Article
Radiology, Nuclear Medicine & Medical Imaging
Pei Nie, Ning Wang, Jing Pang, Guangjie Yang, Shaofeng Duan, Jingjing Chen, Wenjian Xu
Summary: This study evaluated the value of a radiomics nomogram in differentiating HCA from HCC in the noncirrhotic liver, showing that the radiomics nomogram has the potential to improve diagnostic accuracy compared to other models.
ACADEMIC RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
K. Rajender Reddy, Dale McLerran, Tracey Marsh, Neehar Parikh, Lewis R. Roberts, Myron Schwartz, Mindie H. Nguyen, Alex Befeler, Stephanie Page-Lester, Runlong Tang, Sudhir Srivastava, Jo Ann Rinaudo, Ziding Feng, Jorge A. Marrero
Summary: This is the largest prospective and geographically diverse study of a U.S. cohort of patients with cirrhosis, validating known risk factors for HCC.
Article
Gastroenterology & Hepatology
Ji H. Nahm, Hye S. Lee, Haeryoung Kim, Sun Y. Yim, Ji-hyun Shin, Jeong E. Yoo, Sang H. Ahn, Jin S. Choi, Ju-Seog Lee, Young N. Park
Summary: This study developed a nomogram for predicting late recurrence of hepatocellular carcinoma (HCC) based on clinicopathological and molecular factors. The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis was found to predict late HCC recurrence.
LIVER INTERNATIONAL
(2021)
Article
Cell Biology
Naoto Fujiwara, Naoto Kubota, Emilie Crouchet, Bhuvaneswari Koneru, Cesia A. Marquez, Arun K. Jajoriya, Gayatri Panda, Tongqi Qian, Shijia Zhu, Nicolas Goossens, Xiaochen Wang, Shuang Liang, Zhenyu Zhong, Sara Lewis, Bachir Taouli, Myron E. Schwartz, Maria Isabel Fiel, Amit G. Singal, Jorge A. Marrero, Austin J. Fobar, Neehar D. Parikh, Indu Raman, Quan-Zhen Li, Masataka Taguri, Atsushi Ono, Hiroshi Aikata, Takashi Nakahara, Hayato Nakagawa, Yuki Matsushita, Ryosuke Tateishi, Kazuhiko Koike, Masahiro Kobayashi, Takaaki Higashi, Shigeki Nakagawa, Yo-ichi Yamashita, Toru Beppu, Hideo Baba, Hiromitsu Kumada, Kazuaki Chayama, Thomas F. Baumert, Yujin Hoshida
Summary: This study analyzed multiple cohorts of NAFLD patients globally to define and validate signatures predictive of long-term HCC risk in NAFLD patients. These signatures can accurately predict the risk of developing HCC in patients and provide assistance for clinical treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
In Rae Cho, Sang-Wook Yi, Ja Sung Choi, Jee-Jeon Yi
Summary: Cholangiocarcinoma (CCA) shares many risk factors with hepatocellular carcinoma (HCC), but liver cirrhosis does not increase the risk for CCA and there are differences in the magnitude of common risk factors between CCA and HCC.
Article
Oncology
Zhong-Ping Xu, Yan Liu, Zhen-Ru Wu, Jian-Ping Gong, Yun-Bing Wang
Summary: This study revealed differential expression of SOX9 in cirrhotic hepatocellular carcinoma (CHCC) and noncirrhotic hepatocellular carcinoma (NCHCC), with high SOX9 expression being closely related to overall survival in NCHCC but not in CHCC. SOX9 had reliable and comparable diagnostic value in both CHCC and NCHCC, with no significant difference in differentiation between HCC and adjacent normal tissues.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Chemistry, Medicinal
Bowen Chen, Linzhi Zhang, Jiamin Cheng, Tong Wu, Jin Lei, Xu Yang, Rongling Zhang, Rifaat Safadi, Yinyin Li, Tongguo Si, Yinying Lu
Summary: The purpose of this study was to investigate the incidence rate and risk factors for hepatic encephalopathy (HE) among uHCC patients with liver cirrhosis who received sorafenib or lenvatinib treatment. The study found that patients with alcoholic cirrhosis, Child-Pugh >7, high blood ammonia and total bile acid levels, and longer duration of treatment were at higher risk for developing HE during first-line systemic therapy.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Oncology
Jin Gu, Erlei Zhang, Binyong Liang, Zunyi Zhang, Xiaoping Chen, Min Xiong, Zhiyong Huang
Summary: In HCC patients with Child-Pugh grade A liver function, cirrhosis staging can be determined by measuring liver collagen contents using Collagen Proportional Area (CPA), which significantly affects the risk of Posthepatectomy Liver Failure (PHLF). The study also found a significant correlation between CPA and a non-invasive method called Cirrhotic Severity Scoring (CSS) proposed by the team, showing that higher CPA values and extent of hepatectomy are independent risk factors for PHLF, and there is a positive correlation between CPA and CSS.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Kenneth I. Zheng, Ming-Hua Zheng
Summary: This article is linked to the paper by Estes et al. Visit the link to view the article.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Koya Yasukawa, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Kiyotaka Hosoda, Hikaru Hayashi, Yuji Soejima
Summary: This study aimed to investigate the impact of liver fibrosis on the prognosis of patients with hepatocellular carcinoma (HCC). The results showed that patients with more severe liver fibrosis had worse cancer-specific prognosis. Moreover, patients with liver fibrosis had a higher incidence of multiple recurrences.
