Review
Pharmacology & Pharmacy
Yanhui Liu, Haobo Kong, Heping Cai, Guanru Chen, Huiying Chen, Wenyi Ruan
Summary: This paper reviews the association between the PI3K/Akt pathway and COPD, aiming to identify new therapeutic targets for clinical intervention in this disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xue Zhang, Wenchao Cong, Aiping Lu
Summary: This study evaluated the expression of Vanin-1 in COPD patients and found that Vanin-1 was significantly upregulated in the sera and lung tissues of COPD patients. The expression of Vanin-1 showed positive correlations with levels of pro-inflammatory cytokines and ROS. These findings suggest that Vanin-1 may serve as a potential biomarker and new target for the diagnosis or treatment of COPD.
Review
Medicine, General & Internal
Elisabetta Zinellu, Alessandro G. Fois, Elisabetta Sotgiu, Sabrina Mellino, Arduino A. Mangoni, Ciriaco Carru, Angelo Zinellu, Pietro Pirina
Summary: This systematic review and meta-analysis revealed that serum albumin concentrations are significantly lower in patients with stable COPD compared to non-COPD controls, indicating a deficiency in systemic anti-inflammatory and antioxidant defense mechanisms in COPD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Yun-Tian Chen, Kang Miao, Linfu Zhou, Wei-Ning Xiong
Summary: COPD, one of the most widespread chronic lung diseases globally, currently lacks effective treatments beyond symptom relief. Stem cell therapy shows promise in restoring lung function and improving quality of life for patients with COPD.
CHINESE MEDICAL JOURNAL
(2021)
Review
Medicine, General & Internal
Annalisa Frizzelli, Marina Aiello, Luigino Calzetta, Giuseppina Bertorelli, Alfredo Chetta
Summary: Chronic obstructive pulmonary disease (COPD) and diabetes mellitus (DM) are common and chronic disorders. The relationship between the two conditions is not completely understood and conflicting results are reported in the literature. Many studies have investigated the mechanisms and risk factors associated with the coexistence of COPD and DM, as well as potential treatment interactions.
Review
Respiratory System
Heena Kansal, Vishal Chopra, Kranti Garg, Siddharth Sharma
Summary: This article introduces the Thioredoxin (Trx) system as a potential treatment approach for Chronic Obstructive Pulmonary Disease (COPD), with a focus on its role and mechanism in COPD treatment. It also covers the pathophysiology of COPD and the pharmacognosy of anti-COPD drugs, providing an expert opinion on the limited research targeting the Trx system as an anti-COPD drug.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: The downregulation of DUOX1 in the airways of patients with Chronic Obstructive Pulmonary Disease (COPD) may contribute to the pathogenesis of COPD, leading to airway remodeling and emphysema. Animal studies also demonstrate that Duox1 deficiency exacerbates lung pathology induced by smoke exposure.
Review
Respiratory System
Siqi Li, Qiong Huang, Baimei He
Summary: Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by irreversible airflow obstruction and lung function decline. SIRT1, a member of the Sir2 family, plays important roles in oxidative stress, apoptosis, inflammation, autophagy, and cellular senescence, which are involved in the pathogenesis and development of COPD. SIRT1 activation may be a potential therapeutic strategy for COPD.
Review
Biochemistry & Molecular Biology
Yue Yu, Ailin Yang, Ganggang Yu, Haoyan Wang
Summary: This review explores the relationship between ER stress and UPR with COPD, as well as drug intervention strategies targeting the UPR pathway in COPD. By analyzing other cellular processes, new therapeutic approaches and preventive measures for COPD are investigated.
Review
Medicine, Research & Experimental
Kurt Brassington, Stavros Selemidis, Steven Bozinovski, Ross Vlahos
Summary: COPD and atherosclerosis are chronic irreversible diseases with common causative factors such as cigarette smoking. They both involve inflammation and oxidative stress, and current treatments are limited in effectiveness, highlighting the need for novel therapies.
Review
Pharmacology & Pharmacy
Aleksandar Dobric, Simone N. De Luca, Sarah J. Spencer, Steven Bozinovski, Michael M. Saling, Christine F. McDonald, Ross Vlahos
Summary: Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden and a leading cause of death worldwide. Cognitive dysfunction is highly prevalent in COPD and has significant impacts on quality of life and survival. Understanding the mechanisms underlying cognitive dysfunction in COPD could lead to novel therapeutic opportunities.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Elisabetta Zinellu, Angelo Zinellu, Alessandro G. Fois, Maria Carmina Pau, Valentina Scano, Barbara Piras, Ciriaco Carru, Pietro Pirina
Summary: Studies show an imbalance between oxidant and antioxidant molecules favoring the former in exacerbations of COPD, suggesting the potential usefulness of targeting oxidative stress in monitoring disease progression, particularly in patients more prone to exacerbations. Additional research with standardized methods in well-characterized populations is needed.
Review
Medicine, General & Internal
Shouxiong Huang, Quan He, Linfu Zhou
Summary: This article critically reviews the activation, effector, and regulation of T cells in respiratory viral infections and chronic inflammations associated with COPD, highlighting the importance of crosstalk among T cells, innate immune cells, and airway epithelial cells in the pathogenesis of viral infections and COPD. It emphasizes the specificity of peptide antigens and the functional heterogeneity of conventional CD4(+) and CD8(+) T cells as potential targets for future development of therapeutics against respiratory viral infections and inflammations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Nakwon Kwak, Kyoung-Hee Lee, Jisu Woo, Jiyeon Kim, Chang-Hoon Lee, Chul-Gyu Yoo
Summary: Investigating the role of NE in inflammation in COPD, the study found that NE degrades PPAR gamma which regulates IL-8 production, exacerbating inflammation in COPD. This suggests PPAR gamma as a potential target for the development of COPD treatments.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Hsien-Feng Liao, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su, Jane Pei-Chen Chang
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally, particularly in individuals over 40 years old. Mood disorders are frequently comorbid with COPD, but often overlooked or undiagnosed, leading to poor treatment outcomes and increased mortality. The exact link between COPD and mood disorders is still uncertain, but it is believed that inflammation in the lungs, blood, and brain may contribute to the development of mood disorders in COPD. Antidepressants are commonly used to manage mood disorders in COPD, but their efficacy is limited due to tolerability issues. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which regulate inflammatory responses, may offer promising alternatives for managing mood disorders in COPD.
JOURNAL OF CLINICAL MEDICINE
(2023)