Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne M. Wong, Phoebe Luo, Benjamin Keunen, Samuel Pichardo, James M. Drake, Adam C. Waspe
Summary: An adaptive targeting algorithm was developed for real-time correction of misplanned hyperthermia treatments, improving the accuracy and precision of MRgHIFU therapy.
Review
Pharmacology & Pharmacy
Harshini Ashar, Ashish Ranjan
Summary: High intensity focused ultrasound (HIFU) is a non-invasive therapeutic technology that uses sonic energy to induce thermal and non-thermal effects in tissues. It can ablate tissues, improve drug delivery, and mechanically fragment cells. HIFU has potential applications in treating cancers, infectious diseases, and neuromodulation. This review discusses the role of HIFU in enhancing drug delivery and immunomodulation in soft and calcified tissues.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Acoustics
Paul Christopher Lyon, Christophoros Mannaris, Michael Gray, Robert Carlisle, Fergus Gleeson, David Cranston, Feng Wu, Constantin C. Coussios
Summary: LTSLs are designed to release chemotherapy agents under mild hyperthermia conditions. By utilizing ultrasound-guided FUS systems, it is possible to rapidly induce and sustain mild hyperthermia in large tissue volumes, showing promise for successful application in drug delivery and cancer treatment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia Antoniou, Nikolas Evripidou, Leonidas Georgiou, Antreas Chrysanthou, Cleanthis Ioannides, Christakis Damianou
Summary: This study presents the development and evaluation of a tumor-bearing tissue phantom model for testing MRgFUS ablation protocols and equipment. The results suggest that the proposed tumor phantom model is a simple and inexpensive tool for preclinical MRgFUS ablation studies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Beatrice Lena, Lambertus W. Bartels, Cyril J. Ferrer, Chrit T. W. Moonen, Max A. Viergever, Clemens Bos
Summary: Interleaved MR thermometry can effectively monitor temperature changes in water and fat tissues with sufficient temporal resolution, which is crucial for the treatment of bone lesions with HIFU. By using PRFS and 2D-VFA thermometry, this method allows for the observation of temperature variations in muscle and fat tissues during MR-HIFU sonication.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chien-Feng Judith Huang, Win-Li Lin, San-Chao Hwang, Ching Yao, Hsu Chang, Yung-Yaw Chen, Li-Wei Kuo
Summary: This study introduces a wireless inductively coupled surface (WICS) coil design for MRgHIFU ablation on a clinical 3 T MRI system. Ex vivo and in vivo experiments were performed to evaluate the temperature accuracy improvement of the WICS coil.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Ngo Fung Daniel Lam, Ian Rivens, Sharon L. Giles, Emma Harris, Nandita M. deSouza, Gail ter Haar
Summary: Tumor treatability was overestimated by 52% of tumor volume, while the difference between predicted and clinical treatability was only 9%. The volume and position of ablated tissues varied with the length of the beam path through tissue.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Oncology
Dacheng Qu, Yue Liu, Jing Jiang, Qiuling Shi, Honggui Zhou, Zhibiao Wang
Summary: A retrospective observational study on 32 women with submucous leiomyomas who underwent ultrasound-guided high-intensity focused ultrasound (USgHIFU) showed that USgHIFU could effectively shrink the volume of submucous leiomyomas, resulting in improved pregnancy success and full-term delivery rates.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Engineering, Environmental
Tianzhi Liu, Qian Wan, Chao Zou, Mengjie Chen, Gang Wan, Xin Liu, Hangrong Chen
Summary: This study demonstrates the sophisticated combination of smart mesoporous nanocarriers and the MR-FUS technique for precise regulation of drug release kinetics. Utilizing temperature control and phase transition mechanisms, the efficiency of multi-modal drug release is enhanced, showing significant tumor growth inhibition in in vivo experiments.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Engineering, Biomedical
Vismaya S. Bachu, Jayanidhi Kedda, Ian Suk, Jordan J. Green, Betty Tyler
Summary: HIFU is an emerging and increasingly useful modality in the treatment of cancer and other diseases, using high-energy ultrasound pulses to target specific areas while minimizing damage to surrounding tissues. Its wide applications across various tumor types and organ systems, along with its potential future pathways, highlight the growing importance of this technology in biomedical fields.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Sitong Liu, Xiuqi Hou, Wenjian Zhu, Fang Zhang, Weiling Chen, Binjian Yang, Xin Luo, Dalin Wu, Zhong Cao
Summary: Magnetic resonance imaging-guided high-intensity focused ultrasound (MRI-guided HIFU) is a non-invasive strategy for tumor diagnosis and treatment. Researchers prepared a multifunctional nanotheranostic agent (SSPN) by loading perfluorohexane (PFH) and superparamagnetic iron oxides (SPIOs) in silica lipid, aiming for MRI-guided HIFU ablation of tumors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Acoustics
Yun Zhou, Xiang Ji, Jianmei Niu, Taotao Sun, Zhaoxia Qian, Yuhong Li, Jiangjing Yuan, Qiong Fan, Qianwen Huang, Jingfeng Bai, Yudong Wang
Summary: This study demonstrates the feasibility of ultrasound-guided high-intensity focused ultrasound for devascularization of uterine fibroids, with significant reduction in fibroid volume and improvement in symptoms and quality of life. No serious adverse events were observed, suggesting the need for further studies on safety and efficacy.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Huan Liu, Cheng Yu, Min Lyu, Shiyi Lyu, LiNan Hu, Enhua Xiao, Pengfei Xu
Summary: The development of a targeted and novel albumin-binding strategy has led to the creation of an organic small molecule-based photosensitizer, EB-Ppa, which shows high photodynamic therapeutic efficiency in treating solid tumors. EB-Ppa is stable in serum-containing aqueous media and accumulates effectively in the tumor site through the enhanced permeability and retention (EPR) effect. Treatment with EB-Ppa using photodynamic therapy results in fast shrinkage of breast tumors (4T1 cell line) xenografted in nude mice, due to the singlet oxygen generated by EB-Ppa with laser irradiation. Furthermore, EB-Ppa exhibits negligible toxicity in major organs. These findings indicate the great potential of EB-Ppa for efficient tumor treatment through photodynamic therapy.
