Imatinib Attenuates Hypoxia-induced Pulmonary Arterial Hypertension Pathology via Reduction in 5-Hydroxytryptamine through Inhibition of Tryptophan Hydroxylase 1 Expression

Targeted approaches to the treatment of pulmonary hypertension

(2012) Wassim H. Fares et al.   Therapeutic Advances in Respiratory Disease

PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells

(2011) Aiko Ogawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Novel Murine Model of Severe Pulmonary Arterial Hypertension

(2011) Loredana Ciuclan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary Hypertension

(2011) Jennifer I. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pulmonary Arterial Hypertension

(2011) Vallerie V. McLaughlin et al.   CURRENT PROBLEMS IN CARDIOLOGY

Imatinib mesylate for the treatment of pulmonary arterial hypertension

(2011) Henrik ten Freyhaus et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Collagen I Induces Discoidin Domain Receptor (DDR) 1 Expression through DDR2 and a JAK2-ERK1/2-mediated Mechanism in Primary Human Lung Fibroblasts

(2011) Pedro A. Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of pulmonary arterial hypertension with targeted therapies

(2011) Dermot S. O'Callaghan et al.   Nature Reviews Cardiology

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH

(2011) Kevin White et al.   PHYSIOLOGICAL GENOMICS

Hypoxic Pulmonary Hypertension in Mice with Constitutively Active Platelet-Derived Growth Factor Receptor-β

(2011) Bhola K. Dahal et al.   Pulmonary Circulation

Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells

(2010) Wenying Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy

(2010) Hossein A. Ghofrani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib

(2010) Paul W. Manley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Continuing Medical Education (CME) questions: Essential thrombocythemia

(2010)   BLOOD

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

(2010) V. J. Burton et al.   BLOOD

The serotonin transporter, gender, and 17  oestradiol in the development of pulmonary arterial hypertension

(2010) K. White et al.   CARDIOVASCULAR RESEARCH

Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats

(2010) R. Dumitrascu et al.   EUROPEAN RESPIRATORY JOURNAL

Clinical perspective: biomarkers in pulmonary arterial hypertension

(2010) G. A. Heresi   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention

(2010) M. Konigshoff et al.   THORAX

Serotonin and pulmonary hypertension—from bench to bedside?

(2009) Margaret R MacLean et al.   CURRENT OPINION IN PHARMACOLOGY

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

(2009) Paul M. Hassoun et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension

(2008) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts

(2008) K M Mair et al.   BRITISH JOURNAL OF PHARMACOLOGY

Serotonin and Angiotensin Receptors in Cardiac Fibroblasts Coregulate Adrenergic-Dependent Cardiac Hypertrophy

(2008) Fabrice Jaffré et al.   CIRCULATION RESEARCH

Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib

(2008) Elizabeth Day et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage

(2008) Steven Dooley et al.   GASTROENTEROLOGY

Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans

(2008) Roger Pocock et al.   NATURE NEUROSCIENCE

Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension

(2008) Marc Humbert et al.   VASCULAR PHARMACOLOGY