Article
Pharmacology & Pharmacy
Yun-yun Yang, Hua-hui Yu, Xiao-lu Jiao, Lin-yi Li, Yun-hui Du, Juan Li, Qian-wen Lv, Hui-na Zhang, Jing Zhang, Chao-wei Hu, Xiao-ping Zhang, Yong-xiang Wei, Yan-wen Qin
Summary: The lack of ANGPTL8 can prevent CIH-induced aortic vascular remodeling, possibly through the inhibition of the ERS pathway. Therefore, ANGPTL8 may be a potential target in CIH-induced aortic vascular remodeling.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Bala S. C. Koritala, Laetitia S. Gaspar, Shweta S. Bhadri, Kyla S. Massie, Yin Yeng Lee, Jiffin Paulose, David F. Smith
Summary: This study aimed to investigate the effects of intermittent hypoxia (IH) on pro-inflammatory mediators in vulnerable organs impacted by obstructive sleep apnea (OSA). The results showed that short-term exposure to IH led to a decrease in immune response pathways in the heart, lung, and liver, while long-term exposure to IH resulted in an increase in inflammatory mediators in the serum, lung, and heart.
Article
Biochemistry & Molecular Biology
Li-Pang Chuang, Huang-Pin Wu, Li-Ang Lee, Li-Chung Chiu, Shih-Wei Lin, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Jung-Wei Tsai, Jong-Hwei Su Pang
Summary: This study found that under intermittent hypoxia conditions, the expression of IL-8 was enhanced in monocytes of adult OSA patients, leading to an increase in the migration ability of monocytes towards IL-8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Ming Deng, Yi-teng Huang, Jian-qing Xu, Xiao Ke, Yi-fei Dong, Xiao-shu Cheng
Summary: The study found that patients with severe OSAHS were more likely to have hypertension and higher LV mass and LV mass index. The association between intermittent hypoxia and left ventricular remodeling was significant, with oxygen desaturation index (ODI) being the most relevant parameter to LV remodeling among various intermittent hypoxia parameters.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Clinical Neurology
Yang Ji, Yingmin Liang, Judith C. W. Mak, Mary S. M. Ip
Summary: Obesity is a strong risk factor for both obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD). Intermittent hypoxia plays an important role in the development of NAFLD in OSA. Understanding the roles of obesity and intermittent hypoxia in NAFLD is crucial for gaining more knowledge about the health consequences of OSA and devising effective therapeutic strategies.
Article
Biochemistry & Molecular Biology
Fatima O. Martins, Joana F. Sacramento, Elena Olea, Bernardete F. Melo, Jesus Prieto-Lloret, Ana Obeso, Asuncion Rocher, Paulo Matafome, Emilia C. Monteiro, Silvia Conde
Summary: Several studies have shown a connection between obstructive sleep apnea (OSA) and insulin resistance. This study investigated the effects of chronic intermittent hypoxia (CIH) on metabolic deregulation and adipose tissue dysfunction, as well as the impact of obesity on CIH-induced metabolic disturbances. The results suggest that adipose tissue dysfunction may not be the main trigger for initial dysmetabolism in CIH.
Article
Biochemistry & Molecular Biology
Abdelnaby Khalyfa, Wesley Warren, Jorge Andrade, Christopher A. Bottoms, Edward S. Rice, Rene Cortese, Leila Kheirandish-Gozal, David Gozal
Summary: The research evaluated the cellular heterogeneity in visceral white adipose tissues (vWAT) following intermittent hypoxia (IH) exposures mimicking obstructive sleep apnea using single nucleus RNA sequencing. The study revealed transcriptional changes, metabolic signaling pathways, and cellular subpopulation enrichment in vWAT under IH. Different adipocyte types were found to be differentially involved in key aspects of metabolic dysfunction, highlighting the importance of cellular heterogeneity in understanding and potentially targeting metabolic morbidity associated with OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Chunyan Bai, Yingfei Zhu, Qiaoliang Dong, Yuwei Zhang
Summary: Obstructive sleep apnea syndrome (OSAS) is characterized by chronic intermittent hypoxia (CIH), which leads to injuries on renal tubular epithelial cells. The study investigates the effects of CIH on the pyroptosis of renal tubular epithelial cells, showing increased apoptosis rate, thickening of glomerular bottom membrane, and upregulation of NLRP3 inflammasome. The results suggest that CIH triggers pyroptosis by activating the NLRP3 inflammasome in renal tubular epithelial cells.
Article
Critical Care Medicine
Gino S. Panza, Shipra Puri, Ho-Sheng Lin, M. Safwan Badr, Jason H. Mateika
Summary: Daily exposure to mild intermittent hypoxia (MIH) shows beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. This study demonstrates that after 15 days of MIH treatment, participants experienced a reduction in blood pressure, accompanied by increased parasympathetic activity and decreased sympathetic activity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Nutrition & Dietetics
Charlotte Breuillard, Sophie Moulin, Sophie Bouyon, Morgane Couchet, Christophe Moinard, Elise Belaidi
Summary: Obstructive sleep apnea syndrome (OSAS) is associated with chronic intermittent hypoxia (cIH) that causes slight impairment of nutritional status and immunity.
