Article
Cell Biology
Tayyab Shahzad, Cho-Ming Chao, Stefan Hadzic, Judith Behnke, Luisa Biebach, Eva Boettcher-Friebertshaeuser, Jochen Wilhelm, Anne Hilgendorff, Klaus-Peter Zimmer, Rory E. Morty, Saverio Bellusci, Harald Ehrhardt
Summary: Hyperoxia-induced inflammation and tissue damage are crucial steps leading to BPD. TRAIL plays a protective role in lung development, and its depletion leads to structural damage.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Lu-Yang Yeh, Yu-Ting Fang, Hong-Sheng Lee, Chia-Hao Liu, You-Yin Chen, Yu-Chun Lo, Vincent Laiman, Jing-Ping Liou, Kian Fan Chung, Hsiao-Chi Chuang, Chien-Huang Lin
Summary: This study found that the potent HDAC inhibitor MPT0E028 can reduce the severity and inflammation of emphysema and improve lung function, which may be regulated by the Hippo signaling pathway.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Chenchen Hou, Lifeng Yan, Ke Sun, Tianyu Zhou, Yuxin Zou, Weining Xiong, Sheng-Zhong Duan
Summary: NCOR1 deficiency in macrophages exacerbates allergic airway inflammation and promotes macrophage polarization through interaction with PPAR gamma.
CELL DEATH DISCOVERY
(2023)
Editorial Material
Oncology
Cecilia Garlanda, Alberto Mantovani
Summary: IL-1 plays a crucial role in inflammation and tumor progression, and targeting IL-1 may be considered for treating selected human tumors and in prevention and interception settings based on preclinical models and genetic associations.
Article
Pharmacology & Pharmacy
Chun Wang, Ruiqi Hao, Baowei Peng, Jiang Chang, Shisheng Chen, Yanxin Chen, Xiaohang Yin, Yumei Que, Chen Fan, Yuhong Xu
Summary: The pathology of psoriasis involves over-proliferation and inflammation of keratinocytes, as well as infiltration of inflammatory cells such as macrophages. Current treatments targeting single pathological processes are not satisfactory. This study investigated the effects of beta-Elemene on both psoriatic keratinocytes and M1-type macrophages, and found that it can induce apoptosis and inhibit inflammation of keratinocytes. In addition, the study also demonstrated that beta-Elemene-loaded hyaluronic acid microneedles can alleviate symptoms in a psoriatic mice model by inducing keratinocytes apoptosis and inhibiting macrophage infiltration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Song Zhao, Sining Xing, Lili Wang, Mingyue Ouyang, Shuo Liu, Lingyan Sun, Huiying Yu
Summary: In this study, the effects of Docetaxel (Doc) on non-small cell lung cancer and the formation of polyploid giant cancer cells (PGCCs) were investigated. It was found that Doc induced cell cycle arrest and cell death, but some cells survived and transformed into PGCCs. The PGCCs exhibited senescence features and showed increased expression of p21 and p-histone H2A.X. Furthermore, the mRNA level of IL-1β in the senescence-associated secretory phenotype was significantly increased with the development of PGCCs. Inhibition of IL-1β reduced p-histone H2A.X expression and promoted polyploidy, enhancing the proapoptotic effect of Doc. Thus, targeting IL-1β in PGCCs could be a potential approach to overcome drug resistance.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Ying Wang, Jiajun Chen, Tingting Sang, Chaojie Chen, He Peng, Xiaojian Lin, Qian Zhao, Shengjia Chen, Thomas Eling, Xingya Wang
Summary: The study found that NAG-1/GDF15 transgenic mice are resistant to diabetogenesis induced by multiple low-dose streptozotocin. Overexpression of NAG-1/GDF15 significantly reduced the incidence of diabetes and improved glucose intolerance and insulin resistance.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Jitendra Kumar, Rakesh Verma, Chandana Haldar
Summary: The study found that BPS has detrimental effects on the testes of male golden hamsters, while melatonin can alleviate these damages.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Satoshi Kawata, Junji Kozawa, Sho Yoneda, Yukari Fujita, Risa Kashiwagi-Takayama, Takekazu Kimura, Yoshiya Hosokawa, Megu Y. Baden, Sae Uno, Rikako Uenaka, Kazuyuki Namai, Yoko Koh, Yoshito Tomimaru, Haruhiko Hirata, Motohide Uemura, Satoshi Nojima, Eiichi Morii, Hidetoshi Eguchi, Akihisa Imagawa, Iichiro Shimomura
Summary: Immune checkpoint inhibitors (ICIs) can cause type 1 diabetes (T1D). The study found that ICI therapy itself could reduce PD-L1 expression on islets, which may be related to beta-cell vulnerability. In addition, the absence of PD-L1 expression on beta-cells, genetic susceptibility, and infiltration of macrophages and T lymphocytes around islets might be responsible for T1D onset.
