on brain volume and cognitive behavior.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Behavioral Sciences
Anthony Yuan, Natasha Kharas, Nicholas King, Pamela Yang, Nachum Dafny
Summary: The study found that cross-sensitization between MPD and AMP is dose-dependent, with exposure to 2.5 mg/kg and 10.0 mg/kg MPD in adolescence and adulthood or in adulthood alone leading to cross-sensitization with AMP, while exposure to 0.6 mg/kg MPD in adolescence and adulthood or in adulthood alone did not result in cross-sensitization with AMP.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Wei Wei, Li Chen, Hui Zhou, Jinfeng Liu, Yue Zhang, Shiyu Feng, Yingtao Bai, Yanen Leng, En Chang, Liang Huang
Summary: This study conducted a comprehensive analysis of the safety profiles of methylphenidate, atomoxetine, and Amphetamine, the three most commonly used medications for ADHD, across different age groups and genders using the FDA Adverse Event Reporting System (FAERS) database. The analysis revealed significant safety concerns, including dyskinesia, myocardial infarction, hypertension, and neonatal exposures via breast milk for methylphenidate; hostility/aggression, taste and smell disorders, and hostility/aggression for atomoxetine; psychosis and psychotic disorders, hostility/aggression, and Other ischaemic heart disease for Amphetamine. Male patients showed a higher occurrence of adverse events, particularly in terms of cardiac disorders.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Jack L. Demaree, Richard J. Ortiz, Xuezhu Cai, Dipak Aggarwal, Ilakya Senthilkumar, Christopher Lawson, Praveen Kulkarni, Bruce S. Cushing, Craig Ferris
Summary: This study used multimodal magnetic resonance imaging to assess the effects of psychostimulants on brain morphology and functional connectivity in juvenile and peri-adolescent rats. The results suggest that chronic psychostimulant exposure may decrease connectivity between different brain regions, but have minimal effects on brain volume and gray matter microstructure.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Austin R. Swisher, Richard Pham, Bassam Theodory, Shawn Valiani, Nandini Gowda
Summary: Rhabdomyolysis is a potentially life-threatening condition involving multiple organ systems, with muscular trauma being the most common cause. However, enzyme deficiencies, electrolyte abnormalities, drugs, toxins, and endocrinopathies can also contribute. This case report presents a patient who developed rhabdomyolysis after starting a new exercise program, with the use of dextroamphetamine potentially exacerbating the symptoms. The combination of exercise and dextroamphetamine use may predispose patients to develop rhabdomyolysis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Tori E. Abdalla, Daniela Kotsonis, Jordan Best, Ranjith Ramasamy, Ellen Wood
Summary: The use of stimulant medications in ADHD patients may lead to negative interactions between excess dopamine and the endocrine system, causing male factor infertility.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Neurosciences
Jennifer K. Hoots, Heather E. Webber, Cecilia Nunez, Jessica A. Cooper, Paula Lopez-Gamundi, Victoria M. Lawlor, Scott D. Lane, Michael T. Treadway, Margaret C. Wardle
Summary: The study found that individuals reported a stronger desire to re-use 20 mg of dextroamphetamine in a work context. At 20 mg, liking/wanting subjective effects predicted the desire to use dextroamphetamine again in a work environment, while psychomotor speed mainly affected the interest in reusing dextroamphetamine in a recreational setting.
PSYCHOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jiska van Schaik, Mila S. Welling, Corjan J. de Groot, Judith P. van Eck, Alicia Juriaans, Marcella Burghard, Sebastianus B. J. Oude Ophuis, Boudewijn Bakker, Wim J. E. Tissing, Antoinette Y. N. Schouten-van Meeteren, Erica L. T. van den Akker, Hanneke M. van Santen
Summary: This study retrospectively evaluated the treatment of children with HO with dextroamphetamine. The results showed that dextroamphetamine treatment can improve BMI, decrease hyperphagia, and improve energy level and behavior in some patients. However, some patients experienced side effects such as hypertension during treatment. Future studies are needed to further validate these findings.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Khadija Jalloh, Nicole Roeder, John Hamilton, Foteini Delis, Michael Hadjiargyrou, David Komatsu, Panayotis K. Thanos
Summary: This study examined the effects of chronic oral MP treatment on NMDA glutamate receptor binding in rat brain, finding that MP altered NMDA receptor expression throughout the brain and this effect was eliminated following cessation of treatment.
Article
Medicine, General & Internal
Charles White, Rebecca Jeanmonod
Summary: Stress-induced cardiomyopathy, also known as Takotsubo cardiomyopathy, is a clinical syndrome that is difficult to distinguish from acute myocardial infarction (AMI). This article presents a case of a 50-year-old woman who developed symptoms after ingesting a sympathomimetic drug accidentally. The patient was eventually diagnosed with Takotsubo cardiomyopathy based on cardiac evaluation and examination. Reverse Takotsubo cardiomyopathy, a rare variant, was also discussed and associated with a good prognosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Neurosciences
Kathleen R. McNealy, Sydney D. Houser, Scott T. Barrett, Rick A. Bevins
Summary: Nicotine enhances the rewarding effects of other environmental stimuli, potentially encouraging and maintaining nicotine consumption. Using nicotine first may lead to the use of other psychostimulants, but receiving a stimulant prescription also predicts future smoking.
Review
Cardiac & Cardiovascular Systems
Fiona Thoi, Daniel J. Scherer, David M. Kaye, Prashanthan Sanders, Michael B. Stokes
Summary: The increasing usage of methamphetamine worldwide has led to the emergence of methamphetamine-associated cardiomyopathy (MA-CMP), which is becoming a significant cause of heart failure burden. MA-CMP presents unique challenges, including its recognition, severity, complications, and management options. With high levels of methamphetamine use in Australia, it is crucial for clinicians responsible for heart failure management to be aware of this disease entity and its specific clinical challenges.
HEART LUNG AND CIRCULATION
(2022)
Article
Psychology, Developmental
Sarah D. Lopera, Victoria M. O'Kane, Jessica L. Goldhirsh, Brian J. Piper
Summary: The objective of this report was to investigate the regional and state differences in the distribution of prescription methamphetamine and amphetamine in the United States. Data from the Drug Enforcement Administration for 2019 revealed that the per capita distribution of amphetamine was 4,000 times higher than that of methamphetamine. Regionally, the highest per capita distribution of methamphetamine was observed in the West (32.2% of total distribution) and the lowest in the Northeast (17.4%). The highest per capita distribution of amphetamine was in the South (37.0% of total distribution) and the lowest in the Northeast (19.4%). The distribution of amphetamine accounted for 54.0% of its production quota, while methamphetamine only accounted for 16.1%.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Multidisciplinary Sciences
Alex R. De Serrano, Kimberly A. Hughes, F. Helen Rodd
Summary: There is emerging evidence that paternal effects can be transgenerational and span several generations. Studies have shown that exposure to methylphenidate hydrochloride (MPH) by fathers can impact the behavior of offspring and great-grandoffspring, particularly in male descendants. These effects highlight the transgenerational potential of MPH.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Stephanie Harris, Maureen A. McMichael, Roy Harmon, Dawn Boothe
Summary: This article reports a case of using IVLE for the treatment of amphetamine toxicosis, which resulted in a significant decrease in serum and plasma amphetamine levels after IVLE treatment.
FRONTIERS IN VETERINARY SCIENCE
(2022)
