Article
Oncology
Antonia P. M. Jones, Monica F. G. McGauran, Nisha Jagasia, Richard J. Hiscock, Simon Hyde, Peter Grant
Summary: The study evaluated the efficacy of dexamethasone in managing symptoms of MSBO in women with EOC, finding that most patients achieved partial or complete symptom control with the drug. Dexamethasone responsiveness remained consistent in recurrent admissions, and platinum-sensitive patients were more likely to respond to dexamethasone than platinum-resistant patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Yuko Horiba, Tetsuhiro Yoshino, Megumi Yokota, Takashi Iwata, Kenji Watanabe, Masaru Mimura, Daisuke Aoki
Summary: This study compared climacteric symptoms among patients who underwent surgery for endometrial, ovarian, and cervical cancer, finding that symptoms were more severe in patients with cervical cancer and decreased with longer time elapsed since surgery.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Obstetrics & Gynecology
Nicole Minalt, Amy Caldwell, Grace M. Yedlicka, Sophia Joseph, Sharon E. Robertson, Lisa M. Landrum, Jeffrey F. Peipert
Summary: The intrauterine device (IUD) is a highly effective form of contraception and its use has been increasing in the United States. The two types of IUDs available are the levonorgestrel-releasing IUD and the copper IUD. The levonorgestrel IUD suppresses the endometrium and thickens cervical mucus, while the copper IUD creates an inflammatory response to prevent fertilization. The evidence suggests that both types of IUDs reduce the risk of gynecologic cancers, although the effects on cervical and ovarian cancers are less consistent.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jan Korbecki, Mateusz Bosiacki, Katarzyna Barczak, Ryta Lagocka, Agnieszka Brodowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: CXCL1, a member of the CXC chemokine subfamily, is mainly responsible for attracting neutrophils in the immune system. This review summarizes the clinical significance and involvement of CXCL1 in major reproductive cancers, including breast cancer, cervical cancer, endometrial cancer, ovarian cancer, and prostate cancer. It focuses on the clinical aspects, molecular contributions, and impact of CXCL1 on the tumor microenvironment. The significance of introducing CXCL1-targeting drugs and the role of ACKR1/DARC in reproductive cancers are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Feng Pang, Dong Shi, Lin Yuan
Summary: Cervical cancer, ovarian cancer, and endometrial cancer are the top three cancers in women. This study utilized gene chip and high-throughput sequencing technology to analyze genomic functional omics data and identify potential markers for diagnosis and treatment. The study also explored common differentially expressed genes (DEGs) among these cancers using public databases. The results revealed that DEGs were involved in biological processes such as cell division, mitotic nuclear division, sister chromatid cohesion, and DNA replication. The DEGs also exhibited specific functions in cell components and molecular functions. Additionally, pathway analysis indicated enrichment of upregulated DEGs in cell cycle-related pathways, while downregulated DEGs were enriched in pathways related to thiamine metabolism and protein processing in the endoplasmic reticulum. The most significant module was associated with cell division and microtubule motor activity.
