Article
Medicine, Research & Experimental
Xiang-nan Yu, Lu-ming Xu, Ya-wen Bin, Ye Yuan, Shao-bo Tian, Bo Cai, Kai-xiong Tao, Lin Wang, Guo-bin Wang, Zheng Wang
Summary: This study retrospectively analyzed data of rectal cancer patients undergoing anterior resection and found that being male and having T3-T4 stage were independent risk factors for anastomotic leakage (AL). Additionally, defunctioning stoma (DS) was found to reduce the occurrence of symptomatic AL.
CURRENT MEDICAL SCIENCE
(2022)
Article
Surgery
Zhao-liang Yu, Xuan-hui Liu, Hua-shan Liu, Jia Ke, Yi-feng Zou, Wu-teng Cao, Jian Xiao, Zhi-yang Zhou, Ping Lan, Xiao-jian Wu, Xian-rui Wu
Summary: The study evaluated the impact of pelvic dimensions on the risk of anastomotic leak in rectal cancer patients. The results showed that pelvic inlet and intertuberous distance were independent predictors for postoperative anastomotic leak. The incorporation of pelvic dimensions with other factors in the nomogram may provide a clinical tool for predicting anastomotic leak.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Nynke G. Greijdanus, Kiedo Wienholts, Sander Ubels, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Francisco B. de Lacy, Jeremie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo O. Perez, Tsuyoshi Konishi, Yves Panis, Martin Rutegard, Roel Hompes, Camiel Rosman, Frans van Workum, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: The study developed a prediction model for 1-year stoma-free survival in rectal cancer patients with anastomotic leakage. The model, consisting of 18 clinically relevant factors, showed good discrimination and calibration, providing guidance for patient counseling and future treatment strategies analysis.
Article
Gastroenterology & Hepatology
Frans van Workum, Kevin Talboom, Gerjon Hannink, Albert Wolthuis, Borja F. de Lacy, Jeremie H. Lefevre, Michael Solomon, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo Oliva Perez, Tsuyoshi Konishi, Yves Panis, Camiel Rosman, Roel Hompes, Pieter J. Tanis, Johannes H. W. de Wilt
Summary: This study aims to investigate the factors contributing to the severity of anastomotic leakage after low anterior resection for rectal cancer, create a severity score, and evaluate the effects of different treatment approaches on outcome parameters. The international multicentre retrospective cohort study, TENTACLE-Rectum, will provide valuable evidence-based recommendations for improving outcomes in patients with severe treatment-related morbidity.
COLORECTAL DISEASE
(2021)
Article
Oncology
Keli Wang, Meijiao Li, Rui Liu, Yang Ji, Jin Yan
Summary: This study aimed to explore the risk factors of anastomotic leakage (AL) after laparoscopic anterior resection (AR) of rectal cancer and established a prediction model to assess its occurrence probability. By analyzing the clinical and surgical data of patients, it was found that factors such as male gender, tumor distance from the anus verge, tumor growth pattern, operation time, and whether diverting stoma was performed were associated with the occurrence of AL. The established prediction model based on these factors can effectively predict the probability of AL.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Surgery
Thomas W. A. Koedam, Boukje T. Bootsma, Charlotte L. Deijen, Tim van de Brug, Geert Kazemier, Miguel A. Cuesta, Alois Furst, Antonio M. Lacy, Eva Haglind, Jurriaan B. Tuynman, Freek Daams, Hendrik J. Bonjer
Summary: Anastomotic leakage after rectal cancer surgery negatively affects long-term oncological outcomes, leading to increased local recurrences and decreased disease-free survival. However, its impact on outcomes after colon cancer surgery remains inconclusive.
