Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 64, Issue 1, Pages 4-11Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0897.2010.00812.x
Keywords
Decidua; inflammation; miscarriage; Th17
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [17390447, 18591797]
- Ministry of Health, Labour, and Welfare [H20-kodomo-ippan-002]
- Grants-in-Aid for Scientific Research [17390447, 18591797] Funding Source: KAKEN
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Problem Th17 cells, a new subset of helper T cells, have been focused on as a producer pro-inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion. Method of study IL-17 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry. Results IL-17+ cells were accumulated in decidua and were detected in decidual CD4+ T cells and few decidual CD8+ T cells in spontaneous abortion cases. The number of decidual IL-17+ cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases (P < 0.05). On the other hand, there were no significant differences in the numbers of decidual IL-17+ cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL-17+ cells was positively correlated with the number of neutrophils in spontaneous abortion cases. Conclusion IL-17+ cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.
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