Article
Multidisciplinary Sciences
Tomomi Kogiso, Takaomi Sagawa, Makiko Taniai, Eriko Shimada, Kei Inai, Tokuko Shinohara, Katsutoshi Tokushige
Summary: This study found that the complication of polysplenia and a higher MELD-XI score may be independent risk factors for the development of hepatocellular carcinoma (HCC) in patients with Fontan-associated liver disease (FALD), and patients with these risk factors tend to have a poor prognosis.
Article
Gastroenterology & Hepatology
David Goldberg, Katherine Ross-Driscoll, Raymond Lynch
Summary: This study highlights significant intrastate differences in liver disease-related mortality, with more than 60% of the variability explained by patient demographics, clinical risk factors for liver disease, and access to specialty liver care. Despite adjustments, there were still significant variations in county-level mortality rates within states, with the majority of high mortality counties located in Oklahoma, Texas, and New Mexico.Adjusted mortality rates revealed 5 clusters of high liver disease mortality, suggesting the presence of geographical hotspots for liver disease mortality.
Article
Economics
Hannah E. Carter, Gary P. Jeffrey, Grant A. Ramm, Louisa G. Gordon
Summary: The study found that risk-stratified screening and all-inclusive screening for HCC in Australia are more cost-effective compared to no formal screening, with all-inclusive screening being the most likely cost-effective option at a WTP threshold of A$50,000 per QALY. Risk-stratified screening using a serum biomarker test may be cost-effective at lower WTP thresholds, such as between A$25,000 and A$35,000 per QALY.
Article
Oncology
Jae Seung Lee, Dong Hyun Sinn, Soo Young Park, Hye Jung Shin, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Joo Hyun Oh, Jung Il Lee, Seung Up Kim
Summary: A new liver stiffness-based risk prediction model for the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease showed acceptable performance in both internal and external validation, demonstrating its usefulness in predicting the risk of HCC development in NAFLD patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Neeraj Lalwani, Rania Farouk El Sayed, Amita Kamath, Sara Lewis, Hina Arif, Victoria Chernyak
Summary: Functional defecation disorders consist of constipation causes related to anorectal dysfunction, with unclear etiology requiring comprehensive clinical assessment and physiological tests for accurate diagnosis, where defecography plays a crucial role in evaluation.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Neeraj Lalwani, Gaurav Khatri, Rania Farouk EL Sayed, Roopa Ram, Kedar Jambhekar, Victoria Chernyak, Amita Kamath, Sara Lewis, Milana Flusberg, Francis Scholz, Hina Arif-Tiwari, Suzanne L. Palmer, Mark E. Lockhart, Julia R. Fielding
Summary: Expert radiologists on the Society of Abdominal Radiology's disease-focused panel reached consensus on recommendations for magnetic resonance (MR) defecography technique, including coaching for patients, rectal distension, and imaging protocol standards.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne L. Palmer, Neeraj Lalwani, Simin Bahrami, Francis Scholz
Summary: Fluoroscopic defecography (FD) is an important diagnostic tool for defecatory disorders, providing qualitative and quantitative information to help patients understand the severity of their condition and aid surgeons in planning treatment for complex pelvic floor and defecatory problems.
ABDOMINAL RADIOLOGY
(2021)
Article
Medicine, Research & Experimental
Harrison Cash, Randall Bly, Vanessa Masco, Manjiri Dighe, Edith Cheng, Shani Delaney, Kimberly Ma, Jonathan A. Perkins
Summary: Detection of fetal airway compromise through imaging may require ex utero intrapartum treatment (EXIT) procedures. Analysis of prenatal consultations with potential fetal airway obstruction shows that imaging characteristics and obstetric findings play important roles in determining management strategy. Factors such as midline neck mass location are associated with performance of EXIT procedures.
