Article
Biology
Oana Belei, Diana-Georgiana Basaca, Elena Rodica Heredea, Emil Radu Iacob, Laura Olariu, Roxana Folescu, Andrei Gheorghe Marius Motoc, Anda-Maria Nanu, Otilia Marginean
Summary: VIPoma is a rare neuroendocrine tumor that produces vasoactive intestinal peptide (VIP). While rare in adults without pancreatic ailments, VIPoma originating in the pancreas is exceedingly uncommon in children. Instead, WDHA syndrome, characterized by watery diarrhea, hypokalemia, and achlorhydria, is more commonly associated with neurogenic tumors located in the retroperitoneum or mediastinum. Chronic diarrhea in infants is a prevalent issue that requires attention from pediatric gastroenterologists, and delays in diagnosis can lead to complications.
Article
Medicine, Research & Experimental
Tangxiele Liu, Wenqin Xiao, Mengting Chen, Rui Mao, San Xu, Qinqin Peng, Zhixiang Zhao, Qian Wang, Hongfu Xie, Zhili Deng, Ji Li
Summary: This study identified altered metabolic signatures and highlighted amino acid-related metabolic pathways in patients with rosacea. Glutamic acid and aspartic acid were found to be positively correlated with disease severity and could promote the development of characteristic features of rosacea. The findings suggest that abnormal amino acid metabolism plays a role in neurovascular reactivity in rosacea and targeting dysregulated metabolism could be a promising strategy for clinical treatment.
Article
Agriculture, Dairy & Animal Science
Katarzyna Palus, Jaroslaw Calka, Barbara Jana
Summary: The study examined the abundances of VIP receptors (VPAC1, VPAC2) in the pig myometrium and their role in regulating inflamed uterine contractility. VIP was found to decrease myometrial contractility in the inflamed pig uterus through VPAC1 and VPAC2 receptors.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Multidisciplinary Sciences
Rozalyn A. Simon, Nawroz Barazanji, Michael P. Jones, Olga Bednarska, Adriane Icenhour, Maria Engstrom, J. Paul Hamilton, Asa V. Keita, Susanna Walter
Summary: Plasma VIP levels are negatively correlated with symptoms of anxiety and depression, and positively correlated with functional connectivity and brain volume in specific brain regions associated with anxiety and depression.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Zhiqiang Zhang, Qi Li, Yongxiong Huang, Zhou Xu, Xinjin Chen, Baijian Jiang, Yu Huang, Jichang Jian
Summary: This study identified and characterized the VIP precursor gene and its receptor gene in Nile tilapia, and investigated their roles in immune modulation and protection against bacterial infection. The results showed that both genes were highly expressed in the intestine and induced by Streptococcus agalatiae. In vitro and in vivo experiments demonstrated immune functions of VIP, including inflammation suppression and promotion of apoptosis and pyroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Raul Villanueva-Romero, Alicia Cabrera-Martin, Emigdio alvarez-Corrales, Mar Carrion, Selene Perez-Garcia, Amalia Lamana, David Castro-Vazquez, Carmen Martinez, Rosa P. Gomariz, Irene Gutierrez-Canas, Yasmina Juarranz
Summary: This study investigates the behavior of human CD4(+)CD45RA(+) T cells after in vitro activation and the role of the VIP system in this process. The findings show that without polarizing conditions, these T cells mainly differentiate into pathogenic Th17 subset and an unpaired Treg subset. The study also confirms the important immunomodulatory role of VIP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xiang Yan, Yayue Zhang, Haiyan Lang, Ziming Huang, Xinyi Chen, Hao He, Qian Zhao, Jun Wang
Summary: This study investigated the effects of prednisone on platelet, VIP, and PACAP levels in ITP mice, as well as the regulatory system that controls intestinal immunity. The results showed that prednisone increased VIP and PACAP levels, decreased the expression of p53 protein and apoptosis rate in mesenteric lymph node lymphocytes, and affected cytokine expression.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Ophthalmology
Dingwen Xu, Feipeng Wu, Yixian Yu, Xiaotong Lou, Meng Ye, Hong Zhang, Yin Zhao
Summary: This study demonstrates that sympathetic activation promotes the release of VIP from TM cells, leading to the expansion of SC through the stabilization of cytoskeleton, resulting in a reduction in intraocular pressure.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ingrid Langer, Dorota Latek
Summary: VIP and PACAP are neuropeptides that regulate intestinal processes through VPAC1, VPAC2, and PAC1 receptors. Due to lack of specificity, poor bioavailability, and short half-life, new therapeutic options are sought. Drug repositioning led to the identification of ticagrelor as a VPAC1 and VPAC2 inhibitor, showing an allosteric mechanism of action. Further studies on ticagrelor's binding modes and comparisons with cangrelor may improve selectivity for VIP and PACAP receptor sub-types.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Allergy
Yuan Zhang, Feng Lan, Luo Zhang
Summary: Allergic rhinitis is a growing global public health issue, and future research should focus on environmental exposures, climate changes, and their impact on health. A combination of precise diagnosis and traditional methods may enhance the treatment of allergic rhinitis.
