Review
Critical Care Medicine
Zaccaria Ricci, Stefano Romagnoli, Thiago Reis, Rinaldo Bellomo, Claudio Ronco
Summary: This narrative review provides an overview of the current knowledge regarding technical concepts, safety, and clinical results of hemoperfusion. It also focuses on the most recent literature on adsorption applied in critically ill patients, including randomized controlled trials, and future areas of investigation.
INTENSIVE CARE MEDICINE
(2022)
Article
Medical Laboratory Technology
Yuichiro Shimoyama, Noriko Kadono, Osamu Umegaki, Toshiaki Minami
Summary: The combination of NGAL and ΔNGAL with inflammation-based prognostic scores provides better prediction of mortality in septic patients, particularly on day 2 after ICU admission and beyond.
CLINICA CHIMICA ACTA
(2021)
Article
Pharmacology & Pharmacy
Juan Carlos Ayala, Adriana Grismaldo, Andres Felipe Aristizabal-Pachon, Elizaveta Mikhaylenko, Vladimir N. Nikolenko, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland, Gjumrakch Aliev, Ludis Morales
Summary: The study revealed a significant increase in reactive oxygen species and mitochondrial oxygen consumption in critically ill patients immediately after exposure to pathogen-associated molecular patterns/damage-associated molecular patterns. However, there were no significant changes in mitochondrial membrane potential. A strong correlation between C-reactive protein and central venous saturation was observed, indicating that clinical markers of inflammation can indirectly evaluate mitochondrial function.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Gastroenterology & Hepatology
Anna DeVeaux, Jian Ryou, Gautam Dantas, Barbara B. Warner, Phillip I. Tarr
Summary: Microbiome-targeting therapies, such as probiotics and prebiotics, have shown mixed results in preventing diseases in preterm infants. While they are generally considered safe, there is uncertainty regarding their effectiveness in neonatal intensive care units. Recent comprehensive meta-analyses highlight limitations in the trials supporting the routine use of probiotics, making it challenging to confidently recommend their universal administration to preterm infants.
Article
Hematology
Eric Mariotte, Lara Zafrani, Jehane Fadlallah, Lionel Galicier, Etienne Ghrenassia, Lionel Kerhuel, Laure Calvet, Audrey De Jong, Virginie Lemiale, Sandrine Valade, Berangere S. Joly, Alain Stepanian, Elie Azoulay, Michael Darmon
Summary: This study evaluated the accuracy of diagnostic scores for thrombotic thrombocytopenic purpura (TTP) in an intensive care unit (ICU) setting, finding that platelet count could be similarly used to differentiate TTP from non-TTP patients as the Coppo score.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Infectious Diseases
Cecilia Herbozo, Irene Julca, Fiorella Flores, Roger Hernandez, Jaime Zegarra
Summary: This study aimed to determine the incidence of late onset sepsis and the most frequent causative microorganisms in the neonatal unit at Hospital Cayetano Heredia in Lima, Peru. The results showed that late onset sepsis was more prevalent in low birth weight infants, with gram-negative bacteria being the main causative microorganism in very low birth weight infants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Drew J. Schwartz, Nitan Shalon, Kate Wardenburg, Anna DeVeaux, Meghan A. Wallace, Carla Hall-Moore, I. Malick Ndao, Janice E. Sullivan, Paula Radmacher, Marilyn Escobedo, Carey-Ann D. Burnham, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas
Summary: BSI in preterm infants is commonly transmitted through the gut microbiome and is associated with antibiotic exposure. Ampicillin, gentamicin, or vancomycin can increase the abundance of Enterobacteriaceae and Enterococcaceae in the gut of preterm infants. This study suggests that the microbial composition of the gut can be utilized to predict the risk of BSI in hospitalized preterm infants.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Critical Care Medicine
Geoffroy Hariri, Vincent Belossi, Louis Perol, Louai Missri, Paul Gabarre, Vincent Bonny, Tomas Urbina, Jean-Luc Baudel, Bertrand Guidet, Jeremie Joffre, Eric Maury, Guillaume Dumas, Hafid Ait-Oufella
Summary: This study found that plasma urea levels and the presence of skin purpura are helpful in identifying thrombocytopenic patients at high-risk of bleeding during ICU stay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Multidisciplinary Sciences
Jan Heil, Martin Schlapfer
Summary: The article introduces a simple, reliable, and reproducible animal model for sepsis treatment research. The model operates based on strict protocols to simulate the process of infection treatment in clinical intensive care units.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Critical Care Medicine
Damien Contou, Gaetan Beduneau, Charlotte Rabault, Romain Sonneville, Antoine Marchalot, Remi Coudroy, Damien Roux, Martin Cour, Julien Massol, Sebastien Preau, Nicolas de Prost
Summary: This study aimed to assess the sensitivity of skin biopsy in adult patients with meningococcal purpura fulminans. The results showed that skin biopsy combined with conventional culture and meningococcal PCR had a global sensitivity of 88%, and should be considered even after the initiation of antimicrobial treatment.
