Article
Endocrinology & Metabolism
Amir Roointan, Saba Shafieizadegan, Maryam Ghaeidamini, Yousof Gheisari, Kelly L. Hudkins, Alieh Gholaminejad
Summary: This meta-analysis investigated the association between the cardiac biomarkers NT-proBNP and TnT with the progression of diabetic nephropathy (DN). It found that higher levels of NT-proBNP and TnT were associated with a higher likelihood of DN progression in diabetic individuals.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Alexandra Kiess, Jessica Green, Anja Willenberg, Uta Ceglarek, Ingo Daehnert, Wieland Kiess, Mandy Vogel
Summary: This study identified age- and sex-dependent interactions between metabolic markers (IGF-1, IGF-BP3, CysC, and HbA1c) and cardiac markers (NT-proBNP and hs-TnT). These associations provide new insights into the understanding of cardiovascular health in children.
ENDOCRINE CONNECTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Peder L. Myhre, Helge Rosjo, Sebastian Sarvari, Heikki Ukkonen, Frank Rademakers, Jan E. Engvall, Tor-Arne Hagve, Eike Nagel, Rosa Sicari, Jose L. Zamorano, Mark Monaghan, Jan D'hooge, Thor Edvardsen, Torbjorn Omland
Summary: This study found that NT-proBNP and cTnT are associated with reversible and irreversible ischemia in patients with chronic coronary syndrome, particularly with reversible hypokinesis. The diagnostic performance of both biomarkers is comparable, and very low concentrations can reliably rule out ischemia.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shoko Aoki, Kazumasa Yamagishi, Tomomi Kihara, Mari Tanaka, Hironori Imano, Isao Muraki, Yuji Shimizu, Mina Hayama-Terada, Mitsumasa Umesawa, Tomoko Sankai, Takeo Okada, Akihiko Kitamura, Masahiko Kiyama, Hiroyasu Iso
Summary: This retrospective cohort study in Japan aimed to identify risk factors for pre-heart failure or symptomatic heart failure based on NT-proBNP levels. The results showed that factors such as body mass index, blood pressure, diabetes, and smoking are associated with a higher risk of heart failure.
Article
Cardiac & Cardiovascular Systems
Alexandra Kiess, Jessica Green, Anja Willenberg, Uta Ceglarek, Ingo Daehnert, Anne Jurkutat, Antje Koerner, Andreas Hiemisch, Wieland Kiess, Mandy Vogel
Summary: This study aimed to provide reliable pediatric reference values for NT-proBNP and hsTnT, and investigate their associations with sex, pubertal status, BMI, and serum lipid levels. The results showed that NT-proBNP values decreased with age and were strongly associated with BMI and serum lipids. For hsTnT levels, approximately half of the measurements were below the detection limit, with age and gender differences.
PEDIATRIC CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Emanuel Matusch, Mirjam Frank, Kaffer Kara, Amir A. Mahabadi, Nico Dragano, Raimund Erbel, Karl-Heinz Joeckel, Boerge Schmidt
Summary: This study aimed to explore the interaction between cardiovascular risk factors and NT-proBNP genetic effects, and found that the genetic effects of NT-proBNP increasing alleles are stronger in higher SEP groups.
SCIENTIFIC REPORTS
(2022)
Article
Medical Laboratory Technology
Moises Rodriguez-Gonzalez, Lorena Estepa-Pedregosa, Ana Estalella-Mendoza, Ana Castellano-Martinez, Patricia Rodriguez-Campoy, Jose Carlos Flores-Gonzalez
Summary: In infants with bronchiolitis, elevated NT-proBNP but not hs-cTnI is associated with disease severity, need for PICU admission, and echocardiographic cardiac dysfunction, suggesting that NT-proBNP may be a useful biomarker for myocardial strain in this population.
CLINICA CHIMICA ACTA
(2021)
Article
Cardiac & Cardiovascular Systems
Giuseppe Vergaro, Francesco Gentile, Alberto Aimo, James L. Januzzi, A. Mark Richards, Carolyn S. P. Lam, Rudolf A. Boer, Laura M. G. Meems, Roberto Latini, Lidia Staszewsky, Inder S. Anand, Jay N. Cohn, Thor Ueland, Lars Gullestad, Pal Aukrust, Hans-Peter Brunner-La Rocca, Antoni Bayes-Genis, Josep Lupon, Akiomi Yoshihisa, Yasuchika Takeishi, Michael Egstrup, Ida Gustafsson, Hanna K. Gaggin, Kai M. Eggers, Kurt Huber, Greg D. Gamble, Lieng H. Ling, Kui Toh Gerard Leong, Poh Shuah Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze P. Ng, Richard Troughton, Robert N. Doughty, Gerry Devlin, Mayanna Lund, Alberto Giannoni, Claudio Passino, Michele Emdin
Summary: This study aims to investigate the plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression of tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with chronic heart failure (HF). The results showed that women had lower concentrations of sST2 and hs-cTnT, while the NT-proBNP concentrations remained similar. The use of sex-specific cut-offs improved risk prediction, especially for hs-cTnT, and allowed for better risk reclassification.
