Article
Gastroenterology & Hepatology
Masaya Sato, Makoto Moriyama, Tsuyoshi Fukumoto, Tomoharu Yamada, Taijiro Wake, Ryo Nakagomi, Takuma Nakatsuka, Tatsuya Minami, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Shuichiro Shiina, Kazuhiko Koike, Mitsuhiro Fujishiro, Ryosuke Tateishi
Summary: This study developed a transformer model to predict overall survival in HCC patients treated with RFA and compared its performance with a deep learning model. The transformer-based model showed better discrimination performance and the ability to stratify patients into different risk groups. It also provided personalized cumulative recurrence prediction for each patient.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Oncology
Noriyuki Umakoshi, Yusuke Matsui, Koji Tomita, Mayu Uka, Takahiro Kawabata, Toshihiro Iguchi, Takao Hiraki
Summary: This review summarizes the current evidence on image-guided thermal ablation therapies for extrahepatic metastases from hepatocellular carcinoma (HCC). Local ablative therapies, such as radiofrequency ablation, microwave ablation, and cryoablation, can be used in select patients for curative or palliative intent. The local control rate of thermal ablation therapy is relatively favorable, at approximately 70-90% in various organs.
Article
Oncology
Taiyang Zuo, Wenli Lin, Fengyong Liu, Jinshun Xu
Summary: The artificial pneumothorax technique is a feasible, safe, and efficient method for treating pulmonary metastases from HCC contiguous with the mediastinum.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiu-Mei Bai, Zhong-Hu He, Hao Wu, Wei Yang, Song Wang, Zhong-Yi Zhang, Wei Wu, Kun Yan, Min -Hua Chen, S. Nahum Goldberg
Summary: This study demonstrated that improved progression-free survival (PFS) was achieved in patients with hepatocellular carcinoma (HCC) receiving radiofrequency ablation (RFA) as first-line treatment in the second decade. However, long-term overall survival (OS) was not significantly increased compared to the first decade, suggesting that while RFA treatment has improved, it still might not substantially affect OS results.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Ruizhi Wang, Hengtian Xu, Wufei Chen, Liang Jin, Zhuangxuan Ma, Lei Wen, Hongwei Wang, Kun Cao, Xia Du, Ming Li
Summary: This study investigated the role of gadoxetic acid-enhanced MRI based on LI-RADS v2018 imaging features in the prognosis prediction of sHCC patients treated with RFA. A total of 204 patients were enrolled, and a predictive nomogram was formulated. The nomogram showed superior predictive performance in both the training and validation groups.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Qunfang Zhou, Xiaohui Wang, Ruixia Li, Chenmeng Wang, Juncheng Wang, Xiaoyan Xie, Yali Li, Shaoqiang Li, Xianhai Mao, Ping Liang
Summary: This study aimed to evaluate the efficacy of combined use of RFA and sorafenib in the treatment of recurrent hepatocellular carcinoma. The study found that the RFA-sorafenib group had significantly better survival outcomes compared to the RFA group. Additionally, a quantitative risk score system was established to accurately screen out patients who would benefit from RFA-sorafenib treatment.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hang Zheng, Kaiwen Liu, Yao Yang, Bo Liu, Xinya Zhao, Yong Chen, Yuemin Feng, Min Meng, Xu Tan, Qiang Zhu
Summary: Compared to RFA, MWA showed better tumor control for subcapsular HCC within the Milan criteria. There was no difference in the incidence of major complications between the two groups.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Jian Liu, Hao Shen, Shengyu Huang, Jianbo Lin, Zhenlin Yan, Guojun Qian, Zhenghua Lu, Xuying Wan, Fabiao Zhang, Kui Wang, Yongjie Zhang, Jun Li
Summary: This study observed the effect of antiviral therapy (AVT) on viral reactivation and long-term outcomes after percutaneous radiofrequency ablation (PRFA) for HBV-related HCC. The results showed that AVT can reduce the occurrence of viral reactivation, decrease distal intrahepatic recurrence and late recurrence after 2 years, and improve the overall survival of patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Dong Ik Cha, Soo Hyun Ahn, Min Woo Lee, Woo Kyoung Jeong, Kyoung Doo Song, Tae Wook Kang, Hyunchul Rhim
Summary: This study aimed to stratify HCC patients according to their risk of recurrence-free survival (RFS) and early tumor recurrence (ETR) after RFA based on predictive models and nomograms, and to compare the survival times of the risk groups derived from the models. The predictive models were able to stratify patients into three groups according to their risk of RFS and ETR, and differences in restricted mean survival times (RMSTs) were observed among the risk groups, suggesting the potential for establishing different follow-up protocols for different risk groups.