Review
Oncology
Rajneesh Mungur, Jiesheng Zheng, Ben Wang, Xinhua Chen, Renya Zhan, Ying Tong
Summary: The use of LIFU+MBs in drug delivery for glioblastoma has shown to be a safe and effective method, with improved drug uptake and tumor control without causing harm to brain structures.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Cai Zhang, Mengdi Liang, Tiansong Xia, Heng Yin, Hongwei Yang, Zhibiao Wang, Lian Zhang
Summary: This study investigates the factors influencing the sonication dosage and efficiency of ultrasound-guided high intensity focused ultrasound (USgHIFU) for breast fibroadenomas. The results show that fibroadenoma size, distance from the shallow margin of the fibroadenoma to skin, and type of near field acoustic pathway have significant correlation with the energy efficiency factor (EEF). A dosimetry model is established, which can be used to predict the dosage delivery of USgHIFU treatment for breast fibroadenomas.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Multidisciplinary Sciences
Bingbing Cheng, Yonatan Chatzinoff, Debby Szczepanski, Chenchen Bing, Sumbul Shaikh, Omar Wyman, Cameron E. Perry, James A. Richardson, Dennis K. Burns, Bret M. Evers, David E. Greenberg, Rajiv Chopra
Article
Urology & Nephrology
Durgesh Kumar Dwivedi, Yonatan Chatzinoff, Yue Zhang, Qing Yuan, Michael Fulkerson, Rajiv Chopra, James Brugarolas, Jeffrey A. Cadeddu, Payal Kapur, Ivan Pedrosa
Article
Multidisciplinary Sciences
Zhiyue J. Wang, Yong Jong Park, Michael C. Morriss, Youngseob Seo, Trung Nguyen, Rami R. Hallac, Ana Nava, Rajiv Chopra, Yonatan Chatzinoff, Khyana Price, Nancy K. Rollins
SCIENTIFIC REPORTS
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihua Zhang, Joel Wells, Riham Dessouky, Adam Gleason, Rajiv Chopra, Yonatan Chatzinoff, Nicholas P. Fey, Yin Xi, Avneesh Chhabra
BRITISH JOURNAL OF RADIOLOGY
(2018)
Article
Oncology
Chenchen Bing, Pratik Patel, Robert M. Staruch, Sumbul Shaikh, Joris Nofiele, Michelle Wodzak Staruch, Debra Szczepanski, Noelle S. Williams, Theodore Laetsch, Rajiv Chopra
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riham Dessouky, Avneesh Chhabra, Lihua Zhang, Adam Gleason, Rajiv Chopra, Yonatan Chatzinoff, Nicholas P. Fey, Yin Xi, Joel Wells
EUROPEAN RADIOLOGY
(2019)
Article
Acoustics
Bingbing Cheng, Chenchen Bing, Yin Xi, Bhavya Shah, Agata A. Exner, Rajiv Chopra
ULTRASOUND IN MEDICINE AND BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Bingbing Cheng, Chenchen Bing, Rajiv Chopra
SCIENTIFIC REPORTS
(2019)
Article
Nanoscience & Nanotechnology
Ahmet Alptekin, Mohammad B. Khan, Roxan Ara, Mohammad H. Rashid, Fengchong Kong, Mahrima Parvin, Joseph A. Frank, Rajiv Chopra, Krishnan Dhandapani, Ali S. Arbab
Summary: Exosomes have been shown to carry important biomolecules and can be delivered to stroke areas using pulsed focused ultrasound, but the administration of nanobubbles has detrimental effects on brain structures.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qi Wang, Jonathan Vachon, Bibin Prasad, Christine A. Pybus, Norman Lapin, Rajiv Chopra, David E. Greenberg
Summary: The combination of heat and antibiotics has been shown to have synergistic effects in eliminating biofilm, reducing bacterial burden significantly. This noninvasive method shows promise in reducing biofilm on metallic implants, with efficacy across different settings and potential for broader application.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Oncology
Bibin Prasad, Sumbul Shaikh, Reshu Saini, Qi Wang, Serena Zadoo, Varun Sadaphal, David E. Greenberg, Rajiv Chopra
Summary: The study found that intermittent and slow heating can reduce biofilm with less than 3 mm tissue damage around the implant. The results emphasize the importance of uniform implant heating for effective biofilm reduction.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Pharmacology & Pharmacy
Andrei Molotkov, Mikhail Doubrovin, Nikunj Bhatt, Fang-Chi Hsu, Amanda Beserra, Rajiv Chopra, Akiva Mintz
Article
Oncology
Bingbing Cheng, Chenchen Bing, Robert M. Staruch, Sumbul Shaikh, Michelle Wodzak Staruch, Debra Szczepanski, Noelle S. Williams, Theodore W. Laetsch, Rajiv Chopra
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Rajiv Chopra, Steffen Sammet, Z. Xu, M. O'Reilly
Article
Oncology
Chenchen Bing, Bingbing Cheng, Robert M. Staruch, Joris Nofiele, Michelle Wodzak Staruch, Debra Szczepanski, Alan Farrow-Gillespie, Adeline Yang, Theodore W. Laetsch, Rajiv Chopra
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2019)