Review
Endocrinology & Metabolism
Manuel S. Vidal, Ryan C. V. Lintao, Mary Elise L. Severino, Ourlad Alzeus G. Tantengco, Ramkumar Menon
Summary: Survivors of preterm birth face various disabilities, and addressing the rates of low birth weight, neonatal and maternal morbidities and mortalities is crucial. Research has provided theories on risk factors and clinical manifestations, but there is a lack of biomarkers for early diagnosis. To overcome current limitations, an integrated approach studying the network interaction between different tissues and organs is needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nursing
Susana Eulalia Duenas Matute, Carmen Amelia Salvador Pinos, Stephanie Michelena Tupiza, Marisa Afonso Andrade Brunherotti, Edson Zangiacomi Martinez
Summary: This study investigates the factors associated with premature birth and low birth weight in an Ecuadorian tertiary hospital. The findings show a higher proportion of low birth weight and preterm births compared to studies conducted in Latin America. Younger mothers, illiterate mothers, and those with gestational hypertension are more likely to have low birth weight newborns, while older mothers are more likely to have large-for-gestational-age infants. Maternal obesity and gestational diabetes are also associated with an increased percentage of large-for-gestational-age births.
Article
Reproductive Biology
Hossam El-Sheikh Ali, Kirsten Scoggin, Harutaka Murase, Jamie Norris, Bruno Menarim, Pouya Dini, Barry Ball
Summary: This study aimed to characterize the transcriptome of equine chorioallantois during spontaneous labor and compare it with that of normal preterm chorioallantois. The results showed differential gene expression between labor and preterm, with upregulation of proinflammatory mediators and matrix metalloproteinases, and downregulation of collagens. This study provides insights into the molecular mechanisms underlying labor in horses.
BIOLOGY OF REPRODUCTION
(2022)
Article
Reproductive Biology
Nardhy Gomez-Lopez, Roberto Romero, Jose Galaz, Gaurav Bhatti, Bogdan Done, Derek Miller, Corina Ghita, Kenichiro Motomura, Marcelo Farias-Jofre, Eunjung Jung, Roger Pique-Regi, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Adi L. Tarca
Summary: By analyzing the transcriptomic data, it was found that women undergoing term labor exhibit labor-specific gene expression changes in their peripheral blood, which correlate with gene changes in the chorioamniotic membranes, myometrium, and cervix, partially overlapping with changes observed in asymptomatic women prior to preterm birth, potentially serving as a tool for assessing labor status and identifying preterm birth risk.
BIOLOGY OF REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Karina Cristina Rouwe de Souza, Thales Philipe Rodrigues da Silva, Ana Kelve de Castro Damasceno, Bruna Figueiredo Manzo, Kleyde Ventura de Souza, Maria Margarida Leitao Filipe, Fernanda Penido Matozinhos
Summary: This study analyzed the coexistence and prevalence of obstetric interventions in maternity hospitals in Belo Horizonte City, as well as investigated sociodemographic and obstetric factors associated with these interventions. The results highlighted two conflicting obstetric profiles, one including beneficial practices and the other including harmful or ineffective practices. The study emphasized the persistence of an obstetric care model not based on scientific evidence.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Reproductive Biology
C. Trachsel, S. Kueker, H. Nathues, A. Grahofer
Summary: The study found correlations between sow traits such as backfat thickness, number and weight of placenta parts, parturition duration, and placenta expulsion duration. The expulsion of the first placenta part was also related to the timing of the last piglet's birth. Additionally, placental efficiency was associated with the number of liveborn piglets.
Article
Agriculture, Dairy & Animal Science
Joanna Jaworska, Katarzyna Ropka-Molik, Katarzyna Piorkowska, Tomasz Szmatola, Ilona Kowalczyk-Zieba, Izabela Woclawek-Potocka, Marta Siemieniuch
Summary: Retained fetal membranes (RFM) in mares is a complex post-partum disease with unclear pathogenesis. This study used RNA sequencing to compare genes expressed in the placenta of mares with RFM and those without, revealing potential pathways involved in apoptosis, inflammation, and extracellular matrix metabolism. Results suggest that further research into these differential gene expressions may help in understanding the pathogenesis of RFM.
