Article
Clinical Neurology
Emily A. Sloan, Jason Chiang, Javier E. Villanueva-Meyer, Sanda Alexandrescu, Jennifer M. Eschbacher, Wesley Wang, Manuela Mafra, Nasir Ud Din, Emily Carr-Boyd, Michael Watson, Michael Punsoni, Angelica Oviedo, Ahmed Gilani, Bette K. Kleinschmidt-DeMasters, Dylan J. Coss, M. Beatriz Lopes, Corey Raffel, Mitchel S. Berger, Susan M. Chang, Alyssa Reddy, Biswarathan Ramani, Sean P. Ferris, Julieann C. Lee, Jeffrey W. Hofmann, Soo-Jin Cho, Andrew E. Horvai, Melike Pekmezci, Tarik Tihan, Andrew W. Bollen, Fausto J. Rodriguez, David W. Ellison, Arie Perry, David A. Solomon
Summary: This study comprehensively analyzed 20 patients with intracranial mesenchymal tumors harboring FET-CREB fusion, showing diverse clinical and genetic characteristics including various fusion gene types. These tumors, distinct from typical intracranial neoplasms, exhibit unique morphology and immunophenotype profiles.
Article
Multidisciplinary Sciences
Joshua Byers, Hong Yin, Heather Rytting, Suzanna Logan, Mai He, Zhongxin Yu, Dehua Wang, Mikako Warren, Shamlal Mangray, Louis P. Dehner, Shengmei Zhou
Summary: This study evaluated the expression of PD-L1 in pediatric AFHs and found that 61% of tumors were positively stained for PD-L1, with a positive correlation between tumor cell PD-L1 expression and CD8+ T-cell infiltration.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Nicholas J. H. Tan, Patricia Diana Pratiseyo, Eka J. Wahjoepramono, Chik Hong Kuick, Jian Yuan Goh, Kenneth T. E. Chang, Char Loo Tan
Summary: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue neoplasm with diverse morphological features, posing diagnostic challenges. Intracranial myxoid AFH and IMMT show significant overlaps in clinical and molecular genetic aspects, with the main difference being the presence of peritumoral lymphoplasmacytic cuffing in AFH but absence in IMMT.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Logan P. Haug, Matthew A. Zarka, Jonathan D'Cunha, Francis X. Downey, Mahesh Seetharam, Ming Yang
Summary: This case report describes a patient with pulmonary artery thromboembolism mimicking angiomatoid fibrous histiocytoma, which was confirmed by various imaging studies and histopathological examination.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Louis Garnier, Tanguy Fenouil, Daniel Pissaloux, Roxana Ameli, Francois Ducray, David Meyronet, Jerome Honnorat
Summary: AFH is a rare soft tissue tumor with a high recurrence rate post-surgery and challenging pathological diagnosis. It often involves characteristic translocations and can be treated with Doxorubicin, showing promise in some cases. This report presents a successful case of Doxorubicin treatment in an adult with progressive intracranial AFH.
MOLECULAR AND CLINICAL ONCOLOGY
(2021)
Review
Clinical Neurology
Moshe Spatz, Eric S. Nussbaum, Lisa Lyons, Simi Greenberg, Kevin M. Kallmes, Leslie A. Nussbaum
Summary: Angiomatoid fibrous histiocytoma (AFH) is a rare tumor that primarily occurs in the extremities but can rarely present as an isolated intracranial lesion. We report a case of a 22-year-old woman who presented with generalized seizure and visual field deficit due to an occipital mass, which was found to be AFH on immunohistochemistry.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Mohammed A. Alzahim, Abdulaziz H. Abed, Hosam T. Mashrah, Akeel M. Almahdaly, Mahmood Shaheen
Summary: Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor with minimal metastatic potential. Patients with AFH may present with painful masses, and MRI findings are often unspecific for diagnosis. Surgical excision is the main treatment approach for this tumor.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Clinical Neurology
Na Rae Kim, Seong-Ik Kim, Jin Woo Park, Chul-Kee Park, Chun Kee Chung, Seung-Hong Choi, Hongseok Yun, Sung-Hye Park
Summary: In this study, two cases of rare angiomatoid fibrous histiocytomas (AFH) were reported, one in the brain parenchyma and the other in the spinal cord. Molecular investigations revealed that both cases harbored FET:CREB fusion. A comprehensive review of 40 cases of central nervous system AFHs/myxoid mesenchymal tumors showed that they predominantly occurred in children and young adults, were dura-based, and were associated with EWSR1 rearrangements.