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Chen-Yu Wang, Wei-Ning Lin, Ya-Fang Shih, Yi-Wen Chen, Rou-Ling Cho, Hui-Ching Tseng, Chuen-Mao Yang
Summary: This study demonstrates that kaempferol (KPR) can induce HO-1 expression and attenuate inflammation in pulmonary alveolar epithelial cells (HPAEpiCs) through the activation of NOX/ROS/c-Src/Pyk2/PKCα/p38α MAPK and JNK1/2 pathways. The findings suggest that KPR could be a potential strategy for protecting against pulmonary inflammation.
Article
Surgery
Tianzhu Tao, Bo Ye, Yuhai Xu, Yi Wang, Ying Zhu, Ye Tian
Summary: In this study, the protective effects of beta-patchoulene (beta-PAE) on hepatic ischemia-reperfusion (I/R) injury were investigated. The results demonstrated that beta-PAE could alleviate tissue damage and inflammation induced by hepatic I/R injury, and it exerted its effects by modulating the balance between Nrf2/HO-1 and NF-kappa B pathways.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wei Dong, Jun-Fei Weng, Jian-Bing Zhu, Yao-Fu Zheng, Lei-Lei Liu, Chen Dong, Yang Ruan, Xu Fang, Jin Chen, Wen-Yu Liu, Xiao-Ping Peng, Xuan-Ying Chen
Summary: Myocardial ischemia/reperfusion injury (MIRI) is a common condition associated with various critical clinical conditions. miR-322 has been implicated in MIRI through mechanisms that are not well understood. The CBP/HIF-1 alpha/beta-catenin/ miR-322 axis may play a role in MIRI by regulating the expression of miR-322.
Article
Biochemistry & Molecular Biology
Nada F. Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H. Eisa
Summary: The study demonstrates that quinacrine alleviates cisplatin-induced renal toxicity by upregulating SIRT-1, downregulating inflammatory markers (ICAM-1 and TNF-alpha), reducing oxidative stress, and inhibiting apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Miaomiao Wu, Fan Yin, Xiaoli Wei, Ruixue Ren, Chongqing Chen, Menghua Liu, Ruyu Wang, Liu Yang, Ruiqian Xie, Shanyue Jiang, Ziming Wang, Rui Liu, Wentao Xu, Xuefu Wang, Jing Li, Hua Wang
Summary: Alcohol-associated liver disease (ALD) is a global health problem with no effective pharmacological treatments. This study reveals the role of CREG1 protein in the pathogenesis of ALD and suggests CREG1 as a potential therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Marine & Freshwater Biology
Hahyun Park, Bo Hyun Yun, Whasun Lim, Gwonhwa Song
Summary: The study showed that exposure to the herbicide DN led to abnormal cardiac and vascular development, cell apoptosis, and activation of the inflammatory response in zebrafish embryos, which may impair embryonic growth and survival.
AQUATIC TOXICOLOGY
(2021)