Review
Immunology
Anthony M. Joudi, Carla P. Reyes Flores, Benjamin D. Singer
Summary: FoxP3(+) regulatory T cells play a crucial role in maintaining immune homeostasis, self-tolerance, and resolving inflammation and tissue damage. However, their plasticity in inflammatory microenvironments could lead to loss of function and contribute to inflammatory pathology, presenting a barrier to Treg cell immunotherapy. Understanding the determinants of Treg cell stability and utilizing epigenetic mechanisms could enhance the efficacy and minimize toxicity of Treg cell-based therapeutics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
N. R. C. Wilson, Olivia J. Veatch, Steven M. Johnson
Summary: This review provides an overview of the relationship between diabetes, obstructive sleep apnea (OSA), obesity, and heart disease, questioning the traditional understanding. It explores the evolutionary rationale for OSA and the concept of epigenetics, and presents the results of a literature search on epigenetic marks and gene expression changes. Alternative explanations for the etiology of these interlinking diseases are also explored.
Article
Pharmacology & Pharmacy
Viseslav Popadic, Milica Brajkovic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Danica Popovic Lisulov, Anica Divac, Tatjana Ivankovic, Andrea Manojlovic, Novica Nikolic, Lidija Memon, Marija Brankovic, Maja Popovic, Ana Sekulic, Jelica Bjekic Macut, Olivera Markovic, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Marija Zdravkovic
Summary: In a retrospective cohort study involving 328 patients with newly diagnosed obstructive sleep apnea, significant associations were found between lipid abnormalities, inflammatory markers, and other clinically important data with the severity of obstructive sleep apnea. These findings may contribute to a better understanding of the underlying pathophysiological processes and potential therapeutic modalities.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Dipanwita Das, Nandini Karthik, Reshma Taneja
Summary: Inflammation is a crucial immune response against infection and tissue damage, but chronic inflammation is linked to cancer development. Immune cells produce inflammatory mediators to facilitate tumor growth, while aberrant expression of inflammatory factors by tumor cells recruits immune cells for mutual crosstalk, creating a conducive environment for tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ante Mihovilovic, Zoran Dogas, Dinko Martinovic, Daria Tokic, Ema Puizina Mladinic, Marko Kumric, Natalija Ivkovic, Marino Vilovic, Josko Bozic
Summary: Obstructive sleep apnea (OSA) is a major public concern and this study aimed to evaluate serum Urotensin II (UII) levels in OSA patients and controls. The study included 89 OSA patients and 89 controls, and UII levels as well as other parameters were assessed. The OSA group had higher levels of hsCRP and serum UII compared to the control group, and there was a positive correlation between UII levels and hsCRP and systolic blood pressure. Multiple regression analysis showed significant associations of UII levels with AHI, SBP, and hsCRP. These findings suggest that UII may play a role in the complex pathophysiology of OSA and its cardiometabolic complications.
Review
Medicine, General & Internal
Yanru Ou, Dandan Zong, Ruoyun Ouyang
Summary: This article explores the relationship between obstructive sleep apnea (OSA) and epigenetics, and provides better diagnostic methods and treatment options. Epigenetic modifications, including post-translational modifications in DNA and histone proteins, and regulation of non-coding RNAs, are involved in the progression of OSA and various multiorgan injuries. This article offers deeper insights into the disease mechanism of OSA and potential applications of targeted diagnosis, treatment, and prognosis in OSA complications.
CHINESE MEDICAL JOURNAL
(2023)
Review
Cell Biology
Rodrigo Villasenor, Tuncay Baubec
Summary: Nucleosomes are basic structures used to package genetic information, subject to diverse chemical modifications. These modifications serve as interaction hubs for nuclear proteins, ensuring correct deposition to the genome. The regulation of chromatin marks relies on coordinated activities of writer, eraser, and reader enzymes, often depending on complex multicomponent regulatory circuits.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lu Bai, Xiaolei Hao, Julia Keith, Yongqiang Feng
Summary: DNA methylation as an epigenetic marker plays a crucial role in regulating the differentiation and function of regulatory T cells. The dynamic regulation of DNA methylation affects various stages of Treg cell lifespan and immunological function. Further research is needed to fully understand the differential DNA methylation and its regulatory role in Treg cell fate and immunological function.
