Article
Public, Environmental & Occupational Health
Majda Sahman, Snezana Mugosa, Nemanja Rancic
Summary: The utilization of immunosuppressive drugs is increasing in transplant patients in Montenegro and other observed countries. However, despite a decrease in the price per defined daily dose (DDD) for certain drugs, the overall cost of immunosuppressants is rising annually, which poses a significant financial burden on healthcare systems.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Zhi-yu Zou, Lin-rui Dai, Yi-bo Hou, Chen-zhen Yu, Ren-jie Chen, Yan-yan Chen, Bin Liu, Hui-bo Shi, Nian-qiao Gong, Zhi-shui Chen, Song Chen, Sheng Chang, Wei-jie Zhang
Summary: This study found that an immunosuppressive regimen of SRL combined with low-dose ER-TAC is equally effective and safe as standard immunosuppressive regimens for renal transplant recipients, and may improve graft renal function and medication adherence.
FRONTIERS IN MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Karin Garming Legert, Olle Ringden, Mats Remberger, Johan Torlen, Jonas Mattsson, Goran Dahllof
Summary: The study found that using tacrolimus plus sirolimus as a prophylaxis for graft-versus-host disease following haematopoietic stem cell transplantation did not increase the incidence or severity of oral mucositis, nor did it prolong the healing time compared to cyclosporine plus methotrexate.
Article
Hematology
Linda Arrabi, Anna Jan, Chitra Hosing, Denai R. Milton, Jason Yeh
Summary: The study examined the efficacy of transitioning from tacrolimus to sirolimus in allo-HCT patients. While the conversion showed promising resolution of acute toxicities, overall mortality rates remained high, and patients transitioning before day 55 post-allo-HCT were more likely to develop new or worsening aGVHD.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Gwendal Coste, Florian Lemaitre
Summary: This review summarizes the evidence on the intra-patient pharmacokinetic variability (IPV) of tacrolimus concentrations in solid organ transplant recipients other than kidney transplantation. It discusses factors influencing IPV, the potential use of IPV as a biomarker for graft outcomes, and strategies to reduce IPV.
Article
Health Care Sciences & Services
Yi-Fan Cui, Yan Pan, Min-Fang Zhu, Zheng Jiao
Summary: This study aimed to investigate the pharmacokinetics of tacrolimus and the influential factors in Chinese patients after lung transplantation. The results showed a significant correlation between CYP3A5*3 genetic polymorphisms and the pharmacokinetics of tacrolimus.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Faiza Ahmed, Faiza Zakaria, Godsgift Enebong Nya, Mohamad Mouchli
Summary: Liver transplantation is the most preferred treatment option for patients with hepatocellular carcinoma and cirrhosis. Immunosuppression is necessary post-transplant to improve prognosis and prevent rejection. Recent research compared the effectiveness and tolerability of sirolimus and tacrolimus in liver transplantation for hepatocellular carcinoma, providing valuable information for clinicians to make treatment decisions.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Neurosciences
Jacqueline D. Silva, Giulio Taglialatela, Daniel C. Jupiter
Summary: This study found that patients prescribed CNIs have a reduced prevalence of dementia, with tacrolimus showing better results. Inhibition of calcineurin within the brain is more effective in reducing dementia than peripheral inhibition.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Infectious Diseases
Natalia A. Diaz, Juan Ambrosioni, Montserrat Tuset, Merce Brunet, Frederic Cofan, Gonzalo Crespo, Pablo Ruiz, Dolores Redondo-Pachon, Marta Crespo, Monica Marin-Casino, Asuncion Moreno, Jose M. Miro
Summary: People living with HIV can be candidates for solid-organ transplantation, but managing the drug interactions between antiretroviral drugs and immunosuppressive agents post-transplantation is a major challenge.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Pere Fontova, Lisanne N. van Merendonk, Anna Vidal-Alabro, Raul Rigo-Bonnin, Gema Cerezo, Stefaan van Oevelen, Oriol Bestard, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Joan Torras, Josep M. Cruzado, Josep M. Grinyo, Helena Colom, Nuria Lloberas
Summary: Despite monitoring whole blood tacrolimus concentrations, acute rejection can still occur during tacrolimus therapy after kidney transplantation. This study aimed to investigate the intracellular pharmacokinetics (PK) of two tacrolimus formulations (immediate-release and extended-release) and their correlation with whole blood PK and pharmacodynamics (PD).
