Article
Physiology
Elvedin Lukovi, Jose F. Perez-Zoghbi, Yi Zhang, Yingdong Zhu, Shengmin Sang, Charles W. Emala
Summary: The study shows that metabolites and synthetic derivatives of the primary active component, 6-shogaol, in ginger can inhibit airway constriction and enhance relaxation, offering potential therapeutic options for asthma and other bronchoconstrictive diseases. This suggests that natural metabolites could inspire the development of novel therapeutics in the treatment of respiratory conditions.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Nathalie Fuentes, Morgan McCullough, Reynold A. Panettieri, Kirk M. Druey
Summary: Asthma is a prevalent disorder characterized by chronic lung inflammation and reversible airways obstruction, with features including increased airway narrowing, excessive mucus secretion, airway remodeling, and airways hyperresponsiveness. Environmental factors such as allergens, viruses, and air pollution can promote asthma, leading to symptoms like cough, wheezing, and shortness of breath. G-protein-coupled receptors play a central role in asthma, with various treatments targeting these receptors to regulate airway smooth muscle tone and lung inflammation.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Physiology
Dora (Jun Ping) Xiong, James G. Martin, Anne-Marie Lauzon
Summary: Asthma is a common chronic inflammatory disease of the airways that varies in its presentation and severity. Airway smooth muscle is the major contributor to airway narrowing and asthma symptoms. Various factors can contribute to the dysfunction of airway smooth muscle. Methodological limitations in studying the airways have hindered our understanding of asthma mechanisms.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Colleen M. Bartman, Aleksey Matveyenko, Christina Pabelick, Y. S. Prakash
Summary: This study explores the impact of hyperoxia on the clock function in human fetal airway smooth muscle cells and how manipulating clock genes can alleviate the deleterious effects of oxygen on developing airways. Findings suggest that manipulating clock proteins can modulate intracellular calcium regulation in fASM, particularly under hyperoxia, offering a potential new therapeutic avenue for neonatal airway diseases following prematurity.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Immunology
Yali Zhao, Xiangli Zhang, Guizuo Wang, Hua Wu, Ruilin Chen, Yongqing Zhang, Shumei Yang, Lu Liu
Summary: The present study aimed to investigate the signaling mechanisms of TGF beta 1-induced rat ASMCs proliferation and migration and the effect of LXA4 on this process. TGF-beta 1 upregulated YAP expression by activating Smad2/3, leading to ASMCs proliferation and migration. The effect was reversed by the TGF-beta 1 receptor inhibitor SB431542. Knockdown of YAP disrupted the pro-airway remodeling function of TGF-beta 1. Preincubation of rat ASMCs with LXA4 inhibited TGF-beta 1-induced activation of Smad2/3 and suppressed ASMCs proliferation and migration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Hyun-Jung Kim, Paul Cheng, Stanislao Travisano, Chad Weldy, Joao P. Monteiro, Ramendra Kundu, Trieu Nguyen, Disha Sharma, Huitong Shi, Yi Lin, Boxiang Liu, Saptarsi Haldar, Simon Jackson, Thomas Quertermous
Summary: Genes encoding risk for coronary disease are crucial for developing new therapies. A particular gene, PDGFD, has been identified as a culprit gene and it promotes disease risk. Mechanistic studies confirm that rs2019090 and PDGFD represent the functional genetic variant and gene responsible for coronary artery disease. PDGFD mediates CAD risk by promoting deleterious phenotypic changes in smooth muscle cells and an inflammatory response primarily focused in the adventitia.
NATURE COMMUNICATIONS
(2023)
Article
Respiratory System
Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu, Rodney D. Britt
Summary: In this study, the effects of TNF alpha and IFN gamma on corticosteroid sensitivity in pediatric airway smooth muscle tissue were investigated. The results showed that TNF alpha had a greater impact on gene expression compared to IFN gamma, and the combined effects of TNF alpha and IFN gamma enhanced the expression of pro-inflammatory genes and pathways related to asthma pathogenesis. These findings highlight the importance of Th1-associated cytokines in promoting inflammation and hypercontractility in severe asthma.
