Article
Medicine, General & Internal
Sara Torresan, Gaia Zussino, Francesco Cortiula, Alessandro Follador, Gianpiero Fasola, Rossano Girometti, Lorenzo Cereser
Summary: We report a case of radiation recall pneumonitis followed by immune-checkpoint inhibitor-induced pneumonitis in a patient with non-small cell lung cancer. This case emphasizes the importance of considering radiation recall pneumonitis in the differential diagnosis of lung consolidation during immunotherapy and suggests that it may anticipate more extensive immune-checkpoint inhibitor-induced pneumonitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Min Wang, Shuhui Xu, Hui Zhu
Summary: This report presents a rare case of double pneumonitis (RP and RRP) in a patient with non-small lung cancer (NSCLC), with RP occurring at 3 months and RRP induced by anti-PD-1 sintilimab at 10 months after radiotherapy. This case draws attention to the identification of immune or radiation pneumonitis, its potential mechanism, and the treatment strategy for RRP.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Colton Ladbury, Richard Li, Anseh Danesharasteh, Zeynep Ertem, Andrew Tam, Jason Liu, Claire Hao, Rose Li, Heather McGee, Sagus Sampath, Terence Williams, Scott Glaser, Mohammad Khasawneh, Zhongxing Liao, Percy Lee, Jeff Ryckman, Parvez Shaikh, Arya Amini
Summary: This study used machine learning and explainable artificial intelligence to analyze the dosimetric predictors of toxicity in patients treated as part of a prospective clinical trial and identified relevant dosimetric thresholds.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Ditte Sloth Moller, Christina Maria Lutz, Azza Ahmed Khalil, Markus Alber, Marianne Ingerslev Holt, Maria Kandi, Hjordis Hjalting Schmidt, Marie Tvilum, Ane Appelt, Marianne Marquard Knap, Lone Hoffmann
Summary: This study investigated the clinical benefits of tumor match and adaptive radiotherapy for non-small cell lung cancer patients. The results showed that tumor match and adaptive radiotherapy significantly reduced the incidence of radiation pneumonitis and improved progression-free and overall survival.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Anne G. H. Niezink, Arjen van der Schaaf, Robin Wijsman, Olga Chouvalova, Anthonie J. van der Wekken, Steven R. Rutgers, Remge M. Pieterman, John W. G. van Putten, Sander M. de Hosson, Annija H. D. van der Leest, Jan F. Ubbels, Marleen Woltman-van Iersel, Joachim Widder, Johannes A. Langendijk, Christina Muijs
Summary: This study aimed to externally validate the QUANTEC and APPELT models for radiation pneumonitis (RP) prediction in a large cohort of lung cancer patients treated with IMRT or VMAT. These models were revised and updated, with the APPELT model showing better discrimination than the recalibrated QUANTEC model.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Immunology
Xiaotong Lu, Jianyang Wang, Tao Zhang, Zongmei Zhou, Lei Deng, Xin Wang, Wenqing Wang, Wenyang Liu, Wei Tang, Zhijie Wang, Jie Wang, Wei Jiang, Nan Bi, Luhua Wang
Summary: This retrospective study investigated the risk of treatment-related pneumonitis in Chinese lung cancer patients who received thoracic radiotherapy (TRT) followed by immune checkpoint inhibitor (ICI) therapy. The results showed that the occurrence of pneumonitis was relatively high, but manageable, and dosimetric parameters could improve the prediction of radiation recall pneumonitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mizuki Nishino
Summary: Treatment-related pneumonitis is a major challenge in oncology patients, and imaging is crucial in its detection, diagnosis, and monitoring. Immune checkpoint inhibitor-related pneumonitis has been a topic of interest in the radiology and oncology communities since 2015 due to increasing clinical indications for this therapy. New combination approaches, such as ICI with EGFR inhibitors and ICI with radiotherapy, present emerging challenges. Radiologists play a central role in understanding and overcoming this challenging toxicity.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Review
Medicine, Research & Experimental
Sahar Sheikholeslami, Tayebeh Aryafar, Razzagh Abedi-Firouzjah, Amin Banaei, Masoumeh Dorri-Giv, Hamed Zamani, Gholamreza Ataei, Mehrsa Majdaeen, Bagher Farhood
Summary: According to the study, melatonin can play a protective role in treating radiation-induced pneumonitis and lung fibrosis by alleviating oxidative stress and inflammation. This is achieved through melatonin's upregulation of enzymes and downregulation of inflammatory markers, ultimately reducing histological damages caused by ionizing radiation.
