Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Review
Biochemistry & Molecular Biology
Pengxu Wei, Ruixue Bao
Summary: Knee osteoarthritis is a common problem, especially in older individuals, and can eventually lead to disability. Injecting mesenchymal stem cells (MSCs) into the knee joint has been shown to induce cartilage regeneration in several studies. Additionally, understanding the anatomical, biomechanical, and biochemical changes associated with knee osteoarthritis can help develop appropriate interventions to delay disease progression and improve cartilage repair induced by MSC injection. Post-injection rehabilitation programs and related mechanisms are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ming Zhang, Zhihui Li, Hanqi Wang, Tongtong Chen, Yong Lu, Fuhua Yan, Yuyao Zhang, Hongjiang Wei
Summary: UTE-QSM enables simultaneous susceptibility mapping of the articular cartilage and cortical bone of human in vivo. Good association between susceptibility and CT values in cortical bone suggests the potential of UTE-QSM for bone mapping for further clinical application.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Masanori Watanabe, T. Mark Campbell, Katherine Reilly, Hans K. Uhthoff, Odette Laneuville, Guy Trudel
Summary: After immobilizing rat knees in flexion, bone replacement in the anterior tibial articular cartilage began after 2 weeks, became prevalent after 4 weeks, and progressed in an anterior-to-posterior direction, stopping at the area of contact between tibia and femur. These findings highlight the importance of maintaining joint health through mobility.
Article
Cell & Tissue Engineering
Zhi-Ling Li, Xiao-Tong Li, Rui-Cong Hao, Fei-Yan Wang, Yu-Xing Wang, Zhi-Dong Zhao, Pei-Lin Li, Bo-Feng Yin, Ning Mao, Li Ding, Heng Zhu
Summary: In this study, human articular cartilage stem cells (ACSCs) were isolated from osteoarthritic articular cartilage and their protective effects on osteoarthritis (OA) tissues were evaluated. ACSCs were found to suppress osteoarthritic osteoclasts formation and the inflammatory joint microenvironment enhanced this inhibitory effect. ACSC-derived TNFAIP3 was identified to contribute significantly to the inhibition of osteoarthritic osteoclasts and the improvement of abnormal subchondral bone remodeling.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Moon-Chang Choi, Jiwon Jo, Myeongjin Lee, Jonggwan Park, Yoonkyung Park
Summary: The study found that the antimicrobial peptide Cramp induces chondrocyte catabolism via the NF-kappa B signaling pathway, accelerating the progression of OA and leading to cartilage degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
M. Jarraya, A. Guermazi, J. W. Liew, I. Tolstykh, J. A. Lynch, P. Aliabadi, D. T. Felson, M. Clancy, M. Nevitt, C. E. Lewis, J. Torner, T. Neogi
Summary: The aim of this study was to report the prevalence of CT-detected intra-articular mineralization. It was found that 9.8% of knees had intra-articular mineralization based on CT imaging. Mineralization predominantly occurred in the three compartments of the joint, especially the patellofemoral compartment.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Endocrinology & Metabolism
Weirong Xing, Sheila Pourteymoor, Yian Chen, Subburaman Mohan
Summary: Studies show that targeted deletion of the Cldn12 gene in mice increases articular cartilage, potentially by promoting articular chondrocyte phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Anatomy & Morphology
Piero Antonio Zecca, Marcella Reguzzoni, Marina Protasoni, Mario Raspanti
Summary: In the synovial joints, the transition between the soft articular cartilage and the subchondral bone is mediated by a calcified cartilage layer with similar characteristics to bone. This layer is not directly accessible and is visualized through histological sections of decalcified tissue. This study used conventional histology and scanning electron microscopy to discriminate between the calcified and uncalcified cartilage, revealing a high heterogeneity of the calcified layer and a different mineralization process compared to other hard tissues. Selective removal of the soft matrix allowed for a 3D view of the mineralization front.