Article
Oncology
M. Adelita Vizcaino, Caterina Giannini, Howard T. Chang, Benjamin R. Kipp, Karen Fritchie, Rachael Vaubel
Summary: Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that commonly occurs in the extremities of young individuals with a favorable prognosis. While intracranial location is uncommon and often associated with myxoid change, AFH is characterized by EWSR1 gene fusions with CREB family members. The presence of an EWSR1-ATF1 gene fusion supported the diagnosis of a rare rhabdoid variant of AFH in a 50-year-old woman with good outcomes following gross total resection of the tumor.
BRAIN TUMOR PATHOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Gerardo Cazzato, Carmelo Lupo, Nadia Casatta, Flavia Riefoli, Andrea Marzullo, Anna Colagrande, Eliano Cascardi, Senia Maria Rosaria Trabucco, Giuseppe Ingravallo, Biagio Moretti, Eugenio Maiorano, Vito Pesce, Leonardo Resta
Summary: Angiomatoid fibrous histiocytoma (AFH) is a rare neoplasm with intermediate malignant potential, mostly occurring in the subcutis. It is characterized by varying proportions of epithelioid, ovoid and spindle cells in a nodular and syncytial growth pattern. This paper presents the case of a 62-year-old man with AFH on his right arm, which relapsed after three years and later developed intramuscular localization and pulmonary metastasis.
Article
Clinical Neurology
Zach Pennington, Andrew Hersh, Daniel M. Sciubba
Summary: Retroperitoneal sarcomas in elderly patients may grow slowly and have high surgical risks; surgical indications should consider the patient's overall clinical condition.
WORLD NEUROSURGERY
(2021)
Review
Medical Laboratory Technology
Deepa Rani, Arsh Gupta, Atul Gupta, Kanika Rastogi
Summary: Angiomatoid fibrous histiocytoma (AFH) is a rare superficial tumor that primarily affects children and young adults, growing slowly and often appearing on the extremities. Due to its rarity and superficial location, there is limited literature on the cytological findings of AFH.
DIAGNOSTIC CYTOPATHOLOGY
(2021)
Article
Medicine, General & Internal
Hina Maqbool, Shaarif Bashir, Usman Hassan, Mudassar Hussain, Sajid Mushtaq, Sheeba Ishtiaq
Summary: The study aimed to share the clinical and histological features, as well as survival data, of angiomatoid fibrous histiocytoma (AFH), a rare soft tissue neoplasm with uncertain differentiation. The majority of reported cases were in males with a mean age of 31.8 years at diagnosis. Most lesions were located in the lower extremity, particularly the thigh, and were superficial with a solid appearance. Microscopically, classic spindle cell morphology with lymphoid cuff and intralesional hemorrhage was common. AFH has a low malignant potential and most patients are alive.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pathology
Changwen Zhai, Cuncun Yuan, Ji Sun, Wanjing Song, Shuyi Wang, Lan Lin
Summary: This study evaluated the clinicopathologic features, molecular characteristics, treatment strategy, and prognosis of nasopharyngeal hyalinizing clear cell carcinoma (HCCC). The study found the clinical features and molecular markers of HCCC, as well as wide local excision as the optimal treatment choice.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Elizabeth A. Corley, Erika Pace, Alex M. Barnacle, Premal A. Patel, Khin Thway, Julia C. Chisholm
Summary: Angiomatoid fibrous histiocytoma (AFH) is a soft tissue neoplasm with intermediate biological potential. Metastatic AFH is usually fatal, but our report presents 3 cases of metastatic AFH with sustained response to chemotherapy, including one case with complete remission after cryoablation. These cases highlight the potential value of chemotherapy and cryoablation in some patients with unresectable metastatic AFH.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
