Article
Endocrinology & Metabolism
Jiajie G. Lu, Emily T. Lo, Cleandrea Williams, Brian Ma, Andy E. Sherrod, Guang-Qian Xiao
Summary: This study identified HMWCK-expressing prostate adenocarcinoma (PAC) as a novel subtype of innate androgen deprivation therapy (ADT)-resistant PAC. HMWCK expression in PAC cells was associated with high Gleason scores, unfavorable growth patterns, and advanced tumor stages. Most of the HMWCK-expressing PACs had no prior ADT history. These findings suggest that HMWCK overexpression can serve as a surrogate biomarker for aggressive and innate hormone-refractory PACs. Additionally, genetic alterations in the PTEN/PI3K/MAPK pathway imply potential therapeutic implications of PI3K/MAPK inhibitors in the treatment of these deadly diseases.
Article
Oncology
Su Ir Lyu, Thaddaeus Krey, Alexander M. Damanakis, Yue Zhao, Christiane Bruns, Thomas Schmidt, Felix Popp, Alexander Quaas, Karl Knipper
Summary: CK6 is a putative biomarker for the basal-like subtype of PDAC, and high CK6 tumor expression is associated with shorter survival. CK6 can be considered as an independent biomarker for shorter overall survival and can be used for subtyping and treatment decision-making in PDAC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hao Lu, Wenlong Liu, Guangliu Ran, Zezhou Liang, Hongxiang Li, Nan Wei, Hongbo Wu, Zaifei Ma, Yahui Liu, Wenkai Zhang, Xinjun Xu, Zhishan Bo
Summary: This study utilizes a high-pressure method to address processing challenges in high molecular weight polymers, achieving the dissolution and production of hybrid films with superior properties. The organic solar cells prepared using this method exhibit outstanding power conversion efficiency, setting a new record for binary devices. Furthermore, this high-pressure method shows potential for enhancing device performance in other common systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Oncology
Hong Wang, William Yan, Yuhai Sun, Chung S. Yang
Summary: High-fat diet-induced hyperinsulinemia increases the risk of prostate cancer, suggesting a potential link between metabolic syndrome and prostate cancer risk increase.
Article
Chemistry, Multidisciplinary
Anping Zeng, Xiaoling Ma, Mingao Pan, Yuzhong Chen, Ruijie Ma, Heng Zhao, Jianquan Zhang, Ha Kyung Kim, Ao Shang, Siwei Luo, Indunil Chathurangani Angunawela, Yuan Chang, Zhenyu Qi, Huiliang Sun, Joshua Yuk Lin Lai, Harald Ade, Wei Ma, Fujun Zhang, He Yan
Summary: In the field of non-fullerene organic solar cells, a chlorinated donor polymer named D18-Cl is reported in this study, which can achieve high performance with a wide range of polymer molecular weight. Devices based on D18-Cl show higher open-circuit voltage and outstanding short-circuit current density, resulting in higher efficiency compared to those based on D18.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jin-Woo Lee, Tan Ngoc-Lan Phan, Eun Sung Oh, Heung-Goo Lee, Taek-Soo Kim, Bumjoon J. Kim
Summary: Carboxylate-containing poly(thiophene vinylene) (PTV) derivatives with tuned molecular weight (MW) have been developed for intrinsically stretchable (IS) organic solar cells (OSCs). Increasing the MW of PTVs enhances their crystallinity, leading to improved hole mobility and reduced charge recombination. Furthermore, high MW PTVs exhibit superior mechanical stretchability and electrical properties due to the formation of tie-chains that connect the crystalline domains. Thus, IS-OSCs employing high MW PTVs demonstrate the highest power conversion efficiency (PCE) and strain at PCE80%.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yun Li, Qian Li, Yunhao Cai, Hui Jin, Jianqi Zhang, Zheng Tang, Chunfeng Zhang, Zhixiang Wei, Yanming Sun
Summary: This study developed a series of polymer acceptors using a random copolymerization strategy, which demonstrated better optical and electronic properties compared to traditional polymer acceptors. The highest efficiency all-polymer solar cell to date was successfully fabricated.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Article
Immunology
Chao Li, Dongyi Peng, Yu Gan, Lei Zhou, Weibin Hou, Bingzhi Wang, Peng Yuan, Wei Xiong, Long Wang
Summary: This study explores the potential relationship between m6A RNA modification and the development of prostate cancer (PCa) and analyzes its clinical relevance. The study identifies differentially expressed m6A-related genes in PCa tissues and constructs protein-protein interaction and RNA networks. Furthermore, the study reveals differences in immune characteristics between high- and low-risk groups in PCa patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiyue Yuan, Yunli Zhao, Tao Zhan, Jiyeon Oh, Jiadong Zhou, Junyu Li, Xiaojing Wang, Zhiqiang Wang, Shuting Pang, Ping Cai, Changduk Yang, Zhicai He, Zengqi Xie, Chunhui Duan, Fei Huang, Yong Cao
Summary: A new building block, 3-cyanothiophene (CT), was reported for constructing high-performance donor polymers in organic solar cells (OSCs). The donor polymer (PBCT-2F) based on the CT unit achieved a remarkable power conversion efficiency (PCE) of 17.1% and exhibited excellent batch-to-batch reproducibility, showing great potential for industrial synthesis and large-scale manufacturing.