Article
Materials Science, Multidisciplinary
Jun Wu, Linjun Jiang, Lingpeng Ju, Yuan Zhang, Ming Li, Xing Liu, Xiangyang Qu
Summary: This study successfully combined bone morphogenetic protein-9 (BMP-9) with deproteinized osteoarticulation (DPOA) to achieve excellent osteogenic and angiogenic effects in a canine femoral condylar defect model, demonstrating outstanding osteoarticular repair outcomes.
MATERIALS & DESIGN
(2021)
Article
Endocrinology & Metabolism
Zelong Dou, Daniel Muder, Marta Baroncelli, Ameya Bendre, Alexandra Gkourogianni, Lars Ottosson, Torbjorn Vedung, Ola Nilsson
Summary: The study found that perichondrium and periosteum transplanted into articular cartilage defects can be transformed into cartilaginous articular surfaces. Perichondrium transplants developed into an articular-like, hyaline cartilage, while periosteum transplants produced a less resilient fibro-cartilage.
Review
Biochemistry & Molecular Biology
Dawid Szwedowski, Joanna Szczepanek, Lukasz Paczesny, Jan Zabrzynski, Maciej Gagat, Ali Mobasheri, Slawomir Jeka
Summary: Knee osteoarthritis (KOA) treatment options include medication, physical therapy, braces, activity modification, and surgery, with intra-articular injections commonly used when non-operative treatment fails. PRP may improve the metabolic function of damaged structures, but its effects on chondrogenesis and stem cell proliferation are still controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chenshuang Li, Zhong Zheng
Summary: There are significant differences at the transcriptomic level in knee articular cartilage among healthy and OA individuals, particularly with regards to sex distinctions. Females showed more differential gene expression and enriched pathways in comparison to males, both in healthy cartilage and in OA conditions. Male and female cartilage responded differently to OA, with notable differences in the expression of genes related to various pathways, suggesting potential implications for OA prognosis and treatment outcomes in males and females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Jiazi Gao, Pengling Ren, He Gong
Summary: This study investigated the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs. The results showed that the micromechanical properties of articular cartilage were the lowest at 1 month of age, and the earliest degeneration of articular cartilage occurred at 6 months of age. No degeneration in the micro- or nanostructure of subchondral bone was observed before 9 months. These findings provide valuable insights into the formation and progression of hip osteoarthritis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Multidisciplinary
Liangbin Zhou, Peng Guo, Matteo D'Este, Wenxue Tong, Jiankun Xu, Hao Yao, Martin J. Stoddart, Gerjo J. V. M. van Osch, Kevin Ki-Wai Ho, Zhen Li, Ling Qin
Summary: Articular cartilage (AC) is a flexible connective tissue located on the bone surface in the joints. AC defects are common in physically active individuals. Functionalized hydrogels have emerged as promising substitutes for damaged cartilage in AC repair due to their favorable properties. This article introduces the composition, structure, and function of AC and its defects, and reviews the design and fabrication of functionalized hydrogels for AC repair.
