Article
Nutrition & Dietetics
Atsushi Nakamura, Tsubasa Yoshimura, Hitoshi Asakura
Summary: This study investigated the relationship between hepatic fat loss and malnutrition in chronic liver disease using magnetic resonance imaging. The results showed that decreased body fat mass and triglycerides, as well as increased nutritional assessment score, were associated with hepatic fat loss. Furthermore, hepatic fat loss and Child-Pugh score were identified as independent prognostic factors for patients with cirrhosis. These findings emphasize the importance of preserving liver fat content in nutritional therapy for cirrhotic patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Mi Na Kim, Kyungdo Han, Juhwan Yoo, Seong Gyu Hwang, Sang Hoon Ahn
Summary: This study found that patients with chronic viral hepatitis and concurrent fatty liver have a higher risk of developing hepatocellular carcinoma and mortality, highlighting the importance of managing fatty liver in reducing these risks for patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Zakaria Boulahtouf, Alessia Virzi, Thomas F. Baumert, Eloi R. Verrier, Joachim Lupberger
Summary: Chronic viral hepatitis is a major cause of liver disease and hepatocellular carcinoma. Despite being caused by different viruses, hepatitis B, C, and D have striking similarities in pathological impact. The advancements in omics and bioinformatics have revealed the important role of signaling networks in viral pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Rong Fan, Guanlin Li, Ning Yu, Xiujuan Chang, Tamoore Arshad, Wen-Yue Liu, Yan Chen, Grace Lai-Hung Wong, Yiyue Jiang, Xieer Liang, Yongpeng Chen, Xiao-Zhi Jin, Zheng Dong, Howard Ho-Wai Leung, Xiao-Dong Wang, Zhen Zeng, Terry Cheuk-Fung Yip, Qing Xie, Deming Tan, Shaoli You, Dong Ji, Jun Zhao, Arun J. Sanyal, Jian Sun, Ming-Hu Zheng, Vincent Wai-Sun Wong, Yongping Yang, Jinlin Hou
Summary: This study evaluated the performance of the aMAP score in diagnosing fibrosis in patients with chronic hepatitis B (CHB). The results showed that the aMAP score had higher accuracy in diagnosing cirrhosis and advanced fibrosis compared to other markers. The combination of aMAP and LSM further improved the accuracy in detecting cirrhosis and advanced fibrosis. The aMAP-LSM model had satisfactory performance in diagnosing fibrosis stage for treated CHB patients, especially those with a significant decrease in LSM after treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Francesco Paolo Russo, Alberto Zanetto, Elisa Pinto, Sara Battistella, Barbara Penzo, Patrizia Burra, Fabio Farinati
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Helenie Kefalakes, Xylia J. Horgan, Min Kyung Jung, Georgios Amanakis, Devika Kapuria, Fabian J. Bolte, David E. Kleiner, Christopher Koh, Theo Heller, Barbara Rehermann
Summary: This study found that patients infected with HDV had reduced but more activated innate immune cell populations in the liver, and an activated, memory-like, tissue-resident HDV-specific CD8(+) T-cell cluster was identified. Antigen-nonspecific activation of liver-resident CD8(+) T cells may contribute to inflammation and disease progression in HDV infection.
Article
Immunology
Milan J. Sonneveld, Bettina E. Hansen, Willem P. Brouwer, Henry L-Y Chan, Teerha Piratvisuth, Ji-Dong Jia, Stefan Zeuzem, Rong-Nan Chien, Robert J. de Knegt, Cynthia Wat, Vedran Pavlovic, Anuj Gaggar, Qing Xie, Maria Buti, Robert A. de Man, Harry L. A. Janssen
Summary: This study investigated the relationship between HBsAg levels and hepatic fibrosis and cirrhosis in patients with chronic hepatitis B. The results showed that lower HBsAg levels were associated with higher rates of fibrosis and cirrhosis in HBeAg-positive patients, but not in HBeAg-negative patients. Additionally, genotype-specific HBsAg cutoffs could be used to rule out the presence of cirrhosis. These findings are important for the diagnosis and treatment of chronic hepatitis B patients.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Virology
Ana Carolina Cardoso, Claudio Figueiredo-Mendes, Cristiane A. Villela-Nogueira, Patrick Marcellin
Summary: Staging liver fibrosis has always been a challenge in viral hepatitis and other liver diseases. Non-invasive tests have been developed to overcome the limitations of liver biopsy. This review discusses the use of serological and physical markers for liver fibrosis staging in chronic hepatitis B and C. Furthermore, it addresses the issue of evaluating liver fibrosis after HCV cure.
