Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zhanying Wu, Biao Li, Kaiwei Yu, Nana Zheng, Feifei Yuan, Jingjing Miao, Meijia Zhang, Zhijuan Wang
Summary: Porcine spermatozoa are stored in the oviductal isthmus after natural mating, and the number of spermatozoa is increased in the oviductal ampulla when the mature cumulus-oocyte complexes (COCs) are transferred into the ampulla. The study found that natriuretic peptide type C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2) play a role in sperm release from oviduct istsmic cells. The mature COCs promote NPPC expression in the ampulla through TGF-beta signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Bing Wang, Xiaohua Wang, Yixin Dong, Xiaohui Liu, Liming Xu, Yong Liu, Yan Wu, Chuntao Wang, Haifeng Liu
Summary: This study identified a novel tT beta RII variant Z-tT ss RII that interacts with TGF-beta 1, showing high targeting ability towards TGF-beta 1-activated cells and fibrotic kidneys, and exhibiting strong anti-renal fibrosis activity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Medicine, Research & Experimental
Wanangkan Poolsri, Rattikarn Noitem, Promsuk Jutabha, Manasanan Raveesunthornkiat, Ade Danova, Warinthorn Chavasiri, Chatchai Muanprasat
Summary: This study identified a novel anti-fibrotic agent, AD-021, which effectively reduced collagen accumulation in renal proximal tubule epithelial cells (RPTEC) by inhibiting the TGF-beta 1 pathway. AD-021 suppressed TGF-beta 1-induced collagen production and activation of pro-fibrotic proteins, and ameliorated mitochondrial fission in RPTEC cells. In a mouse model of renal fibrosis, AD-021 reduced plasma TGF-beta 1, improved renal fibrosis, and enhanced renal function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Review
Medicine, Research & Experimental
Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K. Mainigi
Summary: Atrial fibrillation is a common clinically significant arrhythmia with four fundamental pathophysiological mechanisms, with TGF-beta playing a key role. Studies have shown that TGF-beta 1 is involved in the development and propagation of atrial fibrillation.
Article
Immunology
Ha-Yeon Song, Fengjia Chen, Hae Ran Park, Jeong Moo Han, Hyun Jung Ji, Eui-Baek Byun, Yeongkag Kwon, Min-Kyu Kim, Ki Bum Ahn, Ho Seong Seo
Summary: Low-dose radiation therapy (LDRT) can effectively reduce the severity of coronavirus disease (COVID-19) and other cases of viral pneumonia. In this study, the molecular mechanism underlying immunological alterations in influenza pneumonia after LDRT was investigated.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Meng-Yan Wang, Wen-Juan Liu, Le-Yi Wu, Gang Wang, Cheng-Lin Zhang, Jie Liu
Summary: This article provides a comprehensive review of the research progress in TGF-beta 2, highlighting its role in various biological processes and its association with diseases related to dysregulation of its signaling.
Review
Biochemistry & Molecular Biology
Jinwook Chung, Md Nazmul Huda, Yoonhwa Shin, Sunhee Han, Salima Akter, Insug Kang, Joohun Ha, Wonchae Choe, Tae Gyu Choi, Sung Soo Kim
Summary: The interaction between reactive oxygen species (ROS) and transforming growth factor-beta (TGF-beta) signaling pathway plays a critical role in tumor development and progression. While ROS can influence TGF-beta signaling, the TGF-beta pathway can regulate ROS production, leading to a complex relationship between the two in cancer cells. Understanding this crosstalk may provide new insights and potential approaches in cancer biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xuanyan Cai, Huiyan Zha, Zhaoxu Yang, Yiwen Du, Xiaoyang Dai, Bo Yang, Jiajia Wang, Qiaojun He, Qinjie Weng
Summary: In this study, the relationship between TGF-beta 1 polymorphisms and susceptibility to chronic liver disease (CLD) was systematically analyzed using 35 eligible studies. The findings indicate that certain TGF-beta 1 gene variations are associated with an increased risk of CLD. Additionally, TGF-beta 1 gene expression is significantly elevated in CLD patients, and a TGF-beta 1 codon 263 variant may affect the secretion of TGF-beta 1 by altering its dimerization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beatriz Ballester, Javier Milara, Paula Montero, Julio Cortijo
Summary: The study reveals the overexpression of MUC16 in lung tissue of IPF patients and its collaboration with the TGF-beta 1 pathway to induce fibrotic processes. Repression of MUC16 expression can inhibit fibrotic processes, suggesting that targeting MUC16 may be a potential drug target for human IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Liubin Yang, Jinping Cai, Li Rong, Sendong Yang, Shijun Li
Summary: This study investigated the development regulation of the uterine-vaginal junction (UVJ) epithelial folds in female birds and its crucial role in sperm storage and fertilization. The study classified the development of UVJ folds into 4 stages based on morphological characteristics. RNA-seq analysis identified different stages of regulation and genes involved in cell proliferation, differentiation, polarity, migration, adhesion, and junction during UVJ fold formation. The study also found significant differences between different cell types within UVJ, and highlighted the importance of genes in the TGF-beta and WNT pathways in regulating epithelium proliferation and differentiation for UVJ fold formation. This research provides new insights into the differential regulation of fertilization traits from a developmental biology perspective.
