Article
Oncology
Kensuke Kudou, Yuichiro Nakashima, Yasuhiro Haruta, Sho Nambara, Yasuo Tsuda, Eiji Kusumoto, Koji Ando, Yasue Kimura, Kenkichi Hashimoto, Keiji Yoshinaga, Hiroshi Saeki, Eiji Oki, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Koji Ikejiri, Mototsugu Shimokawa, Masaki Mori
Summary: This study found that inflammation-based prognostic scores, specifically PI and PNI, were more strongly associated with poor prognosis in patients who underwent surgery for adenocarcinoma of the esophagogastric junction and upper gastric cancer.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Erkan Erdur, Ozgen Ahmet Yildirim, Kerem Poyraz, Ferit Aslan, Fatih Yildiz, Halil Komek
Summary: The roles of inflammatory parameters such as NLR and CAR in predicting disease recurrence were investigated in patients with stage IIA colon cancer. NLR >= 3.12 and CAR >= 0.027 were found to be independent prognostic markers for predicting relapse in patients who did not receive adjuvant chemotherapy due to low clinical risk.
POSTGRADUATE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Arik Sheinenzon, Mona Shehadeh, Regina Michelis, Ety Shaoul, Ohad Ronen
Summary: This study examined the correlation between albumin levels and inflammatory indices in hospitalized patients, showing negative correlations between albumin and CRP/white blood cell levels and positive correlations with platelets/hemoglobin levels. The strongest negative correlation between albumin and CRP was found in the Internal Medicine departments. Linear regression analysis revealed a minor effect of CRP on albumin levels, particularly at very high CRP levels. Further exploration of the mechanisms underlying this negative correlation is needed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Shahin Hajibandeh, Shahab Hajibandeh, Saleh Romman, Alessandro Parente, Richard W. Laing, Thomas Satyadas, Daren Subar, Somaiah Aroori, Anand Bhatt, Damien Durkin, Tejinderjit S. Athwal, Keith J. Roberts
Summary: This study evaluated the ability of CAR to predict outcomes in patients undergoing pancreatic cancer resection. Eight studies with a total of 1056 patients were identified. Higher CAR values were found to be independent and significant predictors of poor overall survival in these patients. However, the determination of an optimal cut-off value for CAR is currently unclear due to heterogeneity in reporting.
Article
Cell Biology
Jiahui Zhou, Wene Wei, Hu Hou, Shufang Ning, Jilin Li, Baoyue Huang, Kaisheng Liu, Litu Zhang
Summary: The study found that CRP, GPS, and CAR have independent prognostic values in patients with CRC. Survival nomograms based on these markers can provide more valuable clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ibrahim Halil Ozdemir, Bulent Ozlek, Mehmet Burak Ozen, Ramazan Gunduz, Nurullah Cetin, Eda Ozlek, Bekir Serhat Yildiz, Ali Riza Bilge
Summary: The study showed that the C-reactive protein/albumin ratio can serve as a strong and independent prognostic marker for predicting mortality and disease progression in hypertensive COVID-19 patients.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Gastroenterology & Hepatology
Varun Peri, Eunice Lee, Michael Fink, Graham Starkey, Mehrdad Nikfarjam, Osamu Yoshino, Ruelan Furtado, Marie Sinclair, Adam Testro, Avik Majumdar, Robert Jones, Vijayaragavan Muralidharan, Marcos Vinicius Perini
Summary: This study evaluated the clinical utility and survival outcomes of the C-reactive protein to albumin ratio, albumin-bilirubin index, and platelet-albumin-bilirubin index in patients with hepatocellular carcinoma. The results showed that a C-reactive protein-albumin ratio greater than 0.034 was associated with poor prognosis following liver resection.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Chun-Kai Liao, Yen-Lin Yu, Yueh-Chen Lin, Yu-Jen Hsu, Yih-Jong Chern, Jy-Ming Chiang, Jeng-Fu You
Summary: This study included 15 studies involving 6329 patients and found that a high pre-treatment CAR was associated with poor overall survival and disease-free survival/progression-free survival in colorectal cancer patients. Despite variations in study regions, sample sizes, cancer stages, treatment methods, or cut-off values, the prognostic value of pre-treatment CAR remained consistent.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Simcha R. Meisel, Hamuda Nashed, Randa Natour, Rami Abu Fanne, Majdi Saada, Naama Amsalem, Carmel Levin, Ofer Kobo, Aaron Frimerman, Yaniv Levi, Jameel Mohsen, Avraham Shotan, Ariel Roguin, Michael Kleiner-Shochat
Summary: The study aimed to differentiate between myopericarditis and AMI by evaluating the CRP/troponin ratio on admission, showing that myopericarditis patients had significantly higher CRP/troponin ratios compared to AMI patients.