Article
Chemistry, Physical
Giovanni Scala, Mathilde N. Delaval, Sourav P. Mukherjee, Antonio Federico, Timur O. Khaliullin, Naveena Yanamala, Liliya M. Fatkhutdinova, Elena R. Kisin, Dario Greco, Bengt Fadeel, Anna A. Shvedova
Summary: The study revealed that MWCNTs exert epigenetic effects in the lungs, potentially driving subsequent gene expression changes. Muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways.
Article
Immunology
Minhan Yi, Wangcheng Zhao, Quanming Fei, Yun Tan, Kun Liu, Ziliang Chen, Yuan Zhang
Summary: This study found that the levels of interleukins were altered in obstructive sleep apnea (OSA), but the MR analysis did not identify significant causal relationships between these interleukins.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Marija Zdravkovic, Viseslav Popadic, Slobodan Klasnja, Natasa Milic, Nina Rajovic, Anica Divac, Andrea Manojlovic, Novica Nikolic, Filip Lukic, Esma Rasiti, Katarina Mircetic, Djordje Marinkovic, Sofija Nikolic, Bogdan Crnokrak, Danica Popovic Lisulov, Sinisa Djurasevic, Maja Stojkovic, Zoran Todorovic, Ratko Lasica, Biljana Parapid, Predrag Djuran, Milica Brajkovic
Summary: This study found that lipid abnormalities and inflammation play an important role in the development of cardiovascular risk in patients with OSA, and emphasized the importance of obesity as a common comorbidity in these patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Brittany A. Leader, Bala S. C. Koritala, Charles A. Moore, Elaine H. Grigg Dean, Leah C. Kottyan, David F. Smith
Summary: Obstructive sleep apnea (OSA) is a chronic disease associated with multiple health disorders, and current diagnostic strategies are limited. Epigenetic signatures could play a significant role in developing diagnostic and therapeutic tools for OSA. Studies have found unique epigenetic changes in OSA patients compared to healthy controls, mainly related to metabolic and inflammatory pathways.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Peripheral Vascular Disease
Xuan Sun, Yuting Feng, Chenyi Gong, Xue Bao, Zhonghai Wei, Lei Chang, Haiting Chen, Biao Xu
Summary: Hypertension leads to proinflammatory Th1-like Treg subsets with compromised suppressive capacity. Dysfunction Tregs induced by hypertension play a pathogenic role in the progression of myocardial ischemia-reperfusion injury. Targeting disturbed Tregs may be a new strategy to treat AMI patients with hypertension.
