Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 66, Issue -, Pages 63-71Publisher
WILEY
DOI: 10.1111/j.1600-0897.2011.01034.x
Keywords
Infection; inflammation; ovary; toll-like receptor; uterus
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Funding
- Biotechnology and Biological Sciences Research Council [BB/F005121/1, BB/I017240/1]
- BBSRC [BB/F005121/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I017240/1, BB/F005121/1] Funding Source: researchfish
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Problem Microbial infections of the upper female genital tract perturb the function of the endometrium and ovary. Defense of these tissues is predominantly dependent on innate immunity. This review gives a perspective on innate immunity in the non-pregnant upper female genital tract of women. Method of study Literature review of innate immunity in the human endometrium and ovary. Results The endometrium is defended against microbes by physical barriers, antimicrobial peptides, complement, Toll-like receptors (TLRs), and other pattern recognition receptors. Endometrial epithelial and stromal cells express TLRs, which sense pathogen-associated molecular patterns (PAMPs), leading to an inflammatory response with the influx of neutrophils and macrophages. Innate immunity in the endometrium is regulated by steroids, eicosanoids, and cytokines. Granulosa cells also express TLRs and respond to PAMPs. Conclusion Pattern recognition receptors have roles in endometrial and ovarian inflammation, and innate immunity is central to the defense of the endometrium against pathogens.
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