Review
Obstetrics & Gynecology
Clara Q. Wu, Kelly Nichols, Matthew Carwana, Nicholas Cormier, Christina Maratta
Summary: This study conducted a systematic review and meta-analysis to evaluate the impact of recurrent pregnancy loss (RPL) on the risk of preterm birth (PTB) in subsequent pregnancies. The results showed that women with a history of RPL had significantly higher odds of delivering preterm infants in subsequent pregnancies, and the risk of PTB increased with the number of pregnancy losses.
FERTILITY AND STERILITY
(2022)
Article
Peripheral Vascular Disease
Leandro De Oliveira, James M. Roberts, Arundhathi Jeyabalan, Kasey Blount, Christopher W. Redman, Lucilla Poston, Paul T. Seed, Lucy C. Chappell, Marcos Augusto Bastos Dias
Summary: The implementation of a risk stratification model based on biomarkers and clinical factors did not lead to reductions in preterm deliveries. Further training and development of additional risk stratification methods are needed before adopting this intervention into clinical practice.
Article
Medicine, General & Internal
Anadeijda J. E. M. C. Landman, Marjon A. de Boer, Laura Visser, Tobias A. J. Nijman, Marieke A. C. Hemels, Christiana N. Naaktgeboren, Marijke C. van der Weide, Ben W. Mol, Judith O. E. H. van Laar, Dimitri N. M. Papatsonis, Mireille N. Bekker, Joris van Drongelen, Marielle G. van Pampus, Marieke Sueters, David P. van der Ham, J. Marko Sikkema, Joost J. Zwart, Anjoke J. M. Huisjes, Marloes E. van Huizen, Gunilla Kleiverda, Janine Boon, Maureen T. M. Franssen, Wietske Hermes, Harry Visser, Christianne J. M. de Groot, Martijn A. Oudijk
Summary: The study aimed to evaluate the effectiveness of low-dose aspirin compared to placebo in preventing preterm birth in women with a previous spontaneous preterm birth. The results showed that low-dose aspirin did not significantly reduce the preterm birth rate. However, a modest reduction in preterm birth with aspirin cannot be ruled out. Further research is needed to determine the potential benefits of low-dose aspirin in women with a previous spontaneous preterm birth.
Article
Endocrinology & Metabolism
Yu Zheng, Biao Chen, Jun Dai, Bei Xu, Jihui Ai, Lei Jin, Xiyuan Dong
Summary: A thin endometrium may be associated with a higher incidence of preterm birth, low birth weight, and miscarriage.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Arash Derakhshan, Tuija Mannisto, Liangmiao Chen, Joris A. J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fang-Biao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena A. Vasukova, Abel Lopez-Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernandez-Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt-Rasmussen, Elena N. Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Monica Guxens, Eila Suvanto, Kypros H. Nicolaides, Tim I. M. Korevaar
Summary: This study explores the association between gestational FT3 and TT3 levels and adverse obstetric outcomes. The findings suggest that FT3 and TT3 levels have different associations with various adverse obstetric outcomes, with high TT3 associated with an increased risk of gestational hypertension and low TT3 associated with a higher risk of very preterm birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Lan-Wan Wang, Hung-Chih Lin, Ming-Luen Tsai, Yu-Tzu Chang, Yu-Chia Chang
Summary: This study investigated the relationship between hypertensive disorders of pregnancy (HDP) and the risk of autism spectrum disorder (ASD) in children. It found that children born to mothers with HDP had higher rates of preterm-birth and small-for-gestational-age, both of which are risk factors for ASD. The study also suggested that HDP may not be a major contributor to ASD, but rather preterm-birth and SGA play a moderating role in increasing ASD risks.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Heather M. Brockway, Samantha L. Wilson, Suhas G. Kallapur, Catalin S. Buhimschi, Louis J. Muglia, Helen N. Jones
Summary: Preterm birth is a global public health crisis with high mortality rates for both neonates and mothers. The molecular mechanisms of idiopathic spontaneous preterm birth are poorly understood and there are few diagnostic markers for assessing placental development and function. This study found that placental hypermaturity may play a role in idiopathic spontaneous preterm birth and identified similarities in DNA methylation patterns between idiopathic spontaneous preterm birth and term birth samples. Pathway analysis revealed differences in genes related to placental development and maturation. These findings suggest that the hypermature methylation signature in idiopathic spontaneous preterm birth samples may impact birth timing.
