Review
Allergy
Xinni Xu, Sietze Reitsma, De Yun Wang, Wytske J. Fokkens
Summary: Endotyping is now favored over phenotype-based classifications in the management of Chronic Rhinosinusitis (CRS), particularly in challenging cases with nasal polyposis. The latest update from EPOS2020 includes revised classifications and care pathways for rhinosinusitis. Balancing the responsibility of managing patients' upper airway while protecting themselves from droplet and aerosol transmission is crucial for physicians and rhinologists during the COVID-19 pandemic.
Article
Otorhinolaryngology
Vidit M. Talati, Hannah J. Brown, Young-Jae Kim, Mary K. Allen-Proctor, Paolo Gattuso, Mahboobeh Mahdavinia, Peter Papagiannopoulos, Pete Batra, Bobby A. Tajudeen
Summary: This retrospective study examined the impact of diabetes mellitus on chronic rhinosinusitis clinically and on structured histopathology. The findings suggest that diabetic patients with chronic rhinosinusitis have increased fungal elements on histopathology. This has important implications for the management of diabetic patients with chronic rhinosinusitis.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Lauren T. Roland, Alan Regenberg, Amber U. Luong, Sarah K. Wise, Elina Toskala, Kent K. Lam, Joshua M. Levy, Christine B. Franzese, Kristine Smith, Jean Kim
Summary: Biologics have been approved for use in chronic rhinosinusitis with nasal polyps patients, showing effectiveness in controlling the disease in both subjective and objective short-term outcomes. However, the high costs of biologics may pose a burden for the healthcare system with widespread and prolonged use. Cost-effectiveness analyses are needed to determine appropriate usage, along with addressing patient preferences, counseling on side effects, and healthcare economics.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Review
Allergy
Stephanie Shintani Smith, Raymond Kim, Richard Douglas
Summary: This review article examines the rationale for and against the use of antibiotics for treating chronic rhinosinusitis, based on current evidence and understanding of pathophysiology. It also summarizes the current guidelines.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jae Min Shin, Hyun Woo Yang, Jae Hyung Park, Tae Hoon Kim
Summary: Chronic rhinosinusitis (CRS) is a complex inflammatory disease affecting the nose and sinuses, with a prevalence of over 10% in adults globally. Different subtypes of CRS have been identified based on inflammatory response and immune cell distribution. CRS leads to tissue remodeling, characterized by extracellular matrix accumulation, immune cell infiltration, and epithelial changes. Nasal fibroblasts play a crucial role in tissue remodeling and wound healing. This review explores recent advancements in understanding the modulation of tissue remodeling by nasal fibroblasts in CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Concepcio Marin, Thomas Hummel, Zheng Liu, Joaquim Mullol
Summary: The COVID-19 pandemic has increased awareness of olfactory dysfunction, with chronic rhinosinusitis being one of the common causes. However, there is still limited scientific information about chronic rhinosinusitis in the context of COVID-19. This review focuses on the potential effects of COVID-19 on chronic rhinosinusitis symptoms, diagnosis, and treatment options.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Allergy
Tim Delemarre, Bruce S. Bochner, Hans-Uwe Simon, Claus Bachert
Summary: Chronic rhinosinusitis is often characterized by eosinophilic inflammation, but a third of patients have mucosal inflammation dominated by neutrophils. Understanding the interactions between eosinophilic and neutrophilic inflammation in pathophysiology, as well as the mixed presentation in patients with severe type 2 CRS with nasal polyps, is crucial for treatment.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Annina Wuokko-Landen, Karin Blomgren, Anni Suomalainen, Hannamari Valimaa
Summary: The study found that odontogenic causes are often overlooked in diagnosing chronic rhinosinusitis (CRS), highlighting the need for routine assessment of patients' dental history, careful radiograph evaluation, utilization of microbial findings, and close cooperation with dentists to provide adequate treatment.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Otorhinolaryngology
Lillian W. Dattilo, Alan D. Workman, Neil Bhattacharyya
Summary: The study shows a significant association between chronic rhinosinusitis and erectile dysfunction, which remains even when the interval between diagnosis and treatment is restricted. This adds to the literature demonstrating the link between chronic rhinosinusitis and sexual dysfunction.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Allergy
Yibo Liang, Runxiang Xie, Xin Xiong, Zhanjun Hu, Xiang Mao, Xiaoyu Wang, Jinmei Zhang, Peiyong Sun, Zhenzhong Yue, Wei Wang, Guimin Zhang
Summary: This study aimed to investigate the dysbiosis of nasal microbiome in patients with eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). The results show that the nasal microbiome of eCRSwNP patients has higher a-diversity and a distinct composition of microbes. These differences can be used to distinguish eCRSwNP patients from healthy controls, suggesting the potential of using the nasal microbiota as a noninvasive predictive classifier for the diagnosis of eCRSwNP.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
M. De Filippo, M. Votto, M. Benazzo, E. Gitto, A. Salpietro, F. Pagella, A. Licari, G. L. Marseglia
Summary: Chronic rhinosinusitis is a heterogeneous chronic inflammatory condition that requires a multidisciplinary approach for evaluation and treatment. Only two biologicals have been approved for severe CRS with nasal polyps in adults, and clinical trials for children and adolescents are needed to confirm their efficacy and safety.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Jong-Gyun Ha, Hyung-Ju Cho
Summary: This review provides a comprehensive understanding of the significance of nasal epithelial cells in chronic rhinosinusitis (CRS). Recent research has highlighted the role of epithelial dysfunction in the development of CRS through various mechanisms, including weakened barrier function, impaired mucociliary clearance, and irregular immune responses. Understanding the role of epithelial cells can enhance our knowledge of the disease's pathogenesis and offer insights for new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Jacek Brzost, Katarzyna Czerwaty, Karolina Dzaman, Nils Ludwig, Katarzyna Piszczatowska, Miroslaw J. Szczepanski
Summary: The recent classification of chronic rhinosinusitis (CRS) focuses on studying the underlying immunopathophysiological mechanisms. The treatment selection depends on the immunotype dominance, and endoscopic sinus surgery is conducted when drug therapy fails. Aspirin treatment after desensitization is an option for NSAID-exacerbated respiratory disease (N-ERD) patients. This review highlights the role of monoclonal antibodies as a biological treatment for CRS and presents potential targets for immunotherapy.
Article
Medicine, Research & Experimental
Eva C. Meier, Stefanie L. Terryn, Gregori H. A. Binz, Christian M. Meerwein, Michael B. Soyka
Summary: This study found that the total number of ethmoid cells (EC) in patients with chronic rhinosinusitis (CRS) was significantly higher compared to healthy controls and odontogenic CRS patients, suggesting a potential contribution of cell count to the pathogenesis of CRS.
Review
Immunology
Oghenefejiro Okifo, Amrita Ray, David A. Gudis
Summary: This study aims to characterize the microbiome associated with acute exacerbations in chronic rhinosinusitis by conducting a systematic review of the literature. Understanding the underlying microbiology and clinical characteristics can help in targeted antibiotic therapy, reducing antibiotic resistance, and improving disease control and treatment efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
