Review
Pharmacology & Pharmacy
Zhiwen Fu, Liu Wang, Shijun Li, Fen Chen, Kathy Ka-Wai Au-Yeung, Chen Shi
Summary: miRNAs play a crucial role in cancer treatment by regulating gene expression and influencing the growth and survival of cancer cells. They are considered an attractive target for anticancer drug development and have shown promising results in research and therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Sonnie Kim, Thomas C. Williams, Cecile Viboud, Harry Campbell, Jiani Chen, David J. Spiro
Summary: RSV is a common cause of serious respiratory illness in infants, and efforts are being made to develop vaccines and therapeutics, although the impact of RSV genomic variability on treatment remains unclear. Research gaps and priorities were discussed at a workshop, focusing on the implications of viral evolution and genomic variability for vaccine development.
Editorial Material
Medicine, General & Internal
Athalia Christie, Sarah A. Mbaeyi, Rochelle P. Walensky
Summary: The CDC recommends that fully vaccinated individuals can resume low-risk gatherings but should maintain public health measures in activities involving unvaccinated people.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Biotechnology & Applied Microbiology
Yiming Meng, Jing Sun, Guirong Zhang, Tao Yu, Haozhe Piao
Summary: Neutrophils play key roles in various diseases and have become potential important targets for therapeutic interventions. Molecular probes designed based on neutrophil characteristics show great potential for diagnosis and targeted therapy of inflammatory diseases and tumors, offering new ideas and research methods.
Editorial Material
Medicine, General & Internal
Pedro L. Alonso, Katherine L. O'Brien
Summary: The World Health Organization has recommended the use of a malaria vaccine for children living in areas with moderate-to-high malaria transmission.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Microbiology
Wanderson Rezende, Hadley E. Neal, Rebecca E. Dutch, Pedro A. Piedra
Summary: Respiratory syncytial virus (RSV) is a major cause of hospitalizations and deaths in young children and older adults. The development of an RSV vaccine, primarily targeting the fusion (F) protein, has become a global priority. However, there are still unanswered questions about the mechanism of RSV entry and the process of RSV F triggering and fusion promotion. This review focuses on these questions, particularly the cleaved peptide p27 within the F protein.
FRONTIERS IN MICROBIOLOGY
(2023)
Editorial Material
Cell Biology
Patrick A. Lewis
Summary: A phase 1 clinical trial for kinase inhibitors targeting LRRK2 lays the groundwork for evaluating the effectiveness of LRRK2 kinase inhibitors in Parkinson's disease.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Business
Abid Haleem, Shahbaz Khan, Sunil Luthra, Harshit Varshney, Musaib Alam, Mohd Imran Khan
Summary: This research presents a framework for evaluating suppliers in the implementation of circular economy, with the use of CRITIC to determine weighted criteria and TOPSIS to rank suppliers in the Indian automobile industry. The study underscores the importance of proper supplier selection in fostering a circular economy and provides a basis for organizations to evaluate and develop effective and efficient CE-based supply chains.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2021)
Editorial Material
Neurosciences
Hugo G. Marques, Pedro L. Castelhanito, Megan R. Carey
Summary: A recent study has identified a mechanistic pathway by which norepinephrine alters cerebellar Purkinje output to trigger attacks in a mouse model of EA2, and a pharmacological intervention that effectively reduces them.
TRENDS IN NEUROSCIENCES
(2022)
News Item
Geosciences, Multidisciplinary
Audrey Gaudel
Summary: For decades, efforts to mitigate ozone pollution have relied on two chemical regimes. However, a recent global modeling analysis has revealed a third regime involving aerosols that could help concurrently control both ozone and particulate pollution.
Article
Plant Sciences
Jasmin Goemann, Cornelia Herrfurth, Krzysztof Zienkiewicz, Tegan M. Haslam, Ivo Feussner
Summary: Glycosylceramides play crucial roles in cell differentiation, organogenesis, and protein secretion in plants and fungi. Research on the bryophyte Physcomitrium patens highlights the importance of LCB Delta 4-desaturation in the formation of abundant glycosylceramides and the severe growth and development defects caused by the blockage of glycosylceramide synthesis.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Guido Zichittella, Amedeo Ceruti, Gonzalo Guillen-Gosalbez, Javier Perez-Ramirez
Summary: This article introduces the educational background and research interests of Guido Zichittella, Amedeo Ceruti, Gonzalo Guillen-Gosalbez, and Javier Perez-Ramirez.
Article
Multidisciplinary Sciences
Alexis Villars, Alexis Matamoro-Vidal, Florence Levillayer, Romain Levayer
Summary: Using the Drosophila pupal notum, the authors demonstrate that effector caspases disassemble microtubules to initiate cell extrusion independently of actomyosin regulation. This study provides insights into the mechanism of caspase-mediated cell extrusion and reveals a general function of microtubules in epithelial cell shape stabilisation.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Svenja M. Sake, Christina Kosch, Sebastian Blockus, Sibylle Haid, Antonia P. Gunesch, Xiaoyu Zhang, Martina Friesland, Sofie B. Trummer, Christina Grethe, Anne Kuehnel, Jessica Rueckert, W. Paul Duprex, Jiabin Huang, Marie-Anne Rameix-Welti, Martin Empting, Nicole Fischer, Anna K. H. Hirsch, Thomas F. Schulz, Thomas Pietschmann
Summary: This study aimed to discover new candidates for hRSV drug development by using a two-step screening method. 23 primary candidates were identified from 6,048 molecules, and four of them showed inhibitory effects on hRSV with different modes of action.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Chemistry, Medicinal
Silvia Lomartire, Joao Cotas, Diana Pacheco, Joao Carlos Marques, Leonel Pereira, Ana M. M. Goncalves
Summary: Phenolic compounds from seaweeds have diverse bioactivities and can replace synthetic compounds in various industries, playing a crucial role in disease prevention and health promotion. With antioxidant, antiviral, and antimicrobial properties, these compounds applied in pharmaceuticals, nutraceuticals, cosmetics, and food industries can enhance human health.
