Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 73, Issue 4, Pages 285-291Publisher
WILEY-BLACKWELL
DOI: 10.1111/aji.12340
Keywords
Angiotensin II receptor; autoantibody; preeclampsia; soluble endoglin; trophoblast
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Funding
- Ministry of Education
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ProblemThis study investigated whether angiotensin II type 1 receptor agonistic autoantibodies (AT(1)-AAs) mediate the increased release of soluble endoglin (sEng) in women with preeclampsia. Method of studySerum samples were obtained from women with normal pregnancies or with preeclampsia. Human first-trimester trophoblast cells were cultured with purified IgG derived from these sera, and the sEng protein and mRNA expression levels were measured in the supernatants. We also determined the effects of the AT(1)-AAs on these cells following treatment with an AT(1) receptor antagonist (losartan). ResultsCompared with the IgG isolated from the women with normal pregnancies, treatments of the preeclamptic patients markedly increased sEng production and mRNA expression in trophoblast cells. Co-treatment with losartan significantly attenuated the release of sEng and sEng mRNA expression in the trophoblast cells. ConclusionAT(1)-AAs may be related to the increased release of sEng observed during preeclampsia and may play important roles in the pathology of this disorder.
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