Article
Allergy
Matthew A. Rank, Derek K. Chu, Antonio Bognanni, Paul Oykhman, Jonathan A. Bernstein, Anne K. Ellis, David B. K. Golden, Matthew Greenhawt, Caroline C. Horner, Dennis K. Ledford, Jay Lieberman, Amber U. Luong, Richard R. Orlandi, Shefali A. Samant, Marcus S. Shaker, Zachary M. Soler, Whitney W. Stevens, David R. Stukus, Julie Wang, Anju T. Peters
Summary: These evidence-based guidelines provide support in making decisions regarding the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP), specifically the use of intranasal corticosteroids (INCS), biologics, and aspirin therapy after desensitization (ATAD). The guidelines emphasize the use of INCS, biologics, and ATAD based on a consensus reached by a diverse panel of experts. However, other treatment options and surgery were not assessed in this guideline. The recommendations are based on systematic reviews and are intended to guide clinicians and stakeholders in managing CRSwNP effectively.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Eun-Kyung Kwon, Tae-Wook Kang, Taeyun Oh, Oak-Sung Choo, Young-Min Ye, Hae-Sim Park, Ga-Young Ban
Summary: This study aimed to determine the novel pathogenic features of aspirin-exacerbated respiratory disease (AERD) by performing integrative analysis of transcriptomic and epigenomic profiling with network analysis. The results identified differentially expressed genes and differentially methylated probes between patients with AERD and those with aspirin tolerant asthma (ATA), and revealed the involvement of genes related to vesicle transport and sphingolipid dysregulation in AERD. Furthermore, the study generated signaling pathways related to T helper cell differentiation/activation and Fc epsilon receptor I, and found significant up-regulation of specific genes in AERD compared to ATA. This study provides insights into the distinct pathogenic features of AERD.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gunseli Katirci, Esra Uzer Celik
Summary: This study aimed to determine the prevalence of dentine hypersensitivity (DH) among adults in Turkey and ascertain the association between DH and etiological predictors and patient characteristics. It found that exposure to cold air, consumption of sweet food, gingival recession, and the presence of noncarious cervical lesions were strongly linked to DH.
Article
Otorhinolaryngology
S. Shahzad Mustafa, Karthik Vadamalai, Bryan Scott, Allison Ramsey
Summary: The study evaluated the efficacy of dupilumab in patients with AERD and found that the drug is highly effective in improving patient outcomes in those with uncontrolled chronic rhinosinusitis with nasal polyposis.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Review
Psychiatry
Wymann Shao Wen Tang, Li Ling Christine Chiang, Kay Wee Kwang, Melvyn Wei Bin Zhang
Summary: This meta-analysis examines the prevalence of depression among patients with enterostomy and identifies potential factors contributing to heterogeneity. The pooled prevalence of depression is found to be 41.6%, with indications for enterostomy formation and geographical region identified as potential sources of heterogeneity.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Otorhinolaryngology
Aleksandar Peric, Svjetlana Matkovic, Aleksandra Barac, Tijana Vukadinovic, Ljiljana Cvorovic, Danilo Vojvodic
Summary: Neurogenic inflammation plays a significant role in the pathogenesis of chronic rhinitis. This study aimed to investigate the importance of neurogenic inflammation in nasal polyposis (NP), particularly in NP as part of aspirin-exacerbated respiratory disease (AERD). The concentrations of neuropeptides substance P (SP) and bradykinin (BK) in nasal secretions were examined. The results showed a more intense release of SP and BK in AERD patients compared to NP patients without aspirin sensitivity. Additionally, the level of BK in nasal fluid was positively correlated with disease severity.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Immunology
Aleksandar Peric, Dejan Gacesa, Gordana Cvetkovic, Danilo Vojvodic
Summary: This study compared the levels of inflammatory mediators in nasal secretions between asthma and sinusitis patients, and correlated the concentrations with clinical parameters. The results showed higher levels of inflammatory mediators and lower levels of respiratory epithelial biomarkers in asthma patients. The results in sinusitis patients were different from the control group.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Allergy