Article
Multidisciplinary Sciences
Nicholas R. Spencer, Enkhtuya Radnaa, Tuvshintugs Baljinnyam, Talar Kechichian, Ourlad Alzeus G. Tantengco, Elizabeth Bonney, Ananth Kumar Kammala, Samantha Sheller-Miller, Ramkumar Menon
Summary: This study developed a mouse model of ascending infection and inflammation associated with preterm birth. Clinically, these models can help understand the mechanism of infection-related preterm birth, determine intervention targets, or identify potential biomarkers for predicting high-risk pregnancy status early in pregnancy.
Review
Nutrition & Dietetics
Nikoletta Lis, Demetris Lamnisos, Aikaterini Bograkou-Tzanetakou, Elena Hadjimbei, Irene P. Tzanetakou
Summary: Preterm birth is a global epidemic and factors such as maternal nutrition and placental-infant TL influence the risk of PTB. Maternal nutrition affects PTB risk through its influence on maternal TL. PTB also independently affects TL regulation in offspring. However, the strength of these associations and the influence of other factors remain unclear. Whether maternal TL is simply a biomarker of maternal nutrition status and PTB risk or a causative factor of PTB is yet to be determined.
Article
Immunology
Anya L. Arthurs, Melanie D. Smith, Mhyles D. Hintural, James Breen, Dylan McCullough, Francesca I. Thornton, Shalem Y. Leemaqz, Gustaaf A. Dekker, Tanja Jankovic-Karasoulos, Claire T. Roberts
Summary: Parturition signals the end of immune tolerance in pregnancy. The activation of placental inflammasome differs in terms of mode of delivery and neonatal sex. Assessing placental inflammasome activation may identify babies who have been exposed to aberrant inflammation at birth.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Tusar Giri, Jia Jiang, Zhiqiang Xu, Ronald McCarthy, Carmen M. Halabi, Eric Tycksen, Alison G. Cahill, Sarah K. England, Arvind Palanisamy
Summary: By creating and validating a high-fidelity pregnant rat model, researchers have successfully simulated the process of labor induction with oxytocin and conducted experimental studies on labor-related issues. Their findings suggest that there is no significant oxidative stress in the newborn brain during labor induction with oxytocin.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Maryam Najjarzadeha, Sakineh Mohammad-Alizadeh-Charandabi, Shamsi Abbasalizadeh, Mohammad Asghari-Jafarabadi, Mojgan Mirghafourvand
Summary: This prospective cohort study aimed to determine the technology-free predictors of preterm birth in singleton women with threatened preterm labor. Seven variables were determined as predictors: rupture of membranes, cervical dilation, gravidity, psychological violence during pregnancy, medical problems in pregnancy onset, vaginal bleeding/spotting, and woman age. These factors seem to have moderate power in predicting preterm birth in singleton pregnant women.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Pediatrics
Elisabeth B. Budal, Cathrine Ebbing, Jorg Kessler, Sukhjeet Bains, Olav H. Haugen, Stein M. Aukland, Geir Egil Eide, Thomas Halvorsen, Mariann H. L. Bentsen, Karin Collett
Summary: This study evaluated the role of placental pathology in predicting adverse outcomes for neonates born extremely preterm. The results showed that placental histology provided important information when assessing the risk of adverse neonatal outcomes following EPT birth.
Review
Reproductive Biology
Chandrashekara Kyathanahalli, Madeline Snedden, Emmet Hirsch
Summary: Although inflammation is present during term labor, it may not be the initiating signal. Further research is needed to understand the processes underlying normal labor. Inconsistencies in defining the onset of labor should be addressed.
BIOLOGY OF REPRODUCTION
(2022)
Review
Obstetrics & Gynecology
Longkun Ding, Lu Gao
Summary: Preterm birth is the leading cause of mortality and morbidity in newborns and children under 5. Identifying the specific mechanisms underlying labor initiation, including fetal origin factors, is crucial for improving preterm infant outcomes.