FRONTIERS IN NUTRITION
(2023)
Article
Clinical Neurology
Yajie Zhang, Hong Luo, Yaqiong Niu, Xin Yang, Zhaojie Li, Kun Wang, Huijun Bi, Xiaoyan Pang
Summary: Chronic intermittent hypoxia exposure alters gut microbiota in mice, leading to systemic inflammation and metabolism disorder. Certain bacterial groups are positively correlated with inflammation, while others are negatively correlated. Changes in microbiota mainly impact on bile acid and fatty acid metabolism pathways in response to IH treatment.
Article
Clinical Neurology
Cuilian Weng, Long Huang, Hangwei Feng, Quanying He, Xingsheng Lin, Tingting Jiang, Jian Lin, Xincai Wang, Qinghua Liu
Summary: The study showed that gestational chronic intermittent hypoxia can lead to gestational hypertension, proteinuria, fetal and placental growth restriction, as well as impairments in placental angiogenesis and vascular remodeling.
SLEEP AND BREATHING
(2022)
Article
Gastroenterology & Hepatology
Sha-Sha Tang, Cheng-Hong Liang, Ya-Lei Liu, Wei Wei, Xin-Ru Deng, Xiao-Yang Shi, Li-Min Wang, Li-Jun Zhang, Hui-Juan Yuan
Summary: For T2DM patients with OSAHS, IH may contribute to specific changes in the gut microbiota, which can affect the pathophysiological development of T2DM and its related complications.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Clinical Neurology
Yayong Li, Yuanguo Chen, Jingjie Kuang, Silei Deng, Yina Wang
Summary: In this study, it was found that intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), can induce liver aging through oxidative stress. Antioxidant therapy with tempol effectively mitigated the effects of IH on oxidative stress and aging-related liver injury.
SLEEP AND BREATHING
(2023)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Joel Reiter, Maya Ramagopal, Alex Gileles-Hillel, Erick Forno
Summary: Asthma and sleep disorders are common in children and often coexist, with one potentially influencing the other. Children with asthma may experience complaints of poor sleep quality, insomnia, and daytime sleepiness, while also having higher rates of parasomnias. The bidirectional interaction between sleep-related breathing disorders and asthma may worsen each condition, emphasizing the importance of considering both when managing asthma in children.
PEDIATRIC PULMONOLOGY
(2022)
Article
Respiratory System
Ines Lopez-Alonso, Cecilia Lopez-Martinez, Paula Martin-Vicente, Laura Amado-Rodriguez, Adrian Gonzalez-Lopez, Juan Mayordomo-Colunga, Cecilia del Busto, Marina Bernal, Irene Crespo, Aurora Astudillo, Miguel Arias-Guillen, Antonio Fueyo, Isaac Almendros, Jorge Otero, Hector Sanz-Fraile, Ramon Farre, Guillermo M. Albaiceta
Summary: The study found that mechanical stretch can increase invasiveness of lung cancer cells, which may have clinically relevant consequences. Pharmacological manipulation of cholesterol endocytosis could be a novel therapeutic target in this setting.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Laia Yanez-Bisbe, Anna Garcia-Elias, Marta Tajes, Isaac Almendros, Antonio Rodriguez-Sinovas, Javier Inserte, Marisol Ruiz-Meana, Ramon Farre, Nuria Farre, Begona Benito
Summary: This study found that elderly female mice are more vulnerable to developing HFrEF compared to young animals, and exhibit impaired reverse remodeling with persistent tissue fibrosis and cardiac dysfunction even after beta-adrenergic withdrawal.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Irene Buj-Corral, Hector Sanz-Fraile, Anna Ulldemolins, Aitor Tejo-Otero, Alejandro Dominguez-Fernandez, Isaac Almendros, Jorge Otero
Summary: Three-dimensional printing is revolutionizing scaffold development. This study explores the use of metal-polymer composites as 3D printed scaffolds. The results show that steel-filled PLA polymers are biocompatible and can serve as valid scaffolds for bone tissue engineering.
Article
Cell Biology
Bryan Falcones, Zackarias Soderlund, Arturo Ibanez-Fonseca, Isaac Almendros, Jordi Otero, Ramon Farre, Sara Rolandsson Enes, Linda Elowsson Rendin, Gunilla Westergren-Thorsson
Summary: MSC-based therapies for inflammatory diseases rely on their paracrine ability to modulate macrophage activity. This study found that physiomimetic cultures can alter the secretome of MSCs and influence macrophage activity. Lung-derived hydrogels showed different secretions compared to conventionally cultured samples, and secretome from lung-mimetic environments resulted in decreased phagocytic capacity and M1 subtype of macrophages.