Joaquim Mullol, Antoine Azar, Kathleen M. Buchheit, Claire Hopkins, Jonathan A. Bernstein
Summary: This review summarizes the clinical evidence on quality of life outcomes with current treatments for CRSwNP up to 2021, and assesses the improvement in QoL after biologic treatments, especially for patients with reported comorbidities in interventional studies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Sen Hee Tay, Amelia Santosa, Eugene Chen Howe Goh, Chun Xiang Xu, Lik Hang Wu, Mei Bigliardi-Qi, Leroy Sivappiragasam S. O. Pakkiri, Bernett Teck Kwong Lee, Chester Lee Drum, Paul Lorenz Bigliardi
Summary: This study is the first to combine both transcriptomic and metabolomic approaches in patients with NIUA, contributing to a deeper understanding of the pathogenesis of NIUA and potentially paving the way for a molecular diagnosis of NSAID hypersensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Allergy
Paul Oykhman, Fernando Aleman Paramo, Jean Bousquet, David W. Kennedy, Romina Brignardello-Petersen, Derek K. Chu
Summary: Multiple biologics and ASA-D effectively improve patient-important outcomes, with variations in effects among different agents. Dupilumab stands out as the most beneficial treatment for all studied outcomes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Otorhinolaryngology
Christine Kim, Joseph Han, Tara Wu, Claus Bachert, Wytske Fokkens, Peter Hellings, Claire Hopkins, Stella Lee, Joaquim Mullol, Jivianne T. Lee
Summary: The review found promising evidence to support the safety and efficacy of biologics in the treatment of chronic rhinosinusitis with nasal polyposis. However, further large-scale randomized studies with longer follow-up are needed to determine which patients would benefit the most from these novel systemic treatments.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Public, Environmental & Occupational Health
Keisuke Suzuki, Madoka Okamura, Yasuo Haruyama, Shiho Suzuki, Tomohiko Shiina, Gen Kobashi, Koichi Hirata
Summary: This study assessed the frequency of multiple chemical sensitivity (MCS) and its related factors in patients with migraine and found that 20% of patients with migraine had MCS. The results suggest a possible association of MCS with central sensitization and hypersensitivity-related symptoms in patients with migraine.
JOURNAL OF OCCUPATIONAL HEALTH
(2022)
Article
Allergy
Philippe Gevaert, Claus Bachert, Jorge Fernando Maspero, Mandy Cuevas, David Steele, Sandip Acharya, Pablo Altman
Summary: The THUNDER study found that the prostaglandin D-2 receptor 2 (DP2) antagonist fevipiprant is not effective in treating patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma. Future studies may explore the role of other DP2 antagonists in patients with aspirin-exacerbated respiratory disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Dermatology
David Chromy, Tina Bartosik, Faris F. Brkic, Tamara Quint, Aldine Tu, Julia Eckl-Dorna, Sven Schneider, Christine Bangert
Summary: Patients with CRSwNP treated with dupilumab may experience dermatologic side effects, including dermatitis, folliculitis, and alopecia. Further interdisciplinary management may be necessary.
JOURNAL OF DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Murdaca, Francesca Paladin, Sebastiano Gangemi
Summary: Vitamin D, known for its effects on calcium homeostasis and bone metabolism, has recently gained interest for its immunomodulatory effects with anti-inflammatory and anti-oxidant properties in various immune-mediated pathologies and pro-inflammatory processes affecting the airways. Supplementation of vitamin D has been shown to improve clinical outcomes in certain conditions like CRSwNP/sNP.
Article
Allergy
Sevim Bavbek, Mauro Pagani, Emilio Alvarez-Cuesta, Mariana Castells, Adile Berna Dursun, Sahar Hamadi, Ricardo Madrigal-Burgaleta, Soledad Sanchez-Sanchez, Alessandra Vultaggio
Summary: Biologicals are important therapeutic agents for oncological, immunological, and inflammatory diseases, but they can cause hypersensitivity reactions. The optimal management pathways for these reactions are still uncertain.