Article
Cardiac & Cardiovascular Systems
Karola S. Jering, Brian L. Claggett, Marc A. Pfeffer, Christopher B. Granger, Lars Kober, Eldrin F. Lewis, Aldo P. Maggioni, Douglas L. Mann, John J. V. McMurray, Margaret F. Prescott, Jean L. Rouleau, Scott D. Solomon, Phillippe Gabriel Steg, Dirk von Lewinski, Eugene Braunwald
Summary: NT-proBNP is an important prognostic factor in patients with acute myocardial infarction and certain risk factors. It is associated with heart failure, death, and atherosclerotic events, and this predictive information is independent of hs-cTnT.
CIRCULATION-HEART FAILURE
(2023)
Article
Medicine, General & Internal
Carmen-Ioana Marta, Anca Laura Maghiari, Elena Bernad, Lavinia Stelea, Brenda Bernad, Lioara Boscu, Radu Neamtu, Adrian Gluhovschi, Mircea Diaconu, Catalin Dumitru, Bogdan Sorop, Katalin Babes
Summary: This study compares NT-proBNP levels between pregnant patients with SARS-CoV-2 infection and cardiovascular risk factors and low-risk pregnant patients, finding higher levels in the former group. This suggests that NT-proBNP can be a relatively important marker to consider in the management and treatment of these cases.
Article
Cardiac & Cardiovascular Systems
Jacopo Sabbatinelli, Angelica Giuliani, Anna Rita Bonfigli, Deborah Ramini, Giulia Matacchione, Carla Campolucci, Artan Ceka, Elena Tortato, Maria Rita Rippo, Antonio Domenico Procopio, Marco Moretti, Fabiola Olivieri
Summary: sST2, hs-cTnI, and NT-proBNP are associated with 15-year mortality and onset of CV events in T2DM.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Laia C. Belarte-Tornero, Sandra Valdivielso-More, Miren Vicente Elcano, Eduard Sole-Gonzalez, Sonia Ruiz-Bustillo, Alicia Calvo-Fernandez, Isaac Subinara, Paula Cabero, Cristina Soler, Hector Cubero-Gallego, Beatriz Vaquerizo, Nuria Farre
Summary: The study found that all-cause mortality was higher in CHF patients hospitalized due to SARS-CoV-2 infection, and pre-existing CHF was independently associated with a higher risk of 30-day mortality. High-sensitivity troponin T and NT-proBNP levels may have guiding implications for prognosis in CHF patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Fang Zhu, Banafsheh Arshi, Maarten J. G. Leening, Elif Aribas, M. Arfan Ikram, Eric Boersma, M. Kamran Ikram, Maryam Kavousi
Summary: This study aimed to evaluate the sex-specific predictive value of NT-proBNP, hs-cTnT, and CK-MB for 10-year risk prediction of CHD, stroke, HF, and composite outcomes. The results showed that NT-proBNP and hs-cTnT provided added predictive value for various cardiovascular outcomes above traditional risk factors and there were sex differences in the predictive performance of these biomarkers.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Clinical Neurology
Jorge Pagola, Jesus Juega, Jaume Francisco-Pascual, Alejandro Bustamante, Anna Penalba, Elena Pala, Maite Rodriguez, Mercedes De Lera-Alfonso, Juan F. Arenillas, Juan Antonio Cabezas, Francisco Moniche, Reyes de Torres, Joan Montaner, Teresa Gonzalez-Alujas, Jose Alvarez-Sabin, Carlos A. Molina
Summary: The study aimed to determine markers of atrial dysfunction in patients with cryptogenic stroke to predict episodes of paroxysmal atrial fibrillation with high risk of embolization. The results showed that the combination of age and PALS, NT-proBNP can independently predict paroxysmal atrial fibrillation, and the validity of PALS and NT-proBNP in detecting patients at risk of HpAF was higher than age.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Medical Laboratory Technology
Meraj Neyazi, Jan P. Bremer, Marius S. Knorr, Stefan Gross, Jan Brederecke, Nils Schweingruber, Dora Csengeri, Benedikt Schrage, Martin Bahls, Nele Friedrich, Tanja Zeller, Stephan Felix, Stefan Blankenberg, Marcus Doerr, Marcus Vollmer, Renate B. Schnabel