Review
Biochemistry & Molecular Biology
Munsoo Han, Dabin Lee, Sang Hag Lee, Tae Hoon Kim
Summary: Oxidative stress plays a crucial role in redox metabolism in various physiological and pathological conditions, and antioxidants are important in treating associated diseases. Allergic rhinitis significantly impacts daily function and quality of life, with a high socioeconomic burden and prevalence, with recent studies focusing on the role of oxidative stress and antioxidants in this condition.
Review
Chemistry, Multidisciplinary
Elena Cantone, Aikaterini Detoraki, Eugenio De Corso
Summary: This review discusses the features of local allergic rhinitis (LAR) as an independent endotype. Allergic rhinitis (AR) and nonallergic rhinitis (NAR) are two subtypes of chronic rhinitis, while LAR is a subtype of AR characterized by a localized nasal allergic response with negative skin prick testing to allergens in the absence of serum-specific IgE.
APPLIED SCIENCES-BASEL
(2022)
Article
Immunology
Qiubai Jin, Feihong Ren, Dan Dai, Nan Sun, Yiyun Qian, Ping Song
Summary: This study used a bidirectional two-sample Mendelian randomization analysis to confirm the causal relationship between intestinal flora and allergic diseases (specifically atopic dermatitis, allergic rhinitis, and allergic asthma). It also proposed an innovative perspective for the prevention and treatment of these allergic diseases through targeted regulation of dysregulation of specific bacterial taxa.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Allergy
Birgit Pfaller, Sarah Bendien, Agnes Ditisheim, Thomas Eiwegger
Summary: Managing allergic diseases during pregnancy presents challenges and potential risks for mother and child, especially with limited safety data on anti-allergic drugs during pregnancy.
Article
Otorhinolaryngology
Hyun-Woo Yang, Joo-Hoo Park, Jae-Min Shin, Heung-Man Lee, Il-Ho Park
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2020)
Article
Computer Science, Artificial Intelligence
Mohammad Azam Khan, Soonwook Kwon, Jaegul Choo, Seok Min Hong, Sung Hun Kang, Il-Ho Park, Sung Kyun Kim, Seok Jin Hong
Article
Otorhinolaryngology
Ju-Hyung Kang, Hyun-Woo Yang, Joo-Hoo Park, Jae-Min Shin, Tae-Hoon Kim, Seung Hoon Lee, Heung-Man Lee, Il-Ho Park
Summary: LPS induces TSLP production via TLR4, MAPK, Akt, and NF-kappa B pathways, and the effects of corticosteroids and macrolides are related to LPS-induced TSLP expression. We explored new treatment modalities targeting LPS-induced TSLP production that could replace the currently used corticosteroid and macrolides for treatment of CRS.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jae-Min Shin, Ju-Hyung Kang, Joo-Hoo Park, Hyun-Woo Yang, Heung-Man Lee, Ii-Ho Park
Article
Biochemistry & Molecular Biology
Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Tae Hoon Kim, Seung Hoon Lee, Heung-Man Lee, Jae-Gu Cho, Il-Ho Park
Article
Multidisciplinary Sciences
Il-Ho Park, Joong Seob Lee, Joo-Hoo Park, Sung Hun Kang, Seok Min Hong, Il Seok Park, Joo Heung Yoon, Seok Jin Hong
Article
Environmental Sciences
Sang Chul Park, Il-Ho Park, Joong Seob Lee, Sung Min Park, Sung Hun Kang, Seok-Min Hong, Soo-Hwan Byun, Yong Gi Jung, Seok Jin Hong
Summary: This study found that the relative abundances of Staphylococcus and Pseudomonas were significantly lower in samples from the diseased site of unilateral chronic rhinosinusitis, while anaerobes were more abundant in the diseased site.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Jae-Min Shin, Joo-Hoo Park, Hyun-Woo Yang, Jee Won Moon, Heung-Man Lee, Il-Ho Park
Summary: miR-29b and HSP47 play important roles in regulating TGF-beta 1-induced EMT and migration. miR-29b inhibits EMT-related markers expression by modulating HSP47 expression, while HSP47 knockout suppresses TGF-beta 1-induced EMT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Otorhinolaryngology
Jae-Min Shin, Su-Jong Kim, Heung-Man Lee, Il-Ho Park
Summary: The incidence of odontogenic sinusitis has increased due to invasive dental procedures. This study found changes in the clinical features of odontogenic sinusitis and confirmed the importance of endoscopic sinus surgery (ESS). Factors predictive of ESS were identified.
