Article
Infectious Diseases
Sampada Bangar, Pratiksha Sonar, Arati Mane, Suvarna Sane, Abhijit Kadam, Tuman Lal Katendra, Girish Rahane, Anju Sinha, Seema Sahay
Summary: The effectiveness of lactobacilli-containing vaginal tablets in preventing bacterial vaginosis recurrence among women infected with HIV treated with standard oral metronidazole in Pune, India was studied. The study found that lactobacilli-containing vaginal tablets did not provide any additional benefit in preventing bacterial vaginosis recurrence in women infected with HIV.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Microbiology
Eric Armstrong, Rupert Kaul
Summary: HIV incidence remains high in Eastern and Southern Africa, particularly affecting women. The prevalence of bacterial vaginosis in African, Caribbean, and other Black (ACB) women is associated with increased risk of HIV acquisition, with Lactobacillus species such as L. crispatus offering better protection compared to the more common species L. iners. Further research is needed to determine the mechanisms behind the varying levels of HIV protection among different Lactobacillus species.
Article
Biology
Mahima Sharma, Chitrakshi Chopra, Malvika Mehta, Varun Sharma, Sharada Mallubhotla, Srinivas Sistla, Jyothi C. Sistla, Indu Bhushan
Summary: The vaginal microbiota plays a significant role in women's health, and understanding its composition is crucial for accurate diagnosis and better treatment of vaginal disorders. Modern techniques can help study variations in the vaginal microbiota, improving diagnostic and treatment capabilities for vaginal diseases.
Article
Immunology
David N. Fredricks, Anna Plantinga, Sujatha Srinivasan, Antoinette Oot, Andrew Wiser, Tina L. Fiedler, Sean Proll, Michael C. Wu, Jeanne M. Marrazzo
Summary: This study found that the presence or concentrations of BV-associated bacteria in the mouth, anus, labia, and vagina can predict whether women will develop BV in the future.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Obstetrics & Gynecology
Jacques Ravel, Inmaculada Moreno, Carlos Simon
Summary: Bacterial vaginosis, pelvic inflammatory disease, and endometritis can lead to infertility due to factors such as inflammation, immune response, bacterial toxins, and increased risk of sexually transmitted infections. Diagnosing and treating these conditions before attempting conception may improve outcomes of natural and assisted reproduction for symptomatic women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Review
Immunology
Xiaodi Chen, Yune Lu, Tao Chen, Rongguo Li
Summary: The vaginal microbiome is crucial for women's health, with bacterial vaginosis (BV) associated with various adverse gynecologic and obstetric outcomes. Research on diagnosis and treatment strategies for BV is making progress.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Petru Chitulea, Rares Gherai, Cristian Cheta, Tania Marin Negru
Summary: This study demonstrates that vaginal administration of alpha-glyco-oligosaccharides, xylitol, and hyaluronic acid can effectively control symptoms and pathogenic microbial load in vaginal infections, as well as restore a healthy lactobacilli flora.
Article
Biochemistry & Molecular Biology
Reena Nayak, Jitu Halder, Tushar Kanti Rajwar, Deepak Pradhan, Vineet Kumar Rai, Debasmita Dubey, Biswakanth Kar, Goutam Ghosh, Goutam Rath
Summary: In this study, Metronidazole (MTZ)-loaded chitosan nanoparticles (MCSNP) were synthesized using phytic acid (PA) as a crosslinking agent to treat bacterial vaginosis. The optimized formulation showed enhanced efficacy against bacteria and could serve as a potential topical alternative for treating bacterial vaginosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Immunology
Xin Shen, Lin Xu, Zhiquan Zhang, Yitong Yang, Pengxian Li, Teng Ma, Shuai Guo, Lai-Yu Kwok, Zhihong Sun
Summary: Vaginitis is a common gynecological disease caused by vaginal dysbiosis. Clinical treatment using antibiotics often results in adverse reactions and relapse, while probiotics intervention can restore vaginal microbiota and alleviate bacterial vaginitis (BV). In this study, a clinical trial involving 50 BV patients was conducted to evaluate the efficacy of a postbiotic gel applied for one week. The results showed that the postbiotic gel improved symptoms of BV and increased the abundance of vaginal lactobacilli, which were negatively correlated with potential vaginal pathogens and abnormal vaginal secretions. Overall, this study provides valuable clinical data for managing BV.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Soo-Im Choi, GaYeong Won, YongGyeong Kim, Chang-Ho Kang, Gun-Hee Kim
Summary: This study investigated the effects of a mixture of five lactobacilli strains on bacterial vaginitis (BV) in HeLa cells and GV-infected BV mice. The findings suggest that this mixture can inhibit the growth of GV, reduce inflammation, and suppress the exfoliation of vaginal epithelial cells.