CURRENT BIOINFORMATICS
(2023)
Article
Obstetrics & Gynecology
Philippe Van Trappen
Summary: The concept of pelvic sentinel lymph node mapping has been well investigated in endometrial and cervical cancer, showing safety, efficacy, and diagnostic accuracy. The concept of pelvic sentinel lymph node biopsy has been incorporated in international guidelines for early-stage endometrial and cervical cancer. The application of para-aortic sentinel lymph node mapping is still in development but shows promising results in initial studies.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Oncology
Pamela N. Peters, Julia M. Moyett, Brittany A. Davidson, Sarah Cantrell, Sara E. Bliss, Laura J. Havrilesky
Summary: This study compared the cost-effectiveness of different intervention strategies for managing platinum-resistant recurrent ovarian cancer with inoperable malignant bowel obstruction. The results showed that TPN + chemotherapy was the most costly strategy but provided the highest QALYs. On the other hand, hospice was the lowest cost strategy and the preferred choice for most cases.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna Golara, Mateusz Kozlowski, Pawel Guzik, Sebastian Kwiatkowski, Aneta Cymbaluk-Ploska
Summary: Selenium and manganese are essential micronutrients that play important roles in cell metabolism. They are involved in enzyme systems and regulate enzyme activity. Disturbances in their homeostasis can lead to diseases and carcinogenesis due to increased oxidative stress and impaired antioxidant properties. Selenium maintains immune-endocrine, metabolic, and cellular homeostasis, while manganese is important in development, digestion, reproduction, antioxidant defense, energy production, immune response, and regulation of neuronal activity. This review highlights their roles in tumor growth, metastasis, and microenvironment remodeling, and their potential as biomarkers for diagnosis and treatment of reproductive organ cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Fengguang Zhai, Jie Wang, Weili Yang, Meng Ye, Xiaofeng Jin
Summary: This paper summarizes the E3 ligases relevant to endometrial carcinoma (EC) and cervical cancer (CC), highlighting their significant roles in the occurrence and progression of these cancers. Additionally, research progress in targeting the ubiquitination process in EC and CC is discussed in this review.
Review
Medicine, General & Internal
Nicola Rosano, Luigi Gallo, Giuseppe Mercogliano, Pasquale Quassone, Ornella Picascia, Marco Catalano, Antonella Pesce, Valeria Fiorini, Ida Pelella, Giuliana Vespere, Marina Romano, Pasquale Tammaro, Ester Marra, Gabriella Oliva, Marina Lugara, Mario Scuderi, Stefania Tamburrini, Ines Marano
Summary: Ultrasound is crucial for the diagnosis and staging of small bowel obstruction (SBO), with high accuracy and widespread utility in monitoring and follow-up.
Review
Obstetrics & Gynecology
Eduardo Gonzalez-Ochoa, Husam A. Alqaisi, Gita Bhat, Nazlin Jivraj, Stephanie Lheureux
Summary: Malignant bowel obstruction is a common and severe complication in patients with advanced ovarian cancer, with a poor prognosis. The management of this condition is complex and requires a multidisciplinary approach to improve clinical outcomes. Medical treatment and supportive therapy are the main strategies for inoperable patients. However, treatment decision-making is challenging due to a lack of high-quality evidence to guide standardized management.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Oncology
Huida Zheng, Yurong Liu, Zhenze Chen, Yafeng Sun, Jianhua Xu
Summary: This study retrospectively analyzed data from 424 patients who underwent right colectomy, and established a nomogram to predict the incidence of early small bowel obstruction (EPSBO) after the surgery. The predictive performance of the model was evaluated using an area under the receiver operating characteristic curve and calibration chart.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Emergency Medicine
Daniel Sas, Fan Jim Yang, Nestor Agbayani, Siu Fai Li
Summary: A 44-year-old woman presented to the Emergency Department with abdominal pain. Imaging revealed small bowel obstruction and massive uterine fibroids. Surgical intervention was required after conservative therapy failed. Massive uterine fibroids is a rare cause of small bowel obstruction that requires the vigilance of Emergency Medicine physicians.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Oncology
Wenhao Yu, Qi Zhang, Muhammad Ali, Bangquan Chen, Yapeng Yang, Liuhua Wang, Qiannan Sun, Yong Wang, Daorong Wang
Summary: This study aimed to create a nomogram for predicting recurrence of small bowel obstruction (SBO) after gastrectomy in patients with gastric cancer. Several risk factors were identified through regression analysis, and the nomogram showed good predictive performance. It could serve as an early warning indicator to guide treatment decisions for gastric cancer patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Kevin Afshari, Abbas Chabok, Kenneth Smedh, Maziar Nikberg
Summary: About 10% of patients who have undergone open abdominal surgery develop small bowel obstruction (SBO), with rectal resection leading to the highest readmission rates. A study found that SBO is most commonly seen within the first year after rectal cancer surgery, with the greatest risk in patients requiring re-laparotomy due to complications from the initial surgery.