MATERNAL-FETAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Aline R. Lorenzon-Ojea, Hong Wa Yung, Graham J. Burton, Estela Bevilacqua
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Obstetrics & Gynecology
Geovane R. Santos, Clovis A. L. Pinto, Raphael C. S. Prudente, Estela M. A. F. Bevilacqua, Steven S. Witkin, Saulo D. Passos, A. F. Moron, D. F. Ventura, E. Massad, P. M. A. Zanotto, L. C. Rodrigues, A. P. A. P. Bertozzi, A. P. Grion, A. C. Mingotti, A. C. B. Silva, C. M. G. Martins, E. R. Barreira, D. T. Fujiwara, F. M. S. Souza, F. G. Velasco, F. Cangerana, F. N. Arita, F. D. M. Hernandez, H. S. Tabares, H. J. F. Milani, M. M. S. C. Sampaio, M. B. Machado, M. M. A. Silva, M. M. D. Rodrigues, M. F. Almeida, M. F. Rizzo, F. M. Damico, N. S. Clemente, M. P. Cunha, R. Izbicki, R. E. Gazeta, R. C. A. B. Dezena, S. H. A. Bonom, S. Z. Pour, S. Uranjec, S. Rosemberg, S. M. R. Oyama, S. G. P. Sarmento, T. M. Quintella, T. C. G. Fajardo, T. R. G. Ferrareto, W. M. Rodrigues, L. Baran, A. P. Soares, M. Costa, M. T. S. Barboni, Ds Lima, V. C. R. M. Franca, K. S. Vidal, A. R. Barbosa, G. U. Zanquetta, A. B. Silva
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2020)
Review
Obstetrics & Gynecology
Indiomara Baratto, Silvia Daher, Thalita Frutuoso Lobo, Edward Araujo Junior, Cristina Aparecida Falbo Guazzelli
Summary: During pregnancy in adolescents, there are significant changes in serum levels of adiponectin and leptin, which are associated with gestational age progression.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Review
Immunology
Thiago P. B. De Luccia, Karen P. T. Pendeloski, Erika Ono, Rosiane Mattar, David B. S. Pares, Sue Sun, Silvia Daher
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Microbiology
Fernanda C. da Silva, Fernanda M. Magaldi, Helena K. Sato, Estela Bevilacqua
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Aramys S. Reis, Renato Barboza, Oscar Murillo, Andre Barateiro, Erika P. M. Peixoto, Flavia A. Lima, Vinicius M. Gomes, Jamille G. Dombrowski, Vinicius N. C. Leal, Franciele Araujo, Carla L. Bandeira, Rosana B. D. Araujo, Rita Neres, Rodrigo M. Souza, Fabio T. M. Costa, Alessandra Pontillo, Estela Bevilacqua, Carsten Wrenger, Gerhard Wunderlich, Giuseppe Palmisano, Leticia Labriola, Karina R. Bortoluci, Carlos Penha-Goncalves, Ligia A. Goncalves, Sabrina Epiphanio, Claudio R. F. Marinho
Article
Pharmacology & Pharmacy
Aline R. Lorenzon, Jusciele Brogin Moreli, Rafaela de Macedo Melo, Felipe Yukio Namba, Anne Cathrine Staff, Hong Wa Yung, Graham J. Burton, Estela Bevilacqua
Summary: The study explored the relationship between SDF2 expression and ER response in placental cells exposed to hyperglycaemia, with findings indicating an increase in SDF2 expression in GDM placentae treated with diet but not with insulin therapy. Furthermore, high glucose reduced SDF2 expression in BeWo cells, while insulin treatment reversed the increase in ER stress factors CHOP and sXBP1 induced by high glucose. These results highlight the importance of insulin in mitigating ER stress in placental cells under hyperglycaemic conditions.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Daniella S. Battagello, Aline R. Lorenzon, Giovanne B. Diniz, Livia C. Motta-Teixeira, Marianne O. Klein, Jozelia G. P. Ferreira, Carlos M. Arias, Antoine Adamantidis, Luciane Sita, Jose Cipolla-Neto, Estela M. A. F. Bevilacqua, Paul E. Sawchenko, Jackson C. Bittencourt
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Pharmacology & Pharmacy
Andre Tadeu Gotardo, Luciana Lucinio Lippi, Kalan Bastos Violin, Estela Maris Andrade Forell Bevilacqua, Silvana Lima Gorniak
Summary: Ipomoea carnea is a toxic plant containing calystegines and swainsonine, which inhibit key cellular enzymes and cause cell death. This study aimed to determine the teratogenic effects of exposure to I. carnea on fetuses, with results showing deleterious effects on mothers and fetuses, particularly in postnatal evaluation.