RESPIRATORY RESEARCH
(2022)
Article
Cell Biology
Ruth M. Matthews, Eamonn Bradley, Caoimhin S. Griffin, Xin Rui Lim, Nicolas D. Mullins, Mark A. Hollywood, Fionnuala T. Lundy, Lorcan P. McGarvey, Gerard P. Sergeant, Keith D. Thornbury
Summary: Mouse bronchial smooth muscle cells express functional NaV1.7 channels that can modulate contractile activity under experimental conditions.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alina Tokmakova, Donghwa Kim, Brian Guthrie, Soo-Kyung Kim, William A. Goddard, Stephen B. Liggett
Summary: The 25 human bitter taste receptors (TAS2Rs) are an integrated chemosensory system expressed on taste and extra-oral cells. TAS2R14, an archetypal TAS2R, is activated by more than 150 structurally diverse agonists, which raises questions about the accommodation mechanism for these GPCRs. In this study, the researchers computationally derived the structure of TAS2R14 and identified the binding sites and energies for five highly diverse agonists. They found that the binding pocket is the same for all five agonists, and the energetics are consistent with experimental results. The researchers also discovered that TAS2R14 accommodates agonists through unique transmembrane interactions, involving the breaking of a hydrogen bond and the formation of salt bridges.
Review
Biochemistry & Molecular Biology
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Giuseppina Bertorelli, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta
Summary: AHR is a central pathophysiological feature of asthma, involving ASM with pro-inflammatory and immunomodulatory actions. mAbs target various inflammatory mediators to modulate ASM contractility, showing potential in treating severe asthma by preventing AHR.
Review
Plant Sciences
Ashley E. Cannon, Kent D. Chapman
Summary: N-Acylethanolamine (NAE) signaling is important in both vertebrates and plants, where G proteins play a crucial role in transmitting the signal. While similarities exist between plants and animals in NAE signaling, there are also distinct differences, highlighting the complexity of this fundamental lipid signaling pathway in eukaryotes.
TRENDS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Yuting Long, Han Wang, Zitong Ma, Yuman Li, Zaina Ma, Ping Yu, Xiufeng Tang, Renhui Liu
Summary: This study aimed to explore the synergy of Epimedii Folium and Ligustri Lucidi Fructus (ELL) with dexamethasone (Dex) in the proliferation, apoptosis, and autophagy of airway smooth muscle cells (ASMCs). The results of the study suggest that ELL combined with Dex may regulate the proliferation of ASMCs by promoting apoptosis and autophagy and be a potential medicine for the treatment of asthma.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patricia Ramos-Ramirez, Omar Tliba
Summary: Severe asthma patients may have poor response to inhaled glucocorticoid therapy, known as glucocorticoid insensitivity, which poses a challenge in asthma management. Airway smooth muscle cells, a target of glucocorticoid therapy in asthma, play a crucial role in bronchoconstriction, inflammation, and remodeling associated with asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Miguel Angel Hernandez-Lara, Santosh K. Yadav, Sushrut D. Shah, Mariko Okumura, Yuichi Yokoyama, Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande
Summary: Airway remodeling in asthma involves the hyperproliferation of airway smooth muscle (ASM) cells. The inhibition of diacylglycerol kinase (DGK) reduces the conversion of diacylglycerol (DAG) into phosphatidic acid (PA) and inhibits ASM cell proliferation. These findings suggest that DGK may serve as a potential drug target for mitigating airway remodeling in asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Qin Yang, Wei Shi