Review
Surgery
Moustafa Abdalla, Amelia T. T. Collings, Rebecca Dirks, Edwin Onkendi, Daniel Nelson, Ahmad Ozair, Emily Miraflor, Faique Rahman, Jake Whiteside, Mihir M. M. Shah, Subhashini Ayloo, Ahmed Abou-Setta, Iswanto Sucandy, Ali Kchaou, Samuel Douglas, Patricio Polanco, Timothy Vreeland, Joseph Buell, Mohammed T. T. Ansari, Aurora D. D. Pryor, Bethany J. J. Slater, Ziad Awad, William Richardson, Adnan Alseidi, D. Rohan Jeyarajah, Eugene Ceppa
Summary: This study compared laparoscopic versus percutaneous microwave ablation (MWA) and MWA versus radiofrequency ablation (RFA) in the treatment of hepatocellular carcinoma (HCC) and colorectal liver metastases (CRLM) lesions smaller than 5 cm. The meta-analyses showed that laparoscopic MW ablation had higher complication rates compared to a percutaneous approach, while MWA and RFA had similar outcomes for both HCC and CRLM lesions. However, more high-quality studies are needed to make definitive conclusions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Hidekatsu Kuroda, Tomoaki Nagasawa, Yudai Fujiwara, Hiroki Sato, Tamami Abe, Yohei Kooka, Kei Endo, Takayoshi Oikawa, Kei Sawara, Yasuhiro Takikawa
Summary: Microwave ablation using Thermosphere(TM) technology showed similar overall survival and recurrence-free survival outcomes compared to radiofrequency ablation for hepatocellular carcinoma. Despite no significant differences in survival outcomes between the two methods, microwave ablation required fewer insertions, making it a recommended treatment option for tumors larger than 2 cm.
Article
Oncology
Ancelin Preel, Margaux Hermida, Carole Allimant, Eric Assenat, Chloe Guillot, Cecilia Gozzo, Serge Aho-Glele, Georges-Philippe Pageaux, Christophe Cassinotto, Boris Guiu
Summary: The study found that in Western patients, bi- and trifocal HCC significantly increased the risk of distant recurrence, especially very early recurrence. Overall survival after PTA of trifocal HCC was significantly below what was expected after curative treatment.
Article
Surgery
Hong Jae Jeon, Hyuk Soo Eun, In Sun Kwon, Byung Seok Lee, Eaum Seok Lee, Woo Sun Rou, Jae Kyu Sung, Hee Seok Moon, Sun Hyung Kang, Hyun Seok Lee, Seok-Hwan Kim, Kwangsik Chun, Seok Hyun Kim
Summary: This study compared the therapeutic outcomes of laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation (PRFA) in patients with hepatocellular carcinoma (HCC). The results revealed that LRFA was associated with longer recurrence-free survival and favorable overall survival compared to PRFA. Therefore, LRFA should be considered as the primary therapy for eligible HCC patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Feng Cen, Xu Sun, Zhiping Pan, Qiang Yan
Summary: This study assessed the outcomes of repeated hepatectomy (RH) for postoperative intrahepatic recurrence of hepatocellular carcinoma (HCC) among patients undergoing initial hepatectomy (IH). Results showed that RH had better efficacy for HCC recurrence in IH patients, and age ≥ 50 years, Child-Pugh class A, and negative HBV-DNA were independent risk factors for the 1-year postoperative tumor-free survival rate in recurrent HCC patients undergoing RH.
FRONTIERS IN MEDICINE
(2023)
Review
Oncology
Yasunori Minami, Tomoko Aoki, Satoru Hagiwara, Masatoshi Kudo
Summary: Thermal ablation therapy, including RFA and MWA, is a widely used treatment for hepatocellular carcinomas. It achieves good outcomes with minimal invasiveness. Successful thermal ablation therapy requires understanding the principles and characteristics of the treatment, assessing the benefits and risks, precise needle control and visualization, utilizing imaging guidance techniques, and evaluating therapeutic response. This overview provides essential information for the clinical application of thermal ablation.