Article
Multidisciplinary Sciences
Ana Carolina Lima Ralph, Iuri Cordeiro Valadao, Elaine Cristina Cardoso, Vilma Regina Martins, Luanda Mara Silva Oliveira, Estela Maris Andrade Forell Bevilacqua, Murilo Vieira Geraldo, Ruy Gastaldoni Jaeger, Gary S. Goldberg, Vanessa Morais Freitas
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Livia Rosa-Fernandes, Carla Bandeira, Shahab Zaki Pour, Viviane de Fatima Benedetti, Daniel Ferreira, Aline R. Lorenzon, Jusciele B. Moreli, Claudio Romero Farias Marinho, Martin R. Larsen, Paolo Zanotto, Giuseppe Palmisano, Estela Bevilacqua
Summary: The study utilized quantitative proteomics analysis to investigate the impact of ZIKV infection on placental cells, revealing altered levels of proteins involved in cell proliferation, apoptosis, and inflammatory processes. The findings suggest that antibody-opsonized ZIKV particles may play a pivotal role in determining infection outcomes and the role of mixed infections, providing valuable insights for infection control strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Physiology
Karla R. Castro, Karen M. Prado, Aline R. Lorenzon, Mara S. Hoshida, Eliane A. Alves, Rossana P. V. Francisco, Marcelo Zugaib, Aldilane L. X. Marques, Elaine C. O. Silva, Eduardo J. S. Fonseca, Alexandre U. Borbely, Mariana M. Veras, Estela Bevilacqua
Summary: This study found that serum factors in pregnant women with preeclampsia may impact placental morphology, viability, and secreted functional factors, while triggering endoplasmic reticulum stress and unfolded protein responses. The study also revealed molecular differences between preeclampsia and control groups.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Rodrigo Barbano Weingrill, Sandra Luft Paladino, Matheus Leite Ramos Souza, Eduardo Manoel Pereira, Aldilane Lays Xavier Marques, Elaine Cristina Oliveira Silva, Eduardo Jorge da Silva Fonseca, Jeferson Santana Ursulino, Thiago Mendonca Aquino, Estela Bevilacqua, Johann Urschitz, Jean Carl Silva, Alexandre Urban Borbely
Summary: In this study, an analysis of exosome-enriched maternal plasma showed potential for early diagnosis of hypertensive disorders of pregnancy (HDP) using Raman spectroscopy and proton nuclear magnetic resonance metabolomics. Significant differences in metabolite levels were found in HDP patients, as indicated by Raman bands intensity and H-1 NMR analysis results. The study suggested that analyzing exosome-enriched plasma could be useful for assessing placental function and identifying early biomarkers for HDP.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Fabio Roberto Cabar, Pedro Paulo Pereira, Carla Leticia Bandeira, Estela Bevilacqua, Regina Schultz, Rossana Pulcineli Vieira Francisco
Summary: This study evaluated the relationship between the expression of CRIPTO-1 and the degree of trophoblast invasion into the tubal wall. The results showed that the quantitative expression of CRIPTO-1 differed in different degrees of trophoblast invasion. Deeper invasion was associated with stronger expression of CRIPTO-1.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Jusciele Brogin Moreli, Mayk Ricardo dos Santos, Iracema de Mattos Paranhos Calderon, Cristina Bichels Hebeda, Sandra Helena Poliselli Farsky, Estela Bevilacqua, Sonia Maria Oliani
Summary: The role of ANXA1 in protecting against DNA damage in the nucleus is investigated in placental cells of ANXA1 knockout mice and pregnant women with gestational diabetes mellitus. The results show increased DNA damage and impaired function in the absence of ANXA1, suggesting its involvement in the DNA damage response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
