Article
Obstetrics & Gynecology
Riddhi Thaker, Hina Oza, Vinita Verma, Mansi Gor, Sunil Kumar
Summary: This study explored the role of cytokines IL-6 and IL-10 in cases of spontaneous abortion, finding a positive correlation between IL-6 and the number of SAb cases, and a negative correlation with IL-10. The results suggest a beneficial role for IL-10 and detrimental role for IL-6 on pregnancy outcomes. Additional data is needed to confirm these findings.
REPRODUCTIVE SCIENCES
(2021)
Article
Oncology
Gang Liu, Xiang-Ting Chen, Hao Zhang, Xin Chen
Summary: This study investigated the relationship between changes in peripheral blood VEGF, IL-5, IL-6, IL-8, and IL-17 concentrations in breast cancer patients and their significance in breast cancer staging and invasive metastasis. The results showed that IL-6, IL-17, and VEGF were strongly associated with breast cancer development and could be used as reference indicators for diagnosis and postoperative follow-up.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tyler Barker, Vanessa T. Henriksen, Victoria E. Rogers, Roy H. Trawick, Nathan G. Momberger, G. Lynn Rasmussen
Summary: The study found that taking a multi-vitamin with mineral supplement before total knee arthroplasty (TKA) surgery can significantly reduce the post-operative increase in interleukin ratio, but does not alleviate the rise in IL-6 and hsCRP levels. More research is needed to confirm or refute these findings.
Review
Pharmacology & Pharmacy
Morry Silberstein
Summary: Vitamin D may be more effective than IL-6 antagonists like tocilizumab in treating COVID-19, as it modulates IL-6 immune responses and potentially reduces pro-inflammatory effects. Current studies indicate a positive therapeutic effect of Vitamin D in COVID-19 patients, providing a strong rationale for its use.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hyejung Jo, Dahae Lee, Cheolhyeon Go, Yoojin Jang, Naghyung Chu, Suhyun Bae, Dongmin Kang, Jong Pil Im, Yejin Kim, Jae Seung Kang
Summary: This study examined the influence of vitamin C on the development and progression of inflammatory bowel disease (IBD). The results suggest that vitamin C insufficiency can lead to severe colitis and can also play a preventive role by regulating the production of cytokines and the induction of inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Huakai Wang, Longxian Li, Nan Zhang, Yongxi Ma
Summary: The study found that VK2 promotes osteogenic differentiation by modulating the Bcl-6/STAT axis and IL-6/JAK/STAT signaling pathway, increasing alkaline phosphatase activity and related protein levels, and influencing the expression of associated genes.
Article
Genetics & Heredity
Lin Zhao, Li Han, Guozhen Hei, Ran Wei, Zhen Zhang, Xiaoxiao Zhu, Qiang Guo, Chu Chu, Xiaoxiao Fu, Ke Xu, Xia Li
Summary: Unexplained recurrent spontaneous abortion (URSA) is a common condition that significantly affects women's reproductive health. This study demonstrates that downregulated miR-374c-5p is involved in the pathogenesis of URSA by enhancing IL-6 expression, suggesting that modulation of miR-374c-5p expression may be a potential therapeutic target for URSA.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Editorial Material
Immunology
Travis E. Faust, Dorothy P. Schafer
Summary: The study reveals that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Review
Rheumatology
Desh Nepal, David Gazeley
Summary: This narrative review examines the role of IL-6 in murine and human SLE, and its potential use as a targeted therapy in future studies. Currently, there are no registered clinical trials assessing IL-6 inhibition in SLE.
Article
Biochemistry & Molecular Biology
Yongbo Zhao, Jiani Sun, Liping Jin
Summary: The study reveals the important role of N6-methyladenosine regulators in stromal cell-immune cell interactions. The overexpression of the eraser gene ALKBH5 leads to the hyposecretion of VEGF, which impairs macrophage recruitment and M2 differentiation, potentially causing recurrent spontaneous abortion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chun-Te Wu, Yun-Ching Huang, Wen-Cheng Chen, Miao-Fen Chen
Summary: IL-6 plays a critical role in the radiation response of prostate cancer, with IL-6 positivity predicting biochemical failure-free survival in PCa patients. Inhibition of IL-6 increases tumor sensitivity to radiation, while calcitriol supplementation suppresses IL-6 signaling and enhances radiation response.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Noorwati Sutandyo, Della Manik Worowerdi Cintakaweni, Lyana Setiawan, Ririn Hariani, Nani Utami
Summary: This study aimed to investigate the association of interleukin-6 (IL-6) and vitamin D levels with cachexia in cancer patients, as well as the relationship between body composition profile and cachexia, IL-6, and vitamin D levels. The results showed that cancer patients with cachexia had higher IL-6 levels, while no association was found between cachexia and vitamin D levels. Patients with cachexia had lower body composition components. Vitamin D levels were positively correlated with muscle mass, visceral fat, and handgrip strength, while no association between IL-6 and body composition was found.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Joel Corin, Amanda Carlsson, Bjorn Peters
Summary: This article presents a rare coexistence of granulomatosis with polyangiitis and myxomas, along with the first verified case. It also explores and discusses two possible risk factors (VEGF and IL-6) for developing myxomas.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Immunology
Joanna Kaminska, Violetta Dymicka-Piekarska, Robert Chrzanowski, Karol Sawicki, Anna J. Milewska, Justyna Zinczuk, Marzena Tylicka, Marek Jadeszko, Zenon Mariak, Ewa M. Kratz, Joanna Matowicka-Karna, Johannes Kornhuber, Piotr Lewczuk, Olga M. Koper-Lenkiewicz
Summary: Research has shown that in patients with un-ruptured brain aneurysms, both the IL-6 Quotient and CSF IL-6 concentration are significantly higher, especially in those with multiple aneurysms. This indicates that IL-6 may serve as a biomarker for UIA formation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, General & Internal
Nan Zhu, Haochen Guan, Xuan Wang, Yueyue Zhang, Lijie Gu, Jieshuang Jia, Ling Wang, Weijie Yuan
Summary: This study found that EZH2 plays a crucial role in IL-6/sIL-6R signaling by epigenetically regulating SP4 expression, thereby promoting VEGF production and angiogenesis in PD. Targeting EZH2 may be a novel therapeutic approach for ESRD patients undergoing PD treatment.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