Article
Allergy
Annick Barbaud, Lene Heise Garvey, Alessandra Arcolaci, Knut Brockow, Francesca Mori, Cristobalina Mayorga, Patrizia Bonadonna, Marina Atanaskovic-Markovic, Luis Moral, Giovanna Zanoni, Mauro Pagani, Angele Soria, Maja Jost, Jean-Christoph Caubet, Abreu Carmo, Al-Ahmad Mona, Alberto Alvarez-Perea, Sevim Bavbek, Biagioni Benedetta, M. Beatrice Bilo, Natalia Blanca-Lopez, Herrera Gador Bogas, Alessandro Buonomo, Gianfranco Calogiuri, Giulia Carli, Josefina Cernadas, Gabriele Cortellini, Gulfem Celik, Semra Demir, Inmaculada Dona, Adile Berna Dursun, Bernadette Eberlein, Emilia Faria, Bryan Fernandes, Tomaz Garcez, Ignacio Garcia-Nunez, Radoslaw Gawlik, Asli Gelincik, Eva Gomes, Jimmy H. C. Gooi, Martine Grosber, Theo Gulen, Florence Hacard, Cyrille Hoarau, Christer Janson, Sebastian L. Johnston, Lukas Joerg, Secil Kepil Ozdemir, Ludger Klimek, Mitja Kosnik, Marek L. Kowalski, Semanur Kuyucu, Violeta Kvedariene, Jose Julio Laguna, Carla Lombardo, Susana Marinho, Hans Merk, Elisa Meucci, Martine Morisset, Rosa Munoz-Cano, Francesco Murzilli, Alla Nakonechna, Florin-Dan Popescu, Grzegorz Porebski, Anna Radice, Frederico S. Regateiro, Heike Rockmann, Antonino Romano, Ravishankar Sargur, Joaquin Sastre, Kathrin Scherer Hofmeier, Lenka Sedlackova, Marta Sobotkova, Ingrid Terreehorst, Regina Treudler, Jolanta Walusiak-Skorupa, Bettina Wedi, Stefan Wohrl, Mihael Zidarn, Torsten Zuberbier, Ioana Agache, Maria J. Torres
Summary: Background anaphylaxis after COVID-19 vaccination is rare, and its management is not standardized. The authors propose allergy evaluation and prick test for individuals with specific allergy histories, aiming to improve the understanding and management of anaphylaxis to COVID-19 vaccines and facilitate vaccination for people with allergy history.
Article
Allergy
Mauro Pagani, Sevim Bavbek, Emilio Alvarez-Cuesta, Adile Berna Dursun, Patrizia Bonadonna, Mariana Castells, Josefina Cernadas, Anca Chiriac, Hamadi Sahar, Ricardo Madrigal-Burgaleta, Soledad Sanchez Sanchez
Summary: Chemotherapeutic drugs can induce hypersensitivity reactions, being the third leading cause of fatal drug-induced anaphylaxis. Deaths related to chemotherapy have been reported in Europe and the United States. The European Network on Drug Allergy organized a task force to provide data and recommendations regarding allergological work-up in this field.
Article
Allergy
Betuel oezdel oeztuerk, Zeynep Yavuz, Dilek Eraslan, Dilsad Mungan, Yavuz Selim Demirel, Oemuer Aydin, Betuel Ayse Sin, Sevim Bavbek
Summary: The study shows that mepolizumab effectively helps patients with severe eosinophilic asthma improve asthma control, reduce exacerbation frequency, lower steroid usage, enhance lung function and quality of life.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Begum Gorgulu Akin, Merve Erkoc, Elif Tugce Korkmaz, Betul Ozdel Ozturk, Sevgi Colak, Funda Seher Ozalp Ates, Sevim Bavbek
Summary: In this study, we investigated patients with platinum allergy and validated the effectiveness of the rapid drug desensitization protocol. The results showed that a positive drug skin test result can serve as a potential marker for identifying high-risk patients who may experience breakthrough reactions during desensitization.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Allergy
Merve Erkoc, Betel Ozdel Ozturk, Dilsad Mungan, Derya Oztuna, Sevim Bavbek, Yavuz Seim Demirel, Omiir Aydin, Sethi Aye Sin
Summary: COVID-19 pandemic has affected compliance to AIT, but no severe COVID-19 infection or related deaths were observed in patients receiving AIT. Compliance rate for AIT was highest in venom immunotherapy.