Article
Cardiac & Cardiovascular Systems
Laurent Godinas, Fabienne Dobbels, Leni Hulst, Ive Verbeeck, Ines De Coninck, Pieter Berrevoets, Veronique Schaevers, Jonas Yserbyt, Lieven J. Dupont, Stijn E. Verleden, Bart M. Vanaudenaerde, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Arne Neyrinck, Geert M. Verleden, Robin Vos
Summary: Conversion from twice daily to once daily tacrolimus in lung transplant patients requires close monitoring of tacrolimus trough levels. Post-conversion, once daily tacrolimus is safe with respect to renal function, metabolic parameters and allograft function, and improves patient adherence.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Immunology
Yuqiu Han, Li Wu, Qi Ling, Pin Wu, Chenzhi Zhang, Longfei Jia, Honglei Weng, Baohong Wang
Summary: This study demonstrates that sirolimus can induce metabolic disorders in mice, potentially due to intestinal dysbiosis, leading to intestinal barrier disruption and systemic inflammation. Oral intervention with Lactobacillus can protect against intestinal dysbiosis and alleviate sirolimus-induced metabolic disorders.
Article
Immunology
Yuan Liu, Rui Wang, Peizhen Wen, Wenbin An, Jinxin Zheng, Tao Zhang, Pengshan Zhang, Haoyu Wang, Fan Zou, Hui Pan, Junwei Fan, Zhihai Peng
Summary: This study investigated the genetic risk of patients with tacrolimus intolerance after liver transplantation. The results suggested that switching to cyclosporine (SFTC) may increase the risk of dyslipidemia and insulin resistance, while specific SNPs of CYP3A5 gene could be potential genetic risks for tacrolimus intolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiang-Qian Gu, Dan Tang, Ping Wan, Tian Qin, Tai-Hua Yang, Ji Wu, Hao Ji, Jin-Chuan Liu, Feng Xue, Yuan-Jia Tang, Qiang Xia
Summary: The study shows that CYP3A5 gene polymorphism is the major factor influencing tacrolimus pharmacokinetics. Four miRNAs, including miR-29a-3p, miR-99a-5p, miR-532-5p, and miR-26b-5p, are identified as novel regulators of tacrolimus metabolism by affecting CYP3A5 expression through various mechanisms.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Respiratory System
You Min Sohn, Ryoung-Eun Ko, Hyo Jung Park, Eunjung Choo, Minji Jung, Sukhyang Lee, Kyeongman Jeon
Summary: A single-center cohort study found that continuous intravenous administration of tacrolimus with daily monitoring and dose adjustment of drug trough concentrations allowed the therapeutic range of tacrolimus to be reached within 1 week without significant adverse events.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Tereza Martinu, Angela Koutsokera, Christian Benden, Edward Cantu, Daniel Chambers, Marcelo Cypel, Jeffrey Edelman, Amir Emtiazjoo, Andrew J. Fisher, John R. Greenland, Don Hayes, David Hwang, Brain C. Keller, Erika D. Lease, Michael Perch, Masaaki Sato, Jamie L. Todd, Stijn Verleden, Jan von der Thusen, S. Samuel Weigt, Shaf Keshavjee
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2020)
Article
Immunology
Nicole M. Theodoropoulos, Ricardo M. La Hoz, Cameron Wolfe, Gabriel Vece, Remzi Bag, Gerald J. Berry, Jamie Bucio, Lara Danziger-Isakov, Diana F. Florescu, David Goldberg, Chak-Sum Ho, Kathleen Lilly, Maricar Malinis, Aneesh K. Mehta, Michael A. Nalesnik, Robert Sawyer, Lynne Strasfeld, R. Patrick Wood, Marian G. Michaels