Article
Engineering, Biomedical
Nicolas Bailly, Lucien Diotalevi, Marie-Helene Beausejour, Eric Wagnac, Jean-Marc Mac-Thiong, Yvan Petit
CLINICAL BIOMECHANICS
(2020)
Article
Computer Science, Interdisciplinary Applications
Marie-Helene Beausejour, Yvan Petit, Jeremy Hagen, Pierre-Jean Arnoux, Jean-Marc Mac Thiong, Eric Wagnac
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2020)
Article
Clinical Neurology
Julien Goulet, Andreane Richard-Denis, Yvan Petit, Lucien Diotalevi, Jean-Marc Mac-Thiong
EUROPEAN SPINE JOURNAL
(2020)
Article
Acoustics
Jawad Dahmani, Catherine Laporte, Daniel Pereira, Pierre Belanger, Yvan Petit
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2020)
Article
Multidisciplinary Sciences
Marion Fournely, Yvan Petit, Eric Wagnac, Morgane Evin, Pierre-Jean Arnoux
Article
Chemistry, Multidisciplinary
Nicolas Bailly, Yvan Petit, Jean-Michel Desrosier, Olivier Laperriere, Simon Langlois, Eric Wagnac
APPLIED SCIENCES-BASEL
(2020)
Article
Engineering, Biomedical
Patrice Sudres, Morgane Evin, Eric Wagnac, Nicolas Bailly, Lucien Diotalevi, Anthony Melot, Pierre-Jean Arnoux, Yvan Petit
Summary: This study aimed to quantify the elastic meningeal mechanical properties of porcine spinal cord, revealing the diverse mechanical properties of spinal meninges along the length of the spinal cord.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Analytical
Satyendra Kumar Mishra, Jean-Marc Mac-Thiong, Eric Wagnac, Yvan Petit, Bora Ung
Summary: This study presents an optical pressure sensing scheme that detects and demonstrates transverse compression inside spinal cord surrogate in real-time, with a response time of 20 microseconds and a five orders of magnitude enhancement over comparable schemes. The improvement in measurement speed comes with a negligible loss in sensitivity, helping to better understand the biomechanics during traumatic SCI.
Article
Chemistry, Multidisciplinary
Olly Duncan, Nicolas Bailly, Tom Allen, Yvan Petit, Eric Wagnac, Andrew Alderson
Summary: This study aimed to measure the effect of strain rate on the stiffness and Poisson's ratio of auxetic and conventional foams. The results showed that the Poisson's ratio of auxetic foams halved at high strain rates, while the Young's moduli of conventional foam approximately doubled at the highest applied strain rate.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Florian Guillaume, Sophie Le Cann, Alessandro Tengattini, Elin Tornquist, Celine Falentin-Daudre, Hugues Albini Lomami, Yvan Petit, Hanna Isaksson, Guillaume Haiat
Summary: The study aimed to evaluate the potential of neutron tomography for characterizing bone tissue near metallic implants. Results indicate reliable detection of mineralized bone tissue with neutron tomography, but potential overestimation of BIC ratio and bone content. Further work will focus on distinguishing soft tissues from bone tissue, possibly aided by contrast agents.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Biophysics
Marie-Helene Beausejour, Eric Wagnac, Pierre-Jean Arnoux, Jean-Marc Mac Thiong, Yvan Petit
Summary: This study analyzed how posterior disco-ligamentous injuries affect the severity and mechanism of traumatic cervical spinal cord injury. The most severe injury occurred when there was complete intervertebral disc rupture combined with rupture of the posterior ligamentous complex. The main post-trauma SCI mechanism was identified as compression of the anterior white matter and distraction of the posterior spinal cord during flexion.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2022)
Article
Engineering, Biomedical
Morgane Evin, Patrice Sudres, Pascal Weber, Yves Godio-Raboutet, Pierre-Jean Arnoux, Eric Wagnac, Yvan Petit, Yannick Tillier
Summary: This study aims to investigate the mechanical characteristics of swine pia mater and dura and arachnoid complex under bi-axial loading conditions. The results show that the anisotropic Gasser model is the most suitable for modeling the tissue. This research provides reference values for further studies and finite element modeling for physiological applications.
ACTA BIOMATERIALIA
(2022)
Article
Veterinary Sciences
Caroline Constant, Vladimir Brailovski, Eric Wagnac, Yvan Petit, Andre Desrochers, Sylvain Nichols
Summary: Replacing the CCL with nylon can restore joint stability, while nitinol prostheses passed through single femoral and tibial bone tunnels (bone-to-bone) are the only techniques that reduce tibial translation.
VETERINARY SURGERY
(2021)
Proceedings Paper
Engineering, Biomedical
I. Benasson, E. Wagnac, L. Diotalevi, D. Moore, J-M. Mac-Thiong, Y. Petit
42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20
(2020)
Proceedings Paper
Engineering, Biomedical
L. Diotalevi, E. Wagnac, H. Laurent, Y. Petit
42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20
(2020)