Article
Surgery
Jordan Rosales, Megan Ireland, Kathia Gonzalez-Gallo, Jon Wisler, Anahita Jalilvand
Summary: This study investigated the association between sepsis sources and cumulative 90-day mortality in surgical patients admitted to the surgical intensive care unit. The results showed that urologic infections were an independent negative predictor of 90-day mortality compared to other sources of sepsis.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Immunology
Kathleen Chiotos, Jennifer Blumenthal, Juri Boguniewicz, Debra L. Palazzi, Erika L. Stalets, Jessica H. Rubens, Pranita D. Tamma, Stephanie S. Cabler, Jason Newland, Hillary Crandall, Emily Berkman, Robert P. Kavanagh, Hannah R. Stinson, Jeffrey S. Gerber
Summary: In a multicenter study of pediatric intensive care unit patients, it was found that the majority of patients receive antibiotics. However, based on the results of this study, it is estimated that one-third of antibiotic orders are inappropriate.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Jorge W. Velez, Davi C. Aragon, Eduardo A. Donadi, Ana P. C. P. Carlotti
Summary: This study investigated risk factors for mortality from sepsis in an ICU in Quito-Ecuador and found that multiple organ dysfunction, successful early resuscitation, and appropriate antibiotic treatment were protective factors for reducing sepsis mortality.
Review
Cardiac & Cardiovascular Systems
Yichi Zhang, Michael T. McCurdy, Jonathan Ludmir
Summary: The management of septic shock in the cardiac intensive care unit (CICU) is challenging due to the complex interaction of pathophysiology between vasodilatory and cardiogenic shock. Familiarity with contemporary clinical evidence is crucial for addressing the wide range of complications that can arise.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Trinh Manh Hung, Nguyen Van Hao, Lam Minh Yen, Angela McBride, Vu Quoc Dat, H. Rogier van Doorn, Huynh Thi Loan, Nguyen Thanh Phong, Martin J. Llewelyn, Behzad Nadjm, Sophie Yacoub, C. Louise Thwaites, Sayem Ahmed, Nguyen Van Vinh Chau, Hugo C. Turner
Summary: This study investigates the direct medical costs of patients with key infectious diseases (tetanus, sepsis, and dengue) admitted to the ICU in a hospital in Ho Chi Minh City, Vietnam. It explores the variation in costs and cost drivers between different diseases.
FRONTIERS IN PUBLIC HEALTH
(2022)
Letter
Genetics & Heredity
Pauline Bataille, Vincent Michaud, Matthieu P. Robert, Lilia Bekel, Stephanie Leclerc-Mercier, Annie Harroche, Charlotte Celerier, Eulalie Lasseaux, Delphine Borgel, Dominique Bremond-Gignac, Christine Bodemer, Benoit Arveiler, Smail Hadj-Rabia
Article
Microbiology
Alberto J. Martin-Rodriguez, Mikael Rhen, Keira Melican, Agneta Richter-Dahlfors
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Chemistry, Analytical
Martial Rey, Jonathan Dhenin, Youxin Kong, Lucienne Nouchikian, Isaac Filella, Magalie Duchateau, Mathieu Dupre, Riccardo Pellarin, Guillaume Dumenil, Julia Chamot-Rooke
Summary: The study developed an advanced in vivo cross-linking mass spectrometry platform for investigating cellular interactome of living bacterial cells. The approach successfully captured and characterized highly dynamic multiprotein complexes in all bacterial compartments, demonstrating the potential and precision of the proteome-wide approach.
