Article
Engineering, Multidisciplinary
Xiaofei Xue, Xiujian Liu, Zhifan Gao, Rui Wang, Lei Xu, Dhanjoo Ghista, Heye Zhang
Summary: This study proposes a personalized coronary flow model, CTPV, based on dynamic stress computed tomographic perfusion, to achieve a noninvasive estimation of coronary outlet resistance and FFRCT. The CTPV model directly quantifies the total hyperemic coronary blood flow using myocardial blood flow obtained from CTP. It then distributes the outlet coronary blood flow based on myocardial perfusion territories corresponding to coronary artery branches. The experimental results demonstrate that the CTPV model accurately estimates FFRCT compared to the CTPD and LVMD models.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Engineering, Biomedical
Wenbing Jiang, Yibin Pan, Yumeng Hu, Xiaochang Leng, Jun Jiang, Li Feng, Yongqing Xia, Yong Sun, Jian'an Wang, Jianping Xiang, Changling Li
Summary: The study introduced a novel non-invasive method for calculating FFR, AccuFFRct, which showed high diagnostic performance for detecting ischemia caused by coronary stenosis, outperforming CCTA in terms of accuracy, specificity, and AUC.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mark G. Rabbat, Suvasini Lakshmanan, Mina M. Benjamin, Gheorghe Doros, April Kinninger, Matthew J. Budoff, Deepak L. Bhatt
Summary: The EVAPORATE trial demonstrated that IPE significantly reduced plaque burden. This study assessed the impact of IPE on coronary physiology using FFRCT. The results showed that IPE improved coronary distal segment FFRCT, providing mechanistic insight into the clinical benefit observed in the REDUCE-IT trial.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Oncology
Quan Li, Yang Zhang, Chunliang Wang, Shiming Dong, Yijin Mao, Yida Tang, Yong Zeng
Summary: The study on 20 consecutive patients with suspected CAD suggests that CT-derived resting Pd/Pa may have potential advantage over CT-FFR in diagnosing functionally significant CAD, showing higher sensitivity, specificity, negative predictive value, positive predictive value, and accuracy. Area under the receiver-operating characteristic curve (AUC) for CT-(Pd/Pa)rest and CT-FFR to detect functionally significant stenoses were 0.87 and 0.90 respectively.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Akos Varga-Szemes, U. Joseph Schoepf, Pal Maurovich-Horvat, Rui Wang, Lei Xu, Danielle M. Dargis, Tilman Emrich, Andrew J. Buckler
Summary: The study evaluated the feasibility of using plaque morphology assessment from CCTA to estimate non-invasive FFR, which outperformed traditional stenosis interpretation and showed comparable sensitivity and specificity. The results suggest that non-invasive plaque morphology-based FFR assessment may be a useful tool for predicting lesion-specific ischemia in hemodynamically significant CAD.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiujian Liu, Chuangye Xu, Simin Rao, Ye Zhang, Dhanjoo Ghista, Zhifan Gao, Guang Yang
Summary: This study introduces a physiologically personalized coronary blood flow model for estimating outlet resistance and FFRCT, demonstrating significant improvement in diagnostic performance compared to the LVM-based model. Additionally, a standardized outlet truncation strategy was found to have good repeatability in enhancing the repeatability of FFRCT.
