Article
Respiratory System
Lee M. Fidler, Andrea Gershon, Jolene H. Fisher, Matthew B. Stanbrook, Teresa To, Meyer Balter
Summary: This study analyzed the hospitalization rates of patients with sarcoidosis in Ontario, Canada from 1996 to 2015. It found significant decreases in all-cause and sarcoidosis-related hospitalization rates, particularly among younger patients. Differences in hospitalization risk based on sex, socioeconomic factors, and geographic factors were observed in patients with sarcoidosis.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Review
Medicine, General & Internal
Irina R. R. Strambu
Summary: Sarcoidosis is a disease of unknown origin that can affect multiple organs. Cardiac sarcoidosis is particularly challenging due to its potential for serious cardiac complications and difficulty in diagnosis. This manuscript reviews the current understanding and guidelines for diagnosing and treating cardiac sarcoidosis, highlighting a case study of a young adult with no known risk factors or prior diagnosis of sarcoidosis presenting with disabling cardiac symptoms.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Pilar Brito-Zeron, Roberto Perez-Alvarez, Manuel Ramos-Casals
Summary: Sarcoidosis is a systemic autoimmune disease primarily affecting lymph nodes, lungs, skin, and eyes. It is relatively uncommon but not rare, with higher prevalence in northern Europe, the United States, and India. The disease predominantly affects women aged 30 to 50 and is closely linked to environmental factors, particularly occupational exposures. Diagnosis requires multidisciplinary clinical units to integrate clinical, analytical, radiological, and histopathological data. Treatment options include corticosteroids as first-line therapy, immunosuppressants as second-line therapy, and anti-TNF agents for severe and/or refractory cases.
Article
Allergy
Trine Gerner, Jeanette Halskou Haugaard, Christian Vestergaard, Mette Deleuran, Gregor Borut Jemec, Charlotte Gotthard Mortz, Tove Agner, Alexander Egeberg, Lone Skov, Jacob P. Thyssen
Summary: The study observed an association between severity of pediatric atopic dermatitis (AD) and increased healthcare visits, as well as a significant linear trend between parental educational level and the fear of topical corticosteroids. Lower parental education level was linked to delayed treatment for AD flares.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Siavosh Fazelpour, Mouhannad M. Sadek, Pablo B. Nery, Rob S. Beanlands, Niko Tzemos, Mustafa Toma, David H. Birnie
Summary: The best quality data relate to atrioventricular nodal conduction and left ventricular function recovery. In both situations, therapy with corticosteroids and/or immunosuppressant therapy were sometimes associated with positive outcomes. The data quality is too limited to draw conclusions for ventricular arrhythmias and mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Clinical Neurology
Itay Lotan, Mark A. Hellmann, Adi Wilf-Yarkoni, Israel Steiner
Summary: Corticosteroids are widely used immunosuppressive agents for conditions like myasthenia gravis, but treatment with them may result in exacerbation of symptoms. The rate of exacerbation varies with different types of corticosteroids, with cortisone having the highest rate and methylprednisolone the lowest. Factors like age, symptom type, disease severity, and thymus-related factors may increase the risk of exacerbation.
JOURNAL OF NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Raluca Ioana Arcana, Radu Crisan-Dabija, Andrei Tudor Cernomaz, Ioana Buculei, Alexandru Burlacu, Mihai Lucian Zabara, Antigona Carmen Trofor
Summary: Sarcoidosis is a complex granulomatous disease of unknown etiology. Diagnosis can be challenging due to the heterogeneous nature of the disease, often requiring a thorough and complex investigation. Starting unnecessary corticosteroid treatment can worsen the patient's prognosis, as many other granulomatous diseases can mimic sarcoidosis and lead to more difficult to treat side effects.
