Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: The systematic review and meta-analysis showed that F-18-FDG PET/CT has good diagnostic performance in detecting lymph node metastasis in penile cancer patients, with similar accuracy in detecting inguinal and pelvic lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Dan Cohen, Chava Perry, Shir Hazut-Krauthammer, Mikhail Kesler, Yair Herishanu, Efrat Luttwak, Einat Even-Sapir, Irit Avivi
Summary: This paper summarizes the experience in assessing the extent and metabolic characteristics of MALT lymphomas using [F-18]FDG PET-CT. It reveals that PET-CT has a high detection rate for extranodal lesions located in tissues with low/homogeneous physiologic [F-18]FDG uptake, and increased [F-18]FDG uptake in extranodal lesions predicts worse disease progression.
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yong-Jin Park, Seung Hyup Hyun, Seung Hwan Moon, Kyung-Han Lee, Byung Hoon Min, Jun Haeng Lee, Won Seog Kim, Seok Jin Kim, Joon Young Choi
Summary: The study found that F-18 FDG PET/CT plays an important role in the prognosis of gastric MALT lymphoma without HT, aiding in better staging. Treatment modality was identified as an independent prognostic factor, with HP infection and PET/CT staging also impacting DFS.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeeban P. Das, Hebert A. Vargas, Soleen Ghafoor, Alvin C. Goh, Gary A. Ulaner
Summary: F-18-FDG PET/CT can identify metastatic disease in patients with UrC-ADC, leading to changes in disease staging and patient management.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of dual-time-point F-18-FDG PET/CT for detecting metastatic mediastinal lymph nodes in NSCLC patients. Results showed that dual-time-point F-18-FDG PET/CT exhibited good diagnostic performances for detecting metastatic mediastinal LNs, with retention index or %Delta SUVmax being superior to early or delayed images for detection of mediastinal LN metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lara Marchetti, Luca Perrucci, Fabio Pellegrino, Luca Baroni, Annalisa Merlo, Massimo Tilli, Ilaria Rambaldi, Elisa Maietti, Aldo Carnevale, Mirco Bartolomei, Melchiore Giganti
Summary: The study aimed to evaluate the diagnostic value of contrast-enhanced CT (CECT) compared to unenhanced CT (UECT) in PET/CT staging and treatment response assessment of F-18-FDG-avid lymphomas. Results showed that CECT did not provide significant additional diagnostic value compared to UECT, suggesting that CECT examination may be unnecessary for these purposes.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Biology
Kuifei Chen, Liqiao Hou, Meng Chen, Shuling Li, Yangyang Shi, William Y. Raynor, Haihua Yang
Summary: The purpose of this study was to develop a radiogenomic model using F-18-FDG PET/CT radiomics and clinical-parameter EGFR to predict PFS stratification in lung cancer patients after SBRT treatment. The results showed that the radiogenomic model had good accuracy and clinical value in predicting PFS stratification.
Article
Oncology
Joohee Lee, Young Seok Cho, Jhingook Kim, Young Mog Shim, Kyung-Han Lee, Joon Young Choi
Summary: This study retrospectively reviewed data from 83 patients with thymic epithelial tumors who underwent pretreatment F-18-FDG PET/CT, and found that SUVavg and Masaoka stage were independent prognostic factors for progression-free survival in thymic epithelial tumors.
Article
Gastroenterology & Hepatology
Dae-Weung Kim, Soon-Ah Park, Myoung Hyoun Kim
Summary: A 77-year-old woman underwent F-18 FDG PET/CT for evaluation of fever focus. Diffuse and intense hepatosplenic uptake was noted, suggesting lymphoma or tuberculosis. Liver biopsy revealed chronic granulomatous inflammation with Langerhans-type giant cells and necrosis. A follow-up PET/CT after anti-tuberculosis treatment showed resolution of hepatosplenic uptake.