Article
Oncology
Dieuwke L. Marvin, Vivian M. Spaans, Cor D. De Kroon, Roderick C. Slieker, Maryam Khelil, Peter Ten Dijke, Laila Ritsma, Ekaterina S. Jordanova
Summary: Cervical cancer is the fourth most common cancer in women worldwide, with adenocarcinoma patients having a worse prognosis. The tumor suppressor function of TGF-beta is lost in tumor cells. Analysis of RNA-seq data showed that TGF-beta plays different roles in squamous cell carcinoma and adenocarcinoma. In adenocarcinoma patients, low expression of T beta R2 and SMAD4 was associated with worse survival, while high expression of PAI-1 and alpha v beta 6 was also correlated with worse survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
T. Nii, T. Bungo, N. Isobe, Y. Yoshimura
Article
Immunology
Fika Yuliza Purba, Jo Ueda, Takahiro Nii, Yukinori Yoshimura, Naoki Isobe
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
T. Terada, T. Nii, N. Isobe, Y. Yoshimura
Article
Agriculture, Dairy & Animal Science
Masahiro Shimizu, Takahiro Nii, Naoki Isobe, Yukinori Yoshimura
Article
Agriculture, Dairy & Animal Science
Fika Yuliza Purba, Takahiro Nii, Yukinori Yoshimura, Naoki Isobe
REPRODUCTION IN DOMESTIC ANIMALS
(2020)
Article
Physiology
Takahiro Nii, Takashi Bungo, Naoki Isobe, Yukinori Yoshimura
Summary: The oral administration of a lower dose of DSS caused slight disruptions in the intestinal environment, resulting in poor intestinal morphology and decreased cecal microbiome diversity. This led to a decrease in egg yolk size but did not reduce the supply of VLDLy from the liver. The reduction in egg yolk size was likely due to dysfunction in the uptake of egg-yolk precursors in ovarian follicles.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Yukinori Yoshimura, Hiroya Kondo, Kyota Takamatsu, Yusaku Tsugami, Takahiro Nii, Naoki Isobe
Summary: This study aimed to investigate the response of the innate immune system in the proventriculus of broiler chicks to lipopolysaccharide (LPS) and how this response is influenced by Newcastle disease and infectious bronchitis (ND/IB) vaccination. The results showed that LPS derived from gram-negative bacteria can upregulate the innate immune system in the proventriculus, including the synthesis of antimicrobial peptides. ND/IB vaccination may not significantly affect antimicrobial peptide synthesis in response to LPS, but it can upregulate Toll-like receptor 21 expression.
Article
Agriculture, Dairy & Animal Science
T. Nii, T. Shinkoda, N. Isobe, Y. Yoshimura
Summary: This study aimed to investigate the effects of vaginal administration of Lactobacillus johnsonii on the mucosal barrier function of the oviduct. The results showed that vaginal administration of L. johnsonii improved the oviductal mucosa microbiota, enhanced the mucosal barrier function, and increased the ratio of beneficial bacteria while decreasing the ratio of pathogenic bacteria.
Article
Reproductive Biology
M. Elhamouly, T. Nii, N. Isobe, Y. Yoshimura
Summary: This study aimed to identify the cause for inferior quality egg production of aged hens by investigating the aging-associated molecular changes related to eggshell formation and determining the role of nitric oxide in decreasing egg quality. The results showed that molecular changes in the uterine mucosa affect eggshell membrane formation and eggshell biomineralization, while nitric oxide overproduction may play a role in this dysfunction.
Article
Agriculture, Dairy & Animal Science
Naoki Suzuki, Fika Yuliza Purba, Yoshiaki Hayashi, Takahiro Nii, Yukinori Yoshimura, Naoki Isobe
ANIMAL SCIENCE JOURNAL
(2020)
Article
Agriculture, Dairy & Animal Science
Naoki Isobe, Shoko Matsukawa, Kota Kubo, Kazutoshi Ueno, Toshihisa Sugino, Takahiro Nii, Yukinori Yoshimura
ANIMAL SCIENCE JOURNAL
(2020)
Article
Agriculture, Dairy & Animal Science
Takumi Terada, Takahiro Nii, Naoki Isobe, Yukinori Yoshimura
JOURNAL OF POULTRY SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Takahiro Nii, Haruna Kakuya, Naoki Isobe, Yukinori Yoshimura
JOURNAL OF POULTRY SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Takahiro Nii, Jirapat Jirapat, Naoki Isobe, Yukinori Yoshimura
JOURNAL OF POULTRY SCIENCE
(2020)
Article
Agriculture, Dairy & Animal Science
Takumi Terada, Takahiro Nii, Naoki Isobe, Yukinori Yoshimura
JOURNAL OF POULTRY SCIENCE
(2020)