Review
Gastroenterology & Hepatology
Maria Stella Franze, Teresa Pollicino, Giovanni Raimondo, Giovanni Squadrito
Summary: The clinical implications of hepatitis B virus occult infection (OBI) are still uncertain, particularly in the development of liver disease and hepatocellular carcinoma (HCC). OBI may contribute to worsening liver disease and promote HCC development through specific mechanisms. However, data on OBI prevalence and clinical impact in non-hepatitis C virus (HCV)-related liver disease are limited.
LIVER INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Phunchai Charatcharoenwitthaya, Kamonthip Sukonrut, Pornpim Korpraphong, Ananya Pongpaibul, Pairash Saiviroonporn
Summary: This study confirmed the diagnostic accuracy of diffusion-weighted magnetic resonance imaging for cirrhosis in patients with chronic viral hepatitis, proposing a sequential approach combining normalized liver ADC measurement with the Fibrosis-4 index to reduce the need for liver biopsies.
Review
Gastroenterology & Hepatology
Abhilash Perisetti, Hemant Goyal, Rachana Yendala, Ragesh B. Thandassery, Emmanouil Giorgakis
Summary: Primary liver cancers, specifically Hepatocellular carcinoma (HCC), are associated with significant morbidity and mortality. While HCC mostly develops within the hepatic parenchyma, a portion may arise in a non-cirrhotic milieu known as non-cirrhotic-HCC (NCHCC). NCHCC is often diagnosed late due to lack of surveillance and is linked to factors like non-alcoholic fatty liver disease, diabetes, and viral infections such as chronic Hepatitis B. Early identification and monitoring strategies are crucial for improving outcomes in NCHCC patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Carl-Philipp Hackstein, Jasper Spitzer, Konstantinos Symeonidis, Helena Horvatic, Tanja Bedke, Babett Steglich, Sabine Klein, Lisa M. Assmus, Alexandru Odainic, Jennifer Szlapa, Nina Kessler, Marc Beyer, Ricarda Schmithausen, Eicke Latz, Richard A. Flavell, Natalio Garbi, Christian Kurts, Beate M. Kuemmerer, Jonel Trebicka, Axel Roers, Samuel Huber, Susanne V. Schmidt, Percy A. Knolle, Zeinab Abdullah
Summary: Patients with chronic liver disease (CLD) are more susceptible to viral infections and have a reduced response to vaccination. The study found that liver injury leads to microbial translocation and increased levels of type I interferon (IFN-I), which induces excessive IL-10 production during viral infection, leading to dysfunctional T-cell immunity. Blocking IFN-I and IL-10 signaling can restore antiviral immunity in patients with liver injury.