LIVER INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ray Ma, Alexandra McHaffie, Rathan M. Subramaniam, Megan Anakin
Summary: This study investigated the experience of students and educators in an integrated medical imaging curriculum. Findings suggest that the curriculum was perceived as being everywhere and nowhere, with repetitive and patchy teaching events emphasizing exposure and absorption. However, this integrated approach may lead to medical imaging losing visibility and importance as a distinct learning area.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brendan C. Stack Jr, Fenghai Duan, Justin Romanoff, JoRean D. Sicks, Rathan M. Subramaniam, Val J. Lowe
Summary: This study prospectively investigated the use of FDG PET/CT in 287 cN0 head and neck cancer patients, and analyzed the impact of neck FDG uptake on recurrence-free survival (RFS) and overall survival (OS). The results showed that visual assessment and SUVmax can be used to compare the effects of neck FDG uptake on RFS and OS.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Emrullah Yilmaz, Nofisat Ismaila, Julie E. Bauman, Raetasha Dabney, Gregory Gan, Richard Jordan, Marnie Kaufman, Kedar Kirtane, Sean Matthew McBride, Matthew O. Old, Lisa Rooper, Nabil F. Saba, Siddharth Sheth, Rathan M. Subramaniam, Trisha Michel Wise-Draper, Deborah Wong, Loren K. Mell
Summary: The purpose of this study is to provide evidence-based recommendations for immunotherapy and biomarker testing in the treatment of head and neck cancers. A literature search was conducted to identify relevant studies, and a panel of experts developed evidence-based guideline recommendations based on the available evidence and consensus.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ajitha Ramesh, Aniruddha Chatterjee, Rathan M. Subramaniam
Article
Radiology, Nuclear Medicine & Medical Imaging
Asha Kandathil, Rathan M. Subramaniam
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyesun Park, Rathan M. Subramaniam
Article
Radiology, Nuclear Medicine & Medical Imaging
Charles Marcus, Rathan M. Subramaniam
Article
Radiology, Nuclear Medicine & Medical Imaging
Grayson Wass, Kari Clifford, Rathan M. Subramaniam
Summary: This study evaluated the diagnostic performance of fibroblast-activation protein (FAP) PET/CT compared to 18F-FDG PET/CT in cancer. The results showed that FAP PET/CT had higher sensitivity in detecting primary lesions, nodal metastases, and distant metastases. Further studies are needed to assess its utility and indication in specific cancer types and clinical settings.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kit Chi Chan, Jose A. U. Perucho, Rathan M. Subramaniam, Elaine Y. P. Lee
Summary: This study aimed to evaluate the discriminative performance and predictive ability of texture features in determining lymph node involvement in cervical cancer using F-18-FDG PET/CT imaging. The results showed that PET-derived radiomic features had moderate performance in discriminating nodal involvement in cervical cancer, but did not outperform models based on conventional indices.
NUCLEAR MEDICINE COMMUNICATIONS
(2023)
Article
Medical Informatics
Benjamin H. Kann, Jirapat Likitlersuang, Dennis Bontempi, Zezhong Ye, Sanjay Aneja, Richard Bakst, Hillary R. Kelly, Amy F. Juliano, Sam Payabvash, Jeffrey P. Guenette, Ravindra Uppaluri, Danielle N. Margalit, Jonathan D. Schoenfeld, Roy B. Tishler, Robert Haddad, Hugo J. W. L. Aerts, Joaquin J. Garcia, Yael Flamand, Rathan M. Subramaniam, Barbara A. Burtness, Robert L. Ferris
Summary: This study evaluated a CT-based deep learning algorithm for predicting pathological extranodal extension (ENE) in patients with HPV-associated oropharyngeal carcinoma. The algorithm showed better performance than four board-certified head and neck radiologists in classifying ENE, suggesting its potential as a treatment selection tool.
LANCET DIGITAL HEALTH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jim Smith, Edward Barnett, Euan J. Rodger, Aniruddha Chatterjee, Rathan M. Subramaniam
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasemin Sanli, Dilara Denizmen, Rathan M. Subramaniam
Summary: Lu-DOTA-TATE therapy is a highly effective treatment for metastatic, well-differentiated, SSTR-positive GEP-NETs with manageable side effects. PRRT is generally recommended as a second-line therapy after SSA for gastroenteric diseases, and as a second or third-line therapy for pancreatic NETs to improve survival rates and quality of life. Although more data is needed, Lu-DOTA-TATE therapy may also have a role in high-grade NET therapy, often in combination with chemotherapy. Liver-dominant metastatic disease usually has poor prognosis and requires liver-targeted therapies alone or in combination with PRRT based on the disease status.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Rathan M. Subramaniam
Article
Primary Health Care
Valerie Xiang, Sherly Parackal, Gagan Gurung, Rathan M. Subramaniam
Summary: This study aimed to investigate and analyze the resources available on general practice websites in New Zealand that aid in optimal health care navigation for Asians, and to explore the barriers perceived by Asian migrants to navigating the New Zealand Health System, particularly primary care. The study found that the analyzed general practice websites lack relevant and reliable information for Asians to effectively navigate the New Zealand health system. Participants reported significant difficulties in navigating and understanding New Zealand primary care services. Therefore, providing information resources in Asian languages as well as an overview of how Health NZ functions in providing health care and professional interpreter services would have a significant impact on increasing appropriate engagement with healthcare services and improving health outcomes for Asians.
JOURNAL OF PRIMARY HEALTH CARE
(2023)
Review
Oncology
Sean J. Huls, Brian Burkett, Eric Ehman, Val J. Lowe, Rathan M. Subramaniam, A. Tuba Kendi
Summary: Positron emission tomography (PET) imaging has made significant advancements in the diagnosis and treatment of prostate cancer with targeted radiopharmaceuticals. This review focuses on the commonly used PET radiopharmaceuticals in the USA, including prostate-specific membrane antigen (PSMA), fluciclovine, and choline. PET imaging has shown utility over traditional imaging methods in various scenarios, but there are limited studies comparing PET radiopharmaceuticals. PSMA radiopharmaceuticals have unique properties and uses, especially at low prostate-specific antigen (PSA) levels. The choice of PET radiopharmaceutical can impact image interpretation, as some agents have minimal urinary activity while others have high urinary activity.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)