Article
Radiology, Nuclear Medicine & Medical Imaging
Liu Yang, Peng Peng Xu, U. Joseph Schoepf, Christian Tesche, Balakrishnan Pillai, Rock H. Savage, Chun Xiang Tang, Fan Zhou, Hao Dong Wei, Zhong Qiang Luo, Qing Gen Wang, Chang Sheng Zhou, Meng Jie Lu, Guang Ming Lu, Long Jiang Zhang
Summary: Fractional flow reserve and plaque progression assessed by serial coronary CT angiography predicted the risk of future major adverse cardiovascular events (MACE), demonstrating better accuracy compared to traditional assessment markers.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Xuelian Gao, Rui Wang, Zhonghua Sun, Hongkai Zhang, Kairui Bo, Xiaofei Xue, Junjie Yang, Lei Xu
Summary: This study found that the CTP-FFR model has promising value in improving the diagnostic accuracy of CCTA in detecting coronary ischemia. The feasibility of using CTP-FFR to detect coronary artery ischemia in patients with suspected CAD was proven.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leonie M. Becker, Joyce Peper, Bram J. L. A. Verhappen, Laurens A. Swart, Admir Dedic, Willem G. van Dockum, Martin van der Ent, Kees-Jan Royaards, Andre Niezen, Jan-Hein J. Hensen, Jan-Peter van Kuijk, Firdaus A. A. Mohamed Hoesein, Tim Leiner, Tobias A. Bruning, Martin J. Swaans
Summary: This study assessed the impact of CT-derived fractional flow reserve (FFR-CT) on clinical decision-making and patient prognosis in patients with stable coronary artery disease (CAD). The results showed that the addition of FFR-CT resulted in a reduction in invasive diagnostic testing and fewer occurrences of revascularizations.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Jiang, Changqing Du, Yumeng Hu, Hong Yuan, Jianhua Wang, Yibin Pan, Lifang Bao, Liang Dong, Changling Li, Yong Sun, Xiaochang Leng, Jianping Xiang, Lijiang Tang, Jian'an Wang
Summary: This study evaluated the feasibility and diagnostic accuracy of a new computational fluid dynamics (CFD)-based technology, called AccuFFRct, for diagnosing functionally significant lesions using coronary computed tomographic angiography (CCTA) as a reference. The results showed that AccuFFRct performed well in detecting hemodynamically significant coronary stenoses.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Gaurav Chandola, Jun-Mei Zhang, Ru-San Tan, Ping Chai, Lynette Teo, John C. Allen, Ris Low, Weimin Huang, Shuang Leng, Jiang Ming Fam, Chee Yang Chin, Ghassan S. Kassab, Adrian Fatt Hoe Low, Swee Yaw Tan, Terrance Chua, Soo Teik Lim, Liang Zhong
Summary: The study assessed the feasibility and accuracy of a non-invasive FFR calculation based on CTCA for predicting coronary hemodynamics before and after stenting, finding a good correlation and agreement with invasive FFR, especially in predicting the hemodynamic effects post-stenting, indicating its potential as a useful tool in PCI planning.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weifeng Guo, Yuru Lin, Akira Taniguchi, Yaxin Zhu, Pratik Tripathi, Shan Yang, Junzhen Liu, Hong Yun, Hang Jin, Jie Zhang, Jing Yang, Mengsu Zeng
Summary: The study compared the diagnostic power of on-site CT-FFR combined with CCTA versus using CCTA alone in detecting patients with flow-limiting CAD. The results showed that CT-FFR provided significant incremental diagnostic improvement over CCTA in identifying patients with flow-limiting CAD.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yong-Joon Lee, Young Woo Kim, Jinyong Ha, Minug Kim, Giulio Guagliumi, Juan F. Granada, Seul-Gee Lee, Jung-Jae Lee, Yun-Kyeong Cho, Hyuck Jun Yoon, Jung Hee Lee, Ung Kim, Ji-Yong Jang, Seung-Jin Oh, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Hyuk-Jae Chang, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Joon Sang Lee, Jung-Sun Kim
Summary: Computational fractional flow reserve (FFR) estimated from coronary CTA-OCT fusion images provides more accurate functional information than coronary CTA or OCT alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maximilian Schuessler, Fuat Saner, Fadi Al-Rashid, Thomas Schlosser
Summary: The study aimed to evaluate the role of CT-FFR in differentiating hemodynamically significant and non-significant coronary stenosis in patients undergoing evaluation for LT. The results showed a diagnostic accuracy of 85% for CT-FFR and correctly excluded the hemodynamic significance of stenosis in 69% of cases.