Article
Immunology
Dorota Iwaszkiewicz-Grzes, Magdalena Piotrowska, Mateusz Gliwinski, Zuzanna Urban-Wojciuk, Piotr Trzonkowski
Summary: The study revealed that insulin beta chain peptide 9-23 favored specific Tregs expression, while whole insulin activated both Tregs and Teffs. Tregs SPECB:9-23 showed the highest level of expression in crucial genes and lower methylation levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Kalina Nikolova-Ganeva, Vasil Vasilev, Simona Kerezieva, Andrey Tchorbanov
Summary: This study aimed to investigate the effect of folate on the secretion of IL10 by PBMCs from lupus patients. The results showed that low or high doses of folate had no effect on the methylation level of B lymphocytes, but led to an increase in the population of CD19 + IL10 + and CD19- IL10 + cells in certain patients.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Physics, Multidisciplinary
Veronica Barroso-Garcia, Gonzalo Cesar Gutierrez-Tobal, Leila Kheirandish-Gozal, Daniel Alvarez, Fernando Vaquerizo-Villar, Andrea Crespo, Felix del Campo, David Gozal, Roberto Hornero
Article
Clinical Neurology
Daniel Alvarez, Maria L. Alonso-Alvarez, Gonzalo C. Gutierrez-Tobal, Andrea Crespo, Leila Kheirandish-Gozal, Roberto Hornero, David Gozal, Joaquin Teran-Santos, Felix Del Campo
JOURNAL OF CLINICAL SLEEP MEDICINE
(2017)
Article
Endocrinology & Metabolism
David Gozal, Abdelnaby Khalyfa, Zhuanghong Qiao, Dale L. Smith, Mona F. Philby, Dorit Koren, Leila Kheirandish-Gozal
Review
Physiology
Pablo E. Brockmann, Dorit Koren, Leila Kheirandish-Gozal, David Gozal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2017)
Review
Physiology
Abdelnaby Khalyfa, Leila Kheirandish-Gozal, David Gozal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2018)
Review
Clinical Neurology
Leila Kheirandish-Gozal, Abdelnaby Khalyfa, David Gozal
SLEEP AND BIOLOGICAL RHYTHMS
(2017)
Article
Clinical Neurology
Dale L. Smith, David Gozal, Scott J. Hunter, Leila Kheirandish-Gozal
Letter
Critical Care Medicine
Abdelnaby Khalyfa, David Gozal, Leila Kheirandish-Gozal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Abdelnaby Khalyfa, Leila Kheirandish-Gozal, David Gozal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Physics, Multidisciplinary
Jorge Jimenez-Garcia, Gonzalo C. Gutierrez-Tobal, Maria Garcia, Leila Kheirandish-Gozal, Adrian Martin-Montero, Daniel Alvarez, Felix del Campo, David Gozal, Roberto Hornero
Review
Pediatrics
Gonzalo C. Gutierrez-Tobal, Daniel alvarez, Leila Kheirandish-Gozal, Felix del Campo, David Gozal, Roberto Hornero
Summary: The study evaluated the reliability of machine-learning-based methods in detecting pediatric obstructive sleep apnea and found that machine learning improved diagnostic performance as OSA severity criteria increased. Publication bias correction had minor effect on summary statistics, but high heterogeneity was observed among the studies.
PEDIATRIC PULMONOLOGY
(2022)
Article
Clinical Neurology
Adrian Martin-Montero, Gonzalo C. Gutierrez-Tobal, Leila Kheirandish-Gozal, Fernando Vaquerizo-Villar, Daniel Alvarez, Felix del Campo, David Gozal, Roberto Hornero
Summary: This study investigates the effects of treatment on heart rate variability (HRV) in pediatric obstructive sleep apnea (OSA) and evaluates whether changes in specific frequency bands can serve as indicators of OSA resolution. The results suggest that changes in the BW2 frequency band can reliably differentiate OSA severity and disease resolution.
Proceedings Paper
Biophysics
Fernando Vaquerizo-Villar, Daniel Alvarez, Gonzalo C. Gutierrez-Tobal, Veronica Barroso-Garcia, Leila Kheirandish-Gozal, Andrea Crespo, Felix del Campo, David Gozal, Roberto Hornero
2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2017)
Article
Critical Care Medicine
Roberto Hornero, Leila Kheirandish-Gozal, Gonzalo C. Gutierrez-Tobal, Mona F. Philby, Maria Luz Alonso-Alvarez, Daniel Alvarez, Ehab A. Dayyat, Zhifei Xu, Yu-Shu Huang, Maximiliano Tamae Kakazu, Albert M. Li, Annelies Van Eyck, Pablo E. Brockmann, Zarmina Ehsan, Narong Simakajornboon, Athanasios G. Kaditis, Fernando Vaquerizo-Villar, Andrea Crespo Sedano, Oscar Sans Capdevila, Magnus von Lukowicz, Joaquin Teran-Santos, Felix Del Campo, Christian F. Poets, Rosario Ferreira, Katalina Bertran, Yamei Zhang, John Schuen, Stijn Verhulst, David Gozal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Review
Critical Care Medicine
Leila Kheirandish-Gozal, David Gozal