Article
Respiratory System
Kevin Duan, Laura J. Spece, Edwin S. Wong, Laura C. Feemster, Lucas M. Donovan, Matthew F. Griffith, Thomas L. Keller, Alexander D. Bryant, David H. Au
Summary: The study found that the use of low-value ICS prescriptions in COPD patients at low risk of exacerbation is associated with higher outpatient healthcare utilization and costs.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Health Care Sciences & Services
Sho Katsuragawa, Atsushi Goto, Yuya Tsurutani, Shingo Fukuma, Kosuke Inoue
Summary: Individuals without healthcare utilization over a year have increased risks of all-cause and cardiovascular mortality, particularly more pronounced among males and uninsured individuals. Further investigation is needed to identify the underlying reasons for the elevated mortality risks due to lack of healthcare utilization.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Annalaura Manes, Tiziana Di Renzo, Loreta Dodani, Anna Reale, Claudia Gautiero, Mariastella Di Lauro, Gilda Nasti, Federica Manco, Espedita Muscariello, Bruna Guida, Giovanni Tarantino, Mauro Cataldi
Summary: This systematic review examined the hypothesis that gut microorganisms may contribute to the variability in the clinical response to classical immunosuppressant drugs (cIMDs) by affecting their pharmacokinetics, efficacy, or tolerability. The review found evidence supporting potential effects on cIMD pharmacokinetics, efficacy, or tolerability in studies of tacrolimus, cyclosporine, mycophenolic acid, and corticosteroids, while data were missing for everolimus and sirolimus. Furthermore, the review found that cIMDs have significant effects on the composition of intestinal microbiota, although no consistent pattern of microbiota modification was observed across studies.
Article
Cardiac & Cardiovascular Systems
Julien Stievenart, Guillaume Le Guenno, Marc Ruivard, Virginie Rieu, Marc Andre, Vincent Grobost
Summary: This study reviewed a case series of cardiac sarcoidosis treated with TNF alpha antagonists, showing that adding TNF alpha antagonists to corticosteroid and immunosuppressive therapy can reduce relapse and major cardiac events without serious adverse events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Marc A. Judson, Evan Adelstein, Kenneth M. Fish, Paul J. Feustel, Recai Yucel, Sara Preston, Rachel Vancavage, Amit Chopra, David A. Steckman
Summary: This study retrospectively examined the effectiveness of three treatment regimens for cardiac sarcoidosis and found that prednisone-tapering regimens containing infliximab were superior to those containing prednisone alone or prednisone plus methotrexate in terms of reducing prednisone dose and achieving the lowest effective dose.
RESPIRATORY MEDICINE
(2022)
Article
Veterinary Sciences
Margaret Gober, Andrew Hillier
Summary: This study aimed to describe the experience and perception of an owner who administered anti-inflammatory doses of oral prednisolone and prednisone to their dog. The results showed that by day 14, 90% of owners reported behavior changes in their dogs, with polyuria and polydipsia being the most commonly reported changes. Although most pet owners expressed satisfaction with steroid treatment, 70% would choose a more expensive treatment option with fewer side effects.
BMC VETERINARY RESEARCH
(2023)
Article
Respiratory System
Robert P. Baughman, Jacob Kotzin, Elyse E. Lower
Summary: A prospective study on sarcoidosis clinic patients found that those who initiated or increased anti-inflammatory treatment had lower PGA scores. No significant difference in initial PGA score based on race, sex, or age was observed. The change in PGA was significantly lower in patients where treatment was increased.
Article
Medicine, General & Internal
Kimito Mio, Kotaro Haruhara, Akihiro Shimizu, Kentaro Oshiro, Rena Kawai, Masato Ikeda, Takashi Yokoo
Summary: Hypercalcemia can be caused by various factors, with hyperparathyroidism and malignancy being the most common. Sarcoidosis and vitamin D supplements can also lead to hypercalcemia, especially when combined. Monitoring serum levels of 25-OH Vit.D-3 and 1,25-(OH)(2) Vit.D-3 is crucial for identifying the underlying cause of hypercalcemia.