Summary: Abnormal airway remodeling in chronic respiratory diseases is characterized by altered proliferation and differentiation of airway smooth muscle cells (ASMCs), which are difficult to restore. Understanding the regulation of airway smooth muscle growth is crucial for identifying intervention targets, including the potentially important RhoA/ROCK-MYOCD/MRTFs pathway.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Physiology
Kentaro Mizuta, Yi Zhang, Fumiko Mizuta, Hiroshi Hoshijima, Toshiya Shiga, Eiji Masaki, Charles W. Emala
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2015)
Article
Medicine, General & Internal
Hiroshi Hoshijima, Risa Takeuchi, Takahiro Mihara, Norifumi Kuratani, Kentaro Mizuta, Zen'ichiro Wajima, Eiji Masaki, Toshiya Shiga
Article
Physiology
Atsuko Matoba, Nao Matsuyama, Sumire Shibata, Eiji Masaki, Charles W. Emala, Kentaro Mizuta
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2018)
Review
Anesthesiology
Hiroshi Hoshijima, Takahiro Mihara, Koichi Maruyama, Yohei Denawa, Kentaro Mizuta, Toshiya Shiga, Hiroshi Nagasaka
JOURNAL OF CLINICAL ANESTHESIA
(2018)
Article
Physiology
Kentaro Mizuta, Haruka Sasaki, Yi Zhang, Atsuko Matoba, Charles W. Emala
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Anesthesiology
Hiroshi Hoshijima, Risa Takeuchi, Kimiharu Kikuchi, Kentaro Mizuta
JOURNAL OF ANESTHESIA
(2020)
Review
Anesthesiology
Hiroshi Hoshijima, Takahiro Mihara, Yohei Denawa, Toshiya Shiga, Kentaro Mizuta
Summary: The meta-analysis found that vasopressin did not improve hypotension more effectively than norepinephrine under general anesthesia. Additionally, there were no significant differences between vasopressin and norepinephrine in terms of heart rate, central venous pressure, cardiac output, and cardiac index under general anesthesia. Further research is needed to reach more robust conclusions.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Letter
Anesthesiology
Haruka Sasaki, Hiroshi Hoshijima, Kentaro Mizuta
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hiroshi Hoshijima, Risa Takeuchi, Kimiharu Kikuchi, Kentaro Mizuta
Summary: The trigeminovagal reflex can cause sudden cardiac issues during maxillofacial surgical procedures, necessitating careful monitoring and management.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Review
Medicine, General & Internal
Hiroshi Hoshijima, Hitoshi Higuchi, Aiji Sato (Boku), Makiko Shibuya, Yoshinari Morimoto, Toshiaki Fujisawa, Kentaro Mizuta
Summary: A systematic review and meta-analysis compared patient satisfaction with deep sedation vs. light/moderate sedation during non-surgical procedures, finding higher satisfaction with deep sedation despite longer recovery times.
Article
Physiology
Haruka Sasaki, Yi Zhang, Charles W. Emala, Kentaro Mizuta
Summary: The melatonin MT2 receptor is expressed in airway smooth muscle and modulates airway smooth muscle tone by reducing cAMP production and increasing [Ca2+](i) levels.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Pediatrics
Hiroshi Hoshijima, Takahiro Mihara, Shinichi Kokubu, Sakura Takeda, Toshiya Shiga, Kentaro Mizuta
Summary: This study used network meta-analysis to rank the effectiveness of intubation devices in pediatric patients. The findings suggest that currently there is no laryngoscope superior to the Macintosh laryngoscope in terms of tracheal intubation failure rate and glottic visualization in pediatric patients.
Review
Medicine, General & Internal
Hiroshi Hoshijima, Takahiro Mihara, Takumi Nagumo, Aiji Sato (Boku), Toshiya Shiga, Kentaro Mizuta
Summary: This article conducted a systematic review and meta-analysis to examine the effect of a nasal protection strategy on nasal pressure injury during nasotracheal intubation. The results showed that using a nasal protection strategy significantly reduced the incidence of nasal pressure injury.
Review
Dentistry, Oral Surgery & Medicine
Kentaro Mizuta, Atsuko Matoba, Sumire Shibata, Eiji Masaki, Charles W. Emala
JAPANESE DENTAL SCIENCE REVIEW
(2019)
Article
Respiratory System
Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala, Kentaro Mizuta
RESPIRATORY RESEARCH
(2018)