Article
Pharmacology & Pharmacy
Margaret O. Ilomuanya, Peace O. Bassey, Deborah A. Ogundemuren, Uloma N. Ubani-Ukoma, Alkiviadis Tsamis, Yuwei Fan, Konstantinos Michalakis, Pavimol Angsantikul, Abdulrahman Usman, Andrew N. Amenaghawon
Summary: This study aimed to develop a novel mucoadhesive polyvinyl alcohol and polycaprolactone electrospun nanofibrous scaffolds for vaginal delivery, incorporating metronidazole, a tenside, and Lactobacilli. The electrospun scaffolds provide a new tool for the treatment and management of recurrent bacterial vaginosis.
Article
Microbiology
Wen-Chun Lin, Yun-Ru Chen, Chi-Mu Chuang, Jyh-Yih Chen
Summary: This study found that the Nile tilapia Piscidin 4 (TP4) has broad-spectrum antimicrobial and antibiofilm activity against bacterial vaginosis (BV)-associated bacteria, without affecting beneficial lactobacilli. The combination of TP4 peptide, disodium EDTA, and chitosan can eradicate biofilms formed by Gardnerella vaginalis and Streptococcus anginosus. The TP4 microbicide formulation shows promise as a topical agent for BV treatment.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Rodman Turpin, Susan Tuddenham, Xin He, Mark A. Klebanoff, Khalil G. Ghanem, Rebecca M. Brotman
Summary: The study found associations between bacterial vaginosis (BV), behaviors like vaginal douching, and incident pelvic inflammatory disease (PID) in a large cohort of cisgender women. Further larger studies are needed to understand how BV, sexually transmitted infections (STIs), behaviors, and host responses interactively affect PID risk.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Farnaz Minooei, Nicole M. Gilbert, Longyun Zhang, Mary Sarah Necamp, Mohamed Y. Mahmoud, Anthony J. Kyser, Kevin M. Tyo, Walter H. Watson, Ruta Patwardhan, Warren G. Lewis, Hermann B. Frieboes, Amanda L. Lewis, Jill M. Steinbach-Rankins
Summary: This study developed a rapid-dissolving electrospun polyethylene oxide (PEO) fibers for the delivery of antibiotic metronidazole or probiotic Lactobacillus acidophilus. The fibers effectively prevented and treated Gardnerella infections and inhibited the growth of bacterial co-cultures and vaginal epithelial cells. The study demonstrated the successful platform for intra-vaginal antibiotic or probiotic delivery using rapid-dissolving electrospun fibers.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Alevtina M. Savicheva, Anna A. Krysanova, Olga V. Budilovskaya, Elena V. Spasibova, Tatiana A. Khusnutdinova, Kira V. Shalepo, Natalia R. Beliaeva, Galina Kh. Safarian, Kirill V. Sapozhnikov, Natalya I. Tapilskaya, Igor Yu. Kogan
Summary: Multiplex real-time PCR test can effectively evaluate the microbial composition and dominant lactobacilli species in women with bacterial vaginosis, and has high sensitivity and specificity for diagnosing the condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)