Review
Radiology, Nuclear Medicine & Medical Imaging
Vikram Sai Shivaji, Joseph Charles Wilson, Noemi L. Schmidt, Orpheus Kolokythas, Neeraj Lalwani
Summary: Carcinoma of Unknown Primary presenting primarily as hepatic metastases represents a poor prognosis with most cases showing undetectable primary tumors. A standardized diagnostic approach is necessary to avoid unnecessary tests and prioritize patient wishes and health status. This review aims to provide an overview of the current literature on this type of cancer and propose a standardized approach for diagnosis.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Courtney C. Moreno, Jason W. Allen, Manjiri Dighe, Mason Frazier, Marta E. Heilbrun, Matthew Larrison, Satinder Singh, Srini Tridandapani
Summary: This article presents perspectives of radiologists from different subspecialties at three institutions in the US on inpatient imaging of patients with confirmed COVID-19 and persons under investigation. The COVID-19 pandemic has prompted radiologists to be aware of imaging findings related to the disease and develop workflows for imaging, emphasizing the importance of optimizing care for all patients.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Milana Flusberg, Yin Xi, Kedar Jambhekar, Simin Bahrami, Victoria Chernyak, Neeraj Lalwani, Mark Lockhart, Roopa Ram, Julia R. Fielding, Rania Farouk El Sayed, Gaurav Khatri
Summary: Variations in pelvic floor imaging techniques and utilization were found between institutions, highlighting the need for further standardization. MRI was the most commonly used imaging technique, followed by fluoroscopic defecography. Ultrasound was utilized by only a small minority of radiologists.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Malak Itani, Neeraj Lalwani, Dhakshinamoorthy Ganeshan, Maria Zulfiqar, Cary Siegel
Summary: More than one-fifth of ovarian cancers are hereditary, with most of them caused by BRCA genes. Malignant ovarian neoplasms are primarily epithelial tumors, a heterogeneous group of tumors with variable genetic backgrounds that translate into different biologic behaviors and morphologic features. Radiologists play an increasingly important role in the diagnosis and management of oncology patients, and familiarity with hereditary ovarian cancers has a positive impact on patient management and radiologists' involvement.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lisa N. Johnson, Shamus K. Moran, Puneet Bhargava, Jonathan W. Revels, Mariam Moshiri, Charles A. Rohrmann, Bahar Mansoori
Summary: This article examines a wide range of conditions that can affect the duodenum, including congenital, infectious, inflammatory, and neoplastic abnormalities, and reviews their typical appearances on fluoroscopy.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Puneet Bhargava
Article
Radiology, Nuclear Medicine & Medical Imaging
Shahjehan Ahmad, Miral D. Jhaveri, Mahmud Mossa-Basha, Murat Oztek, Jason Hartman, Santhosh Gaddikeri
Summary: This study aimed to compare CT-guided bone biopsy and fluoroscopic-guided disc aspirations in terms of radiation exposure, procedure time, sedation requirement, and yield. The results showed that CT-guided bone biopsy required more anesthesia, had longer radiation exposure time, higher radiation dose, and longer procedure time compared to fluoroscopic-guided disc aspirations, but there was no significant difference in yield between the two modalities.
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pokhraj P. Suthar, Kathryn Hughes, Geetanjalee Kadam, Miral Jhaveri, Santhosh Gaddikeri
Summary: A 13-day-old full-term female neonate had a seizure and was diagnosed with meningoencephalitis based on classic imaging findings on brain MRI and confirmed on cerebrospinal fluid analysis.
SA JOURNAL OF RADIOLOGY
(2023)
Review
Neuroimaging
Johnny Ling, Wencheng Li, Neeraj Lalwani
Summary: AUS/FLUS is an intermediate histologic category in The Bethesda System for Reporting Thyroid Cytopathology, with potential higher risk of malignancy than previously estimated. Management of nodules with AUS/FLUS diagnosis involves consideration of their intermediate nature between benign and malignant, including options such as observation, repeat fine-needle aspiration, and surgery.
NEURORADIOLOGY JOURNAL
(2021)
Proceedings Paper
Engineering, Biomedical
Joseph Cox, Sydney Rubin, Joe Adams, Carina Pereira, Manjiri Dighe, Adam Alessio
MEDICAL IMAGING 2020: COMPUTER-AIDED DIAGNOSIS
(2020)
Meeting Abstract
Urology & Nephrology
Dima Raskolnikov, M. Kennedy Hall, Steven D. Ngo, Manjiri Dighe, Joel A. Gross, Jonathan D. Harper, John L. Gore
JOURNAL OF UROLOGY
(2020)