Article
Obstetrics & Gynecology
Rupsa C. Boelig, Corina N. Schoen, Heather Frey, Alexis C. Gimovsky, Edward Springel, Sami Backley, Vincenzo Berghella
Summary: This study aimed to compare vaginal progesterone with 17-hydroxyprogesterone caproate in preventing recurrent preterm birth in singleton pregnancies with previous spontaneous preterm birth. The results showed that vaginal progesterone did not reduce the risk of recurrent preterm birth by 50% compared to 17-OHPC, but it may lead to increased latency to delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Haley G. Genovese, Dana B. Mcqueen
Summary: This manuscript reports on the prevalence of early pregnancy loss and discusses the impact of improved pregnancy diagnosis, as well as the influence of increased age and body mass index at first birth.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Natalie Suff, Vicky X. Xu, Giorgia Dalla Valle, Jenny Carter, Shaun Brennecke, Andrew Shennan
Summary: This study investigated the risk of recurrent spontaneous preterm birth (sPTB) in women with a prior term birth and a subsequent sPTB. The results showed that women with a previous term birth had a higher risk of recurrent sPTB compared to women with only a history of sPTB. The etiology of sPTB may differ in this subgroup of women and further research is needed to identify and treat them effectively.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Hyojeong Kim, Yu Mi Shin, Kyong-No Lee, Hyeon Ji Kim, Young Hwa Jung, Jee Yoon Park, Kyung Joon Oh, Chang Won Choi
Summary: This study aims to compare neonatal outcomes in early preterm births and find that indicated preterm birth is associated with higher neonatal mortality compared to spontaneous preterm birth. Additionally, in the 1-year follow-up, the proportion of body mass below the third percentile is significantly higher in the indicated preterm birth group than in the spontaneous preterm birth group, while diagnoses of developmental delay and cerebral palsy are slightly higher in the indicated preterm birth group.
EARLY HUMAN DEVELOPMENT
(2023)
Article
Computer Science, Information Systems
Ilia Rattsev, Natalie Flaks-Manov, Angie C. Jelin, Jiawei Bai, Casey Overby Taylor
Summary: This study developed a 4-step framework using a clinical phenotyping tool to assess risk factors for recurrent preterm birth, showing that the models stratified by delivery subtype performed better in predicting preterm birth risk.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Cell Biology
Chunzi Lyu, Tianxiang Ni, Yaqiu Guo, Tingting Zhou, Zi-Jiang Chen, Junhao Yan, Yan Li
Summary: Insufficient extravillous trophoblast (EVT) invasion is associated with recurrent pregnancy loss (RPL). This study found that growth differentiation factor 15 (GDF15) levels were decreased in patients with unexplained recurrent pregnancy loss (URPL), which hindered EVT invasion through the suppression of the JAG1/NOTCH3/HES1 pathway. In a mouse model, administration of recombinant GDF15 reversed the reduced GDF15 levels in the placenta and serum and reduced rates of embryonic resorption. These findings suggest that supplementation with GDF15 could be beneficial for early pregnancy maintenance and reducing the risk of early pregnancy loss.
CELL PROLIFERATION
(2023)
Review
Medicine, General & Internal
Simona Daniela Popescu, Andreea Gratiana Boiangiu, Romina-Marina Sima, Liviu Bilteanu, Simona Vladareanu, Radu Vladareanu
Summary: This systematic review examines the impact of HPV infection during pregnancy and the correlation between HPV and adverse pregnancy outcomes. Despite numerous studies conducted, there is still controversy regarding the identification of maternal HPV infection as a risk factor for adverse pregnancy outcomes. More prospective large cohort studies are needed to establish a causative relationship.
