The Crossroads of Iron with Hypoxia and Cellular Metabolism. Implications in the Pathobiology of Pulmonary Hypertension

An Official American Thoracic Society Clinical Practice Guideline: Diagnosis, Risk Stratification, and Management of Pulmonary Hypertension of Sickle Cell Disease

(2014) Elizabeth S. Klings et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Supplementation of Iron in Pulmonary Hypertension: Rationale and Design of a Phase II Clinical Trial in Idiopathic Pulmonary Arterial Hypertension

(2014) Luke S.G.E. Howard et al.   Pulmonary Circulation

The Nuclear Factor Erythroid 2–Related Factor 2 Activator Oltipraz Attenuates Chronic Hypoxia–Induced Cardiopulmonary Alterations in Mice

(2013) Shunsuke Eba et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2  mRNA translation

(2013) N. Wilkinson et al.   BLOOD

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

(2013) Manik C. Ghosh et al.   Cell Metabolism

Sevoflurane Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Caveolin-3-Dependent Cyclooxygenase-2 Inhibition

(2013) J. Zhao et al.   CIRCULATION

Pulmonary Hypertension due to Lung Disease and/or Hypoxia

(2013) Steven D. Nathan et al.   CLINICS IN CHEST MEDICINE

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: Insights into the potential of various iron therapies to induce oxidative and nitrosative stress

(2013) Taija S. Koskenkorva-Frank et al.   FREE RADICAL BIOLOGY AND MEDICINE

Updated Clinical Classification of Pulmonary Hypertension

(2013) Gerald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension

(2013) G. Ruiter et al.   RHEUMATOLOGY

Lung18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension

(2012) Glenn Marsboom et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Iron overload in non-transfusion-dependent thalassemia: a clinical perspective

(2012) Khaled M. Musallam et al.   BLOOD REVIEWS

Pathobiology of pulmonary arterial hypertension and right ventricular failure

(2012) Norbert F. Voelkel et al.   EUROPEAN RESPIRATORY JOURNAL

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Cardiovascular Abnormalities in Sickle Cell Disease

(2012) Mark T. Gladwin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Fatal Mitochondrial Disease Is Associated with Defective NFU1 Function in the Maturation of a Subset of Mitochondrial Fe-S Proteins

(2011) Aleix Navarro-Sastre et al.   AMERICAN JOURNAL OF HUMAN GENETICS

HIF and the Lung

(2011) Larissa A. Shimoda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities

(2011) S. Farha et al.   BLOOD

Pulmonary Hypertension Associated With Hemoglobinopathies

(2011) Dimitrios Farmakis et al.   CIRCULATION

High Levels of Zinc-Protoporphyrin Identify Iron Metabolic Abnormalities in Pulmonary Arterial Hypertension

(2011) Ilka Decker et al.   CTS-Clinical and Translational Science

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

Iron sensing and signalling

(2011) Rayko Evstatiev et al.   GUT

Pulmonary artery pressure and iron deficiency in patients with upregulation of hypoxia sensing due to homozygous VHLR200W mutation (Chuvash polycythemia)

(2011) C. A. Sable et al.   HAEMATOLOGICA

Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension

(2011) C. J. Rhodes et al.   HEART

Effectiveness of deferiprone in transfusion‐independent beta‐thalassemia/HbE patients

(2011) Krittapoom Akrawinthawong et al.   Hematology

Iron Deficiency and Raised Hepcidin in Idiopathic Pulmonary Arterial Hypertension

(2011) Christopher J. Rhodes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension

(2011) E. Soon et al.   THORAX

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

(2010) Iwona Fijalkowska et al.   AMERICAN JOURNAL OF PATHOLOGY

Somatic Chromosome Abnormalities in the Lungs of Patients with Pulmonary Arterial Hypertension

(2010) Micheala A. Aldred et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNA-210: A unique and pleiotropic hypoxamir

(2010) Stephen Y. Chan et al.   CELL CYCLE

Endothelin

(2010) Yoshifumi Kawanabe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Iron deficiency is common in idiopathic pulmonary arterial hypertension

(2010) G. Ruiter et al.   EUROPEAN RESPIRATORY JOURNAL

Hereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment

(2010) Antonello Pietrangelo   GASTROENTEROLOGY

Association of anemia and long-term survival in patients with pulmonary hypertension

(2010) Richard A. Krasuski et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice

(2010) Michele M. Hickey et al.   JOURNAL OF CLINICAL INVESTIGATION

Natural selection on EPAS1 (HIF2 ) associated with low hemoglobin concentration in Tibetan highlanders

(2010) C. M. Beall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Metalloproteomes: A Bioinformatic Approach

(2009) Claudia Andreini et al.   ACCOUNTS OF CHEMICAL RESEARCH

Usefulness of Red Cell Distribution Width as a Prognostic Marker in Pulmonary Hypertension††Conflicts of interest: Dr. Gomberg-Maitland has received research grant support from Actelion Pharmaceuticals Ltd., Allschwil, Switzerland; CoTherix, Inc., South San Francisco, California; Encysive Pharmaceuticals Inc., Houston, Texas; Gilead Sciences Inc., Foster City, California; Eli Lilly/ICOS, Indianapolis, Indiana; Pfizer Inc., New York, New York; and United Therapeutics, Silver Spring, Maryland. Dr. Gomberg-Maitland has served as a consultant and/or on advisory boards for Encysive Pharmaceuticals Inc., Gilead Sciences Inc., Pfizer Inc., and United Therapeutics. Dr. Shah has received research grant support from Actelion Pharmaceuticals Ltd. (Entelligence Young Investigator Award) and is also the recipient of a Scientist Development Grant from the American Heart Association, Dallas, Texas.

(2009) Chetan V. Hampole et al.   AMERICAN JOURNAL OF CARDIOLOGY

Pulmonary Hypertension in Patients with Chronic Obstructive Pulmonary Disease

(2009) Joan Albert Barberà et al.   DRUGS

Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)

(2009) et al.   EUROPEAN HEART JOURNAL

Growth factors and interleukin-6 across the lung circulation in pulmonary hypertension

(2009) N. Selimovic et al.   EUROPEAN RESPIRATORY JOURNAL

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis

(2009) A. A. Salahudeen et al.   SCIENCE

Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase

(2009) A. A. Vashisht et al.   SCIENCE

Pathology of Pulmonary Arterial Hypertension

(2009) Rubin Tuder   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

The Cancer Paradigm of Severe Pulmonary Arterial Hypertension

(2008) Pradeep R. Rai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

(2008) D. P. Gale et al.   BLOOD

Pulmonary Hypertension

(2008) Christopher F. Barnett et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Iron Homeostasis: Recently Identified Proteins Provide Insight into Novel Control Mechanisms

(2008) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

(2008) Thomas G. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON