Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 66, Issue 5, Pages 404-409Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0897.2011.01031.x
Keywords
Antiphospholipid antibodies; anti-prothrombin antibodies; fetal death; placental abruption; pre-eclampsia; pregnancy outcome
Categories
Funding
- Regione Piemonte, Settore Igiene e Sanita Pubblica [15025/2701]
Ask authors/readers for more resources
Problem Women with antiphospholipid antibodies (aPL) such as lupus anticoagulant, anticardiolipin antibodies, and anti-beta(2) glycoprotein-1 antibodies are at high risk of late pregnancy complications, such as severe pre-eclampsia, placental insufficiency, and fetal loss. It has been observed that aPL consists of a heterogeneous group of antibodies targeting several phospholipid-binding plasma proteins, including also antiprothrombin (anti-PT), anti-protein S (anti-PS), and anti-protein C (anti-PC) antibodies. Their potential role in late pregnancy complications is not known. The aim of this work was to investigate the association between those autoantibodies and histories for adverse pregnancy outcome. Method of study Anti-PT, anti-PS, and anti-PC antibodies were evaluated in 163 patients with previous severe pre-eclampsia, fetal death, and/or placental abruption and in as many women with previous uneventful pregnancies, negative for aPL. Results The prevalence of anti-PT antibodies was higher in cases than in controls (OR, 95% CI: 10.92, 4.52-26.38). The highest prevalence was observed in subjects with fetal death. Conclusion Anti-PT antibodies appear to be associated with adverse pregnancy outcome, irrespectively of aPL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available