EUROPEAN RADIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Milan Dobric, Matija Furtula, Milorad Tesic, Stefan Timcic, Dusan Borzanovic, Nikola Lazarevic, Mirko Lipovac, Mihajlo Farkic, Ivan Ilic, Darko Boljevic, Jelena Rakocevic, Srdan Aleksandric, Stefan Juricic, Miodrag Ostojic, Milovan Bojic
Summary: Assessment of coronary artery stenosis using invasive or non-invasive measurements is safe and effective in making clinical decisions on PCI. Non-invasive assessment methods, such as 3D reconstruction and pressure calculations, have shown good correlation with invasive measurements. Clinical trials have demonstrated the potential of non-invasive indices, but more studies with clinical outcomes are needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Bibinaz Eghtedari, Sion K. K. Roy, Matthew J. J. Budoff
Summary: Chronic inflammation plays a key role in the progression of atherosclerotic disease, and targeting inflammation has been shown to halt the development of coronary artery disease. Specific anti-inflammatory therapies, such as colchicine, canakinumab, VIA-2291, and methotrexate, have demonstrated efficacy in inhibiting atherosclerosis and cardiovascular disease progression. This review highlights the potential benefits of these anti-inflammatories, particularly for high-risk individuals already on optimal medical therapy.
CARDIOLOGY IN REVIEW
(2023)
Review
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Alka M. Kanaya, Namratha R. Kandula, Jaideep Patel, Mouaz H. Al-Mallah, Matthew Budoff, Miguel Cainzos-Achirica, Michael H. Criqui, Salim S. Virani
Summary: Individuals of South Asian ancestry have a higher risk of atherosclerotic cardiovascular disease. Coronary artery calcium volume and density can identify unique plaque characteristics in this population, providing important prognostic information. Cardiovascular risk factors are associated with CAC density and volume.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Muhammad A. Latif, Christopher R. Bailey, Mina Motaghi, Moustafa Abou Areda, Panagis Galiatsatos, Sally E. Mitchell, Clifford R. Weiss
Summary: This study compared the effectiveness of coils, AVPs, and MVPs in treating PAVMs. The results showed that MVPs had the lowest risk of persistence, followed by AVPs and coils.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Ilana S. Golub, Orly G. Termeie, Stephanie Kristo, Lucia P. Schroeder, Suvasini Lakshmanan, Ahmed M. Shafter, Luay Hussein, Dhiran Verghese, Jairo Aldana-Bitar, Venkat S. Manubolu, Matthew J. Budoff
Summary: This review provides a summary of global guidelines on coronary artery calcium (CAC) for atherosclerotic cardiovascular disease risk assessment in both clinical and preventive settings. The review compares recommendations from different cardiovascular societies worldwide and identifies common features. Although there are some differences in specific intervals and cut points, international guidelines emphasize the importance of CAC in both primary and secondary prevention of atherosclerotic cardiovascular disease. Understanding the similarities among international guidelines is crucial for clinicians to make informed decisions about personalized treatment.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Gastroenterology & Hepatology
Jacqueline B. B. Henson, Matthew J. J. Budoff, Andrew J. J. Muir
Summary: This study evaluated the performance of the Pooled Cohort Equations (PCE) in non-alcoholic fatty liver disease (NAFLD) patients and found that the PCE performed poorly in cardiovascular risk assessment in NAFLD, particularly in women and individuals with moderate-to-severe steatosis. Therefore, primary prevention may need to be considered at a lower risk threshold in these patients.
LIVER INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Harpreet S. S. Bhatia, Robyn L. L. McClelland, Julie Denenberg, Matthew J. J. Budoff, Matthew A. A. Allison, Michael H. H. Criqui
Summary: This study evaluated the association between coronary artery calcium (CAC) density and cardiovascular disease risk across different levels of CAC volume. The combination of CAC density and volume improved risk prediction for coronary heart disease. Higher density was associated with lower risk at volume ≤ 130 mm(3), suggesting a potentially clinically useful cut point. Further research is needed to integrate these findings into a unified CAC scoring method.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Charles Ginsberg, Andrew N. Hoofnagle, Ronit Katz, Jonathan H. Cheng, Simon Hsu, Matthew J. Budoff, Deborah M. Kado, Bryan Kestenbaum, David S. Siscovick, Erin D. Michos, Joachim H. Ix, Ian H. de Boer
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Letter
Cardiac & Cardiovascular Systems
Yejin Mok, Yasuyuki Honda, Frances M. Wang, Candace M. Howard, Aaron R. Folsom, Josef Coresh, Matthew Budoff, Michael J. Blaha, Kunihiro Matsushita
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Bibinaz Eghtedari, April Kinninger, Sion K. Roy, Matthew J. Budoff
Summary: Annualized coronary artery calcium progression of greater than 20 units per year significantly predicts all-cause mortality, highlighting the importance of close monitoring and aggressive treatment within this range.