Article
Medicine, Research & Experimental
Toru Aoyama, Masato Nakazono, Kenki Segami, Shinsuke Nagasawa, Kazuki Kano, Takanobu Yamada, Yukio Maezawa, Kentaro Hara, Itaru Hashimoto, Hideaki Suematsu, Hayato Watanabe, Kosuke Takahashi, Masakatsu Numata, Hiroshi Tamagawa, Norio Yukawa, Yasushi Rino, Takashi Ogata, Takashi Oshima
Summary: The pre-surgical C-reactive protein-to-albumin ratio (CAR) was found to impact survival and recurrence after curative treatment for gastric cancer, with a CAR of 0.05 identified as the optimal critical point for classification. Higher CAR levels were associated with lower survival and recurrence-free survival rates, as well as higher incidences of post-operative complications.
Article
Oncology
Qiuxing Yang, Aiguo Shen, Xudong Chen, Liyuan Guo, Hui Peng, Mingde Gao
Summary: A meta-analysis showed that decreased GNRI and increased CAR before surgery are associated with poorer survival outcomes in patients with EC.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Melike Elif Kalfaoglu
Summary: This study investigates the role of inflammatory markers in sacroiliitis and suggests that the uric acid to HDL cholesterol ratio (UHR) could be a useful additional diagnostic tool for patients with sacroiliitis.
Article
Multidisciplinary Sciences
Yuexiang Liang, Qiang Li, Donglei He, Yong Chen, Jingquan Li
Summary: The study evaluated the impact of tumor size on the long-term outcome of colon cancer patients after curative surgery, finding it to be a significant prognostic factor for T4a stage patients. Incorporating tumor size into staging systems can enhance the accuracy of prognostic prediction for these patients.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Jari A. Laukkanen
Summary: This study aimed to assess the association between CAR and pneumonia risk. The study found that elevated serum CAR and CRP levels were each associated with an increased risk of pneumonia in middle-aged and older Finnish men. No significant association was found between serum albumin and pneumonia risk.
RESPIRATORY MEDICINE
(2022)
Article
Oncology
Yuhan Huang, Xinwei Hua, Julia D. Labadie, Tabitha A. Harrison, James Y. Dai, Sara Lindstrom, Yi Lin, Sonja Berndt, Daniel D. Buchanan, Peter T. Campbell, Graham Casey, Steven J. Gallinger, Marc J. Gunter, Michael Hoffmeister, Mark A. Jenkins, Lori C. Sakoda, Robert E. Schoen, Brenda Diergaarde, Martha L. Slattery, Emily White, Graham Giles, Hermann Brenner, Jenny Chang-Claude, Amit Joshi, Wenjie Ma, Rish K. Pai, Andrew T. Chan, Ulrike Peters, Polly A. Newcomb
Summary: Elevated levels of C-reactive protein (CRP) in the blood have been associated with colorectal cancer (CRC) survival. This study examined the genetic variants associated with CRP levels and their interactions with sex and lifestyle factors in relation to CRC-specific mortality. The results showed a significant interaction between a genetic variant and sex in determining CRC-specific mortality.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Nutrition & Dietetics
Arwa S. Almasaudi, Ross D. Dolan, Stephen T. McSorley, Paul G. Horgan, Christine Edwards, Donald C. McMillan
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2019)
Review
Oncology
Peter G. Alexander, Donald C. McMillan, James H. Park
CANCER TREATMENT REVIEWS
(2020)
Article
Oncology
Louise E. Daly, Ross D. Dolan, Derek G. Power, Eadaoin Ni Bhuachalla, Wei Sim, Samantha J. Cushen, Marie Fallon, Claribel Simmons, Donald C. Mcmillan, Barry J. Laird, Aoife M. Ryan
Review
Oncology
Ross D. Dolan, Donald C. McMillan
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Ross D. Dolan, Muhammed Alwahid, Stephen T. McSorley, James H. Park, Richard P. Stevenson, Campbell S. Roxburgh, Paul G. Horgan, Donald C. McMillan
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Peter G. Alexander, Antonia K. Roseweir, Kathryn A. F. Pennel, Hester C. van Wyk, Arfon G. M. T. Powell, Donald C. McMillan, Paul G. Horgan, Caroline Kelly, Jennifer Hay, Owen Sansom, Andrea Harkin, Campbell S. D. Roxburgh, Janet Graham, David N. Church, Ian Tomlinson, Mark Saunders, Tim J. Iveson, Joanne Edwards, James H. Park
