Review
Obstetrics & Gynecology
Elias M. Dahdouh, William H. Kutteh
Summary: Genetic testing of products of conception (POC) can help explain over 55% of miscarriage cases and guide the treatment direction for patients with recurrent pregnancy loss (RPL).
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Multidisciplinary Sciences
Doaa A. Khamees, Mushtak T. S. Al-Ouqaili
Summary: This study investigated the frequency of chromosomal abnormalities and immunological factors in couples with recurrent pregnancy loss (RPL) in Iraq. The results showed a high incidence of chromosomal abnormalities in RPL couples, while no significant differences were found in immunological parameters compared to the control group. Therefore, conventional karyotyping is recommended for patients with RPL to identify genetic causes of miscarriage.
Review
Genetics & Heredity
Dan Lei, Xin-Yu Zhang, Peng-Sheng Zheng
Summary: The prevalence of chromosomal abnormalities detected in products of conception (POCs) is lower in recurrent pregnancy loss than in sporadic pregnancy loss, and decreases with an increasing number of pregnancy losses.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Diana Alecsandru, Amber M. Klimczak, Juan A. Garcia Velasco, Paul Pirtea, Jason M. Franasiak
Summary: Immunologic factors may contribute to miscarriages and recurrent pregnancy loss, with disruption of maternal-fetal immune homeostasis being a potential cause. Remodeling of maternal uterine spiral arteries is crucial for fetal development, ensuring adequate oxygen supply for proper placentation. Development of fetal tissues can lead to immunologic challenges, as the fetus may express paternal and gamete donor antigens, triggering a response from the maternal immune system.
FERTILITY AND STERILITY
(2021)
Review
Obstetrics & Gynecology
Charlotte C. Hamel, Steffi van Wessel, Alasdair Carnegy, Sjors F. P. J. Coppus, Marc P. M. L. Snijders, Justin Clark, Mark H. Emanuel
Summary: There is wide variation in diagnosing retained products of conception (RPOC) following induced abortion or early pregnancy loss, with transvaginal ultrasonographic measurement of endometrial thickness being the most commonly used diagnostic approach. Further research is needed to assess the diagnostic accuracy of endometrial thickness in detecting RPOC.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Public, Environmental & Occupational Health
Huijia Lin, Xiaoya Wang, Shuang Qin, Fanglan Luo, Yingmei Cen, Gendie E. Lash, Li Li
Summary: This study investigated the hearing status of Turner Syndrome (TS) patients in China and the influencing factors. It was found that TS patients commonly have mid-frequency and high-frequency hearing loss, and the incidence of hearing loss increases with age. Patients with 45, X haplotype have a higher risk of mid-frequency hearing loss compared to other karyotypes. Therefore, karyotype may serve as a predictor of hearing problems in TS patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Immunology
Hossein Ansariniya, Fateme Zare, Nariman Mosaffa, Farah Idali, Mahdi Shabani, Hossein Hadinedoushan
Summary: This review discusses the role of the immune system in mouse models of RSA. Research has shown that immune system alterations contribute to the development of RSA. These findings offer new possibilities for preventing RSA from an immunological perspective.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Rui Gao, Lang Qin, Peng Bai
Summary: The prevalence of self-reported depression is higher in women with recurrent pregnancy loss compared to healthy controls. Age ≥ 36 years, >2 times of spontaneous miscarriages, and no history of live birth are independent risk factors for self-reported depression in women with recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Marie Carbonnel, Paul Pirtea, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Both congenital and acquired uterine anomalies are associated with recurrent pregnancy loss. Initial evaluation of uterine anatomy is crucial for women with RPL. Surgical management of certain uterine anomalies, such as uterine septa, endometrial polyps, intrauterine adhesions, and submucosal myomas, may improve subsequent pregnancy outcomes in specific circumstances.
FERTILITY AND STERILITY
(2021)
Article
Psychology, Multidisciplinary
Ting-ting Wang, Yi-lin Liu, Yue Hou, Jia-po Li, Chong Qiao
Summary: The aim of this study was to investigate the incidence and risk factors of progestational anxiety, depression, and sleep disturbance in women with a history of recurrent pregnancy loss (RPL). The study included 663 non-pregnant RPL women, and the results showed that the incidence of anxiety, depression, and sleep disturbance in RPL women were 60.3%, 51.7%, and 31.2% respectively. Multiple miscarriages, low household income, interval since last miscarriage <6 months, and sleep disturbance were associated with the occurrence of depressive symptoms. Therefore, it is important to pay attention to the psychological state of RPL women and provide appropriate support to reduce negative emotions.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Immunology
R. Yokote, Y. Kuwabara, S. Kasano, M. Yonezawa, N. Ouchi, T. Ichikawa, S. Suzuki, T. Takeshita
Summary: Antiphospholipid syndrome (APS) is an established cause of recurrent pregnancy loss (RPL). This study aimed to identify risk factors for persistent anticardiolipin (aCL) antibody positivity in women with a history of RPL. The study found that a high antibody titer during the initial test is the only risk factor for persistently positive aCL antibodies. This information can help define therapeutic strategies in subsequent pregnancies without waiting for 12 weeks.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Obstetrics & Gynecology
Shan Li, Peng-Sheng Zheng, Hong Mei Ma, Qian Feng, Yan Ru Zhang, Qin Shu Li, Jing Jing He, Wen Fang Liu
Summary: This study evaluates the pregnancy outcomes of couples with recurrent pregnancy loss (RPL) and abnormal karyotypes. Couples with abnormal karyotypes have a higher miscarriage rate but can achieve a noninferior accumulated live birth rate through multiple conception attempts. In couples with RPL and abnormal karyotypes, preimplantation genetic diagnosis (PGD) treatment does not increase the accumulated live birth rate but significantly reduces the miscarriage rate compared to expectant management.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Panagiotis Cherouveim, Despoina Mavrogianni, Eirini Drakaki, Anastasios Potiris, Athanasios Zikopoulos, Myrto Papamentzelopoulou, Konstantina Kouvoutsaki, Nikolaos Machairiotis, Theodoros Karampitsakos, Chara Skentou, Ekaterini Domali, Nikolaos Vrachnis, Peter Drakakis, Sofoklis Stavros
Summary: This study demonstrates for the first time an association between RPL and ANRIL rs4977574 gene polymorphism (lower prevalence of allele A), while further research is needed to confirm a difference according to the number of pregnancy losses.
JOURNAL OF CLINICAL MEDICINE
(2023)