Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 59, Issue 4, Pages 347-351Publisher
WILEY
DOI: 10.1111/j.1600-0897.2007.00577.x
Keywords
IL-6; intrauterine fetal death; pre-eclampsia; pre-term delivery; small for gestational age
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Problem To investigate the frequency of the interleukin-6 (IL-6) -174 G/C single nucleotide polymorphism (SNP) in women with intrauterine fetal death (IUFD), pre-eclampsia (PE), preterm delivery (PD), and small for gestational age (SGA) infants. Method of study In a prospective cohort study, DNA from 1626 consecutive pregnant women was analyzed for IL-6 -174 G/C. Women who developed at least one of the predefined pregnancy complications were used as cases and compared with women without pregnancy complications. Results Of 1626 women, 259 (15.9%) developed at least one pregnancy complication. IL-6 -174 G/C allele frequencies and genotype distributions were not significantly different between cases and controls. Similarly, no statistically significant difference in IL-6 -174 G/C genotype distribution in women with IUFD, PE, PD < 34 weeks, PD > 34 weeks and SGA infants < 10th percentile was observed. Conclusion IL-6 -174 G/C is not a genetic marker for identifying women at increased risk of common pregnancy complications.
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