Article
Immunology
Jianping Bi, Jing Qian, Dongqin Yang, Lu Sun, Shouyu Lin, Ying Li, Xudong Xue, Tingting Nie, Vivek Verma, Guang Han
Summary: This study demonstrates for the first time that V20 and MLD may impact the occurrence of aRP in the setting of prior ICIs. However, these results should not be extrapolated to patients without pre-radiotherapy receipt of prior ICIs, or to evaluate the risk of chronic pulmonary effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kyungmi Yang, Changhoon Choi, Hayeong Cho, Won-Gyun Ahn, Shin-Yeong Kim, Sung-Won Shin, Yeeun Kim, Taekyu Jang, Nohyun Lee, Hee Chul Park
Summary: This study investigated the use of mesoporous silica nanoparticles (MSNs) to enhance the effects of radiotherapy (8 Gy of X-rays) on tumors in mice models. Results showed that MSNs enhanced tumor infiltration of cytotoxic T cells and suppressed regulatory T cells, leading to systemic tumor regression. MSNs were found to capture tumor antigens released after RT, which activated dendritic cells and ultimately led to improved anti-tumor effects.
Article
Oncology
Vitali Moiseenko, Lawrence B. Marks, Jimm Grimm, Andrew Jackson, Michael T. Milano, Jona A. Hattangadi-Gluth, Minh-Phuong Huynh-Le, Niclas Pettersson, Ellen Yorke, Issam El Naqa
Summary: This article presents an overview of common approaches used to assess the dose response for radiation therapy-associated endpoints, using lung toxicity data sets as an example. Established methods such as data-driven analysis, dose-response analysis, and calculating uncertainties on model prediction are addressed in detail. The use of maximum likelihood method, profile-likelihood, likelihood ratio, and bootstrap method are discussed for calculating parameter values, confidence intervals, and model predictions. The correlated behavior of model parameters and implications for interpreting dose response are also explored.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Bing Li, Xiaoli Zheng, Jiang Zhang, Saikit Lam, Wei Guo, Yunhan Wang, Sunan Cui, Xinzhi Teng, Yuanpeng Zhang, Zongrui Ma, Ta Zhou, Zhaoyang Lou, Lingguang Meng, Hong Ge, Jing Cai
Summary: The study evaluates the effectiveness of features obtained from proposed incremental-dose-interval-based lung subregion segmentation for predicting grade >= 2 acute radiation pneumonitis (ARP) in lung cancer patients. Results show that features from lung subregions outperform those from the whole lung in predicting ARP, especially when using dosiomics or combined radiomics-dosiomics features. This improved model performance could enhance clinical management and patient quality of life.
Article
Oncology
Jing-Wen Huang, Yi-Hui Lin, Gee-Chen Chang, Jeremy J. W. Chen
Summary: This study investigates the correlation between volumes of radiation pneumonitis (RP) lesions and their RP grades in lung cancer patients after radiotherapy. The results show that RPv max and RP grade max are significantly correlated in all patient groups. Parameters related to the dose-volume histogram (DVH) and RP include lung Vx (x=1-66 Gy, the percentage of lung volume received >= x Gy) and mean lung dose. The study also finds that in cases where RP lesions cover more than 80% of the lung, a dose curve of 26 Gy can be used to determine the presence of radiation-induced lung injury (RILI).
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bing Li, Ge Ren, Wei Guo, Jiang Zhang, Sai-Kit Lam, Xiaoli Zheng, Xinzhi Teng, Yunhan Wang, Yang Yang, Qinfu Dan, Lingguang Meng, Zongrui Ma, Chen Cheng, Hongyan Tao, Hongchang Lei, Jing Cai, Hong Ge
Summary: This study investigates the impact of lung function on radiation pneumonitis prediction using a dual-omics analysis method, and finds that dual-omics features from different lung functional regions can improve the prediction of radiation pneumonitis for lung cancer patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Hakyoung Kim, Jeongeun Hwang, Sun Myung Kim, Juwhan Choi, Dae Sik Yang
Summary: This study identified idiopathic pulmonary fibrosis as an underlying lung disease and the concurrent use of chemotherapy as risk factors for the development of severe radiation pneumonitis in patients with non-small cell lung cancer treated with curative high-dose radiotherapy.