Article
Medicine, General & Internal
Tamar Wainstock, Ruslan Sergienko, Eyal Sheiner
Summary: The study revealed that complications during the first pregnancy may increase the risk of preterm delivery in subsequent pregnancies. Therefore, the first pregnancy, even if carried to term, could be a crucial period for identifying women at risk for future preterm deliveries.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Carla Meurk, Susan Roberts, Michael Lam, Lisa Wittenhagen, Leonie Callaway, Katherine Moss, Jayne Lucke, Ruth Barker, Elissa Waterson, Catherine Rawlinson, Natasha Malmstrom, Edward Weaver, Elisabeth Hoehn, Emma Bosley, Shelby Watson, Ed Heffernan
Summary: This study examines the prevalence, demographic characteristics, and timing of contact with first responders and health services for women who experienced suicidality during and around pregnancy. The findings highlight the need to improve service responses for women with mental health needs during these phases of life.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Susan de Jersey, Nina Meloncelli, Taylor Guthrie, Hilary Powlesland, Leonie Callaway, Angela T. Chang, Shelley Wilkinson, Tracy Comans, Elizabeth Eakin
Summary: The "LWdP" program, implemented through telephone coaching, resulted in positive improvements in care access and diet quality for pregnant women. It was as effective as face-to-face appointments, but further research is needed to engage women earlier in pregnancy and reduce appointment burden.
BMC HEALTH SERVICES RESEARCH
(2022)
Correction
Medicine, Research & Experimental
Nigel Lee, Yu Gao, Lena B. Martensson, Leonie Callaway, Belinda Barnett, Sue Kildea
Article
Obstetrics & Gynecology
Susan de Jersey, Taylor Guthrie, Leonie Callaway, Jeanette Tyler, Karen New, Jan Nicholson
Summary: This study aimed to examine the impact of implementing a service wide education program and antenatal care pregnancy weight gain chart combined with brief advice on women's knowledge of recommended gestational weight gain (GWG), the advice received and actual GWG. The results showed that service wide changes can improve the advice received by women and prevent excessive weight gain for women with normal weight.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Endocrinology & Metabolism
Tanya S. McDonald, Titaya Lerskiatiphanich, Trent M. Woodruff, Pamela A. McCombe, John D. Lee
Summary: Neurodegeneration refers to the progressive loss of neurons in disorders like Alzheimer's, Huntington's, and Parkinson's disease. Energy metabolism disturbances and alterations are common features in the onset and progression of these diseases. Understanding these metabolic changes could lead to improved treatment options for neurodegenerative disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Eduardo A. Albornoz, Alberto A. Amarilla, Naphak Modhiran, Sandra Parker, Xaria X. Li, Danushka K. Wijesundara, Julio Aguado, Adriana Pliego Zamora, Christopher L. D. McMillan, Benjamin Liang, Nias Y. G. Peng, Julian D. J. Sng, Fatema Tuj Saima, Jenny N. Fung, John D. Lee, Devina Paramitha, Rhys Parry, Michael S. Avumegah, Ariel Isaacs, Martin W. Lo, Zaray Miranda-Chacon, Daniella Bradshaw, Constanza Salinas-Rebolledo, Niwanthi W. Rajapakse, Ernst J. Wolvetang, Trent P. Munro, Alejandro Rojas-Fernandez, Paul R. Young, Katryn J. Stacey, Alexander A. Khromykh, Keith J. Chappell, Daniel Watterson, Trent M. Woodruff
Summary: COVID-19 infection may lead to neurological symptoms similar to Parkinson's disease. The study found that SARS-CoV-2 and spike protein can directly activate the NLRP3 inflammasome in microglial cells, which may contribute to the development of neuroinflammation.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Xaria X. Li, John D. Lee, Han S. Lee, Richard J. Clark, Trent M. Woodruff
Summary: TLQP-21 is a neuropeptide derived from the VGF precursor protein and has pleiotropic roles in regulating metabolism, nociception, and microglial functions. TLQP-21 acts through several receptors, with C3aR being the most commonly reported. However, its activity in immune cells, which express C3aR, remains understudied. This study found that TLQP-21 induced ERK signaling in human and mouse macrophages, with mouse TLQP-21 being more potent than the human counterpart. These findings suggest a significant discrepancy in TLQP-21 C3aR activity between human and murine receptors in immune cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Andrew O. Yam, Jacqueline Bailey, Francis Lin, Arnolda Jakovija, Scott E. Youlten, Claudio Counoupas, Matthias Gunzer, Tobias Bald, Trent M. Woodruff, James A. Triccas, Leonard D. Goldstein, David Gallego-Ortega, Shane T. Grey, Tatyana Chtanova
Summary: Intratumoral injection of microbial bioparticles stimulates neutrophil antitumor functions, leading to remodeling of tumor tissue, repression of tumor growth, and enhancement of checkpoint inhibitor therapy. This indicates the potential of microbial therapy in the treatment of solid cancers.