ASIA PACIFIC ALLERGY
(2022)
Article
Allergy
Sevgi Colak, Merve Erkoc, Betuel A. Sin, Sevim Bavbek
Summary: This study retrospectively analyzed cases diagnosed with anaphylaxis and compared the diagnostic criteria proposed by NIAID/FAAN and WAO. The results showed that the main causes of anaphylaxis were drugs, venom, and food allergies, with chemotherapeutics being the most common drug trigger. According to the NIAID/FAAN criteria, most patients were diagnosed with the second criterion, while according to the WAO criteria, most patients were diagnosed with the first criterion. The study suggests that collecting more details in patients' history can prevent possible underdiagnosis, and the WAO diagnostic criteria may be insufficient in some patients.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Multidisciplinary Sciences
Dilek Karadogan, Tahsin Gokhan Telatar, Halil Donmez, Adile Berna Dursun
Summary: This study examined the relationship between aeroallergen sensitivity and disease control level and severity in asthmatic patients. The results showed that polysensitized asthmatics had better asthma symptom control and milder asthma severity compared to monosensitized asthmatics. However, there was no significant association between aeroallergen sensitivity and asthma control level.
Review
Respiratory System
Gulden Pacaci Cetin, Secil Kepil Ozdemir, Ozge Can Bostan, Nida Oztop, Zeynep Celebi Sozener, Gul Karakaya, Asli Gelincik Akkor, Insu Yilmaz, Dilsad Mungan, Sevim Bavbek
Summary: Severe asthma burdens patients and societies with increased healthcare use, decreased quality of life, and high disease and economic burden. Approved biological agents, including omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab, and tezepelumab, have been shown to effectively reduce asthma exacerbations, oral corticosteroid use, and improve asthma control, quality of life, and pulmonary functions in severe asthma through targeting cells, receptors, and mediators involved in type 2 inflammation. Personalized treatment based on the characterization of asthma endotype and phenotype is crucial for determining the appropriate biologic agent for individual patients.
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX
(2023)
Letter
Allergy
Sevgi Colak, Merve Erkoc, Betuel A. Sin, Sevim Bavbek
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Allergy
Sevim Bavbek, Secil Kepil Ozdemir, Patrizia Bonadonna, Marina Atanaskovic-Markovic, Annick Barbaud, Knut Brockow, Jose Laguna Martinez, Alla Nakonechna, Mauro Pagani, Alessandra Arcolaci, Carla Lombardo, Maria J. Torres
Summary: This paper provides evidence-based recommendations for the diagnosis and management of hypersensitivity reactions (HSRs) to proton pump inhibitors (PPIs), and calls for further in-depth research.
Article
Allergy
Betul Ozdel Ozturk, Irem Akdemir, Alpay Azap, Gulfem Celik, Sevim Bavbek, Dilsad Mungan
Summary: This study aimed to investigate the rate and features of allergic reactions associated with CoronaVac vaccine among healthcare workers. The results showed that the reaction rate was 0.56%, with the most common reaction being systemic skin reactions. Anaphylaxis was rare, and all cases were discharged within 24 hours.
ASIA PACIFIC ALLERGY
(2022)
Meeting Abstract
Allergy
Zeynep Celebi Sozener, Betul Ozdel Ozturk, Omur Aydin, Sevim Bavbek, Dilsad Mungan
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)