JOURNAL OF HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Jana Enderes, Jessica Teschke, Steffen Manekeller, Tim O. Vilz, Joerg C. Kalff, Tim R. Glowka
Summary: According to the study, there was no significant difference in DGE impact after PD between patients with LC and LF and those without liver pathologies. However, patients with LC and LF may have higher ASA score, receive more intraoperative erythrocyte transfusions, stay longer in the ICU, and have more intraabdominal abscess formation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Dong Ji, Yan Chen, Qinghua Shang, Huabao Liu, Lin Tan, Jing Wang, Yongping Chen, Qin Li, Qinghua Long, Laicheng Song, Li Jiang, Guangming Xiao, Zujiang Yu, Liang Chen, Xiaoyu Hu, Xiaodong Wang, Da Chen, Zhiqin Li, Zheng Dong, Guofeng Chen, Yongping Yang
Summary: The study aimed to assess the association between changes in liver stiffness measurement (LSM) and histological outcomes in chronic hepatitis B patients receiving entecavir-based therapy. LSM decrease of ≥30% was associated with regression of fibrosis, significant histological response, and alanine aminotransferase normalization, with a new on-treatment LSM cutoff value established for indicating significant histological response.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Donatas Jocius, Donatas Vajauskas, Kipras Mikelis, Skirmante Jokubauskiene, Jolita Jakutiene, Kestutis Strupas, Algirdas E. Tamosiunas
Summary: This study found that dynamic liver scintigraphy with [Tc-99m]Tc-mebrofenin has potential value in staging and grading chronic liver damage. The main valuable parameters are the ratio between 30 min and the peak of the dynamic curve, and liver clearance corrected for body surface area and liver area.
MEDICINA-LITHUANIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Scott B. Reeder, Matthew R. Smith, Diego Hernando
MAGNETIC RESONANCE IN MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peter Bannas, Utaroh Motosugi, Diego Hernando, Mahdi Salmani Rahimi, James H. Holmes, Scott B. Reeder
MAGNETIC RESONANCE IN MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoke Wang, Diego Hernando, Scott B. Reeder
MAGNETIC RESONANCE IN MEDICINE
(2016)
Review
Radiology, Nuclear Medicine & Medical Imaging
Alejandro Roldan-Alzate, Christopher J. Francois, Oliver Wieben, Scott B. Reeder
AMERICAN JOURNAL OF ROENTGENOLOGY
(2016)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sonja Kinner, Michael D. Repplinger, Perry J. Pickhardt, Scott B. Reeder
AMERICAN JOURNAL OF ROENTGENOLOGY
(2016)
Review
Gastroenterology & Hepatology
Sonja Kinner, Scott B. Reeder, Takeshi Yokoo
DIGESTIVE DISEASES AND SCIENCES
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peter Bannas, Candice A. Bookwalter, Tim Ziemlewicz, Utaroh Motosugi, Alejandro Munoz del Rio, Theodora A. Potretzke, Scott K. Nagle, Scott B. Reeder
EUROPEAN RADIOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tilman Schubert, Peter Bannas, Sonja Kinner, Samir Sharma, James H. Holmes, Mahdi Salmani Rahimi, Frank R. Korosec, Scott B. Reeder
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2017)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Scott B. Reeder, Vera Kimbrell, Titti Owman, Michael Steckner, Fernando Calamante
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Debra E. Horng, Diego Hernando, Scott B. Reeder
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Curtis N. Wiens, Nathan S. Artz, Hyungseok Jang, Alan B. McMillan, Scott B. Reeder
MAGNETIC RESONANCE IN MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nathan S. Artz, Curtis N. Wiens, Matthew R. Smith, Diego Hernando, Alexey Samsonov, Scott B. Reeder
MAGNETIC RESONANCE IN MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Diego Hernando, Samir Sharma, Mounes Aliyari Ghasabeh, Bret Alvis, Sandeep Arora, Gavin Hamilton, Li Pan, Jean Shaffer, Keitaro Sofue, Nikolaus Szeverenyi, E. Brian Welch, Qing Yuan, Mustafa Bashir, Ihab Kamel, Mark Rice, Claude Sirlin, Takeshi Yokoo, Scott Reeder
MAGNETIC RESONANCE IN MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samir D. Sharma, Roland Fischer, Bjoern P. Schoennagel, Peter Nielsen, Hendrik Kooijman, Jin Yamamura, Gerhard Adam, Peter Bannas, Diego Hernando, Scott B. Reeder
MAGNETIC RESONANCE IN MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael D. Repplinger, Andrew C. Weber, Perry J. Pickhardt, Victoria P. Rajamanickam, James E. Svenson, William J. Ehlenbach, Ryan P. Westergaard, Scott B. Reeder, Elizabeth A. Jacobs
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2016)