Article
Respiratory System
Carolina Cubillos-Zapata, Miguel Angel Martinez-Garcia, Elena Diaz-Garcia, Sara Garcia-Tovar, Francisco Campos-Rodriguez, Manuel Sanchez-de-la-Torre, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernandez Blasco, Esther Pastor, Jorge Abad-Capa, Josep Maria Montserrat, Valentin Cabriada-Nuno, Irene Cano-Pumarega, Jaime Corral-Penafiel, Eva Arias, Olga Mediano, Maria Somoza-Gonzalez, Joan Dalmau-Arias, Isaac Almendros, Ramon Farre, David Gozal, Francisco Garcia-Rio
Summary: In patients with obstructive sleep apnoea (OSA), high levels of paraspeckle component (PSPC)1 are associated with increased tumor aggressiveness in cutaneous melanoma. Intermittent hypoxia and soluble PSPC1 play a role in promoting epithelial-mesenchymal transition (EMT) and acquisition of cancer stem cell (CSC)-like features in melanoma cells. These findings suggest a potential link between OSA severity, PSPC1 levels, and melanoma aggressiveness.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Pediatrics
Alex Gileles-Hillel, Liora H. Soesman, Silwan Miari, Oded Breuer, Reuven Tsabari, Hila Elyashar-Earon, Shoshana Armoni, Aline B. Sprikkelman, Joel Reiter, David Zangen, Eran Lavi, Eitan Kerem, Malena Cohen-Cymberknoh
Summary: The area under the curve of glucose (G-AUC) obtained during OGTT can identify abnormal glucose metabolism in CF patients who do not meet the diagnostic criteria for CFRD, and this is associated with an increased number of pulmonary exacerbations.
PEDIATRIC PULMONOLOGY
(2022)
Article
Pediatrics
Alex Gileles-Hillel, Limor Yochi Harpaz, Oded Breuer, Joel Reiter, Reuven Tsabari, Eitan Kerem, Malena Cohen-Cymberknoh, Patrick Stafler, Meir Mei-Zahav, Yazeed Toukan, Lea Bentur, David Shoseyov
Summary: This multicenter retrospective analysis suggests that bronchoscopy has a significant impact on treatment decisions for patients with cystic fibrosis, with a considerable proportion of patients experiencing a change in their treatment regimen. There were no serious adverse events reported, indicating that bronchoscopy is a safe procedure. Further studies should explore whether bronchoscopy-guided decision-making can also lead to improvements in clinical outcomes for patients with cystic fibrosis.
PEDIATRIC PULMONOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Constanca Junior, Anna Ulldemolins, Maria Narciso, Isaac Almendros, Ramon Farre, Daniel Navajas, Javier Lopez, Mar Eroles, Felix Rico, Nuria Gavara
Summary: The extracellular matrix (ECM) of the lung, composed mainly of collagens, elastin, and proteoglycans, provides support to lung cells. Aberrant increased deposition of ECM in lung fibrosis changes filament organization and stiffens the ECM, leading to the profibrotic profile of pulmonary cells. The study examines changes in ECM properties during fibrosis development and identifies potential pharmacological targets to hinder its progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tehila Dahan, Shahd Nassar, Olga Yajuk, Eliana Steinberg, Ofra Benny, Nathalie Abudi, Inbar Plaschkes, Hadar Benyamini, David Gozal, Rinat Abramovitch, Alex Gileles-Hillel
Summary: Obstructive sleep apnea (OSA) is a common disease associated with dyslipidemia, insulin resistance, and metabolic syndrome. Brown adipose tissue (BAT) is believed to affect systemic glucose tolerance through adaptive thermogenesis, while chronic hypoxia affects the function and metabolism of BAT. This study shows that chronic hypoxia leads to browning of BAT, but also tissue-specific and systemic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Anna Ulldemolins, Alicia Jurado, Carolina Herranz-Diez, Nuria Gavara, Jorge Otero, Ramon Farre, Isaac Almendros
Summary: Physiomimetic decellularized extracellular matrix-derived hydrogels are an important source of bioactive vesicles that can modulate lung repair. EVs and ECM-vesicles derived from MSCs and L-HG have similar therapeutic capacity in lung repair, but MSCs-derived EVs show higher therapeutic potential.
Article
Pediatrics
Tehila Adler-Haltovsky, Alex Gileles-Hillel, Ira Erlichman, Smadar Eventov-Friedman
Summary: A retrospective study investigated the changes in ventilation modes in preterm neonates over the last decade and their impact on the prevalence of BPD. The study found an increase in noninvasive ventilation rates, but no decrease in the use of invasive ventilation or the prevalence of BPD. The high prevalence of BPD in extreme prematurity remains a significant problem, suggesting the need for additional interventions.
PEDIATRIC PULMONOLOGY
(2023)
Meeting Abstract
Clinical Neurology
J. Reiter, H. Abuelhija, M. Slae, P. Millman, Z. Davidovics, E. Chaimov, A. Gileles-Hillel, M. Wilschanski
JOURNAL OF SLEEP RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
Malena Cohen-Cymberknoh, Maya Lehavi, Ohad Atia, Alex Gileles-Hillel, Joel Reiter
Meeting Abstract
Pediatrics
I Sadras, O. Breuer, E. Kerem, A. Ta-Shma, M. Cohen-Cymberknoh, A. Gileles-Hillel
PEDIATRIC PULMONOLOGY
(2022)