ENERGY & ENVIRONMENTAL SCIENCE
(2021)
Article
Medicine, General & Internal
Nuray Bostancieri, Kemal Bakir, Seval Kul, Ayhan Eralp, Ozgecan Kayalar, Nur Konyalilar, Hadi Rajabi, Mehmet Yuncu, Ali Onder Yildirim, Hasan Bayram
Summary: This study investigates the expression of progenitor/stem (P/S) cell markers in bronchial epithelial explants and cell cultures, and its effect on bronchial epithelial cell proliferation. The findings suggest that the number of P/S cells in airway epithelium may play a role in the pathogenesis of COPD and the proliferation of airway epithelial cells in vitro.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Muhammad Asyaari Zakaria, Nor Fadilah Rajab, Eng Wee Chua, Gayathri Thevi Selvarajah, Siti Fathiah Masre
Summary: The study successfully developed pre-malignant and malignant lung squamous cell carcinoma (SCC) in mice model using N- nitroso-tris-chloroethylurea (NTCU). Histopathological and protein analysis confirmed the SCC subtype in the cancer group, along with significantly higher epithelium thickness. The vehicle group was suggested as a suitable control group for future research.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Christopher E. Eyermann, Jinyu Li, Evguenia M. Alexandrova
Summary: Pregnancy is known to reduce the risk of breast cancer, but it may promote HER2+ BC. Studies have shown that pregnancy can increase the incidence of HER2+ BC in mice models, possibly linked to the tumor-initiating properties of PIMECs. The gene p63 plays a complex role in maintaining PIMEC quantity while suppressing their tumorigenic capacity.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Yueli Liu, Jiawen Wang, Corrigan Horton, Chuan Yu, Beatrice Knudsen, Joshua Stefanson, Kevin Hu, Ofir Stefanson, Jonathan Green, Charlene Guo, Qing Xie, Zhu A. Wang
Summary: This study reveals that stromal AR inhibits prostate cancer progression by restraining secretory luminal cells, and deletion of stromal AR exacerbates tumor progression and leads to changes in the cellular state of secretory luminal cells.
Article
Biochemistry & Molecular Biology
Yu Jian, Hao Gu, Ke-Bing Luo, Rong-bo Fu, Ze-Ju Zhao
Summary: This study investigated the regeneration of epithelial cells in the long-term observation of ureter reconstruction using demucosalized ileum. Beagle dogs were used for the experiment and the reconstructed ureters were evaluated at different time points. The results showed that initially, there were irregular cytoarchitecture and inflammation, but the injuries improved with time and the expression of CK18 decreased. Overall, demucosalized ileum was deemed feasible and effective for ureteral reconstructive surgery.
Article
Biochemistry & Molecular Biology
Bohyun Kim, Insoon Jang, Kwangsoo Kim, Minsun Jung, Cheol Lee, Jeong Hwan Park, Young A. Kim, Kyung Chul Moon
Summary: Multiple mRNA-based classification systems for urinary bladder urothelial carcinoma (UB UC) have been reported, showing different treatment responses and prognoses for each molecular subtype. In this study, immunohistochemistry (IHC) was used to classify UB UC into different subgroups based on CK5/6 and CK20 expression. The CK5/6 positive subgroup exhibited a gene expression signature related to aggressive behavior and worse clinical outcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)