Article
Pharmacology & Pharmacy
Ram P. Das, Sarjak Chakravarti, Snehal S. Patel, Pooja Lakhamje, Murari Gurjar, Vikram Gota, Beena G. Singh, Amit Kunwar
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Materials Science, Biomaterials
Bijaideep Dutta, Anshika Nema, Neena G. Shetake, Jagriti Gupta, K. C. Barick, Malini A. Lawande, B. N. Pandey, Indira K. Priyadarsini, P. A. Hassan
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Avinash Singh, Sujata Yumnam, Amit Kunwar, V. S. Tripathi, Suman Neogy, M. C. Rath
Review
Biochemistry & Molecular Biology
A. Kunwar, K. Indira Priyadarsini, Vimal K. Jain
Summary: This comprehensive review highlights the potential of the organoselenium compound DSePA for various biological applications, including antioxidative, anticarcinogenic, and radioprotective activities. Studies have shown that DSePA exhibits protective effects against radiation-induced normal tissue side effects, particularly in lung tissue, and has promising pharmacokinetic properties with maximum absorption in the lung.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Chemistry, Multidisciplinary
Kanhu C. Barick, Bijaideep Dutta, Santosh L. Gawali, Prasad P. Phadnis, Kavirayani Indira Priyadarsini, Vimal K. Jain, Puthusserickal A. Hassan
Article
Chemistry, Physical
R. Ganguly, S. Kumar, A. Kunwar, S. Nath, H. D. Sarma, A. Tripathi, G. Verma, D. P. Chaudhari, V. K. Aswal, J. S. Melo
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Materials Science, Biomaterials
Sandeep B. Shelar, Santosh L. Gawali, Kanhu C. Barick, Amit Kunwar, Arivozhi Mohan, Indira K. Priyadarsini, Puthusserickal A. Hassan
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Bharti Patel, Subrata Mishra, Indira K. Priyadarsini, Sirisha L. Vavilala
Summary: The study demonstrates that selenocystine has potential anti-biofilm properties against bacteria causing respiratory tract infections, inhibiting growth and reducing biofilm formation. Selenocystine effectively eradicates preformed biofilms and distorts biofilm structures by degrading eDNA components.
BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
V. V. Gandhi, K. A. Gandhi, L. B. Kumbhare, J. S. Goda, V Gota, K. Priyadarsini, A. Kunwar
Summary: DSePA induces apoptosis in human lung cancer cells by reducing ROS and increasing reducing equivalents, activating intrinsic and extrinsic pathways, and inducing ER stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Gunjan Verma, Akhil Gajipara, Sandeep B. Shelar, K. Priyadarsini, P. A. Hassan
Summary: The CUR-Gel-HAp formulation displayed enhanced cytotoxicity against human lung cancer cells, showed long-term stability, and maintained physicochemical properties and colloidal stability after reconstitution in aqueous medium.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shaukat Ali Shaikh, Bharti Patel, Indira K. Priyadarsini, Sirisha L. Vavilala
Summary: This study discovers that ebselen has potent antibacterial and antibiofilm activity against Serratia marcescens, and it also shows promising anti-quorum sensing potential. This suggests that ebselen could be explored as a treatment for bacterial infections.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shaukat Ali M. Shaikh, S. L. Gawali, V. K. Jain, K. Priyadarsini
Summary: The interaction between diselenodipropionic acid (DSePA) and human serum albumin (HSA) has been investigated using spectroscopic and docking methods. The binding constant between DSePA and HSA was estimated, and the molecular interaction was confirmed using isothermal titration calorimetry. The HSA-DSePA complex was analyzed using small angle X-ray scattering and circular dichroism techniques. Molecular docking studies suggested specific interactions at certain amino acid residues. These findings provide evidence for the interaction between DSePA and HSA.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
V. V. Gandhi, Prasad P. Phadnis, A. Kunwar
Article
Materials Science, Biomaterials
Ram Pada Das, Beena Gobind Singh, Amit Kunwar
BIOMATERIALS SCIENCE
(2020)
Article
Nanoscience & Nanotechnology
Apurav Guleria, Ashlesha P. Chavan, Suman Neogy, V. V. Gandhi, Amit Kunwar, Anil K. Debnath, Soumyakanti Adhikari
ACS APPLIED NANO MATERIALS
(2020)