CORONARY ARTERY DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Mark G. Rabbat, Suvasini Lakshmanan, Mina M. Benjamin, Gheorghe Doros, April Kinninger, Matthew J. Budoff, Deepak L. Bhatt
Summary: The EVAPORATE trial demonstrated that IPE significantly reduced plaque burden. This study assessed the impact of IPE on coronary physiology using FFRCT. The results showed that IPE improved coronary distal segment FFRCT, providing mechanistic insight into the clinical benefit observed in the REDUCE-IT trial.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie E. van Rosendael, A. Maxim Bax, Fay Y. Lin, Stephan Achenbach, Daniele Andreini, Matthew J. Budoff, Filippo Cademartiri, Tracy Q. Callister, Kavitha Chinnaiyan, Benjamin J. W. Chow, Ricardo C. Cury, Augustin J. DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Yong-Jin Kim, Jonathon A. Leipsic, Erica Maffei, Hugo Marques, Pedro de Araujo Goncalves, Gianluca Pontone, Gilbert L. Raff, Ronen Rubinshtein, Todd C. Villines, Hyuk-Jae Chang, Daniel S. Berman, James K. Min, Jeroen J. Bax, Leslee J. Shaw, Alexander R. van Rosendael
Summary: This study found that women develop coronary atherosclerosis approximately 12 years later than men, and post-menopausal women in the highest atherosclerotic burden group have a significantly higher risk for major adverse cardiovascular events (MACE) compared to men.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Keishi Ichikawa, Shriraj Susarla, Matthew J. Budoff
Summary: Although the overall incidence of atherosclerotic cardiovascular disease (ASCVD) is declining in the United States, the incidence of ASCVD events in young adults is increasing. The use of coronary artery calcium (CAC) scores can improve ASCVD risk assessment, but is not recommended for universal screening in young adults.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Rozenn N. N. Lemaitre, Paul N. N. Jensen, Zeneng Wang, Amanda M. M. Fretts, Colleen M. M. Sitlani, Ina Nemet, Nona Sotoodehnia, Marcia C. C. de Oliveira Otto, Weifei Zhu, Matt Budoff, W. T. Longstreth, Bruce M. M. Psaty, David S. S. Siscovick, Stanley L. L. Hazen, Dariush Mozaffarian
Summary: This study examined the association between circulating trimethylamine-N-oxide (TMAO) and incident ischemic stroke in a diverse population. The results showed a positive linear association between TMAO levels and the risk of ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Pamela Pina, Daniel Lorenzatti, Rita Paula, Jonathan Daich, Aldo L. Schenone, Carlos Gongora, Mario J. Garcia, Michael J. Blaha, Matthew J. Budoff, Daniel S. Berman, Salim S. Virani, Leandro Slipczuk
Summary: Atherosclerotic cardiovascular disease (ASCVD) is a ongoing epidemic, primarily caused by lipid abnormalities. Despite being asymptomatic, most individuals who experience a first ASCVD event do not receive preventative therapies. Risk calculators based on traditional risk factors have been the cornerstone of primary prevention, but they often misclassify individuals, resulting in ineffective use of lipid-lowering medication or missed opportunities for prevention. The development of coronary artery calcium scoring (CAC) and CT coronary angiography (CCTA) provide tools to visualize coronary plaque and guide personalized lipid management.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Anandita Agarwala, Jaideep Patel, Michael Blaha, Miguel Cainzos-Achirica, Khurram Nasir, Matthew Budoff
Summary: South Asian individuals, especially those in the United States and other Westernized countries, have a higher risk of ASCVD and ASCVD-related mortality. The use of coronary artery calcium (CAC) scoring can improve risk stratification and the delivery of preventive therapies among South Asian individuals, as it is a cost-effective and highly reproducible marker of subclinical atherosclerosis.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)