Article
Gastroenterology & Hepatology
Henrik Jutesten, Pamela L. Buchwald, Eva Angenete, Martin Rutegard, Marie-Louise Lydrup
Summary: This retrospective observational cohort study found a significant association between anastomotic leakage and the occurrence of major low anterior resection syndrome.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Oncology
Xinyu Qi, Maoxing Liu, Kai Xu, Pin Gao, Fei Tan, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui, Xiangqian Su
Summary: Prolonged duration of operation increased the risk of symptomatic AL after laparoscopic LAR for rectal cancer. No impact of symptomatic AL on long-term survival was observed in this study. Further studies are required for a conclusive result.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Bin Zhang, Guang-Zuan Zhuo, Ke Zhao, Yong Zhao, Dong-Wei Gao, Jun Zhu, Jian-Hua Ding
Summary: The cumulative incidence and risk factors of permanent stoma after intersphincteric resection for ultralow rectal cancer have not been well defined. A retrospective analysis of 185 patients revealed that anastomotic complications were independently predictive of permanent stoma.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Biochemical Research Methods
Xiaowen Qiao, Xinyu Qi, Pu Xing, Tianqi Liu, Hao Hao, Xinying Yang, Beihai Jiang, Ming Cui, Xiangqian Su
Summary: Anastomotic leakage (AL) is a severe complication in rectal surgery, and early diagnosis remains challenging. This study identified potential biomarkers for early diagnosis of AL by analyzing protein expression profiles in patients who underwent surgery for rectal cancer.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Maurizio Degiuli, Ugo Elmore, Raffaele De Luca, Paola De Nardi, Mariano Tomatis, Alberto Biondi, Roberto Persiani, Leonardo Solaini, Gianluca Rizzo, Domenico Soriero, Desiree Cianflocca, Marco Milone, Giulia Turri, Daniela Rega, Paolo Delrio, Corrado Pedrazzani, Giovanni D. De Palma, Felice Borghi, Stefano Scabini, Claudio Coco, Davide Cavaliere, Michele Simone, Riccardo Rosati, Rossella Reddavid
Summary: This retrospective multicentre study aimed to assess the anastomotic leak rate after restorative surgery for rectal cancer, identify independent risk factors, and develop a clinical prediction model. The study found that factors such as sex, body mass index, tumour location, type of approach, and number of cartridges employed were independent risk factors for anastomotic leak. While a stoma did not reduce the leak rate, it significantly decreased the severity of leaks and reoperation rate.
COLORECTAL DISEASE
(2022)
Article
Surgery
Jae-Woo Ju, Ho-Jin Lee, Min Jung Kim, Seung-Bum Ryoo, Won Ho Kim, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park
Summary: This study aimed to investigate the association between early postoperative NSAID use and anastomotic leakage (AL) in patients who underwent colorectal cancer surgery. The findings showed a significant association between early postoperative NSAID use and AL.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Kevin Talboom, Nynke G. Greijdanus, Cyriel Y. Ponsioen, Pieter J. Tanis, Wilhelmus A. Bemelman, Roel Hompes
Summary: Early initiation of EVASC for anastomotic leakage after rectal cancer resection yields high rates of healed and functional anastomosis. EVASC shows increasing success with the implementation of highly selective diversion and early diagnosis of the leak.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
E. Back, J. Haggstrom, K. Holmgren, M. M. Haapamaki, P. Matthiessen, J. Rutegard, M. Rutegard
Summary: Using preoperative data, the risk of permanent stoma after anterior resection for rectal cancer at 2 years can be predicted fairly accurately. Factors such as age, tumor metastasis, and preoperative treatment all play a role in influencing the stoma outcome.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
V. T. Hoek, S. Buettner, C. L. Sparreboom, R. Detering, A. G. Menon, G. J. Kleinrensink, M. W. J. M. Wouters, J. F. Lange, J. K. Wiggers
Summary: This study aimed to develop a robust preoperative prediction model for anastomotic leakage after surgical resection for rectal cancer. Significant risk factors were identified and included in the prediction model, which can be used for patient counselling and risk-stratification before undergoing rectal resection for cancer.