Summary: The Glasgow Microenvironment Score (GMS) is validated as a prognostic tool for patients with stage I-III colorectal cancer, independent of TNM staging, and has the ability to stratify both low- and high-risk disease. Additionally, GMS 0 can be used to identify patients who benefit from FOLFOX over CAPOX chemotherapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Katrina A. Knight, Ioanna Drami, Donald C. McMillan, Paul G. Horgan, James H. Park, John T. Jenkins, Campbell S. D. Roxburgh
Summary: The study found that calcification of the aortoiliac vessels supplying the rectum (AC) was not associated with NACRT response in the examined cohorts. Larger contemporary cohorts are needed to better assess host determinants of NACRT response and develop predictive models to improve patient selection.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Allan M. Golder, Donald C. McMillan, James H. Park, David Mansouri, Paul G. Horgan, Campbell S. Roxburgh
Summary: This study demonstrates that the pre-operative systemic inflammatory response (SIR) in patients undergoing curative surgery for colon cancer is best evaluated using a Systemic Inflammatory Grade (SIG) combining modified Glasgow Prognostic Score (mGPS) and neutrophil-lymphocyte ratio (NLR). Both mGPS and NLR have a significant impact on survival rates in colon cancer patients, and their combined use can better predict outcomes.
BRITISH JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Josh McGovern, Ross Dolan, Conor Richards, Barry J. Laird, Donald C. McMillan, Donogh Maguire
Summary: The study found that sarcopenia in the presence of obesity was associated with higher 30-day mortality in patients with COVID-19.
JOURNAL OF NUTRITION
(2021)
Article
Oncology
Josh McGovern, Ross D. Dolan, Richard J. Skipworth, Barry J. Laird, Donald C. McMillan
Summary: Cancer cachexia has traditionally been viewed as a nutritional syndrome, but recent research suggests that it may be primarily a manifestation of systemic inflammation. This has important implications for future treatment strategies.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell Biology
Suad A. K. Shamis, Jean Quinn, Elizabeth E. A. Mallon, Joanne Edwards, Donald C. McMillan
Summary: The prognostic significance of hypoxia markers in estrogen receptor-positive breast cancer patients was investigated. The expression of these markers was associated with clinicopathological parameters and disease-free survival.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Oncology
P. G. Alexander, H. C. van Wyk, K. A. F. Pennel, J. Hay, D. C. McMillan, P. G. Horgan, C. S. D. Roxburgh, J. Edwards, J. H. Park
Summary: The Glasgow Microenvironment Score (GMS) is associated with the location of recurrence in colorectal cancer. Higher GMS categories (GMS 1 and 2) are associated with an increased risk of local and distant recurrence.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Josh McGovern, Ross D. Dolan, Claribel P. L. Simmons, Louise E. Daly, Aoife M. Ryan, Derek G. Power, Donogh Maguire, Marie T. Fallon, Barry J. Laird, Donald C. McMillan
Summary: This study found a relationship between serum LDH level, phenotypic/aetiologic diagnostic GLIM criteria, and survival in patients with advanced cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Bruna M. M. Rocha, Ross D. Dolan, Carlos E. Paiva, Josh McGovern, Bianca S. R. Paiva, Daniel D. Preto, Donald C. McMillan, Yara C. P. Maia, Barry J. Laird
Summary: This study compares prognostic factors in two international cohorts of patients with advanced cancer and establishes a prognostic framework for treatment. The study finds that despite geographical and socio-demographic differences, similar prognostic factors are associated with long-term survival in both the European and Brazilian cohorts.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Review
Oncology
F. Savioli, J. Edwards, D. McMillan, S. Stallard, J. Doughty, L. Romics
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)