Article
Critical Care Medicine
Kerry M. Hena, Jennifer Yip, Nadia Jaber, David Goldfarb, Kelly Fullam, Krystal Cleven, William Moir, Rachel Zeig-Owens, Mayris P. Webber, Daniel M. Spevack, Marc A. Judson, Lisa Maier, Andrew Krumerman, Anthony Aizer, Simon D. Spivack, Jessica Berman, Thomas K. Aldrich, David J. Prezant
Review
Critical Care Medicine
Amit Chopra, Amit Nautiyal, Alexander Kalkanis, Marc A. Judson
Article
Cardiac & Cardiovascular Systems
Marc A. Judson, Brett M. Elicker, Thomas V. Colby, Sooyeon Kwon, Elizabeth de Windt, Spyros Chalkias, Claudia Prada, Karen Smirnakis, Priya Singhal
RESPIRATORY MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
Marc A. Judson, Sara Preston, Kurt Hu, Robert Zhang, Stephanie Jou, Aakash Modi, Indrawattie Sukhu, Furqan Ilyas, Gavril Rosoklija, Recai Yucel
RESPIRATORY MEDICINE
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Marc A. Judson
RESPIRATORY MEDICINE
(2019)
Editorial Material
Medicine, General & Internal
M. A. Judson
JOURNAL OF INTERNAL MEDICINE
(2020)
Review
Critical Care Medicine
Rohit Gupta, Marc A. Judson, Robert P. Baughman
Summary: Advanced sarcoidosis is a form of sarcoidosis that poses a significant risk of organ function loss or death, with the lung being the most commonly affected organ. It can lead to complications such as pulmonary fibrosis and bronchiectasis. Although it affects a small proportion of patients, it is the leading cause of poor outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Brian Chu, Daniel M. O'Connor, Marilyn Wan, Ian Barnett, Haochang Shou, Marc Judson, Misha Rosenbach
Summary: The study utilized a smartphone app to investigate the impact of sarcoidosis on quality of life, physical activity, and medication usage. Findings showed that a significant number of participants experienced missed school or work days and financial impacts due to the disease.
JMIR MHEALTH AND UHEALTH
(2022)
Review
Medicine, General & Internal
Marc A. Judson
Summary: Sarcoidosis is a global idiopathic granulomatous disease that can affect any organ. Primary care physicians play a crucial role in assessing and managing sarcoidosis patients, as the symptoms are not specific. This article provides guidelines for the evaluation, treatment, and monitoring of sarcoidosis patients by primary care physicians.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Amit Chopra, Peter Doelken, Kurt Hu, John T. Huggins, Marc A. Judson
Summary: Pressure-dependent pneumothorax is a common occurrence after pleural drainage in patients with visceral pleural restriction, partial lung resection, or lobar atelectasis. It is important to recognize this type of pneumothorax as it does not require further intervention.
Editorial Material
Medicine, General & Internal
Marc A. Judson
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Ibrahim Khatim, Marc A. Judson, Artcar Htoo, Amit Chopra
Article
Respiratory System
Boris Shkolnik, Rou Sore, Muhammad Salick, Gowthami Kobbari, Sana Ghalib, Anoosh S. Parimi, Kenneth M. Fish, Robert Deluca, Recai Yucel, Marc A. Judson
Summary: This study retrospectively analyzed a cohort of patients with sarcoidosis and found that sACE is not reliable enough to be used as the sole determinant of treatment escalation.
Review
Medicine, General & Internal
Marc A. Judson
Summary: This manuscript provides a comprehensive review of the etiology, measurement, and treatment of common pulmonary symptoms associated with sarcoidosis. It emphasizes the importance of thorough assessment of symptoms, as they serve as useful tools in diagnosis and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Marc A. Judson, Jianwei Qiu, Camille L. Dumas, Jun Yang, Brion Sarachan, Jhimli Mitra
Summary: The AI/DL-based method using chest CT scan analysis shows promise in reliably distinguishing pulmonary sarcoidosis from negative lung cancer screening chest CT scans.