Editorial Material
Cell Biology
Eduardo A. Albornoz, Richard Gordon, Vinod Kumar, Avril A. B. Robertson, Kate Schroder, Trent M. Woodruff
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Emergency Medicine
Amy L. Sweeny, Nemat Alsaba, Laurie Grealish, Katya May, Ya-Ling Huang, Jamie Ranse, Kerina J. Denny, Bill Lukin, Andrew Broadbent, Erin Burrows, Kristen Ranse, Linda Sunny, Meghna Khatri, Julia Crilly
Summary: This study describes the characteristics and care provided to older people who died within 48 hours of emergency department (ED) presentation. Most patients arrived at the ED by ambulance and were triaged into the most urgent categories. Many of them had a history of independence but had a recent decline in mobility and activities of daily living. A significant proportion of patients had previous ED visits and hospital admissions prior to death.
EMERGENCY MEDICINE AUSTRALASIA
(2023)
Article
Biochemical Research Methods
Xaria X. Li, Trent M. Woodruff
Summary: This study presents a protocol for investigating the effects of C3aR and C5aR1 receptors in vitro using phosphorylated ERK as a readout. The protocol includes steps for isolating human monocyte-derived macrophages, culturing and preparing cell lines expressing the receptors, performing pharmacological assays, and detecting phospho-ERK1/2.
Article
Cell Biology
Julio Aguado, Alberto A. Amarilla, Atefeh Taherian Fard, Eduardo A. Albornoz, Alexander Tyshkovskiy, Marius Schwabenland, Harman K. Chaggar, Naphak Modhiran, Cecilia Gomez-Inclan, Ibrahim Javed, Alireza A. Baradar, Benjamin Liang, Lianli Peng, Malindrie Dharmaratne, Giovanni Pietrogrande, Pranesh Padmanabhan, Morgan E. Freney, Rhys Parry, Julian D. J. Sng, Ariel Isaacs, Alexander A. Khromykh, Guillermo Valenzuela Nieto, Alejandro Rojas-Fernandez, Thomas P. Davis, Marco Prinz, Bertram Bengsch, Vadim N. Gladyshev, Trent M. Woodruff, Jessica C. Mar, Daniel Watterson, Ernst J. Wolvetang
Summary: Senescent cells play a significant role in brain aging and COVID-19-induced neuropathology, and senolytic therapy shows therapeutic potential in protecting against COVID-19-induced brain aging.
Meeting Abstract
Biochemistry & Molecular Biology
John Lee, Jianina Marallag, Trent Woodruff
MOLECULAR IMMUNOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Martin Lo, Alberto Ortiz, John Lee, Eduardo Albornoz, Alexander Khromykh, Daniel Watterson, Trent Woodruff
MOLECULAR IMMUNOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Austin Read, John Lee, Trent Woodruff
MOLECULAR IMMUNOLOGY
(2022)