Summary: DTAC evaluated 105 potential donor-derived transmission events of HBV between 2009-2017, with 25 cases of proven, probable, or possible transmission. Liver graft recipients had the highest infection rate, and 8 out of 11 donors with HBcAb positive/HBsAg negative status infected the recipients.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Meeting Abstract
Critical Care Medicine
Ryan Boente, Kavitha Selvan, Linda Bocanegra-English, John Donatelli, Danielle Stahlbaum, Cathryn Lee, Remzi Bag, Rekha Vij, Steven Montner, Aliya Husain, Mary Strek, Jonathan Chung, Ayodeji Adegunsoye
Meeting Abstract
Critical Care Medicine
Aaron Waxman, Victor Tapson, Reda Girgis, James Runo, Remzi Bag, Arunabh Talwar, Peter Smith, Dana Johnson, Christine Park, Steven Nathan
Article
Respiratory System
Lucas M. Kimmig, Matthew R. Stutz, Aliya N. Husain, Remzi Bag
Summary: Pulmonary capillary hemangiomatosis is a rare pulmonary vascular disease with a poor prognosis. The diagnosis of PCH in this patient was delayed by 2 1/2 years, leading to a delay in treatment. A mutation in the EIF2AK4 gene was found to be associated with the disease.
Review
Respiratory System
Krittika Teerapuncharoen, Remzi Bag
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term complication of pulmonary embolism (PE), and delay in diagnosis and treatment is associated with poor outcomes. High clinical suspicion and accurate interpretation of relevant imaging examinations are crucial for diagnosing CTEPH.
Editorial Material
Critical Care Medicine
Elizabeth Sonntag, Kathleen M. Akgun, Remzi Bag, Erika B. Rosensweig, Roberto J. Bernardo, Colleen Burnetti, Amy Chybowski, Vinicio A. de Jesus Perez, Johnell Diwan, Kate M. Guthrie, Torre Halscott, Tim Lahm, Jason Vaught, Corey E. Ventetuolo, Anna R. Hemnes
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ayodeji Adegunsoye, Chad A. Newton, Justin M. Oldham, Brett Ley, Cathryn T. Lee, Angela L. Linderholm, Jonathan H. Chung, Nicole Garcia, Da Zhang, Rekha Vij, Robert Guzy, Renea Jablonski, Remzi Bag, Rebecca S. Voogt, Shwu-Fan Ma, Anne I. Sperling, Ganesh Raghu, Fernando J. Martinez, Mary E. Strek, Paul J. Wolters, Christine Kim Garcia, Brandon L. Pierce, Imre Noth
Summary: This study investigated the association between leukocyte telomere length (LTL) and age and mortality in racially diverse patients with pulmonary fibrosis (PF). The study found that LTL shortened with increasing age, and this association was even stronger in PF patients. In all racial groups, LTL below the median predicted worse mortality.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Critical Care Medicine
K. Selvan, K. Teerapuncharoen, M. Funk, R. Bag
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
S. E. Morgan, K. R. Jendral, K. C. Russell, P. Hernandez, C. A. Serdiuk, R. Bag, R. P. Jablonski
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
N. Kong, M. Acosta, A. Zahid, M. Clarke, K. Teerapuncharoen, R. Bag, J. Paul
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Rheumatology
Victor Tapson, Steven Nathan, Reda Girgis, James Runo, Remzi Bag, Arunabh Talwar, Peter Smith, Lisa Edwards, Christine Park, Aaron Waxman
ARTHRITIS & RHEUMATOLOGY
(2021)
Meeting Abstract
Critical Care Medicine
N. Nowalk, R. Bag
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Swati Rao, Andrew Beaser, Zaid Aziz, Gaurav Upadhyay, Hemal Nayak, Remzi Bag, Roderick Tung
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Meeting Abstract
Critical Care Medicine
M. Stutz, C. Lee, D. Wu, L. M. Kimmig, O. Shamaa, R. Bag
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)