ANALYTICAL CHEMISTRY
(2021)
Article
Hematology
Marion Egot, Dominique Lasne, Sonia Poirault-Chassac, Tristan Mirault, Dominique Pidard, Elise Dreano, Caroline Elie, Sophie Gandrille, Aurore Marchelli, Dominique Baruch, John Rendu, Julien Faure, Claire Flaujac, Marie-Pierre Gratacap, Pierre Sie, Pascale Gaussem, Remi Salomon, Genevieve Baujat, Christilla Bachelot-Loza
Summary: This study reveals that a deficiency in the OCRL protein results in abnormal actomyosin cytoskeleton reorganization in both platelets and megakaryocytes in patients with Lowe syndrome, affecting both thrombopoiesis and platelet responses to activation essential for hemostasis.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Letter
Hematology
Ladislas Capdevila, Delphine Borgel, Dominique Lasne, Sebastien Lacroix-Desmazes, Maximilien Desvages, Sandrine Delignat, Cecile Bally, Laurent Frenzel, Annie Harroche
Article
Materials Science, Multidisciplinary
Jill Ziesmer, Poojabahen Tajpara, Nele-Johanna Hempel, Marcus Ehrstrom, Keira Melican, Liv Eidsmo, Georgios A. Sotiriou
Summary: A microneedle array with a water-insoluble support layer has been developed for controlled delivery of vancomycin into the skin, showing promising results in reducing local drug concentration issues and systemic exposure risks.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Multidisciplinary Sciences
Valeria Manriquez, Pierre Nivoit, Tomas Urbina, Hebert Echenique-Rivera, Keira Melican, Marie-Paule Fernandez-Gerlinger, Patricia Flamant, Taliah Schmitt, Patrick Bruneval, Dorian Obino, Guillaume Dumenil
Summary: Neisseria meningitidis colonizes blood vessels and hinders the effective action of neutrophils, leading to immune escape and infection progression.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Remy Robinot, Mathieu Hubert, Guilherme Dias de Melo, Francoise Lazarini, Timothee Bruel, Nikaia Smith, Sylvain Levallois, Florence Larrous, Julien Fernandes, Stacy Gellenoncourt, Stephane Rigaud, Olivier Gorgette, Catherine Thouvenot, Celine Trebeau, Adeline Mallet, Guillaume Dumenil, Samy Gobaa, Raphael Etournay, Pierre-Marie Lledo, Marc Lecuit, Herve Bourhy, Darragh Duffy, Vincent Michel, Olivier Schwartz, Lisa A. Chakrabarti
Summary: Understanding how SARS-CoV-2 spreads within the respiratory tract is crucial in determining the severity of COVID-19. This study shows that SARS-CoV-2 infection leads to rapid loss of airway motile cilia, affecting cilia clearance function, with reduced expression of the ciliogenesis regulator Foxj1 preceding cilia loss. Further analysis in Syrian hamsters confirms the loss of motile cilia in vivo.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Svava E. Steiner, Ferdinand X. Choong, Haris Antypas, Carlos E. Morado-Urbina, Anette Schulz, Alex Bersellini Farinotti, Duygu B. Bas, Camilla I. Svensson, Agneta Richter-Dahlfors, Keira Melican
Summary: The study demonstrates the important role of neuro-immune communication in modulating inflammation during the initial stages of a bacterial infection. Nerve signaling triggers IFN-γ response in the spleen within 4 hours of infection, leading to systemic modulation of inflammation. This highlights the potential of nerves in monitoring and modulating the immune response during the early hours of infection.
Article
Medical Laboratory Technology
Alexandre Raynor, Walid Haouari, Bobby G. Ng, Sophie Cholet, Annie Harroche, Celia Raulet-Bussian, Samra Lounis-Ouaras, Sandrine Vuillaumier-Barrot, Tiffany Pascreau, Delphine Borgel, Hudson H. Freeze, Francois Fenaille, Arnaud Bruneel
Summary: SLC37A4-CDG is an emerging congenital disorder of glycosylation characterized by a major coagulopathy originating from the liver. Recent studies have revealed multiple glycosylation abnormalities in this CDG, which could be crucial for diagnosing the disease effectively.
CLINICA CHIMICA ACTA
(2021)
Article
Hematology
Elsa Bianchini, Claire Auditeau, Delphine Borgel
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemical Research Methods
Dmitry Ershov, Minh-Son Phan, Joanna W. Pylvanainen, Stephane U. Rigaud, Laure Le Blanc, Arthur Charles-Orszag, James R. W. Conway, Romain F. Laine, Nathan H. Roy, Daria Bonazzi, Guillaume Dumenil, Guillaume Jacquemet, Jean-Yves Tinevez
Summary: TrackMate is an automated tracking software that is used for analyzing bioimages. The new version, TrackMate 7, addresses modern research challenges by integrating advanced segmentation algorithms into tracking pipelines. This new version demonstrates its effectiveness across a wide range of bio-imaging experiments, combining machine and deep learning-based image segmentation with accurate object tracking for improved 2D and 3D tracking in biological research.
Article
Microbiology
Ferdinand X. Choong, Smilla Huzell, Ming Rosenberg, Johannes A. Eckert, Madhu Nagaraj, Tianqi Zhang, Keira Melican, Daniel E. Otzen, Agneta Richter-Dahlfors
Summary: Biofilms allow bacteria to colonize various environments, and optotracing is a new method for monitoring biofilm growth in real-time, aiding in understanding the formation and development of bacterial biofilms.
Article
Biology
Daria Bonazzi, Valentina Lo Schiavo, Silke Machata, Ilyas Djafer-Cherif, Pierre Nivoit, Valeria Manriquez, Hirokazu Tanimoto, Julien Husson, Nelly Henry, Hugues Chate, Raphael Voituriez, Guillaume Dumenil
COMPTES RENDUS BIOLOGIES
(2020)