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Il-Ho Park
Summary: The pathogenesis of chronic rhinosinusitis is closely related to tissue remodeling, particularly epithelial-mesenchymal transition. Epigenetic mechanisms, such as DNA methylation, mediated by DNA methyltransferases, play key roles in this process. This study aimed to investigate the involvement of DNA methyltransferases in TGF-beta 1-induced epithelial-mesenchymal transition and explore the underlying mechanisms. The results showed that DNA methyltransferases were upregulated in chronic rhinosinusitis tissues and their expression was positively correlated with disease severity. Further experiments revealed that TGF-beta 1 induced the expression of DNA methyltransferases, which led to DNA methylation and epithelial-mesenchymal transition via the p38, JNK, Snail, and Slug signaling pathways. Inhibition of DNA methyltransferases suppressed the epithelial-mesenchymal transition process, suggesting its potential as a therapeutic strategy for chronic rhinosinusitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Soo-Jin Oh, Eun-Na Lee, Joo-Hoo Park, Jae Kyung Lee, Geum Joon Cho, Il-Ho Park, Ok Sarah Shin
Summary: Respiratory virus infections, which cause localized and pandemics, are a significant cause of mortality and morbidity globally. Recently, small extracellular vesicles derived from human umbilical cord mesenchymal stem cells (U-exo) have gained attention as a cell-free therapeutic strategy due to their safety and efficacy potential. This study found that U-exo exhibits antiviral activities against influenza A/B virus (IFV) and human seasonal coronavirus (HCoV) infections, potentially through the suppression of viral replication and the enhancement of IFN signaling and ISGs production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Hyun-Woo Yang, Joo-Hoo Park, Min-Sik Jo, Jae-Min Shin, Dae Woo Kim, Il-Ho Park
Summary: Eosinophils play a role in tissue remodeling in ECRS by inducing the production of pro-inflammatory mediators and ECM components in nasal fibroblasts. Eosinophil-derived OPN is associated with inflammation and severity of ECRS.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Junhu Tai, Munsoo Han, Dabin Lee, Il-Ho Park, Sang Hag Lee, Tae Hoon Kim
Summary: Nasal drug delivery has advantages over other routes, but also has limitations. This review provides an overview of nasal anatomy and mucosal environment, explores methods to enhance absorption and improve delivery, and discusses future prospects.
Article
Multidisciplinary Sciences
Min-Sik Jo, Hyun-Woo Yang, Joo-Hoo Park, Jae-Min Shin, Il-Ho Park
Summary: This study aimed to determine whether glycolytic reprogramming contributes to myofibroblast differentiation and ECM production in nasal fibroblasts. Hypoxia-inducing factor (HIF)-1 alpha was a high-level regulator of glycolysis, and increased HIF-1 alpha expression promoted glycolysis of nasal fibroblasts, and inhibition of HIF-1 alpha down-regulated myofibroblasts differentiation and ECM production. This study suggests that inhibition of the glycolytic enzyme and HIF-1 alpha in nasal fibroblasts regulates myofibroblast differentiation and ECM generation associated with nasal mucosa remodeling.
Article
Cell & Tissue Engineering
Joo-Hoo Park, Yujin Choi, Jae-Min Shin, Hyun-Woo Yang, Seong-Ho Jeong, Il-Ho Park
Summary: This study proposes an ultrasonic cavitation-treated method that can significantly reduce time and avoid the problem of using xenogeneic enzymes in isolating adipose-derived stem cells (ADSCs), offering a promising alternative to the widely used collagenase method.
STEM CELL RESEARCH & THERAPY
(2023)