Summary: This study developed a deep learning model to predict serum levels of NT-proBNP from ECG, aiming to reliably identify individuals at risk for cardiovascular disease (CVD). Validation studies conducted in population-based cohorts demonstrated that the model has high diagnostic and predictive value for heart failure (HF) and other major CVD, making it a valuable tool for identifying high-risk individuals.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Amit Saha, Kershaw Patel, Colby Ayers, Christie M. Ballantyne, Adolfo Correa, Christopher Defilippi, Michael E. Hall, Robert J. Mentz, Stephen L. Seliger, Wondwosen Yimer, Javed Butler, Jarett D. Berry, James A. De Lemos, Ambarish Pandey
Summary: Among Black adults, persistent or worsening levels of cardiac troponin I (hs-cTnI) are associated with an increased risk of heart failure (HF). Participants with incident, stable or improved, or worsened hs-cTnI elevation had higher HF risk compared to those without elevated hs-cTnI.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Miller, Deepak L. Bhatt, Ph Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Lixia Jiao, Jean-Claude Tardif, Christie M. Ballantyne, Matthew Budoff, R. Preston Mason
Summary: The study found that the use of IPE can reduce the risk of cardiovascular disease in smokers to the level observed in non-smokers.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Peripheral Vascular Disease
Matthew F. Blum, Jingsha Chen, Aditya Surapaneni, Stephen T. Turner, Christie M. Ballantyne, Paul A. Welling, Anna Koettgen, Josef Coresh, Deidra C. Crews, Morgan E. Grams
Summary: This study investigated the association of renin with adverse kidney outcomes and compared different measurement strategies. The results showed that renin levels measured by SomaScan modified nucleotide aptamer assay were predictive of chronic kidney disease, end-stage kidney disease, and mortality. The SomaScan measurement was moderately correlated with plasma renin activity and highly correlated with renin level from Olink.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Urology & Nephrology
Donghai Wen, Linda Zhou, Zihe Zheng, Aditya Surapaneni, Christie M. Ballantyne, Ron C. Hoogeveen, Michael G. Shlipak, Sushrut S. Waikar, Ramachandran S. Vasan, Paul L. Kimmel, Ruth F. Dubin, Rajat Deo, Harold I. Feldman, Peter Ganz, Josef Coresh, Morgan E. Grams, Eugene P. Rhee
Summary: Testican-2, a protein released into circulation by the kidneys, is positively correlated with eGFR and eGFR slope. However, it is unknown whether higher testican-2 levels are associated with lower risk of ESKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Medical Laboratory Technology
Seyedmohammad Saadatagah, Christie M. Ballantyne
Summary: Age is a crucial risk factor for cardiovascular disease, as genetic mutations occur with aging, leading to somatic mosaicism. Clonal hematopoiesis resulting from somatic mutations, known as CHIP, has been associated with an increased risk of cardiovascular disease. Recent advances in exome-sequencing projects have enabled the study of CHIP frequency, gene-specific analyses, and potential therapeutic implications for preventing cardiovascular disease.
TRANSLATIONAL RESEARCH
(2023)
Article
Medical Laboratory Technology
Mary R. Rooney, Jingsha Chen, Christie M. Ballantyne, Ron C. Hoogeveen, Olive Tang, Morgan E. Grams, Adrienne Tin, Chiadi E. Ndumele, Faiez Zannad, David J. Couper, Weihong Tang, Elizabeth Selvin, Josef Coresh
Summary: Comparisons of highly multiplexed aptamer-based and proximity-extension immunoassays revealed variations in protein measurements. Furthermore, comparisons between SomaScan and targeted immunoassays showed varying degrees of correlation for different proteins. These findings highlight the importance of considering measurement techniques in protein quantification studies.
CLINICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Anandita Agarwala, Elena Deych, Laney K. Jones, Amy C. Sturm, Karen Aspry, Zahid Ahmad, Christie M. Ballantyne, Anne C. Goldberg
Summary: This study retrospectively examined the burden and risk factors of premature ASCVD in men and women with FH. The results showed a high prevalence of premature ASCVD in both genders, and significant differences were observed in predictive factors and lipid treatment outcomes for women with premature ASCVD.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mini G. Varughese, Matthew R. Deshotels, Lilei Zhang, Christie M. Ballantyne
Summary: A 20-year-old male presented with severe elevation in low-density lipoprotein cholesterol (LDL-C) and was initially tested negative for familial hypercholesterolemia. Further genetic testing revealed homozygous variants in the ALB gene, indicating congenital analbuminemia (CAA) as the cause of severe hyperlipidemia. CAA is a rare autosomal recessive disorder with a frequency of about 1:1,000,000. Pathological variants in the ALB gene disrupt albumin synthesis and can lead to gross hyperlipidemia and hypercholesterolemia. Early diagnosis through genetic examination is crucial for initiating lipid-lowering treatments and preventing premature coronary artery disease.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Letter
Cardiac & Cardiovascular Systems
Salim S. S. Virani, David J. J. Ramsey, Dax Westerman, Mark K. K. Kuebeler, Liang Chen, Julia M. M. Akeroyd, Glenn T. T. Gobbel, Christie M. M. Ballantyne, Laura A. A. Petersen, Alexander Turchin, Michael E. E. Matheny
Letter
Cardiac & Cardiovascular Systems
Yiyi Zhang, Jacqueline S. Dron, Brandon K. Bellows, Amit V. Khera, Junxiu Liu, Pallavi P. Balte, Elizabeth C. Oelsner, Sami Samir Amr, Matthew S. Lebo, Anna Nagy, Gina M. Peloso, Pradeep Natarajan, Jerome I. Rotter, Cristen Willer, Eric Boerwinkle, Christie M. Ballantyne, Pamela L. Lutsey, Myriam Fornage, Donald M. Lloyd-Jones, Lifang Hou, Bruce M. Psaty, Joshua C. Bis, James S. Floyd, Ramachandran S. Vasan, Nancy L. Heard-Costa, April P. Carson, Michael E. Hall, Stephen S. Rich, Xiuqing Guo, Dhruv S. Kazi, Sarah D. de Ferranti, Andrew E. Moran
Article
Cardiac & Cardiovascular Systems
Nicolas Girerd, Daniel Levy, Kevin Duarte, Joao Pedro Ferreira, Christie Ballantyne, Timothy Collier, Anne Pizard, Jens Bjoerkman, Javed Butler, Andrew Clark, John G. Cleland, Christian Delles, Javier Diez, Arantxa Gonzalez, Mark Hazebroek, Jennifer Ho, Anne-Cecile Huby, Shih-Jen Hwang, Roberto Latini, Beatrice Mariottoni, Alexandre Mebazaa, Pierpaolo Pellicori, Naveed Sattar, Peter Sever, Jan A. Staessen, Job Verdonschot, Stephane Heymans, Patrick Rossignol, Faiez Zannad
Summary: This study identified protein biomarkers associated with new-onset heart failure in three independent cohorts. The inclusion of these biomarkers in addition to clinical risk factors improved the prediction of heart failure risk. The B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide were found to be particularly relevant in predicting heart failure.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoming Jia, Leo Buckley, Caroline Sun, Mahmoud Al Rifai, Bing Yu, Vijay Nambi, Salim S. Virani, Elizabeth Selvin, Kunihiro Matsushita, Ron C. Hoogeveen, Josef Coresh, Amil M. Shah, Christie M. Ballantyne
Summary: Higher levels of interleukin-6 and interleukin-18 in older adults are associated with an increased risk of global cardiovascular disease (including coronary heart disease, stroke, and heart failure) and death. The association between interleukin-6 and global cardiovascular disease is stronger than that for interleukin-18, and remains significant even after adjustments for other biomarkers.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Mathews, Xiao Hu, Ning Ding, Junichi Ishigami, Mahmoud Al Rifai, Ron C. C. Hoogeveen, Josef Coresh, Christie M. M. Ballantyne, Elizabeth Selvin, Kunihiro Matsushita
Summary: A study on 9205 participants from the ARIC study found that higher levels of GDF15 protein were associated with bleeding events and improved the prediction of bleeding risk in individuals without cardiovascular disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Marina Cuchel, Paul C. Lee, Lisa C. Hudgins, P. Barton Duell, Zahid Ahmad, Seth J. Baum, MacRae F. Linton, Sarah D. de Ferranti, Christie M. Ballantyne, John A. Larry, Linda C. Hemphill, Iris Kindt, Samuel S. Gidding, Seth S. Martin, Patrick M. Moriarty, Paul P. Thompson, James A. Underberg, John R. Guyton, Rolf L. Andersen, David J. Whellan, Irwin Benuck, John P. Kane, Kelly Myers, William Howard, David Staszak, Allison Jamison, Mary C. Card, Mafalda Bourbon, Joana R. Chora, Daniel J. Rader, Joshua W. Knowles, Katherine Wilemon, Mary P. McGowan
Summary: This study investigated the diagnosis and treatment of HoFH in the United States and found a low diagnosis rate and low treatment rate, highlighting the need for enhanced screening and treatment to reduce the burden of the disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)