Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 69, Issue 5, Pages 486-494Publisher
WILEY
DOI: 10.1111/aji.12084
Keywords
Anticardiolipin antibodies; fetal loss; lupus anticoagulant; miscarriage; placental apoptosis; 2GPI
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Funding
- CSIR, New Delhi [(09/475 0137)/ 2008-EMR-I]
- Matsumae International Foundation, Japan
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Problem To study the histopathology and expression of apoptosis in placenta of pregnancy-complicated antiphospholipid syndrome (APS)-positive mouse models. Method of study ICR mice were immunized with IgG isotype of human anticardiolipin (aCL) and/or lupus anticoagulant (LA). The pathological and apoptotic expression was studied in the placenta of positive APS mice and compared with respective control samples. Results Mice with passive immunization of human aCL and/or LA produced an increase in fetal resorption along with markedly induced thrombosis in the placenta associated with increased placental apoptosis. In addition, fewer mitotic cells, less trophoblast giant cell invasion, and more shrunken cells in the deciduas were seen. Conclusion Our study showed the pathogenic role of aCL and LA in pregnancy complications.
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